S E Schutzer

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease
    S E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Clin Invest 100:763-7. 1997
  2. ncbi Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus
    Steven E Schutzer
    Departments of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Ann Neurol 69:735-8. 2011
  3. ncbi Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
  4. ncbi Whole-genome sequences of thirteen isolates of Borrelia burgdorferi
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Bacteriol 193:1018-20. 2011
  5. ncbi Establishing the proteome of normal human cerebrospinal fluid
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 5:e10980. 2010
  6. ncbi Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from Select Agent lists
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 3:e2058. 2008
  7. ncbi Biocrimes, microbial forensics, and the physician
    Steven E Schutzer
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
    PLoS Med 2:e337. 2005
  8. ncbi Whole-genome sequences of Borrelia bissettii, Borrelia valaisiana, and Borrelia spielmanii
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Bacteriol 194:545-6. 2012
  9. ncbi Identification of potential antibody markers in HIV-associated dementia
    Steven E Schutzer
    Department of Medicine, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    J Neuroimmunol 157:120-5. 2004
  10. ncbi Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome
    S E Schutzer
    Department of Medicine, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103, USA
    Neurology 53:1340-1. 1999

Research Grants

  1. Detection of Virulent Burkholderia mallei
    Steven Schutzer; Fiscal Year: 2006
  2. Assay to detect early neurologic Lyme disease
    Steven Schutzer; Fiscal Year: 2003
  3. ASSAY TO DETECT ACUTE ACTIVE LYME DISEASE
    Steven Schutzer; Fiscal Year: 2005
  4. Complete Proteome of Cerebrospinal Fluid
    Steven Schutzer; Fiscal Year: 2006

Detail Information

Publications22

  1. ncbi Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease
    S E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Clin Invest 100:763-7. 1997
    ..This biologic finding may also provide a discriminating marker for CNS infection in Lyme disease...
  2. ncbi Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus
    Steven E Schutzer
    Departments of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Ann Neurol 69:735-8. 2011
    ..We examined cerebrospinal fluid from 43 CFS patients using polymerase chain reaction techniques, but did not find XMRV or multiple other common viruses, suggesting that exploration of other causes or pathogenetic mechanisms is warranted...
  3. ncbi Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
    ..They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether nPTLS is a subset of CFS...
  4. ncbi Whole-genome sequences of thirteen isolates of Borrelia burgdorferi
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Bacteriol 193:1018-20. 2011
    ..burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies...
  5. ncbi Establishing the proteome of normal human cerebrospinal fluid
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 5:e10980. 2010
    ..Until now technologic hurdles and access to true normal samples hindered attaining this goal...
  6. ncbi Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from Select Agent lists
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 3:e2058. 2008
    ..Whole genomic sequencing (WGS) is an apt approach to characterize newly discovered or poorly understood microbial pathogens...
  7. ncbi Biocrimes, microbial forensics, and the physician
    Steven E Schutzer
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
    PLoS Med 2:e337. 2005
  8. ncbi Whole-genome sequences of Borrelia bissettii, Borrelia valaisiana, and Borrelia spielmanii
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Bacteriol 194:545-6. 2012
    ..Recently, Borrelia valaisiana, Borrelia spielmanii, and Borrelia bissettii have been associated with Lyme disease. We report the complete genome sequences of B. valaisiana VS116, B. spielmanii A14S, and B. bissettii DN127...
  9. ncbi Identification of potential antibody markers in HIV-associated dementia
    Steven E Schutzer
    Department of Medicine, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    J Neuroimmunol 157:120-5. 2004
    ..All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD...
  10. ncbi Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome
    S E Schutzer
    Department of Medicine, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103, USA
    Neurology 53:1340-1. 1999
    ..Centers for Disease Control and Prevention-defined CFS patients lacking antecedent signs of Lyme disease--erythema migrans, Bell's palsy, or large joint arthritis--are not likely to have laboratory evidence of Bb infection...
  11. ncbi Borrelia burgdorferi-specific immune complexes in acute Lyme disease
    S E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
    JAMA 282:1942-6. 1999
    ..Diagnosis of infection with Borrelia burgdorferi, the cause of Lyme disease (LD), has been impeded by the lack of effective assays to detect active infection...
  12. ncbi Early OspA immune complex formation in animal models of Lyme disease
    Steven E Schutzer
    Department of Medicine, Division of Allergy and Immunology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Mol Microbiol Biotechnol 5:167-71. 2003
    ..burgdorferi and the pathogenesis of Lyme disease. With attention to unique B. burgdorferi Ags, these results are likely to have both clinical and diagnostic importance...
  13. ncbi Autoimmune markers in HIV-associated dementia
    Steven E Schutzer
    Department of Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Neuroimmunol 138:156-61. 2003
    ..Reactivity against control tissue was negative. Though the etiopathogenetic relation of these antibrain antibodies remains to be delineated, the data suggest that they may be a marker of HAD...
  14. ncbi Evidence of Borrelia autoimmunity-induced component of Lyme carditis and arthritis
    Elizabeth S Raveche
    Department of Pathology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S. Orange Ave, Newark, NJ 07103, USA
    J Clin Microbiol 43:850-6. 2005
    ..burgdorferi may share common epitopes which mimic self-proteins. These implications could be important for certain autoimmunity-susceptible individuals or animals who become infected with B. burgdorferi...
  15. ncbi The role of the allergist in Lyme disease
    S E Schutzer
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Allergy Asthma Proc 22:29-31. 2001
    ..The allergist as an immunologist can be very helpful in the proper interpretation of the test results. The differential of the rash and the immune response to the infecting agent is described...
  16. ncbi Criteria for validation of methods in microbial forensics
    Bruce Budowle
    UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA
    Appl Environ Microbiol 74:5599-607. 2008
  17. ncbi Non-canonical effects of anthrax toxins on haematopoiesis: implications for vaccine development
    Katherine Liu
    New Jersey Medical School UMDNJ, Department of Medicine Hematology Oncology, Newark, NJ 07103, USA
    J Cell Mol Med 13:1907-19. 2009
    ..The studies show effects of anthrax proteins beginning at the early stage of haematopoiesis, and also show secondary mediators such as IL-10 and CCL3. The roles of other cytokines and additional ATR are yet to be investigated...
  18. ncbi Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing
    Wei Gang Qiu
    Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:14150-5. 2004
    ..Frequent recombination implies a potential for rapid adaptive evolution and a possible polygenic basis of B. burgdorferi pathogenicity...
  19. ncbi Public health. Building microbial forensics as a response to bioterrorism
    Bruce Budowle
    Federal Bureau of Investigation, Laboratory Division, Quantico, VA 22135, USA
    Science 301:1852-3. 2003
    ....
  20. ncbi Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease
    Erol Fikrig
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Microbiol 42:1243-6. 2004
    ..Decorin-binding protein B (BBA25) and BBA50 (hypothetical protein) elicited immunoglobulin G (IgG) or IgM detectable in CSF-but not sera-of patients, demonstrating preferential antibody production during neuroborreliosis...
  21. ncbi Quality sample collection, handling, and preservation for an effective microbial forensics program
    Bruce Budowle
    Laboratory Division, Federal Bureau of Investigation, Quantico, Virginia 22135, USA
    Appl Environ Microbiol 72:6431-8. 2006
  22. ncbi Toward a system of microbial forensics: from sample collection to interpretation of evidence
    Bruce Budowle
    Federal Bureau of Investigation, Laboratory Division, 2501 Investigation Pkwy, Quantico, VA 22135, USA
    Appl Environ Microbiol 71:2209-13. 2005

Research Grants4

  1. Detection of Virulent Burkholderia mallei
    Steven Schutzer; Fiscal Year: 2006
    ..In Phase 2 we will also develop the immuno-based assays. ..
  2. Assay to detect early neurologic Lyme disease
    Steven Schutzer; Fiscal Year: 2003
    ..BbIC Ab and Ag will be identified. Focus will be towards on specific and in vivo expressed Bb Ags. Results will be statistically analyzed. Phase 2 will be designed for broadscale usage and refinement. ..
  3. ASSAY TO DETECT ACUTE ACTIVE LYME DISEASE
    Steven Schutzer; Fiscal Year: 2005
    ..It can also detect infection early than free antibody assays. Therefore this assay can fulfill a great need in Lyme disease diagnosis and has high market potential. ..
  4. Complete Proteome of Cerebrospinal Fluid
    Steven Schutzer; Fiscal Year: 2006
    ..These approaches may prove useful in investigation of this and other diseases such as substance abuse where markers are needed to monitor therapy or to illucidate interactions between drugs and microbes. ..