- Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cellsCatarina Sacristán
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico
Eur J Immunol 39:2584-95. 2009..Mutations within Itk's kinase, pleckstrin-homology, and proline-rich regions did not abolish TFII-I-Itk binding. Our results provide an initial step in understanding the biological role of Itk-TFII-I signaling in T-cell function...
- Functional anatomy of T cell activation and synapse formationDavid R Fooksman
Department of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, 10016, USA
Annu Rev Immunol 28:79-105. 2010..In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward...