A F Schier

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors
    Simon K Cheng
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, USA
    PLoS Biol 2:E30. 2004
  2. ncbi request reprint Genetics of neural development in zebrafish
    A F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Curr Opin Neurobiol 7:119-26. 1997
  3. ncbi request reprint Nodal signaling and the zebrafish organizer
    A F Schier
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Int J Dev Biol 45:289-97. 2001
  4. ncbi request reprint Molecular genetics of axis formation in zebrafish
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 6497, USA
    Annu Rev Genet 39:561-613. 2005
  5. ncbi request reprint Nodal signalling in vertebrate development
    A F Schier
    Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Nature 403:385-9. 2000
  6. ncbi request reprint Axis formation and patterning in zebrafish
    A F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, New York, USA
    Curr Opin Genet Dev 11:393-404. 2001
  7. ncbi request reprint Nodal signaling in vertebrate development
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Cell Dev Biol 19:589-621. 2003
  8. ncbi request reprint Chemokine signaling: rules of attraction
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Curr Biol 13:R192-4. 2003
  9. ncbi request reprint The zebrafish organizer
    A F Schier
    Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Curr Opin Genet Dev 8:464-71. 1998
  10. ncbi request reprint The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
    K Gritsman
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Cell 97:121-32. 1999

Collaborators

Detail Information

Publications50

  1. pmc Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors
    Simon K Cheng
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, USA
    PLoS Biol 2:E30. 2004
    ..These results indicate that coreceptors are targets for both TGFbeta agonists and antagonists and suggest that subtle sequence variations in TGFbeta signals result in greater ligand diversity...
  2. ncbi request reprint Genetics of neural development in zebrafish
    A F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Curr Opin Neurobiol 7:119-26. 1997
    ..Ongoing molecular analyses promise to further elucidate the mechanisms underlying neural development in vertebrates...
  3. ncbi request reprint Nodal signaling and the zebrafish organizer
    A F Schier
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Int J Dev Biol 45:289-97. 2001
    ..The combination of genetic, molecular and embryological approaches in zebrafish has thus provided a framework to understand the mechanisms underlying organizer development...
  4. ncbi request reprint Molecular genetics of axis formation in zebrafish
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 6497, USA
    Annu Rev Genet 39:561-613. 2005
    ..Noncanonical Wnt signaling is required for the morphogenetic movements during gastrulation. We review how the coordinated interplay of these molecules determines the fate and movement of embryonic cells...
  5. ncbi request reprint Nodal signalling in vertebrate development
    A F Schier
    Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Nature 403:385-9. 2000
    ....
  6. ncbi request reprint Axis formation and patterning in zebrafish
    A F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, New York, USA
    Curr Opin Genet Dev 11:393-404. 2001
    ..Detailed analyses have revealed a complex genetic network that patterns the early embryo...
  7. ncbi request reprint Nodal signaling in vertebrate development
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Cell Dev Biol 19:589-621. 2003
    ..These studies demonstrate that Nodal signaling is modulated at almost every level to precisely orchestrate tissue patterning during vertebrate embryogenesis...
  8. ncbi request reprint Chemokine signaling: rules of attraction
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Curr Biol 13:R192-4. 2003
    ..The chemokine SDF-1 and its receptor CXCR4 control cell migration in the immune and nervous systems. Recent studies in zebrafish have shown that SDF-1 and CXCR4 also guide the migration of germ cells and sensory organs of the lateral line...
  9. ncbi request reprint The zebrafish organizer
    A F Schier
    Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Curr Opin Genet Dev 8:464-71. 1998
    ..In addition, embryological studies have suggested that the zebrafish organizer is induced by extraembryonic cues and have defined two novel organizing centers that pattern the nervous system along the anterior-posterior axes...
  10. ncbi request reprint The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
    K Gritsman
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Cell 97:121-32. 1999
    ..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development...
  11. ncbi request reprint Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish
    B Feldman
    Developmental Genetics Program, Division of Developmental Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, The National Institute for Medical Research, New York, London, New York 10016, NW7 1AA, USA, UK
    Curr Biol 10:531-4. 2000
    ..These results demonstrate that nodal-related genes are required for the allocation of dorsal marginal cells to mesendodermal fates and for anteroposterior patterning of the neural tube...
  12. ncbi request reprint Nodal signaling patterns the organizer
    K Gritsman
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 127:921-32. 2000
    ..Together, these results indicate that differential Nodal signaling patterns the organizer before gastrulation, with the highest level of activity required for anterior fates and lower activity essential for posterior fates...
  13. ncbi request reprint Zebrafish organizer development and germ-layer formation require nodal-related signals
    B Feldman
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University Medical Center, New York 10016, USA
    Nature 395:181-5. 1998
    ..Misexpression of sqt RNA within the embryo or specifically in the YSL induces expanded or ectopic dorsal mesoderm. These results establish an essential role for nodal-related signals in organizer development and mesendoderm formation...
  14. ncbi request reprint The zebrafish Nodal signal Squint functions as a morphogen
    Y Chen
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department for Cell Biology, New York University School of Medicine, New York 10016, USA
    Nature 411:607-10. 2001
    ..These results indicate that Squint acts as a secreted morphogen that does not require a relay mechanism...
  15. ncbi request reprint Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation
    J Zhang
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University Medical Center, New York 10016, USA
    Cell 92:241-51. 1998
    ..These results establish an essential but permissive role for an EGF-related ligand during vertebrate gastrulation...
  16. pmc Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning
    R O Karlstrom
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
    Genes Dev 13:388-93. 1999
    ..These findings reveal that truncated zebrafish Gli2 proteins interfere with Hh signaling necessary for differentiation and axon guidance in the ventral forebrain...
  17. ncbi request reprint Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction
    Prabhat S Kunwar
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 130:5589-99. 2003
    ....
  18. ncbi request reprint Single-cell internalization during zebrafish gastrulation
    A Carmany-Rampey
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Biol 11:1261-5. 2001
    ..These results suggest that internalization and mesendoderm formation in zebrafish can be attained autonomously by single cells...
  19. ncbi request reprint Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 312:75-9. 2006
    ..We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis...
  20. ncbi request reprint Assembly of trigeminal sensory ganglia by chemokine signaling
    Holger Knaut
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:653-66. 2005
    ..These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion...
  21. ncbi request reprint MicroRNAs regulate brain morphogenesis in zebrafish
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 308:833-8. 2005
    ..Injection of miR-430 miRNAs rescues the brain defects in MZdicer mutants, revealing essential roles for miRNAs during morphogenesis...
  22. pmc Nodal signaling activates differentiation genes during zebrafish gastrulation
    James T Bennett
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 304:525-40. 2007
    ..These results indicate that Nodal signaling regulates not only specification genes but also differentiation genes...
  23. ncbi request reprint Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors
    Alvaro Sagasti
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Curr Biol 15:804-14. 2005
    ..We investigated the developmental mechanisms that determine the size and shape of individual trigeminal arbors in zebrafish and analyzed how these interactions affect the functional organization of the peripheral sensory system...
  24. ncbi request reprint Conserved and divergent mechanisms in left-right axis formation
    R D Burdine
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Genes Dev 14:763-76. 2000
  25. ncbi request reprint Lefty proteins are long-range inhibitors of squint-mediated nodal signaling
    Yu Chen
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Curr Biol 12:2124-8. 2002
    ..We also find that Lefty restricts the response to both high and low levels of Nodal signaling. These results indicate that Lefty proteins restrict the activity range of Nodal signals by dampening Nodal signaling in surrounding cells...
  26. doi request reprint Clearing the path for germ cells
    Holger Knaut
    Developmental Genetics Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 132:337-9. 2008
    ..These results highlight the importance of ligand clearance during guided cell migration...
  27. ncbi request reprint Maternal nodal and zebrafish embryogenesis
    James T Bennett
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 450:E1-2; discussion E2-4. 2007
    ..Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning...
  28. pmc Planar cell polarity signalling couples cell division and morphogenesis during neurulation
    Brian Ciruna
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Nature 439:220-4. 2006
    ..These results reveal a function for PCP signalling in coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mechanism that might underlie NTDs...
  29. pmc EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1
    Simon K Cheng
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 17:31-6. 2003
    ..These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously...
  30. pmc Production of maternal-zygotic mutant zebrafish by germ-line replacement
    Brian Ciruna
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Proc Natl Acad Sci U S A 99:14919-24. 2002
    ..Furthermore, the ability to generate large clutches of purely mutant embryos will greatly facilitate embryological, genetic, genomic, and biochemical studies...
  31. ncbi request reprint A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening
    Ho Sang Moon
    Department of Chemistry, New York University, New York, NY 10003, USA
    J Am Chem Soc 124:11608-9. 2002
    ..Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay...
  32. ncbi request reprint Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
    Oksana V Tyurina
    Department of Biology, University of Massachusetts, Amherst, MA 01003 9297, USA
    Dev Biol 277:537-56. 2005
    ..These results reveal a conserved role for Gli3 in vertebrate development and uncover novel regional functions and regulatory interactions among gli genes...
  33. ncbi request reprint Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish
    David A Prober
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 26:13400-10. 2006
    ....
  34. ncbi request reprint Stat3 Controls Cell Movements during Zebrafish Gastrulation
    Susumu Yamashita
    Department of Molecular Oncology C 7, Osaka University Graduate School of Medicine, 2 2 Yamada oka, 565 0871, Suita Osaka, Japan
    Dev Cell 2:363-75. 2002
    ..These results reveal a role for Stat3 in controlling cell movements during gastrulation...
  35. ncbi request reprint The maternal-zygotic transition: death and birth of RNAs
    Alexander F Schier
    Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Center for Brain Science, Broad Institute, Harvard University, 16 Divinity Avenue, Room 1027, Cambridge, MA 02138, USA
    Science 316:406-7. 2007
    ..Maternal RNA degradation is induced by the binding of proteins and microRNAs to the 3' untranslated region of target RNAs...
  36. ncbi request reprint Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    Wen Yee Choi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 318:271-4. 2007
    ..These findings establish an approach to analyze the in vivo roles of specific miRNA-mRNA pairs and reveal a requirement for miRNAs in dampening and balancing agonist/antagonist pairs...
  37. pmc Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons
    Adam D Douglass
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Curr Biol 18:1133-7. 2008
    ..These results establish ChR2 as a powerful tool for the manipulation of neural activity in zebrafish and reveal a degree of efficiency in coding that has not been found in primary sensory neurons...
  38. pmc Members of the miRNA-200 family regulate olfactory neurogenesis
    Philip S Choi
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 57:41-55. 2008
    ....
  39. pmc Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430
    Yuichiro Mishima
    Department of Biology, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nadaku, Kobe 657 8501, Japan
    Curr Biol 16:2135-42. 2006
    ..These results indicate that miR-430 targets the 3' UTRs of germline genes and suggest that differential susceptibility to microRNAs contributes to tissue-specific gene expression...
  40. pmc Polycystin-2 immunolocalization and function in zebrafish
    Tomoko Obara
    Nephrology Division, Massachusetts General Hospital 149 8000 and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 17:2706-18. 2006
    ....
  41. ncbi request reprint The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm
    Scott T Dougan
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 130:1837-51. 2003
    ..In addition, the differential timing of dorsal mesendoderm induction in squint and cyclops mutants suggests that dorsal marginal cells can respond to Nodal signals at stages ranging from the mid-blastula through the mid-gastrula...
  42. ncbi request reprint Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003
    ..These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets...
  43. ncbi request reprint Axis formation: squint comes into focus
    Alexander F Schier
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Curr Biol 15:R1002-5. 2005
    ..Gene products provided by the mother to the embryo determine the body axes in most animals. A recent study in zebrafish proposes that the TGFss signal Squint is one such factor...
  44. ncbi request reprint Mesoderm induction and patterning
    David Kimelman
    Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98195 7350, USA
    Results Probl Cell Differ 40:15-27. 2002
  45. ncbi request reprint Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
    Albrecht G Kramer-Zucker
    Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 132:1907-21. 2005
    ..In Kupffer's vesicle, loss of flow is associated with loss of left-right patterning, indicating that the 'nodal flow' mechanism of generating situs is conserved in non-mammalian vertebrates...
  46. ncbi request reprint Nodal stability determines signaling range
    J Ann Le Good
    Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Curr Biol 15:31-6. 2005
    ..These results suggest that increased proteolytic maturation of Nodal potentiates autocrine signaling, whereas increased Nodal stability extends paracrine signaling...
  47. pmc Targeted mutagenesis in zebrafish
    Ian G Woods
    Department of Molecular and Cellular Biology, Broad Institute, Center for Brain Science, Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Biotechnol 26:650-1. 2008
  48. ncbi request reprint A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects
    June M de la Cruz
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, MSC 1852, Building 10 Room 10C103, Bethesda, MD 20892 1852, USA
    Hum Genet 110:422-8. 2002
    ..The mutant protein is inactive in a zebrafish rescue assay, indicating a role for TDGF1 in human midline and forebrain development...
  49. ncbi request reprint Developmental biology: tail of decay
    Alexander F Schier
    Nature 427:403-4. 2004
  50. pmc Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function
    David A Prober
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 28:10102-10. 2008
    ....