Ellen Shapiro

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint The human prostate expresses sonic hedgehog during fetal development
    Daniel H Barnett
    Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA
    J Urol 168:2206-10. 2002
  2. ncbi request reprint Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Urol 174:1695-8; discussion 1698. 2005
  3. ncbi request reprint Immunolocalization of estrogen receptor alpha and beta in human fetal prostate
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Urol 174:2051-3. 2005
  4. ncbi request reprint The prostatic utricle is not a Müllerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus origin
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York, USA
    J Urol 172:1753-6; discussion 1756. 2004
  5. pmc Bmp7 functions via a polarity mechanism to promote cloacal septation
    Kun Xu
    Department of Urology, School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 7:e29372. 2012
  6. ncbi request reprint Cell-specific regulation of androgen receptor phosphorylation in vivo
    Samir S Taneja
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:40916-24. 2005
  7. pmc Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis
    Lan Mo
    Department of Urology, New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    J Clin Invest 117:314-25. 2007
  8. pmc Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism
    Xinyu Wu
    Department of Urology, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Dev Biol 356:337-49. 2011
  9. pmc Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome
    Hong Ying Huang
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Hum Pathol 38:1703-13. 2007
  10. ncbi request reprint Proximal prostatic stem cells are programmed to regenerate a proximal-distal ductal axis
    Ken Goto
    Department of Cell Biology, MSB 634, NYU School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Stem Cells 24:1859-68. 2006

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The human prostate expresses sonic hedgehog during fetal development
    Daniel H Barnett
    Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA
    J Urol 168:2206-10. 2002
    ..Studies in mice have shown that budding requires the signaling peptide, which is expressed in the epithelium of the prostatic anlagen. We report our characterization of (SHH) expression in the human fetal prostate...
  2. ncbi request reprint Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Urol 174:1695-8; discussion 1698. 2005
    ..Expression and cellular localization of the androgen receptor (AR) and estrogen receptor (ER) isoforms were determined using antibodies specific to these receptors and to specific cell types...
  3. ncbi request reprint Immunolocalization of estrogen receptor alpha and beta in human fetal prostate
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Urol 174:2051-3. 2005
    ..We examined the immunolocalization of estrogen receptor (ER)alpha and ERbeta in the human fetal prostate...
  4. ncbi request reprint The prostatic utricle is not a Müllerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus origin
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York, USA
    J Urol 172:1753-6; discussion 1756. 2004
    ..Others propose that the urogenital sinus (UGS) contributes either partially or totally to the development of this structure. Using immunohistochemical probes, we provide strong evidence that the utricle is of UGS origin only...
  5. pmc Bmp7 functions via a polarity mechanism to promote cloacal septation
    Kun Xu
    Department of Urology, School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 7:e29372. 2012
    ..Defects in cloacal development are very common and present clinically as a rectourethral fistula in about 1 in 5,000 live human births. Yet, the cellular mechanisms of cloacal septation remain poorly understood...
  6. ncbi request reprint Cell-specific regulation of androgen receptor phosphorylation in vivo
    Samir S Taneja
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:40916-24. 2005
    ....
  7. pmc Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis
    Lan Mo
    Department of Urology, New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    J Clin Invest 117:314-25. 2007
    ....
  8. pmc Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism
    Xinyu Wu
    Department of Urology, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Dev Biol 356:337-49. 2011
    ..In addition, we found that both positive and negative modulation of Notch signaling results in abnormal organization of the prostate tissue, and can contribute to prostate disease in the adult organ...
  9. pmc Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome
    Hong Ying Huang
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Hum Pathol 38:1703-13. 2007
    ..Our results also suggest that UP-positive and -negative carcinomas have different clonal origins or may be derived from different cancer stem cells...
  10. ncbi request reprint Proximal prostatic stem cells are programmed to regenerate a proximal-distal ductal axis
    Ken Goto
    Department of Cell Biology, MSB 634, NYU School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Stem Cells 24:1859-68. 2006
    ..Together, these novel findings illustrate features of primitive prostate cells that may have implications for the development of therapies for treating proliferative prostatic diseases...
  11. ncbi request reprint Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation
    Lan Mo
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
    Kidney Int 66:1159-66. 2004
    ..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout model that we recently developed...
  12. ncbi request reprint Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27
    Jerome C Nwachukwu
    Department of Microbiology, 550 First Avenue, New York, New York 10016, USA
    Mol Endocrinol 21:2864-76. 2007
    ....
  13. pmc Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases
    Xiang Tian Kong
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 167:1195-204. 2004
    ..These results highlight the functional importance of uroplakins and establish uroplakin defects as a possible cause of major urinary tract anomalies and death...
  14. ncbi request reprint The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors
    John J Liang
    Department of Pathology, New York University School of Medicine, NY, USA
    J Urol 177:1918-22. 2007
    ..We studied the expression of p44 and protein arginine methyltransferase 5 in developing fetal testis and adult testicular tumors, including seminomas and Leydig cell tumors...
  15. ncbi request reprint Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder
    Jin Cheng
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 63:179-85. 2003
    ..On the basis of our current and previous transgenic studies, we have proposed an integrated pathway progression model of bladder cancer...
  16. pmc Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium
    Xinyu Wu
    Department of Urology, New York University School of Medicine, 423 East 23rd Street 18064 South, New York, NY 10010, USA
    Gene Expr Patterns 9:224-30. 2009
    ..Together, our analysis of Bmp7 expression and the null phenotype, indicates that Bmp7 may play an important role in re-organization of the epithelium during cloacal septation and morphogenesis of the genital tubercle...
  17. pmc LEF1 identifies androgen-independent epithelium in the developing prostate
    Xinyu Wu
    Department of Urology, New York University School of Medicine, 423 East 23rd Street, New York, New York 10010, USA
    Mol Endocrinol 25:1018-26. 2011
    ..We conclude that Wnt/Lef1 activity identifies an androgen-independent population of prostate progenitors, which is important for embryonic development and organ maintenance and regeneration in the adult...
  18. doi request reprint The heterochromatin protein 1 family is regulated in prostate development and cancer
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York, USA
    J Urol 179:2435-9. 2008
    ..To examine the possible role of HP1 proteins in fetal prostate development and prostate cancer the protein expression of HP1alpha, beta and gamma was evaluated in human archival tissue...
  19. ncbi request reprint Expression of androgen receptor associated protein 55 (ARA55) in the developing human fetal prostate
    Guoping Cai
    Departments of Pathology, New York University School of Medicine, New York Harbor Healthcare System, New York, USA
    J Urol 173:2190-3. 2005
    ..We investigated whether ARA55 has a role in human prostate development...
  20. ncbi request reprint Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size
    Tetsuya Takao
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Prostate 54:17-24. 2003
    ..To address this issue, we have used murine prostatic cell lines to establish a novel in vivo model for studying prostatic cell interactions...
  21. ncbi request reprint Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Clin Cancer Res 13:4400-6. 2007
    ..Little is known about the expression of this gene in urothelial carcinoma of the bladder (UCB). We profiled DOC-2/DAB2 expression in mouse and human normal and neoplastic urothelia...
  22. ncbi request reprint The development of the bladder trigone, the center of the anti-reflux mechanism
    Renata Viana
    Columbia University, Department of Urology, 650 West 168th Street, New York, NY 10032, USA
    Development 134:3763-9. 2007
    ..These studies suggest that urinary tract development occurs differently than previously thought, providing new insights into the mechanisms underlying normal and abnormal development...
  23. ncbi request reprint ART-27, an androgen receptor coactivator regulated in prostate development and cancer
    Samir S Taneja
    Departments of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 279:13944-52. 2004
    ....
  24. pmc Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies
    Haiping Zhou
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 33:770-80. 2012
    ....
  25. ncbi request reprint New concepts on the development of the vagina
    Ellen Shapiro
    Department of Urology, 150 East 32nd Street, 2nd Floor, New York, NY 10016, USA
    Adv Exp Med Biol 545:173-85. 2004
  26. pmc A recessive gene for primary vesicoureteral reflux maps to chromosome 12p11-q13
    Patricia L Weng
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Am Soc Nephrol 20:1633-40. 2009
    ..In conclusion, this study identifies a major new locus for pVUR and suggests that in addition to genetic heterogeneity, recessive contributions should be considered in all pVUR genome scans...
  27. ncbi request reprint Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth
    Jin Cheng
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 62:4157-63. 2002
    ....
  28. ncbi request reprint Metanephric adenoma in an 8-year-old child: case report and review of the literature
    John B Amodio
    Department of Radiology, New York University Medical Center, New York, NY 10016, USA
    J Pediatr Surg 40:e25-8. 2005
    ..However, the distinction of MA from other metanephric lesions as well as from Wilms' tumor and papillary renal cell carcinoma may not be readily apparent at the time of surgery...
  29. ncbi request reprint Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity
    Songshan Jiang
    Epithelial Biology Unit, Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, New York, USA
    Kidney Int 66:10-9. 2004
    ..Recent studies indicate that genetic ablation of mouse uroplakin (UP) III gene, which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques, causes VUR and hydronephrosis...
  30. pmc Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
    Akira Tsujimura
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 157:1257-65. 2002
    ..This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation...
  31. doi request reprint Clinical implications of genitourinary embryology
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    Curr Opin Urol 19:427-33. 2009
    ..This review focuses on recent advances in molecular embryology of the upper and lower urinary tract with an emphasis on clinical correlation in order to gain a better understanding for the mechanism of congenital anomalies...
  32. doi request reprint The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation
    Krithika Rajagopalan
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochim Biophys Acta 1842:154-63. 2014
    ..To our knowledge, this is the first report demonstrating crosstalk between a CTA and a proto-oncogene. Disrupting PAGE4/c-Jun interactions using small molecules may represent a novel therapeutic strategy for PCa. ..
  33. ncbi request reprint Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
    Am J Physiol Renal Physiol 286:F795-802. 2004
    ..The generation of THP-deficient mice established the role of THP as a first line of urinary defense and should help elucidate other potential functions of this major protein in urinary tract physiology and diseases...
  34. ncbi request reprint Postoperative ureteral obstruction after subureteral injection of dextranomer/hyaluronic Acid copolymer
    David R Vandersteen
    Department of Urology, Children s Hospitals, Minneapolis St Paul, Minnesota, USA
    J Urol 176:1593-5. 2006
    ..Few studies document the incidence of surgically relevant postoperative obstruction or the characteristics of patients at risk...
  35. ncbi request reprint Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra
    Kun Suk Kim
    Department of Urology, University of California, San Francisco, San Francisco, California 94143, USA
    Cell Tissue Res 307:145-53. 2002
    ....
  36. ncbi request reprint Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia
    Bo Xie
    Mass Spectrometry Resource, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    J Biol Chem 281:14644-53. 2006
    ..Results from this study shed light on the molecular pathogenesis of urinary tract infections and may aid in the design of glyco-mimetic inhibitors for preventing and treating this disease...