Mark L Siegal


Affiliation: New York University
Country: USA


  1. Geiler Samerotte K, Sartori F, Siegal M. Decanalizing thinking on genetic canalization. Semin Cell Dev Biol. 2018;: pubmed publisher
    ..We conclude by discussing approaches to address these and other open questions that are brought into focus by re-thinking genetic canalization. ..
  2. Bauer C, Li S, Siegal M. Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness. Mol Syst Biol. 2015;11:773 pubmed publisher
    ..While the fitness profile across a range of expression levels is idiosyncratic to each gene, the global pattern indicates that there is a window in which phenotypic variation can be released before fitness effects are observable. ..
  3. Siegal M, Leu J. On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms. Annu Rev Ecol Evol Syst. 2014;45:496-517 pubmed
    ..We conclude that a profitable way forward is to focus investigations (and rhetoric) less on mutational robustness and more on epistasis. ..
  4. Siegal M, Masel J. Hsp90 depletion goes wild. BMC Biol. 2012;10:14 pubmed publisher
    ..Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation. See research article ..
  5. Siegal M. Crouching variation revealed. Mol Ecol. 2013;22:1187-9 pubmed publisher
    ..melanogaster, and that the variation they reveal can be quite subtle. His results advance our understanding of capacitance and contribute to a new view of its role in evolutionary adaptation. ..
  6. Siegal M, Baker B. Functional conservation and divergence of intersex, a gene required for female differentiation in Drosophila melanogaster. Dev Genes Evol. 2005;215:1-12 pubmed publisher
    ..Our results raise the possibility that a functional association between ix- and dsx-related gene products existed before the origin of the bifunctional dsx gene used in insect sex determination...