NADRIAN SEEMAN

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Nanotechnology and the double helix
    Nadrian C Seeman
    Sci Am 290:64-9, 72-5. 2004
  2. pmc Molecular-dynamics simulations of insertion of chemically modified DNA nanostructures into a water-chloroform interface
    Jianping Lin
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Biophys J 95:1099-107. 2008
  3. pmc From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal
    Jianping Zheng
    Department of Chemistry, New York University, New York 10003, USA
    Nature 461:74-7. 2009
  4. pmc A proximity-based programmable DNA nanoscale assembly line
    Hongzhou Gu
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nature 465:202-5. 2010
  5. ncbi request reprint The design and engineering of nucleic acid nanoscale assemblies
    N C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Curr Opin Struct Biol 6:519-26. 1996
  6. pmc An overview of structural DNA nanotechnology
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Mol Biotechnol 37:246-57. 2007
  7. pmc DNA enables nanoscale control of the structure of matter
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Q Rev Biophys 38:363-71. 2005
  8. pmc Nanomaterials based on DNA
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, New York 10003, USA
    Annu Rev Biochem 79:65-87. 2010
  9. ncbi request reprint At the crossroads of chemistry, biology, and materials: structural DNA nanotechnology
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Chem Biol 10:1151-9. 2003
  10. pmc Structural DNA nanotechnology: growing along with Nano Letters
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 10:1971-8. 2010

Research Grants

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Nanotechnology and the double helix
    Nadrian C Seeman
    Sci Am 290:64-9, 72-5. 2004
  2. pmc Molecular-dynamics simulations of insertion of chemically modified DNA nanostructures into a water-chloroform interface
    Jianping Lin
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Biophys J 95:1099-107. 2008
    ..The driving force for this insertion comes from the entropic contribution to the free energy and the favorable van der Waals interaction of the chloroform molecules with the methyl and benzyl groups of the DNA...
  3. pmc From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal
    Jianping Zheng
    Department of Chemistry, New York University, New York 10003, USA
    Nature 461:74-7. 2009
    ..The data demonstrate clearly that it is possible to design and self-assemble a well-ordered macromolecular 3D crystalline lattice with precise control...
  4. pmc A proximity-based programmable DNA nanoscale assembly line
    Hongzhou Gu
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nature 465:202-5. 2010
    ..We use three different types of gold nanoparticle species as cargo and show that the experimental system does indeed allow the controlled fabrication of the eight different products that can be obtained with three two-state devices...
  5. ncbi request reprint The design and engineering of nucleic acid nanoscale assemblies
    N C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Curr Opin Struct Biol 6:519-26. 1996
    ..DNA polyhedra are complex catenanes. The engineering of single-stranded DNA knots and catenanes exploits the fact that a node can be equated with a half-turn of DNA...
  6. pmc An overview of structural DNA nanotechnology
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Mol Biotechnol 37:246-57. 2007
    ....
  7. pmc DNA enables nanoscale control of the structure of matter
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Q Rev Biophys 38:363-71. 2005
    ..These systems are designed to lead to improvements in crystallography, computation and the production of diverse and exotic materials...
  8. pmc Nanomaterials based on DNA
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, New York 10003, USA
    Annu Rev Biochem 79:65-87. 2010
    ..Devices have been incorporated into two-dimensional DNA arrangements; sequence-dependent devices are driven by increases in nucleotide pairing at each step in their machine cycles...
  9. ncbi request reprint At the crossroads of chemistry, biology, and materials: structural DNA nanotechnology
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Chem Biol 10:1151-9. 2003
    ....
  10. pmc Structural DNA nanotechnology: growing along with Nano Letters
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 10:1971-8. 2010
    ..Biological replication of DNA nanostructures with simple topologies has also been accomplished. The increase in the number of participants in the enterprise holds great promise for the coming decade...
  11. ncbi request reprint Biochemistry and structural DNA nanotechnology: an evolving symbiotic relationship
    Nadrian C Seeman
    Department of Chemistry, New York University, New York 10003, USA
    Biochemistry 42:7259-69. 2003
    ..DNA parallelogram arrays have been used to determine the interhelical angles for a variety of DNA branched junctions. The relationship between biochemistry and structural DNA nanotechnology continues to grow...
  12. ncbi request reprint DNA in a material world
    Nadrian C Seeman
    Department of Chemistry, New York University, New York 10003, USA
    Nature 421:427-31. 2003
    ..The exploitation of DNA for material purposes presents a new chapter in the history of the molecule...
  13. ncbi request reprint DNA nanotechnology: novel DNA constructions
    N C Seeman
    Department of Chemistry, New York University, New York 10003, USA
    Annu Rev Biophys Biomol Struct 27:225-48. 1998
    ..It appears that novel DNA motifs may be of use in the new field of DNA-based computing...
  14. ncbi request reprint DNA engineering and its application to nanotechnology
    N C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Trends Biotechnol 17:437-43. 1999
    ..Future applications range from macromolecular crystallography and new materials to molecular electronics and DNA-based computation...
  15. pmc Emulating biology: building nanostructures from the bottom up
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 99:6451-5. 2002
    ..Can these approaches now be integrated to produce useful systems?..
  16. pmc From genes to machines: DNA nanomechanical devices
    Nadrian C Seeman
    Department of Chemistry, New York University, New York, NY 10003, USA
    Trends Biochem Sci 30:119-25. 2005
    ..The devices are activated by mechanisms as diverse as small molecules, proteins and, most intriguingly, other molecules of DNA...
  17. ncbi request reprint A robust DNA mechanical device controlled by hybridization topology
    Hao Yan
    Department of Chemistry, New York University, New York, NY 10003, USA
    Nature 415:62-5. 2002
    ..We expect that a wide range of analogous yet distinct rotary devices can be created by changing the control strands and the device sequences to which they bind...
  18. doi request reprint Quantitative study of the association thermodynamics and kinetics of DNA-coated particles for different functionalization schemes
    Mirjam E Leunissen
    Center for Soft Matter Research, Physics Department, New York University, 4 Washington Place, New York, New York 10003, USA
    J Am Chem Soc 132:1903-13. 2010
    ....
  19. ncbi request reprint Aggregation-disaggregation transition of DNA-coated colloids: experiments and theory
    Remi Dreyfus
    Center for Soft Matter Research, New York University, New York, New York 10003, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 81:041404. 2010
    ..This model is shown to describe the experiments with excellent agreement for the temperature and width of the transition, which are both essential properties for complex self-assembly processes...
  20. pmc Architecture with GIDEON, a program for design in structural DNA nanotechnology
    Jeffrey J Birac
    Department of Chemistry, New York University, New York, NY 10003, USA
    J Mol Graph Model 25:470-80. 2006
    ..Computer modeling using a graphical user interface overcomes the limited precision of physical models for larger systems, and the limited interaction rate associated with earlier, command-line driven software...
  21. doi request reprint Switchable self-protected attractions in DNA-functionalized colloids
    Mirjam E Leunissen
    Center for Soft Matter Research, Physics Department, New York University, 4 Washington Place, New York 10003, USA
    Nat Mater 8:590-5. 2009
    ..This remarkable functionality makes our self-protected colloids a novel material that greatly extends the utility of DNA-functionalized systems, enabling more versatile, multi-stage assembly approaches...
  22. pmc Design of minimally strained nucleic Acid nanotubes
    William B Sherman
    Department of Chemistry, New York University, New York, New York, USA
    Biophys J 90:4546-57. 2006
    ..Possible applications for such tubes include nanoscale scaffolding as well as custom-shaped enclosures for other nano-objects...
  23. pmc Construction of a DNA nano-object directly demonstrates computation
    Gang Wu
    Department of Chemistry, New York University, New York, NY 10003, USA
    Biosystems 98:80-4. 2009
    ..Our findings show that computation based on "shape processing" is a viable alternative to symbol processing when computing by molecular self-assembly...
  24. pmc RNA used to control a DNA rotary nanomachine
    Hong Zhong
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 6:2899-903. 2006
    ..An RNA strand is used to mask one of these two regions, enabling the machine to assume the state corresponding to the unmasked region...
  25. ncbi request reprint Simple quantitative model for the reversible association of DNA coated colloids
    Remi Dreyfus
    Center for Soft Matter Research, New York University, New York, NY, USA
    Phys Rev Lett 102:048301. 2009
    ....
  26. pmc Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate
    Hongzhou Gu
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nat Nanotechnol 4:245-8. 2009
    ..This capture system can lead to dynamic control either on patterns or on programmed elements; this capability enables computation or a change of structural state as a function of information in the surroundings of the system...
  27. doi request reprint Key experimental approaches in DNA nanotechnology
    Nadrian C Seeman
    New York University, New York, New York, USA
    Curr Protoc Nucleic Acid Chem . 2002
    ..Finally, the use of DNA nanotechnology as a tool in biochemistry is discussed...
  28. pmc Six-helix and eight-helix DNA nanotubes assembled from half-tubes
    Akinori Kuzuya
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 7:1757-63. 2007
    ..We demonstrate the formation of these species by gel electrophoresis, and we examine their arrangement into long one-dimensional arrays by means of atomic force microscopy...
  29. pmc Operation of a DNA robot arm inserted into a 2D DNA crystalline substrate
    Baoquan Ding
    Department of Chemistry, New York University, New York, NY 10003, USA
    Science 314:1583-5. 2006
    ..We used atomic force microscopy to demonstrate that the rotary device is fully functional after insertion. Thus, a nanomechanical device can operate within a fixed frame of reference...
  30. pmc Translation of DNA signals into polymer assembly instructions
    Shiping Liao
    Department of Chemistry, New York University, New York, NY 10003, USA
    Science 306:2072-4. 2004
    ..The device has potential applications that include designer polymer synthesis, encryption of information, and use as a variable-input device for DNA-based computation...
  31. ncbi request reprint A protein-driven DNA device that measures the excess binding energy of proteins that distort DNA
    Wanqiu Shen
    Department of Chemistry, New York University, New York, NY 10003, USA
    Angew Chem Int Ed Engl 43:4750-2. 2004
  32. pmc Thermodynamic analysis of nylon nucleic acids
    Yu Liu
    Department of Chemistry, New York University, 100 Washington Square E, New York, NY 10003, USA
    Chembiochem 9:1641-8. 2008
    ....
  33. pmc Blunt-ended DNA stacking interactions in a 3-helix motif
    Risheng Wang
    Department of Chemistry, New York University, New York, NY 10003, USA
    Chem Commun (Camb) 46:4905-7. 2010
    ..The array can be visualized in the atomic force microscopy through conjugated streptavidin nanoparticles. We estimate the strength of the triple stacking interaction to be -8.6 kcal mol(-1)...
  34. pmc Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini
    Yu Liu
    Department of Chemistry, New York University, New York, New York 10003, USA
    J Am Chem Soc 130:10882-3. 2008
    ..The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies...
  35. ncbi request reprint Atomic force microscopic measurement of the interdomain angle in symmetric Holliday junctions
    Ruojie Sha
    Department of Chemistry, New York University, New York, New York 10003, USA
    Biochemistry 41:5950-5. 2002
    ..We have used hydroxyl radical autofootprinting to establish that the branch point is at the same migratory position seen in the crystals...
  36. ncbi request reprint Paranemic cohesion of topologically-closed DNA molecules
    Xiaoping Zhang
    Department of Chemistry, New York University, New York, New York 10003, USA
    J Am Chem Soc 124:12940-1. 2002
    ..The cohesion goes to completion, demonstrating an alternative to binding nucleic acid molecules through sticky ends...
  37. pmc The flexibility of DNA double crossover molecules
    Phiset Sa-Ardyen
    Department of Chemistry, New York University, New York, New York 10003, USA
    Biophys J 84:3829-37. 2003
    ..Hence, we have estimated the flexibility of antiparallel DNA double crossover molecules by means of ligation-closure experiments. We are able to show that these molecules are approximately twice as rigid as linear duplex DNA...
  38. pmc A simple DNA-based translation system
    Alejandra V Garibotti
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 7:480-3. 2007
    ..It is designed to be useful in a variety of applications that utilize the concept of translating from one code to another...
  39. pmc Paranemic crossover DNA: a generalized Holliday structure with applications in nanotechnology
    Zhiyong Shen
    Department of Chemistry, New York University, New York, NY 10003, USA
    J Am Chem Soc 126:1666-74. 2004
    ..Hydroxyl radical autofootprinting analysis confirms that there is a crossover point at each of the positions expected in the secondary structure. These molecules are generalized Holliday junctions...
  40. pmc DNA scissors device used to measure MutS binding to DNA mis-pairs
    Hongzhou Gu
    Department of Chemistry, New York University, New York, New York 10003, USA
    J Am Chem Soc 132:4352-7. 2010
    ..Our data are in good agreement with previous measurements of MutS binding, indicating that this device is able to measure the strength of binding correctly...
  41. pmc Double cohesion in structural DNA nanotechnology
    Pamela E Constantinou
    Department of Chemistry, New York University, New York, NY 10003, USA
    Org Biomol Chem 4:3414-9. 2006
    ..For comparison, arrays which use another type of double cohesion, double paranemic (PX) cohesion are also presented. Double cohesion of sticky ends proved to be the more effective tool to assemble large motifs into arrays...
  42. pmc Reciprocal DNA nanomechanical devices controlled by the same set strands
    Chunhua Liu
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 9:2641-7. 2009
    ..This system is likely to be of use for molecular robotic applications where reciprocal motions are of value in addition its inherent contribution to molecular choreography and molecular aesthetics...
  43. pmc Two-dimensional nanoparticle arrays show the organizational power of robust DNA motifs
    Jiwen Zheng
    Department of Chemistry, New York University, New York 10003, USA
    Nano Lett 6:1502-4. 2006
    ..Identical motifs, tailed in different sticky ends, enable the two-dimensional periodic ordering of 5 and 10 nm diameter gold nanoparticles...
  44. pmc A DNA-based nanomechanical device with three robust states
    Banani Chakraborty
    Department of Chemistry, New York University, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 105:17245-9. 2008
    ..The control of this system by DNA strands opens the door to trinary logic and to systems containing N devices that are able to attain 3(N) structural states...
  45. pmc Metallic nanoparticles used to estimate the structural integrity of DNA motifs
    Jiwen Zheng
    Department of Chemistry, New York University, New York, New York 10003, USA
    Biophys J 95:3340-8. 2008
    ..This method provides a way to estimate the robustness and potential utility of the many new DNA motifs that are becoming available...
  46. ncbi request reprint Resolution of undistorted symmetric immobile DNA junctions by vaccinia topoisomerase I
    Shiping Liao
    Department of Chemistry, New York University, New York, New York 10003, USA
    Biochemistry 43:1520-31. 2004
    ..Covalent topoisomerase-DNA adducts are precursors to recombinant strands in all reactions, as expected. Kinetic analysis suggests a rate limiting step after the first-strand cleavage...
  47. pmc Six-helix bundles designed from DNA
    Frederick Mathieu
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 5:661-5. 2005
    ..We demonstrate by atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D...
  48. pmc Structural DNA nanotechnology: an overview
    Nadrian C Seeman
    Department of Chemistry, New York University, NY, USA
    Methods Mol Biol 303:143-66. 2005
    ..Structural DNA nanotechnology appears to be at the cusp of a truly exciting explosion of applications, which can be expected to occur by the end of the current decade...
  49. pmc Assembly and characterization of 8-arm and 12-arm DNA branched junctions
    Xing Wang
    Contribution from the Department of Chemistry, New York University, New York, NY 10003, USA
    J Am Chem Soc 129:8169-76. 2007
    ..In principle, the stick structure corresponding to cubic close-packing is now a possible target for assembly by DNA nanotechnology...
  50. pmc Functional DNAzymes organized into two-dimensional arrays
    Alejandra V Garibotti
    Department of Chemistry, New York University, New York 10003, USA
    Nano Lett 6:1505-7. 2006
    ..We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array...
  51. ncbi request reprint Self-assembly of irregular graphs whose edges are DNA helix axes
    Phiset Sa-Ardyen
    Department of Chemistry, New York University, New York, New York 10003, USA
    J Am Chem Soc 126:6648-57. 2004
    ..The correct assembly of the target molecule has been demonstrated unambiguously by restriction analysis...
  52. ncbi request reprint Pseudohexagonal 2D DNA crystals from double crossover cohesion
    Baoquan Ding
    Department of Chemistry, New York University, New York, NY 10003, USA
    J Am Chem Soc 126:10230-1. 2004
    ..Removal of one sticky end precludes lattice formation, suggesting that it is the double sticky end that is the primary factor enabling lattice formation...
  53. ncbi request reprint Parallel symmetric immobile DNA junctions as substrates for E. coli RuvC Holliday junction resolvase
    Ruojie Sha
    Department of Chemistry, New York University, New York, New York 10003, USA
    Biochemistry 41:10985-93. 2002
    ..These data suggest that the presence of two binding sites leads to communication between the two subunits of the enzyme to increase its activity...
  54. ncbi request reprint Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining
    Lei Zhu
    Department of Chemistry, New York University, New York, New York 10003, USA
    J Am Chem Soc 125:10178-9. 2003
    ..The DNA-based ladder oligomers may find application in the antisense area...
  55. pmc Double-stranded DNA homology produces a physical signature
    Xing Wang
    Department of Chemistry, New York University, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 107:12547-52. 2010
    ..Second-site-reversion electrophoresis data support the notion that the shaft contains PX-DNA. Predicted cross-linking patterns generated in vivo suggest that homology-dependent structures can occur within the cell...
  56. ncbi request reprint Prototyping nanorod control: A DNA double helix sheathed within a DNA six-helix bundle
    Risheng Wang
    Department of Chemistry, New York University, New York, 10003, USA
    Chem Biol 16:862-7. 2009
    ..Here, we prototype this kind of control by using a seventh DNA double helix as the nanorod and fixing it inside the 6HB motif...
  57. pmc PX DNA triangle oligomerized using a novel three-domain motif
    Wenyan Liu
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nano Lett 8:317-22. 2008
    ..By combining them with a new mixed-fusion type of three-domain molecule, we demonstrate by AFM that these triangles can be self-assembled into a linear array...
  58. ncbi request reprint Crystal structure of a continuous three-dimensional DNA lattice
    Paul J Paukstelis
    Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, Texas 78712, USA
    Chem Biol 11:1119-26. 2004
    ..Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology...
  59. ncbi request reprint Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding
    Yariv Y Pinto
    Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Nano Lett 5:2399-402. 2005
    ..These results demonstrate the potential for using DNA to self-assemble complex arrays of components with nanometer-scale precision...
  60. pmc Circuits and programmable self-assembling DNA structures
    Alessandra Carbone
    Institut des Hautes Etudes Scientifiques, 35, route de Chartres, F 91440 Bures sur Yvette, France
    Proc Natl Acad Sci U S A 99:12577-82. 2002
    ..The molecular system that we describe is fundamentally a pair of two-dimensional layers, but it seems possible to extend this system to multiple layers...
  61. pmc Rolling circle enzymatic replication of a complex multi-crossover DNA nanostructure
    Chenxiang Lin
    Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA
    J Am Chem Soc 129:14475-81. 2007
    ....
  62. pmc DNA tube structures controlled by a four-way-branched DNA connector
    Masayuki Endo
    Institute of Scientific and Industrial Research, Osaka University, 8 1 Mihogaoka, Ibaraki, Osaka 567 0047, Japan
    Angew Chem Int Ed Engl 44:6074-7. 2005

Research Grants20

  1. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 1992
    ..This series of experiments will yield information which will provide detailed understanding about recombination in the development and evolution of organisms...
  2. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 1999
    ..The ultimate goal is to provide molecular control over natural recombination phenomena and over recombinational interventions done today in the laboratory and tomorrow in the clinic. ..
  3. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 2000
    ..The ultimate goal is to provide molecular control over natural recombination phenomena and over recombinational interventions done today in the laboratory and tomorrow in the clinic. ..
  4. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 2001
    ..These studies are designed to test key hypotheses and make central observations on DNA structures and processes that are involved in genetic recombination. ..
  5. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 2002
    ..These studies are designed to test key hypotheses and make central observations on DNA structures and processes that are involved in genetic recombination. ..
  6. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 2003
    ..These studies are designed to test key hypotheses and make central observations on DNA structures and processes that are involved in genetic recombination. ..
  7. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 2004
    ..These studies are designed to test key hypotheses and make central observations on DNA structures and processes that are involved in genetic recombination. ..
  8. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 2007
    ..In a third aim, we will develop a series of different potential substrates from DNA parallelogram-based structures, that will be tested as possible substrates for human and yeast topoisomerase II. ..
  9. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 1991
    ..This series of experiments will yield information which will provide detailed understanding about recombination in the development and evolution of organisms...
  10. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 1990
    ..This series of experiments will yield information which will provide detailed understanding about recombination in the development and evolution of organisms...
  11. PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATES
    NADRIAN SEEMAN; Fiscal Year: 1993
    ..The ultimate goal is to provide molecular control over natural recombination phenomena and over recombinational interventions done today in the laboratory and tomorrow in the clinic...