Research Topics
Genomes and Genes | A F SchierSummaryAffiliation: New York University Country: USA Publications
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Publications
Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptorsSimon K Cheng
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, USA
PLoS Biol 2:E30. 2004..These results indicate that coreceptors are targets for both TGFbeta agonists and antagonists and suggest that subtle sequence variations in TGFbeta signals result in greater ligand diversity...- Genetics of neural development in zebrafishA F Schier
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
Curr Opin Neurobiol 7:119-26. 1997..Ongoing molecular analyses promise to further elucidate the mechanisms underlying neural development in vertebrates... - Nodal signaling and the zebrafish organizerA F Schier
Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Int J Dev Biol 45:289-97. 2001..The combination of genetic, molecular and embryological approaches in zebrafish has thus provided a framework to understand the mechanisms underlying organizer development... - Molecular genetics of axis formation in zebrafishAlexander F Schier
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 6497, USA
Annu Rev Genet 39:561-613. 2005..Noncanonical Wnt signaling is required for the morphogenetic movements during gastrulation. We review how the coordinated interplay of these molecules determines the fate and movement of embryonic cells... - Nodal signalling in vertebrate developmentA F Schier
Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Nature 403:385-9. 2000.... - Axis formation and patterning in zebrafishA F Schier
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, New York, USA
Curr Opin Genet Dev 11:393-404. 2001..Detailed analyses have revealed a complex genetic network that patterns the early embryo... - Nodal signaling in vertebrate developmentAlexander F Schier
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Annu Rev Cell Dev Biol 19:589-621. 2003..These studies demonstrate that Nodal signaling is modulated at almost every level to precisely orchestrate tissue patterning during vertebrate embryogenesis... - Chemokine signaling: rules of attractionAlexander F Schier
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Curr Biol 13:R192-4. 2003..The chemokine SDF-1 and its receptor CXCR4 control cell migration in the immune and nervous systems. Recent studies in zebrafish have shown that SDF-1 and CXCR4 also guide the migration of germ cells and sensory organs of the lateral line... - The zebrafish organizerA F Schier
Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Curr Opin Genet Dev 8:464-71. 1998..In addition, embryological studies have suggested that the zebrafish organizer is induced by extraembryonic cues and have defined two novel organizing centers that pattern the nervous system along the anterior-posterior axes... - The EGF-CFC protein one-eyed pinhead is essential for nodal signalingK Gritsman
Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Cell 97:121-32. 1999..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development... - Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafishB Feldman
Developmental Genetics Program, Division of Developmental Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, The National Institute for Medical Research, New York, London, New York 10016, NW7 1AA, USA, UK
Curr Biol 10:531-4. 2000..These results demonstrate that nodal-related genes are required for the allocation of dorsal marginal cells to mesendodermal fates and for anteroposterior patterning of the neural tube... - Nodal signaling patterns the organizerK Gritsman
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Development 127:921-32. 2000..Together, these results indicate that differential Nodal signaling patterns the organizer before gastrulation, with the highest level of activity required for anterior fates and lower activity essential for posterior fates... - Zebrafish organizer development and germ-layer formation require nodal-related signalsB Feldman
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University Medical Center, New York 10016, USA
Nature 395:181-5. 1998..Misexpression of sqt RNA within the embryo or specifically in the YSL induces expanded or ectopic dorsal mesoderm. These results establish an essential role for nodal-related signals in organizer development and mesendoderm formation... - The zebrafish Nodal signal Squint functions as a morphogenY Chen
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department for Cell Biology, New York University School of Medicine, New York 10016, USA
Nature 411:607-10. 2001..These results indicate that Squint acts as a secreted morphogen that does not require a relay mechanism... - Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulationJ Zhang
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University Medical Center, New York 10016, USA
Cell 92:241-51. 1998..These results establish an essential but permissive role for an EGF-related ligand during vertebrate gastrulation... - Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterningR O Karlstrom
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
Genes Dev 13:388-93. 1999..These findings reveal that truncated zebrafish Gli2 proteins interfere with Hh signaling necessary for differentiation and axon guidance in the ventral forebrain... - Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm inductionPrabhat S Kunwar
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Development 130:5589-99. 2003.... - Single-cell internalization during zebrafish gastrulationA Carmany-Rampey
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Curr Biol 11:1261-5. 2001..These results suggest that internalization and mesendoderm formation in zebrafish can be attained autonomously by single cells... - Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAsAntonio J Giraldez
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 312:75-9. 2006..We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis... - Assembly of trigeminal sensory ganglia by chemokine signalingHolger Knaut
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Neuron 47:653-66. 2005..These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion... - MicroRNAs regulate brain morphogenesis in zebrafishAntonio J Giraldez
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 308:833-8. 2005..Injection of miR-430 miRNAs rescues the brain defects in MZdicer mutants, revealing essential roles for miRNAs during morphogenesis... - Nodal signaling activates differentiation genes during zebrafish gastrulationJames T Bennett
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Dev Biol 304:525-40. 2007..These results indicate that Nodal signaling regulates not only specification genes but also differentiation genes... - Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arborsAlvaro Sagasti
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Curr Biol 15:804-14. 2005..We investigated the developmental mechanisms that determine the size and shape of individual trigeminal arbors in zebrafish and analyzed how these interactions affect the functional organization of the peripheral sensory system... - Conserved and divergent mechanisms in left-right axis formationR D Burdine
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Genes Dev 14:763-76. 2000 - Lefty proteins are long-range inhibitors of squint-mediated nodal signalingYu Chen
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Curr Biol 12:2124-8. 2002..We also find that Lefty restricts the response to both high and low levels of Nodal signaling. These results indicate that Lefty proteins restrict the activity range of Nodal signals by dampening Nodal signaling in surrounding cells... - Clearing the path for germ cellsHolger Knaut
Developmental Genetics Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Cell 132:337-9. 2008..These results highlight the importance of ligand clearance during guided cell migration... - Maternal nodal and zebrafish embryogenesisJames T Bennett
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nature 450:E1-2; discussion E2-4. 2007..Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning... - Planar cell polarity signalling couples cell division and morphogenesis during neurulationBrian Ciruna
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Nature 439:220-4. 2006..These results reveal a function for PCP signalling in coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mechanism that might underlie NTDs... - EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1Simon K Cheng
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 17:31-6. 2003..These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously... - Production of maternal-zygotic mutant zebrafish by germ-line replacementBrian Ciruna
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Proc Natl Acad Sci U S A 99:14919-24. 2002..Furthermore, the ability to generate large clutches of purely mutant embryos will greatly facilitate embryological, genetic, genomic, and biochemical studies... - A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screeningHo-Sang Moon
Department of Chemistry, New York University, New York, NY 10003, USA
J Am Chem Soc 124:11608-9. 2002..Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay... - Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signalingOksana V Tyurina
Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
Dev Biol 277:537-56. 2005..These results reveal a conserved role for Gli3 in vertebrate development and uncover novel regional functions and regulatory interactions among gli genes... - Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafishDavid A Prober
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 26:13400-10. 2006.... - Stat3 Controls Cell Movements during Zebrafish GastrulationSusumu Yamashita
Department of Molecular Oncology C 7, Osaka University Graduate School of Medicine, 2 2 Yamada oka, 565 0871, Suita Osaka, Japan
Dev Cell 2:363-75. 2002..These results reveal a role for Stat3 in controlling cell movements during gastrulation... - The maternal-zygotic transition: death and birth of RNAsAlexander F Schier
Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Center for Brain Science, Broad Institute, Harvard University, 16 Divinity Avenue, Room 1027, Cambridge, MA 02138, USA
Science 316:406-7. 2007..Maternal RNA degradation is induced by the binding of proteins and microRNAs to the 3' untranslated region of target RNAs... - Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430Wen Yee Choi
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Science 318:271-4. 2007..These findings establish an approach to analyze the in vivo roles of specific miRNA-mRNA pairs and reveal a requirement for miRNAs in dampening and balancing agonist/antagonist pairs... - Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neuronsAdam D Douglass
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Curr Biol 18:1133-7. 2008..These results establish ChR2 as a powerful tool for the manipulation of neural activity in zebrafish and reveal a degree of efficiency in coding that has not been found in primary sensory neurons... - Members of the miRNA-200 family regulate olfactory neurogenesisPhilip S Choi
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Neuron 57:41-55. 2008.... - Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430Yuichiro Mishima
Department of Biology, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nadaku, Kobe 657 8501, Japan
Curr Biol 16:2135-42. 2006..These results indicate that miR-430 targets the 3' UTRs of germline genes and suggest that differential susceptibility to microRNAs contributes to tissue-specific gene expression... - Polycystin-2 immunolocalization and function in zebrafishTomoko Obara
Nephrology Division, Massachusetts General Hospital 149 8000 and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
J Am Soc Nephrol 17:2706-18. 2006.... - The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendodermScott T Dougan
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Development 130:1837-51. 2003..In addition, the differential timing of dorsal mesendoderm induction in squint and cyclops mutants suggests that dorsal marginal cells can respond to Nodal signals at stages ranging from the mid-blastula through the mid-gastrula... - Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate developmentRolf O Karlstrom
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
Development 130:1549-64. 2003..These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets... - Axis formation: squint comes into focusAlexander F Schier
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Curr Biol 15:R1002-5. 2005..Gene products provided by the mother to the embryo determine the body axes in most animals. A recent study in zebrafish proposes that the TGFss signal Squint is one such factor... - Mesoderm induction and patterningDavid Kimelman
Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98195-7350, USA
Results Probl Cell Differ 40:15-27. 2002 - Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesisAlbrecht G Kramer-Zucker
Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Development 132:1907-21. 2005..In Kupffer's vesicle, loss of flow is associated with loss of left-right patterning, indicating that the 'nodal flow' mechanism of generating situs is conserved in non-mammalian vertebrates... - Nodal stability determines signaling rangeJ Ann Le Good
Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Curr Biol 15:31-6. 2005..These results suggest that increased proteolytic maturation of Nodal potentiates autocrine signaling, whereas increased Nodal stability extends paracrine signaling... - Targeted mutagenesis in zebrafishIan G Woods
Department of Molecular and Cellular Biology, Broad Institute, Center for Brain Science, Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nat Biotechnol 26:650-1. 2008 - A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defectsJune M de la Cruz
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, MSC 1852, Building 10 Room 10C103, Bethesda, MD 20892 1852, USA
Hum Genet 110:422-8. 2002..The mutant protein is inactive in a zebrafish rescue assay, indicating a role for TDGF1 in human midline and forebrain development... - Developmental biology: tail of decayAlexander F Schier
Nature 427:403-4. 2004 - Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell functionDavid A Prober
Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 28:10102-10. 2008....