G E Schafe

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint The induction of c-Fos in the NTS after taste aversion learning is not correlated with measures of conditioned fear
    G E Schafe
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Behav Neurosci 114:99-106. 2000
  2. ncbi request reprint Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala
    G E Schafe
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 20:RC96. 2000
  3. ncbi request reprint Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning
    G E Schafe
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 20:8177-87. 2000
  4. ncbi request reprint Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective
    G E Schafe
    W M Keck Foundation, Laboratory of Neurobiology, Center for Neural Science, New York University, New York, NY 10003, USA
    Trends Neurosci 24:540-6. 2001
  5. ncbi request reprint Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
    K Nader
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Nature 406:722-6. 2000
  6. ncbi request reprint Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning
    S M Rodrigues
    W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 21:6889-96. 2001
  7. ncbi request reprint Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 24:3281-8. 2004
  8. ncbi request reprint The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5219-29. 2002
  9. ncbi request reprint Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
    H T Blair
    Center for Neural Science, New York University, New York, New York 10003, USA
    Learn Mem 8:229-42. 2001
  10. ncbi request reprint NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala
    Elizabeth P Bauer
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5239-49. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The induction of c-Fos in the NTS after taste aversion learning is not correlated with measures of conditioned fear
    G E Schafe
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Behav Neurosci 114:99-106. 2000
    ..Further, exposure to a taste CS did not selectively lead to increases in MAP or HR. Results suggest that induction of c-FLI in the iNTS may reflect the activation of a cell population whose function is unique to the CTA paradigm...
  2. ncbi request reprint Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala
    G E Schafe
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 20:RC96. 2000
    ..Findings suggest that the LA is essential for memory consolidation of auditory fear conditioning and that this process is PKA and protein-synthesis dependent...
  3. ncbi request reprint Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning
    G E Schafe
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 20:8177-87. 2000
    ..Collectively, these results demonstrate that ERK/MAPK activation is necessary for both memory consolidation of Pavlovian fear conditioning and synaptic plasticity in the amygdala...
  4. ncbi request reprint Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective
    G E Schafe
    W M Keck Foundation, Laboratory of Neurobiology, Center for Neural Science, New York University, New York, NY 10003, USA
    Trends Neurosci 24:540-6. 2001
    ....
  5. ncbi request reprint Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
    K Nader
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Nature 406:722-6. 2000
    ..Our data show that consolidated fear memories, when reactivated, return to a labile state that requires de novo protein synthesis for reconsolidation. These findings are not predicted by traditional theories of memory consolidation...
  6. ncbi request reprint Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning
    S M Rodrigues
    W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 21:6889-96. 2001
    ..NMDA receptors in LA are thus involved in fear conditioning, and the NR2B subunit appears to make unique contributions to the underlying plasticity...
  7. ncbi request reprint Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 24:3281-8. 2004
    ..Together, the results of these experiments provide the first comprehensive view of the role of CaMKII in the amygdala during fear conditioning...
  8. ncbi request reprint The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5219-29. 2002
    ..Collectively, the results of this study indicate that mGluR5 in the LA plays a crucial role in fear conditioning and in plasticity at synapses involved in fear conditioning...
  9. ncbi request reprint Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
    H T Blair
    Center for Neural Science, New York University, New York, New York 10003, USA
    Learn Mem 8:229-42. 2001
    ....
  10. ncbi request reprint NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala
    Elizabeth P Bauer
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5239-49. 2002
    ..Collectively, the results suggest that two pharmacologically distinct forms of LTP can be isolated in the LA in vitro and that a combination of both contribute to the formation of fear memories in vivo at the cellular level...
  11. ncbi request reprint Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system
    Annemieke M Apergis-Schoute
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:5730-9. 2005
    ....
  12. ncbi request reprint The labile nature of consolidation theory
    K Nader
    Center for Neural Science, New York University, New York, New York 10003, USA
    Nat Rev Neurosci 1:216-9. 2000
    ..Our findings open up a new dimension in the study of memory consolidation. We argue that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories...
  13. ncbi request reprint Long-term potentiation in freely moving rats reveals asymmetries in thalamic and cortical inputs to the lateral amygdala
    Valérie Doyère
    W M Keck Foundation, Laboratory of Neurobiology, Center for Neural Science, NYU, New York, NY 10003, USA
    Eur J Neurosci 17:2703-15. 2003
    ....
  14. ncbi request reprint Molecular mechanisms underlying emotional learning and memory in the lateral amygdala
    Sarina M Rodrigues
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 44:75-91. 2004
    ..Given that the neural circuit underlying fear conditioning has been implicated in emotional disorders in humans, the molecular mechanisms of fear conditioning are potential targets for psychotherapeutic drug development...
  15. ncbi request reprint Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning
    Ann E Wilensky
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York, New York 10003, USA
    J Neurosci 26:12387-96. 2006
    ..These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning...
  16. ncbi request reprint Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala
    Glenn E Schafe
    Department of Psychology, Yale University, 2 Hillhouse Ave, Box 208205, New Haven, CT 06520, USA
    Eur J Neurosci 22:201-11. 2005
    ..Collectively, the findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA...
  17. ncbi request reprint Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storage
    Glenn E Schafe
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 25:10010-4. 2005
    ....
  18. ncbi request reprint Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
    Valérie Doyère
    Neurobiologie de l Apprentissage, de la Mémoire et de la Communication NAMC, Centre National de la Recherche Scientifique CNRS, UMR8620, Universite Paris Sud, 91405 Orsay, France
    Nat Neurosci 10:414-6. 2007
    ..Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses...
  19. pmc Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo
    Glenn E Schafe
    Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
    Learn Mem 15:55-62. 2008
    ..Collectively, results demonstrate that ERK/MAPK activation is necessary for synaptic plasticity in anatomically defined regions of the LA, in vivo...
  20. doi request reprint Rethinking the role of L-type voltage-gated calcium channels in fear memory extinction
    Glenn E Schafe
    Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
    Learn Mem 15:324-5. 2008