B Shen

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107
    B Shen
    Department of Cell Biology, Kaplan Cancer Center, and the Raymond and Beverly Sackler Foundation Laboratory, New York University Medical Center, New York, New York, 10016, USA
    Biochem Biophys Res Commun 252:524-8. 1998
  2. pmc The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein
    J Kim
    Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 16:3381-92. 1996
  3. ncbi request reprint Intracellular distribution and late endosomal effects of the ocular albinism type 1 gene product: consequences of disease-causing mutations and implications for melanosome biogenesis
    B Shen
    The Ronald O. Perelman Department of Dermatology and the Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Traffic 2:202-11. 2001
  4. pmc Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
    B Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 98:8596-601. 2001
  5. pmc Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals
    M Arese
    Department of Cell Biology, New York University Medical Center, New York, New York 10016, USA
    Mol Biol Cell 10:1429-44. 1999
  6. ncbi request reprint The ocular albinism type 1 gene product is an N-glycoprotein but glycosylation is not required for its subcellular distribution
    B Shen
    The Ronald O Perelman Department of Dermatology, NYU School of Medicine, New York, New York 10016, USA
    Pigment Cell Res 14:485-90. 2001
  7. ncbi request reprint Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    Y Xu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 408:111-5. 2000
  8. ncbi request reprint Modulation of cell growth and transformation by doxycycline-regulated FGF-2 expression in NIH-3T3 cells
    A Gualandris
    Department of Cell Biology, New York University Medical Center, New York, New York, USA
    J Cell Physiol 181:273-84. 1999
  9. ncbi request reprint Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
    B Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Development 125:4719-28. 1998
  10. ncbi request reprint The mouse ocular albinism 1 gene product is an endolysosomal protein
    P Samaraweera
    The Ronald O Perelman Department of Dermatology, NYU School of Medicine, New York, NY 10016, USA
    Exp Eye Res 72:319-29. 2001

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107
    B Shen
    Department of Cell Biology, Kaplan Cancer Center, and the Raymond and Beverly Sackler Foundation Laboratory, New York University Medical Center, New York, New York, 10016, USA
    Biochem Biophys Res Commun 252:524-8. 1998
    ..This result suggests a possible role of FGF-2 in Tax-mediated HTLV-1 transformation as well as FGF-2 binding to ribosomes and/or their precursors...
  2. pmc The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein
    J Kim
    Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 16:3381-92. 1996
    ..These results imply that SUHW blocks different enhancers and supports oogenesis by the same or closely related molecular mechanisms...
  3. ncbi request reprint Intracellular distribution and late endosomal effects of the ocular albinism type 1 gene product: consequences of disease-causing mutations and implications for melanosome biogenesis
    B Shen
    The Ronald O. Perelman Department of Dermatology and the Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Traffic 2:202-11. 2001
    ..We propose that OA1 is involved in reorganizing the endolysosomal compartment as a necessary step in ocular melanosome biogenesis...
  4. pmc Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
    B Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 98:8596-601. 2001
    ..dTRAF2 thus appears to be a downstream target of Pelle. We discuss these results in the context of Toll signaling in flies and mammals...
  5. pmc Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals
    M Arese
    Department of Cell Biology, New York University Medical Center, New York, New York 10016, USA
    Mol Biol Cell 10:1429-44. 1999
    ..These data indicate the existence of a specific role for nuclear FGF-2 and suggest that LMW FGF-2 represents the biological messenger in both the autocrine/paracrine and intracrine FGF-2 pathways...
  6. ncbi request reprint The ocular albinism type 1 gene product is an N-glycoprotein but glycosylation is not required for its subcellular distribution
    B Shen
    The Ronald O Perelman Department of Dermatology, NYU School of Medicine, New York, New York 10016, USA
    Pigment Cell Res 14:485-90. 2001
    ..Mutation at amino acid 106 that eliminated glycosylation did not affect the endo/lysosomal distribution of the Oa1 protein in either COS cells or cultured murine melanocytes...
  7. ncbi request reprint Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    Y Xu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 408:111-5. 2000
    ....
  8. ncbi request reprint Modulation of cell growth and transformation by doxycycline-regulated FGF-2 expression in NIH-3T3 cells
    A Gualandris
    Department of Cell Biology, New York University Medical Center, New York, New York, USA
    J Cell Physiol 181:273-84. 1999
    ..This doxycycline-regulatable FGF-2 expression system provides a mechanism to analyze changes in FGF-2 targeted pathways and genes and to characterize pathways specifically activated by either the 18-kDa FGF-2 or the HMW FGF-2 isoforms...
  9. ncbi request reprint Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
    B Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Development 125:4719-28. 1998
    ..These and other results allow us to propose a model by which multiple phosphorylation-regulated interactions between these three proteins lead to activation of the Dorsal signaling pathway...
  10. ncbi request reprint The mouse ocular albinism 1 gene product is an endolysosomal protein
    P Samaraweera
    The Ronald O Perelman Department of Dermatology, NYU School of Medicine, New York, NY 10016, USA
    Exp Eye Res 72:319-29. 2001
    ..Considering the microscopic findings in patients with X-linked ocular albinism 1, we speculate that Oa1 may play a role in the trafficking of vesicles to developing melanosomes...
  11. pmc The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae
    J Kim
    Program in Molecular Biology, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York
    Genetics 135:343-55. 1993
    ..These observations indicate that the observed effects of SUHW on gene expression in Drosophila require specific interactions with other factors that are absent or unrecognizable in yeast...
  12. ncbi request reprint Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity
    C Luo
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Insect Mol Biol 10:457-64. 2001
    ..Thus, Tehao, alone or with Toll as a multimeric complex, has the potential to participate in both the development and innate immune responses of Drosophila...
  13. ncbi request reprint Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region
    G Frank
    Department of Cell and Tumor Biology, City of Hope National Medical Center, Duarte, California 91010, USA
    J Biol Chem 276:36295-302. 2001
    ..All of these mutants retained PCNA-driven nuclease activity stimulation. We therefore conclude that stimulation of eukaryotic hFEN-1 nuclease activities by PCNA is independent of its in vitro interaction via the PCNA binding region...
  14. ncbi request reprint A 'Chinese Spring' wheat (Triticum aestivum L.) bacterial artificial chromosome library and its use in the isolation of SSR markers for targeted genome regions
    B Shen
    CSIRO Plant Industry, 306 Carmody Road, St Lucia, Queensland, 4067, Australia
    Theor Appl Genet 111:1489-94. 2005
    ..The potential impacts of these results on marker isolation in wheat and on library screening in general are discussed...
  15. ncbi request reprint Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tü2353
    E R Rafanan
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    J Nat Prod 64:444-9. 2001
    ....
  16. ncbi request reprint Enhanced maturation and functional capacity of dendritic cells induced by mannosylated L2 domain of ErbB2 receptor
    G Zhong
    Institute of Basic Medical Sciences, Beijing, China
    Scand J Immunol 62:108-16. 2005
    ..The mL2 domain of ErbB2 can induce an enhanced maturation and functional capacity of DC. It may become an effective strategy to induce anti-ErbB2 response...
  17. ncbi request reprint Induction of matrix metalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1beta: a potential pathway of disc degeneration
    B Shen
    The Institute of Bone and Joint Research, The University of Sydney Department of Surgery at the Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Eur Spine J 12:66-75. 2003
    ..However, approximately 70% of the MMP-2 was present as the 72 kDa pro-form, which suggests that some additional steps are involved in its activation in vivo...
  18. ncbi request reprint Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin
    C Sanchez
    Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA
    Chem Biol 8:725-38. 2001
    ..However, sequence analysis of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 failed to reveal an associated PPTase gene...
  19. ncbi request reprint [Activation of PKA pathway inhibits reactivity of human myeloma cell line-U266 to IL-6]
    J Song
    Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China
    Zhonghua Zhong Liu Za Zhi 23:278-80. 2001
    ..CONCLUSION: The inhibition of cell growth, mediated by the activation of the PKA pathway, is related to the down-regulated activation of the two IL-6 signal transduction pathways...
  20. pmc Site-directed mutagenesis of Azotobacter vinelandii ferredoxin I: cysteine ligation of the [4Fe-4S] cluster with protein rearrangement is preferred over serine ligation
    B Shen
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA
    Proc Natl Acad Sci U S A 92:10064-8. 1995
    ..In the C20S protein the [4Fe-4S] cluster has altered stability and redox properties relative to either C20A or the native protein...
  21. pmc Novel function of Rad27 (FEN-1) in restricting short-sequence recombination
    M C Negritto
    Department of Molecular Biology, Beckman Research Institute, Duarte, California 91010-0269, USA
    Mol Cell Biol 21:2349-58. 2001
    ..This suggests that the endonuclease activity of Rad27 (FEN-1) plays a role in limiting recombination between short sequences in eukaryotic cells...
  22. ncbi request reprint Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication
    B R Chapados
    Department of Molecular Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Mol Biol 307:541-56. 2001
    ....
  23. ncbi request reprint Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis
    R G Summers
    Department of Bacteriology, University of Wisconsin, Madison 53706, USA
    Biochemistry 34:9389-402. 1995
    ..This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium...
  24. ncbi request reprint XPG protein has a structure-specific endonuclease activity
    K G Cloud
    Life Sciences Division, Los Alamos National Laboratory, NM 87545, USA
    Mutat Res 347:55-60. 1995
    ..XPG protein showed a structure-specific DNA endonuclease activity, and a preferential affinity to single-stranded DNA and RNA compared to double-stranded DNA...
  25. pmc The enhancer-blocking suppressor of Hairy-wing zinc finger protein of Drosophila melanogaster alters DNA structure
    B Shen
    Cornell University Graduate School of Medical Sciences, New York, New York
    Mol Cell Biol 14:5645-52. 1994
    ..The DNA distortion is not sufficient to block enhancers, and therefore it is suggested that increased DNA flexibility may help SUHW interact and interfere with proteins that support long-distance enhancer-promoter interactions...
  26. ncbi request reprint Azotobacter vinelandii ferredoxin I. Alteration of individual surface charges and the [4FE-4S]2+/+ cluster reduction potential
    B Shen
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    J Biol Chem 269:8564-75. 1994
    ..These differences are therefore most likely to be due to differences in solvent accessibility...
  27. ncbi request reprint Azotobacter vinelandii ferredoxin I. Aspartate 15 facilitates proton transfer to the reduced [3Fe-4S] cluster
    B Shen
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    J Biol Chem 268:25928-39. 1993
    ..Overproduction of D15N FdI, but not native FdI, in A. vinelandii has a negative effect on the growth rate of the organism, suggesting that the rate of protonation or deprotonation of the [3Fe-4S]0 cluster may be important in vivo...
  28. ncbi request reprint Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
    B Shen
    Life Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    J Biol Chem 271:9173-6. 1996
    ..Loss of both binding and cleavage competency for the flap substrate by mutants E156A, G231A, and D233A suggests that these amino acids are involved in substrate binding. Mutants R103A and D179A retained wild type-like enzyme activity...
  29. ncbi request reprint Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity
    D J Hosfield
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 95:135-46. 1998
    ..FEN-1 mutations altering PCNA binding should reduce activity during replication, likely causing DNA repeat expansions as seen in some cancers and genetic diseases...
  30. ncbi request reprint Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance
    J Qiu
    Department of Cell and Tumor Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
    J Biol Chem 274:17893-900. 1999
    ..This result indicates a back-up function of exonuclease 1 to flap endonuclease-1 in RNA primer removal during lagging strand DNA synthesis...
  31. pmc Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease
    J Qiu
    Department of Cell and Tumor Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
    Mol Cell Biol 19:8361-71. 1999
    ..Based on our findings, we suggest that three alternative RNA primer removal pathways of different efficiencies involve RNase H(35) and Rad27 nucleases in yeast...
  32. ncbi request reprint Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair
    J Qiu
    Department of Cell and Tumor Biology, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Biol Chem 276:4901-8. 2001
    ..Yeast RAD27Delta cells transformed with human mutant M(krk) survived poorly upon methyl methanesulfonate treatment or when they were incubated at an elevated temperature...
  33. doi request reprint Overexpression, refolding, purification of Erbin PDZ domain from Escherichia coli and preparation of its polyclonal antibody
    H Zhang
    Institute of Basic Medical Sciences, Beijing, P R China
    Prep Biochem Biotechnol 38:282-93. 2008
    ..The polyclonal antibody against this protein was raised. The antibody can recognize both denatured and natural Erbin protein. It will be used to further identify the new binding partners of Erbin and study its unknown functions...