George Sakoulas

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
  2. pmc Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin
    George Sakoulas
    Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595, USA
    Antimicrob Agents Chemother 50:1581-5. 2006
  3. ncbi request reprint Effects of prolonged vancomycin administration on methicillin-resistant Staphylococcus aureus (MRSA) in a patient with recurrent bacteraemia
    George Sakoulas
    Westchester Medical Center and New York Medical College, Valhalla, USA
    J Antimicrob Chemother 57:699-704. 2006
  4. ncbi request reprint Adaptation of methicillin-resistant Staphylococcus aureus in the face of vancomycin therapy
    George Sakoulas
    Westchester Medical Center, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 42:S40-50. 2006
  5. pmc Evaluation of endocarditis caused by methicillin-susceptible Staphylococcus aureus developing nonsusceptibility to daptomycin
    George Sakoulas
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595, USA
    J Clin Microbiol 46:220-4. 2008
  6. pmc Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia
    Carlo McCalla
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 52:3441-3. 2008
  7. ncbi request reprint Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA
    Venkata G Meka
    Division of Infectious Diseases, Department of Medicine, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 190:311-7. 2004
  8. ncbi request reprint Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?
    George Sakoulas
    Department of Medicine, Division of Laboratory and Transfusion Medicine and Harvard Medical School, Boston, Massachussetts, USA
    J Infect Dis 187:929-38. 2003
  9. ncbi request reprint Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
  10. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005

Detail Information

Publications40

  1. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
    ..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...
  2. pmc Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin
    George Sakoulas
    Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595, USA
    Antimicrob Agents Chemother 50:1581-5. 2006
    ..aureus passaged in vancomycin-containing medium. A correlation between vancomycin and daptomycin heteroresistance was noted in some strains, suggesting that exposure of S. aureus to vancomycin may affect susceptibility to daptomycin...
  3. ncbi request reprint Effects of prolonged vancomycin administration on methicillin-resistant Staphylococcus aureus (MRSA) in a patient with recurrent bacteraemia
    George Sakoulas
    Westchester Medical Center and New York Medical College, Valhalla, USA
    J Antimicrob Chemother 57:699-704. 2006
    ..To evaluate microbiological properties of methicillin-resistant Staphylococcus aureus (MRSA) during prolonged vancomycin therapy...
  4. ncbi request reprint Adaptation of methicillin-resistant Staphylococcus aureus in the face of vancomycin therapy
    George Sakoulas
    Westchester Medical Center, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 42:S40-50. 2006
    ..aureus might, in part, explain the decreased efficacy of vancomycin in the therapy of methicillin-resistant S. aureus bacteremia, thus highlighting the need to reevaluate the criteria of susceptibility to vancomycin...
  5. pmc Evaluation of endocarditis caused by methicillin-susceptible Staphylococcus aureus developing nonsusceptibility to daptomycin
    George Sakoulas
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595, USA
    J Clin Microbiol 46:220-4. 2008
    ..Early surgical intervention or combination therapy or both might have prevented the loss of daptomycin susceptibility...
  6. pmc Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia
    Carlo McCalla
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 52:3441-3. 2008
    ..1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure...
  7. ncbi request reprint Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA
    Venkata G Meka
    Division of Infectious Diseases, Department of Medicine, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 190:311-7. 2004
    ..The most recent isolate of this series was recovered 7 months after the patient discontinued linezolid and demonstrated reversion to a susceptible phenotype associated with a loss of the T2500A mutation...
  8. ncbi request reprint Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?
    George Sakoulas
    Department of Medicine, Division of Laboratory and Transfusion Medicine and Harvard Medical School, Boston, Massachussetts, USA
    J Infect Dis 187:929-38. 2003
    ..This study suggests that some S. aureus strains have an intrinsic survival advantage under a glycopeptide selective pressure, which is possibly related to reduced autolysis after exposure to subinhibitory concentrations of glycopeptide...
  9. ncbi request reprint Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    ..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution...
  10. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005
    ..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations...
  11. pmc Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients
    Tahaniyat Lalani
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 46:2890-6. 2008
    ..In this study of bloodstream isolates collected as part of a multinational randomized clinical trial, USA 300 and pvl-constitutive MRSA strains were associated with better clinical outcomes...
  12. ncbi request reprint Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype
    Satish K Pillai
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Infect Dis 186:1603-7. 2002
    ..Compared with 2 linezolid-susceptible S. aureus isolates, the linezolid-resistant S. aureus isolate demonstrated no significant differences in in vitro growth characteristics...
  13. pmc Polyphyletic emergence of linezolid-resistant staphylococci in the United States
    Agnes Wong
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA
    Antimicrob Agents Chemother 54:742-8. 2010
    ..epidermidis isolates. These findings suggest that linezolid resistance has emerged independently in multiple clones of S. aureus and with a variety of ribosomal mutations in multiple clones of S. epidermidis...
  14. pmc Efficacy of daptomycin in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Antimicrob Agents Chemother 47:1714-8. 2003
    ..8. The difference between daptomycin and daptomycin plus rifampin was statistically significant (P = 0.006). These results support the continued evaluation of daptomycin for serious MRSA infections, including infective endocarditis...
  15. ncbi request reprint Perspectives on Daptomycin resistance, with emphasis on resistance in Staphylococcus aureus
    Helen W Boucher
    Division of Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Infect Dis 45:601-8. 2007
    ..Although clinical practitioners must monitor for daptomycin resistance, the available data support the use of daptomycin in the treatment of methicillin-resistant S. aureus bacteremia and endocarditis...
  16. doi request reprint Clinical outcomes of patients receiving daptomycin for the treatment of Staphylococcus aureus infections and assessment of clinical factors for daptomycin failure: a retrospective cohort study utilizing the Cubicin Outcomes Registry and Experience
    George Sakoulas
    Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA
    Clin Ther 31:1936-45. 2009
    ..Daptomycin is most commonly used as a second-line treatment. Previous studies have not differentiated the effect of prior antibiotic therapy on daptomycin clinical outcomes...
  17. doi request reprint Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains
    George Sakoulas
    Division of Infectious Diseases, Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, New York, USA
    Clin Infect Dis 46:S360-7. 2008
    ..aureus. Therefore, it appears that our definition of vancomycin susceptibility requires further scrutiny as applied to serious MRSA infections, such as bacteremia and pneumonia...
  18. pmc Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding
    Abhay Dhand
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA
    Clin Infect Dis 53:158-63. 2011
    ..Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.)...
  19. ncbi request reprint Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
    ..54-2.42; P<.001); significant heterogeneity was present. We explored the reasons for heterogeneity by means of subgroup analyses. MRSA bacteremia is associated with significantly higher mortality rate than is MSSA bacteremia...
  20. ncbi request reprint Daptomycin in the treatment of bacteremia
    George Sakoulas
    New York Medical College, Valhalla, New York, USA
    Am J Med 120:S21-7. 2007
    ..Given the limitations of retrospective studies and lack of follow-up data, additional studies are needed to make definitive evaluations with these pathogens...
  21. doi request reprint Relationship between population density of attorneys and prevalence of methicillin-resistant Staphylococcus aureus: is medical-legal pressure on physicians a driving force behind the development of antibiotic resistance?
    George Sakoulas
    Division of Infectious Diseases, Department of Medicine, School of Public Health, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
    Am J Ther 16:e1-6. 2009
    ..aureus, with global implications on the ethics of the delivery of quality health care to all members of society...
  22. pmc Vancomycin ototoxicity: a reevaluation in an era of increasing doses
    Avisheh Forouzesh
    New York Medical College, Valhalla, USA
    Antimicrob Agents Chemother 53:483-6. 2009
    ....
  23. ncbi request reprint Clinical update on the diagnosis and treatment of bacterial endocarditis
    Patricia Dandache
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Compr Ther 33:192-207. 2007
    ..This review will touch on several aspects of endocarditis, including pathogenesis and treatment...
  24. ncbi request reprint Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin
    Christopher W Woods
    Clinical Microbiology, Durham Veterans Administration Medical Center, Durham, NC 27705, USA
    Clin Infect Dis 38:1188-91. 2004
    ..We report the strain characterization and treatment of a patient with SARV IE...
  25. pmc Clinical implications of varying degrees of vancomycin susceptibility in methicillin-resistant Staphylococcus aureus bacteremia
    Mitchell J Schwaber
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Emerg Infect Dis 9:657-64. 2003
    ..These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin...
  26. pmc Clinical rationale for treatment of endocarditis caused by methicillin-susceptible Staphylococcus aureus developing nonsusceptibility to daptomycin
    Zukile Gqada
    J Clin Microbiol 46:2471; author reply 2471-2. 2008
  27. pmc Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus
    Brian T Tsuji
    Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
    Antimicrob Agents Chemother 51:1089-91. 2007
    ..The free unbound fraction of the area under the concentration-time curve (fAUC/MIC) required to suppress resistance was fourfold higher (P < 0.001) in agr dysfunctional strains (112 to 169) than that in parent wild-type strains (28)...
  28. ncbi request reprint Introduction of erm(C) into a linezolid- and methicillin-resistant Staphylococcus aureus does not restore linezolid susceptibility
    George Sakoulas
    J Antimicrob Chemother 51:1039-41. 2003
  29. doi request reprint Relationship of linezolid minimum inhibitory concentration and time to bacterial eradication in treatment for methicillin-resistant Staphylococcus aureus infection
    Pamela A Moise
    Ann Pharmacother 42:592-3. 2008
  30. doi request reprint Teicoplanin pharmacodynamics in reference to the accessory gene regulator (agr) in Staphylococcus aureus using an in vitro pharmacodynamic model
    Warren E Rose
    Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Antimicrob Chemother 61:1099-102. 2008
    ..We investigated this relationship in agr groups I-IV using another glycopeptide, teicoplanin, in an in vitro pharmacodynamic model...
  31. ncbi request reprint Microbiological effects of prior vancomycin use in patients with methicillin-resistant Staphylococcus aureus bacteraemia
    Pamela A Moise
    University of the Pacific School of Pharmacy and VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Antimicrob Chemother 61:85-90. 2008
    ....
  32. pmc Daptomycin nonsusceptibility in Staphylococcus aureus with reduced vancomycin susceptibility is independent of alterations in MprF
    Satish K Pillai
    Department of Infectious Disease, Cleveland Clinic Foundation, Mailstop S32, Cleveland, OH 44195, USA
    Antimicrob Agents Chemother 51:2223-5. 2007
    ..aureus isolates which developed vancomycin heteroresistance, as well as daptomycin nonsusceptibility despite a lack of exposure to this drug, there were no mutations resulting in amino acid substitutions in MprF...
  33. pmc Vancomycin in vitro bactericidal activity and its relationship to efficacy in clearance of methicillin-resistant Staphylococcus aureus bacteremia
    Pamela A Moise
    University of the Pacific School of Pharmacy and San Diego VA Medical Center, San Diego, California 92161, USA
    Antimicrob Agents Chemother 51:2582-6. 2007
    ..Evaluation of these properties may be useful in the consideration of antimicrobial therapies that can be used as alternatives to vancomycin for the treatment of MRSA bacteremia...
  34. ncbi request reprint Accessory gene regulator group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy
    Pamela A Moise-Broder
    School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Clin Infect Dis 38:1700-5. 2004
    ..aureus clones with this genetic marker under vancomycin selective pressure...
  35. pmc Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding
    Tiffanny Jones
    Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson Street, Bldg RB2, Room 225, Torrance, CA 90502, USA
    Antimicrob Agents Chemother 52:269-78. 2008
    ..aureus. Moreover, the cross-resistance to hNP-1 and tPMP-1 may also impact the capacity of these daptomycin-resistant organisms to be cleared from sites of infection, particularly endovascular foci...
  36. pmc daptomycin activity against Staphylococcus aureus following vancomycin exposure in an in vitro pharmacodynamic model with simulated endocardial vegetations
    Warren E Rose
    Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
    Antimicrob Agents Chemother 52:831-6. 2008
    ..Further evaluation of the susceptibility relationship between daptomycin and vancomycin is necessary to understand the factors involved and their clinical significance...
  37. pmc Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia
    George Sakoulas
    Crystal Run Healthcare, 155 Crystal Run Rd, Middletown, NY 10941, USA
    J Clin Microbiol 42:2398-402. 2004
    ..Prognostic information for vancomycin treatment outcome in MRSA bacteremia may also be obtained by testing the in vitro bactericidal potency of vancomycin...
  38. ncbi request reprint Correlation of vancomycin and daptomycin susceptibility in Staphylococcus aureus in reference to accessory gene regulator (agr) polymorphism and function
    Warren E Rose
    Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI, USA
    J Antimicrob Chemother 59:1190-3. 2007
    ..We investigated the relationship of vancomycin with and without gentamicin or rifampicin, and daptomycin in the development of resistance in agr groups I and II...
  39. ncbi request reprint Hematogenous enterococcal vertebral osteomyelitis: report of 2 cases and review of the literature
    Philip E Tarr
    Washington Hospital Center, Washington, DC, USA
    J Infect 48:354-62. 2004
    ....
  40. ncbi request reprint Effects of glucose on fsr-mediated biofilm formation in Enterococcus faecalis
    Satish K Pillai
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Infect Dis 190:967-70. 2004
    ..The present study provides additional insight into the mechanisms used by E. faecalis to establish nosocomial infection...