Ann Marie Schmidt

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond
    Gurdip Daffu
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Langone Medical Center, 550 First Avenue, Smilow 901C, New York, NY 10016, USA
    Int J Mol Sci 14:19891-910. 2013
  2. doi request reprint RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model
    Alexey Aleshin
    Department of Surgery, Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 294:H1823-32. 2008
  3. doi request reprint PKCbeta modulates ischemia-reperfusion injury in the heart
    Linghua Kong
    Dept of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 294:H1862-70. 2008
  4. ncbi request reprint RAGE and its ligands: a lasting memory in diabetic complications?
    Shi Fang Yan
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Diab Vasc Dis Res 1:10-20. 2004
  5. ncbi request reprint Central role of PKCbeta in neointimal expansion triggered by acute arterial injury
    Martin Andrassy
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Circ Res 96:476-83. 2005
  6. pmc Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals
    Srinivasan Vedantham
    Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY
    Diabetes 63:761-74. 2014
  7. pmc RAGE mediates podocyte injury in adriamycin-induced glomerulosclerosis
    Jiancheng Guo
    Department of Surgery, Columbia University Medical Center, New York, New York 10025, USA
    J Am Soc Nephrol 19:961-72. 2008
  8. pmc Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice
    Evis Harja
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:183-94. 2008
  9. ncbi request reprint Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University, New York, New York 10032, USA
    J Am Coll Cardiol 48:A47-55. 2006
  10. pmc Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice
    De xiu Bu
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Circ Res 106:1040-51. 2010

Collaborators

Detail Information

Publications93

  1. pmc Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond
    Gurdip Daffu
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Langone Medical Center, 550 First Avenue, Smilow 901C, New York, NY 10016, USA
    Int J Mol Sci 14:19891-910. 2013
    ..Blockade of RAGE signal transduction may be a key strategy for the prevention of the deleterious consequences of oxidative stress, particularly in chronic disease. ..
  2. doi request reprint RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model
    Alexey Aleshin
    Department of Surgery, Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 294:H1823-32. 2008
    ....
  3. doi request reprint PKCbeta modulates ischemia-reperfusion injury in the heart
    Linghua Kong
    Dept of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 294:H1862-70. 2008
    ..These data implicate PKCbeta in I/R-mediated myocardial injury, at least in part via phosphorylation of JNK, and suggest that blockade of PKCbeta may represent a potent strategy to protect the vulnerable myocardium...
  4. ncbi request reprint RAGE and its ligands: a lasting memory in diabetic complications?
    Shi Fang Yan
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Diab Vasc Dis Res 1:10-20. 2004
    ..We propose that therapeutic RAGE blockade will intercept maladaptive diabetes-associated memory in the vessel wall and provide cardiovascular protection in diabetes...
  5. ncbi request reprint Central role of PKCbeta in neointimal expansion triggered by acute arterial injury
    Martin Andrassy
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Circ Res 96:476-83. 2005
    ..These data highlight novel roles for PKCbeta in the SMC response to acute arterial injury and suggest that blockade of PKCbeta may represent a therapeutic strategy to limit restenosis...
  6. pmc Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals
    Srinivasan Vedantham
    Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY
    Diabetes 63:761-74. 2014
    ..In conclusion, our data demonstrate a novel mechanism by which glucose flux via AR triggers activation, acetylation, and prolonged expression of Egr-1 leading to proinflammatory and prothrombotic responses in diabetic atherosclerosis. ..
  7. pmc RAGE mediates podocyte injury in adriamycin-induced glomerulosclerosis
    Jiancheng Guo
    Department of Surgery, Columbia University Medical Center, New York, New York 10025, USA
    J Am Soc Nephrol 19:961-72. 2008
    ..These data suggest that RAGE may contribute to the pathogenesis of podocyte injury in sclerosing glomerulopathies such as focal segmental glomerulosclerosis...
  8. pmc Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice
    Evis Harja
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:183-94. 2008
    ..These data highlight unifying mechanisms whereby endothelial RAGE and its ligands mediate vascular and inflammatory stresses that culminate in atherosclerosis in the vulnerable vessel wall...
  9. ncbi request reprint Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University, New York, New York 10032, USA
    J Am Coll Cardiol 48:A47-55. 2006
    ....
  10. pmc Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice
    De xiu Bu
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Circ Res 106:1040-51. 2010
    ..The multiligand RAGE (receptor for advanced glycation end products) contributes to atherosclerosis in apolipoprotein (Apo)E-null mice...
  11. pmc RAGE and modulation of ischemic injury in the diabetic myocardium
    Loredana G Bucciarelli
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York, USA
    Diabetes 57:1941-51. 2008
    ..In diabetic rat hearts, expression of RAGE and its ligands was enhanced and localized particularly to both endothelial cells and mononuclear phagocytes...
  12. ncbi request reprint RAGE ligand upregulation of VEGF secretion in ARPE-19 cells
    Wanchao Ma
    Departments of Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Invest Ophthalmol Vis Sci 48:1355-61. 2007
    ....
  13. doi request reprint Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products
    Jong Sun Chang
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Circ Res 102:905-13. 2008
    ..These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation...
  14. doi request reprint Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury
    Shan Zeng
    Division of Liver Diseases and Transplantation, Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Hepatol 50:929-36. 2009
    ..We previously showed that blockade of RAGE significantly attenuates hepatic ischemia/reperfusion (I/R) injury in mice. Here, we identify that early growth response-1 (Egr-1) is a downstream target of RAGE in hepatic I/R injury...
  15. pmc Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis
    Evis Harja
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    FASEB J 23:1081-91. 2009
    ..Blockade of PKCbeta may be beneficial in mitigating endothelial perturbation and atherosclerosis...
  16. pmc Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages
    Yunlu Xu
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 285:23233-40. 2010
    ..Our findings highlight a novel mechanism by which an extracellular signal initiated by RAGE ligand AGEs regulates Egr-1 in a manner requiring mDia-1...
  17. ncbi request reprint Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury
    Loredana G Bucciarelli
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Circulation 113:1226-34. 2006
    ..In this context, our laboratory has been investigating the role of the receptor for advanced-glycation end products (RAGE) in myocardial I/R injury...
  18. pmc RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB
    Guellue Cataldegirmen
    Division of Liver Diseases and Transplantation, Department of Surgery, Columbia University Medical Center, Columbia University, New York, NY 10032, USA
    J Exp Med 201:473-84. 2005
    ..These data highlight central roles for RAGE and MPDDCs in modulation of cell death-promoting mechanisms in massive hepatectomy and suggest that RAGE blockade is a novel strategy to promote regeneration in the massively injured liver...
  19. ncbi request reprint RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes
    Thoralf Wendt
    Department of Surgery, College of Physicians and Surgeons of Columbia University, 630 W, 168th Street, Black Building 1705, New York, NY 10032, USA
    Atherosclerosis 185:70-7. 2006
    ..Taken together, these findings establish a new murine model for the study of atherosclerosis in type 2 diabetes and highlight important roles for RAGE in proatherogenic mechanisms in hyperglycemia triggered by insulin resistance...
  20. ncbi request reprint RAGE axis: Animal models and novel insights into the vascular complications of diabetes
    Yoshifumi Naka
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 24:1342-9. 2004
    ..Future studies must rigorously test the potential impact of RAGE blockade in human subjects; such trials are on the horizon...
  21. ncbi request reprint RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways
    Ling Ling Rong
    Departments of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    FASEB J 18:1818-25. 2004
    ..These findings suggest that RAGE signaling in inflammatory cells and peripheral neurons plays an important role in plasticity of the peripheral nervous system...
  22. ncbi request reprint Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis
    William Kim
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th St, P and S 17 501, New York, New York 10032, USA
    Ann N Y Acad Sci 1043:553-61. 2005
    ..Studies are in progress to test the premise that antagonism of this interaction is a logical strategy for the prevention and treatment of diabetes...
  23. pmc Novel role for aldose reductase in mediating acute inflammatory responses in the lung
    Thyyar M Ravindranath
    Department of Surgery, Columbia University, New York, NY 10032, USA
    J Immunol 183:8128-37. 2009
    ..These data demonstrate a novel role for AR in regulating the signaling pathways leading to neutrophil-EC adhesion during acute lung inflammation...
  24. pmc The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli
    Denise L Cecil
    Department of Medicine, Rheumatology Section, Veterans Affairs Health Care System University of California, San Diego, CA 92161, USA
    J Immunol 182:5024-31. 2009
    ..Therefore, RAGE and CD36 patterning receptor expression were linked with opposing effects on inflammatory, procatabolic responses to S100A11 and TNF-alpha in chondrocytes...
  25. ncbi request reprint The ligand/RAGE axis: lighting the fuse and igniting vascular stress
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P and S 17 501, New York, NY 10032, USA
    Curr Atheroscler Rep 8:232-9. 2006
    ..This review focuses on the ligand repertoire of RAGE, the impact of ligand-RAGE interaction, and the potent effect of RAGE blockade in rodent models of vascular injury...
  26. pmc Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways
    Fatouma Toure
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Circ Res 110:1279-93. 2012
    ....
  27. pmc RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease
    Fang Fang
    P and S 17 410, Department Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th St, New York, NY 10032, USA
    FASEB J 24:1043-55. 2010
    ..G., Stern, D. M., Yan, S., Schmidt, A. M., Chen, J. X., Yan, S. S. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease...
  28. ncbi request reprint Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice
    Udeme Ekong
    Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Gastroenterol Hepatol 21:682-8. 2006
    ....
  29. pmc Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice
    Srinivasan Vedantham
    Division of Endocrinology, New York University Langone Medical Center, NY 10016, USA
    Arterioscler Thromb Vasc Biol 31:1805-13. 2011
    ..The polyol pathway mediated by aldose reductase (AR) has been postulated to be one such pathway. However, it has been reported that AR reduces toxic lipid aldehydes and, under some circumstances, might be antiatherogenic...
  30. doi request reprint A novel monoclonal antibody for RAGE-directed imaging identifies accelerated atherosclerosis in diabetes
    Yared Tekabe
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Nucl Med 51:92-7. 2010
    ..This study was designed to test the hypothesis that the level of RAGE expression in atherosclerosis can be detected by quantitative in vivo SPECT and that counts in the target will correlate with the strength of the biologic signal...
  31. pmc Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene
    Anastasia Z Kalea
    Division of Surgical Science, Dept of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    FASEB J 23:1766-74. 2009
    ..These differences in RAGE splicing in both physiological and pathogenic states further expand our understanding of the biological repertoire of this receptor in health and disease...
  32. pmc Ultrastructural features of retinal capillary basement membrane thickening in diabetic swine
    Song Eun Lee
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Ultrastruct Pathol 34:35-41. 2010
    ..To assess retinal capillary basement membrane thickening (BMT) in a swine model of type 1 diabetes...
  33. pmc Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse
    Nina Reiniger
    1Department of Surgery, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA
    Diabetes 59:2043-54. 2010
    ....
  34. ncbi request reprint Diabetic vascular disease: it's all the RAGE
    Barry I Hudson
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Antioxid Redox Signal 7:1588-600. 2005
    ..These observations highlight RAGE as a therapeutic target for treatment of diabetic vascular disease...
  35. ncbi request reprint Receptor for advanced glycation end products and the cardiovascular complications of diabetes and beyond: lessons from AGEing
    Shi Fang Yan
    Columbia University Medical Center, 630 West 168th Street, P and S 17 501, New York, NY 10032, USA
    Endocrinol Metab Clin North Am 35:511-24, viii. 2006
    ..This suggests that blocking the generation or molecular impact of AGEs may modulate the complications of diabetes...
  36. ncbi request reprint Upregulation of RAGE and its ligands in proliferative retinal disease
    Sophia I Pachydaki
    Department of Ophthalmology, College of Physician and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Eye Res 82:807-15. 2006
    ..These findings suggest a role for the proinflammatory RAGE axis in the pathogenesis of proliferative retinal diseases...
  37. pmc Tempering the wrath of RAGE: an emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Ann Med 41:408-22. 2009
    ..As RAGE blockade moves further into clinical development, clarifying the biology of RAGE garners ever-increasing importance...
  38. ncbi request reprint Receptor for advanced glycation end products expression on T cells contributes to antigen-specific cellular expansion in vivo
    Bernhard Moser
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 179:8051-8. 2007
    ..These data indicate that RAGE expressed on T cells is required for efficient priming of T cells and elucidate critical roles for RAGE engagement during cognate dendritic cell-T cell interactions...
  39. ncbi request reprint The RAGE axis in early diabetic retinopathy
    Gaetano R Barile
    Department of Ophthalmology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Invest Ophthalmol Vis Sci 46:2916-24. 2005
    ..This study was conducted to characterize the role of the RAGE axis in a murine model of nonproliferative diabetic retinopathy (NPDR)...
  40. ncbi request reprint The RAGE axis and endothelial dysfunction: maladaptive roles in the diabetic vasculature and beyond
    Ravichandran Ramasamy
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Trends Cardiovasc Med 15:237-43. 2005
    ..These considerations support the premise that the ligand-RAGE axis may be an important target for therapeutic intervention in cardiovascular disease and, fundamentally, in initiation and amplification of inflammatory responses...
  41. doi request reprint RAGE: therapeutic target and biomarker of the inflammatory response--the evidence mounts
    Ravichandran Ramasamy
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Leukoc Biol 86:505-12. 2009
    ....
  42. ncbi request reprint Aldose reductase and AGE-RAGE pathways: key players in myocardial ischemic injury
    Michiyo Kaneko
    Division of Surgical Science, P and S 17 401, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    Ann N Y Acad Sci 1043:702-9. 2005
    ..The potent impact of increased flux via the aldose reductase pathway and the increased AGE interactions with its receptor (RAGE) resulting in cardiac dysfunction will be discussed in this chapter...
  43. pmc Opposing roles of RAGE and Myd88 signaling in extensive liver resection
    Shan Zeng
    Department of Surgery, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    FASEB J 26:882-93. 2012
    ..We conclude that blockade of RAGE may rescue liver remnants from the multiple signals that preclude adaptive proliferation triggered primarily by Myd88 signaling pathways...
  44. ncbi request reprint Infection with a periodontal pathogen increases mononuclear cell adhesion to human aortic endothelial cells
    Georg A Roth
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Atherosclerosis 190:271-81. 2007
    ....
  45. pmc RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways
    Linshan Shang
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 5:e10092. 2010
    ..In the current study, adult cardiomyocytes were studied in an in vitro ischemia/reperfusion (I/R) injury model to delineate the molecular mechanisms underlying RAGE-mediated injury due to hypoxia/reoxygenation (H/R)...
  46. ncbi request reprint The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P and S 17 501, New York, NY 10032, USA
    Curr Diab Rep 7:146-53. 2007
    ..Pharmacologic antagonism of RAGE may hold promise for the treatment of diabetic complications...
  47. doi request reprint Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia
    Benjamin G Hassid
    Department of Neurological Surgery, 710 West 168th Street, Room 431, Columbia University, New York, New York 10032, USA
    J Clin Neurosci 16:302-6. 2009
    ..These results indicate that RAGE signaling directly contributes to pathology in cerebral ischemia...
  48. pmc RAGE deficiency improves postinjury sciatic nerve regeneration in type 1 diabetic mice
    Judyta K Juranek
    Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, New York, USA
    Diabetes 62:931-43. 2013
    ..Blockade of RAGE may be beneficial in the acute complications of diabetic neuropathy, at least in part, via upregulation of regeneration signals...
  49. pmc Alternatively spliced RAGEv1 inhibits tumorigenesis through suppression of JNK signaling
    Anastasia Z Kalea
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 70:5628-38. 2010
    ..Our results identify RAGEv1 as a novel suppressor, the study of which may offer new cancer therapeutic directions...
  50. doi request reprint Blockade of receptor for advanced glycation end product attenuates pulmonary reperfusion injury in mice
    David I Sternberg
    Lung Transplant Program, Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Thorac Cardiovasc Surg 136:1576-85. 2008
    ..RAGE blockade has been shown to suppress hepatic and cardiac ischemia and reperfusion injury in mice. Thus we tested the hypothesis that RAGE mediates tissue-injury mechanisms in ischemia and reperfusion injury in the lung...
  51. ncbi request reprint Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response
    Raphael Clynes
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P and S 17 501, New York, NY 10032, USA
    Curr Mol Med 7:743-51. 2007
    ..Ultimately, drawing the fine line between antagonism versus stimulation of the receptor in health and disease will depend on the full characterization of RAGE in repair versus injury...
  52. pmc Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1
    Vivek Rai
    New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 287:5133-44. 2012
    ..The results establish a novel mechanism through which an extracellular signal initiated by RAGE ligands regulates RAGE signaling in a manner requiring mDia1...
  53. pmc Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells
    Georg A Roth
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Thromb Res 123:780-4. 2009
    ..Tissue factor (TF) and its specific tissue factor pathway inhibitor (TFPI) are produced by vascular cells and are important regulators of the coagulation cascade...
  54. pmc Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling
    Vivek Rai
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:2339-50. 2012
    ..These findings identify novel roles for RAGE as a conduit for LPA signaling and suggest targeting LPA-RAGE interaction as a therapeutic strategy to modify the pathological actions of LPA...
  55. doi request reprint Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications
    Ravichandran Ramasamy
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Ann N Y Acad Sci 1243:88-102. 2011
    ....
  56. pmc Imaging of receptors for advanced glycation end products in experimental myocardial ischemia and reperfusion injury
    Yared Tekabe
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    JACC Cardiovasc Imaging 5:59-67. 2012
    ..The aim of this study was to image expression of receptor for advanced glycation end products (RAGE) in a mouse model of myocardial reperfusion injury...
  57. ncbi request reprint Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia
    Paola Pichiule
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:36330-40. 2007
    ..Specific binding of HIF-1 to this putative HRE in hypoxic cells was detected by chromatin immunoprecipitation assay...
  58. doi request reprint Development of receptor for advanced glycation end products-directed imaging of atherosclerotic plaque in a murine model of spontaneous atherosclerosis
    Yared Tekabe
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Circ Cardiovasc Imaging 1:212-9. 2008
    ..We tested the hypothesis that (99m)Tc-labeled anti-RAGE F(ab')(2) can be used as a noninvasive tool to image atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-)) mice...
  59. pmc Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis
    Prabhakara R Nagareddy
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 17:695-708. 2013
    ..In patients with type 1 diabetes, plasma S100A8/S100A9 levels correlate with leukocyte counts and coronary artery disease. Thus, hyperglycemia drives myelopoiesis and promotes atherogenesis in diabetes...
  60. ncbi request reprint Receptor for Advanced Glycation Endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging
    Shi Fang Yan
    Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Curr Mol Med 7:699-710. 2007
    ..We conclude that antagonism of RAGE may reflect a novel and therapeutically logical and safe target in cardiovascular stress induced by aging and chronic diabetes...
  61. pmc PKCbeta regulates ischemia/reperfusion injury in the lung
    Tomoyuki Fujita
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:1615-23. 2004
    ..These findings elucidate key roles for PKCbetaII activation in I/R by coordinated activation of MAPKs (ERK1/2, JNK) and Egr-1...
  62. pmc Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats
    Kellie McCormick Hallam
    Department of Surgery, Columbia University, New York, NY 10032, USA
    Aging Cell 9:776-84. 2010
    ..These data demonstrate for the first time that AR mediates aging-related vascular dysfunction, at least in part, via RAGE...
  63. pmc Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42
    Barry I Hudson
    Division of Surgical Science, Departments of Surgery and Pathology, Columbia University Medical Center, Columbia University, New York, New York, 10032, USA
    J Biol Chem 283:34457-68. 2008
    ....
  64. doi request reprint RAGE, glomerulosclerosis and proteinuria: roles in podocytes and endothelial cells
    VIVETTE D'AGATI
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Trends Endocrinol Metab 21:50-6. 2010
    ..In this review, we summarize the evidence from mouse to man, linking RAGE to the pathogenesis of nephropathy...
  65. pmc RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer
    Joseph DiNorcia
    College of Physicians and Surgeons, Department of Surgery, Columbia University, 161 Fort Washington Avenue, Suite 820, New York, NY 10032 3784, USA
    J Gastrointest Surg 16:104-12; discussion 112. 2012
    ..Activating Kras mutations and p16 inactivation are genetic abnormalities most commonly detected as pancreatic ductal epithelium progresses from intraepithelial neoplasia (PanIN) to adenocarcinoma (PDAC)...
  66. pmc The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University, 630 W 168th St, P and S 17 401, New York, NY 10032, USA
    Circ Res 106:842-53. 2010
    ..Stopping the vicious cycle of AGE-RAGE and RAGE axis signaling in the vulnerable heart and great vessels may be essential in controlling and preventing the consequences of diabetes...
  67. doi request reprint RAGE binds C1q and enhances C1q-mediated phagocytosis
    Wanchao Ma
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cell Immunol 274:72-82. 2012
    ..C1q induced U937 cell adhesion and phagocytosis was inhibited by antibodies to RAGE or Mac-1. These data link C1q and RAGE to the recruitment of leukocytes and phagocytosis of C1q-coated material...
  68. pmc Aldose reductase pathway contributes to vulnerability of aging myocardium to ischemic injury
    Radha Ananthakrishnan
    Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
    Exp Gerontol 46:762-7. 2011
    ..These data indicate that innate increases in activity of the PP enzymes augment myocardial vulnerability to I/R injury in aging, and that blockers of PP protect the vulnerable aging hearts...
  69. pmc The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Expert Rev Mol Med 11:e9. 2009
    ..In this review, we focus on RAGE and the consequences of its activation in the cardiovasculature...
  70. pmc Aldose reductase, oxidative stress and diabetic cardiovascular complications
    Srinivasan Vedantham
    Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
    Cardiovasc Hematol Agents Med Chem 10:234-40. 2012
    ..Stopping AR-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in diabetic cardiovascular complications...
  71. doi request reprint Reduced expression of Munc13-1 in human and porcine diabetic peripheral nerve
    Judyta K Juranek
    Department of Surgery, Columbia University Medical Center, New York, USA Diabetes Research Program, Department of Medicine, NYU Medical Center, New York, USA Electronic address
    Acta Histochem 116:106-11. 2014
    ....
  72. pmc The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes
    Ravichandran Ramasamy
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine, New York, NY 10016, United States
    Vascul Pharmacol 57:160-7. 2012
    ..Lastly, we suggest specific strategies to tackle AGE-ligand-RAGE interactions as potential therapeutic targets for diabetes and its complications...
  73. ncbi request reprint Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice
    Radha Ananthakrishnan
    Department of Medicine, Diabetes Research Program, New York University Langone Medical Center, New York, NY, USA
    Artif Cells Nanomed Biotechnol 41:428-36. 2013
    ..This finding is an important step in exploring the efficacy of a pharmacoinvasive strategy using SANGUINATE(™) in patients with acute coronary syndromes...
  74. pmc Receptor for AGE (RAGE) and its ligands-cast into leading roles in diabetes and the inflammatory response
    Shi Fang Yan
    Department of Surgery, Columbia University, New York, NY 10032, USA
    J Mol Med (Berl) 87:235-47. 2009
    ..Targeting RAGE may be a beneficial strategy in diabetes, its complications, and untoward inflammatory responses...
  75. pmc Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes
    Yared Tekabe
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    EJNMMI Res 1:3. 2011
    ..abstract:..
  76. doi request reprint Receptor for advanced glycation end products (RAGE) and implications for the pathophysiology of heart failure
    Ravichandran Ramasamy
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, NYU School of Medicine, 550 First Avenue, Smilow 901, New York, NY, 10016, USA
    Curr Heart Fail Rep 9:107-16. 2012
    ..Taken together, the ligand-RAGE axis is implicated in heart failure and we predict that therapeutic antagonism of RAGE might be a unique target for therapeutic intervention in this disorder...
  77. pmc Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS)
    Barry I Hudson
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Atherosclerosis 216:192-8. 2011
    ..We hypothesized that sRAGE levels are associated with subclinical cerebrovascular disease in an ethnically diverse population...
  78. pmc Human vascular endothelial cells: a model system for studying vascular inflammation in diabetes and atherosclerosis
    Duygu Onat
    Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, 630 West, 168th Street, PS 17 401, New York, NY 10032, USA
    Curr Diab Rep 11:193-202. 2011
    ..In this article, we appraise the use of endothelial cell-based methodologies to study vascular inflammation in diabetes and atherosclerosis...
  79. ncbi request reprint Impaired slow axonal transport in diabetic peripheral nerve is independent of RAGE
    Judyta K Juranek
    Department of Surgery, Columbia University Medical Center, New York, NY, USA Diabetes Research Center, Department of Medicine, NYU Langone Medical Center, Smilow Building 906, 550 First Avenue, New York, NY, 10016, USA
    Eur J Neurosci 38:3159-68. 2013
    ..Finally, our study demonstrates that mDia1 axonal transport is impaired in diabetes, suggesting that diabetes-related changes affecting actin binding proteins occur early in the course of the disease. ..
  80. pmc Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products
    NILAM S MANGALMURTI
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia 19104, USA
    Transfusion 50:2353-61. 2010
    ....
  81. pmc Glycation and insulin resistance: novel mechanisms and unique targets?
    Fei Song
    Division of Endocrinology, Department of Medicine, New York University School of Medicine, 550 First Ave, Smilow 901C, New York, NY 10016, USA
    Arterioscler Thromb Vasc Biol 32:1760-5. 2012
    ..Strategies to limit AGE accumulation and action may contribute to the prevention of insulin resistance and its consequences...
  82. pmc Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis
    Ravichandran Ramasamy
    Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Ann N Y Acad Sci 1126:7-13. 2008
    ....
  83. pmc Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies
    Judyta K Juranek
    Department of Surgery, Columbia University Medical Center New York, New York Diabetes Research Program, Department of Medicine, NYU Medical Center New York, New York
    Brain Behav 3:701-9. 2013
    ..Here, for the first time, we focused on the expression of RAGE in human peripheral nerve...
  84. ncbi request reprint The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease
    Ann Marie Schmidt
    Columbia University, College of Physicians and Surgeons, Department of Surgery, 630 West 168th Street, P and S 17 401, New York, NY 10032, USA
    Curr Opin Investig Drugs 10:672-80. 2009
    ..These findings suggest that RAGE may mediate a common proinflammatory pathway in neurodegenerative disorders...
  85. pmc Advanced glycation endproducts: from precursors to RAGE: round and round we go
    Ravichandran Ramasamy
    Diabetes Research Program, Department of Medicine, Division of Endocrinology NYU Langone Medical Center, 550 First Avenue, Smilow 9, New York, NY 10016, USA
    Amino Acids 42:1151-61. 2012
    ..Stopping RAGE-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in these disorders...
  86. doi request reprint RAGE: a novel biological and genetic marker for vascular disease
    Anastasia Z Kalea
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Clin Sci (Lond) 116:621-37. 2009
    ..Therapeutic intervention targeted at the RAGE gene may therefore be a useful means of treating pathologies of the vasculature...
  87. pmc Imaging receptor for advanced glycation end product expression in mouse model of hind limb ischemia
    Yared Tekabe
    Department of Medicine, Columbia University Medical Center, 622 West 168th St, PH 10 room 203, New York, NY 10032, USA
    EJNMMI Res 3:37. 2013
    ..The purpose of this study is to image the effect of diabetes on expression of receptor for advanced glycation endproducts (RAGE) in limb ischemia in live animals...
  88. ncbi request reprint RAGE and the pathogenesis of chronic kidney disease
    VIVETTE D'AGATI
    Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Nat Rev Nephrol 6:352-60. 2010
    ..Accumulating evidence links RAGE to the pathogenesis of nephropathies, indicating that antagonism of RAGE might be a strategy for the treatment of chronic kidney disease...
  89. pmc Peripheral venous congestion causes inflammation, neurohormonal, and endothelial cell activation
    Paolo C Colombo
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA
    Eur Heart J 35:448-54. 2014
    ..This study aimed at elucidating whether peripheral venous congestion is sufficient to promote changes in inflammatory, neurohormonal, and endothelial phenotype similar to those observed in HF and RF...
  90. doi request reprint RAGE signaling significantly impacts tumorigenesis and hepatic tumor growth in murine models of colorectal carcinoma
    Joseph DiNorcia
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Gastrointest Surg 14:1680-90. 2010
    ..We hypothesized that RAGE signaling impacts tumorigenesis and metastatic tumor growth in murine models of colorectal carcinoma...
  91. pmc Unlocking the biology of RAGE in diabetic microvascular complications
    Michaele B Manigrasso
    Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Trends Endocrinol Metab 25:15-22. 2014
    ..We review the biology of ligand-RAGE signal transduction and its roles in diabetic microvascular complications, from animal models to human subjects. ..
  92. pmc Diabetes and oral disease: implications for health professionals
    David A Albert
    Columbia University College of Dental Medicine, New York, New York 10032, USA
    Ann N Y Acad Sci 1255:1-15. 2012
    ..This report summarizes the scientific presentations of the event...
  93. pmc Controllable expansion of primary cardiomyocytes by reversible immortalization
    Yue Zhang
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Hum Gene Ther 20:1687-96. 2009
    ....