Alexey G Ryazanov

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase
    A G Ryazanov
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 94:4884-9. 1997
  2. ncbi request reprint [Ribosome and the secret of longevity]
    A G Riazanov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, NJ 08854, USA
    Mol Biol (Mosk) 35:727-30. 2001
  3. ncbi request reprint Protein turnover plays a key role in aging
    Alexey G Ryazanov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mech Ageing Dev 123:207-13. 2002
  4. ncbi request reprint Elongation factor-2 kinase and its newly discovered relatives
    Alexey G Ryazanov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway NJ 08854, USA
    FEBS Lett 514:26-9. 2002
  5. ncbi request reprint Phosphorylation of annexin I by TRPM7 channel-kinase
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:50643-6. 2004
  6. ncbi request reprint Alpha-kinases: analysis of the family and comparison with conventional protein kinases
    Diana Drennan
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Prog Biophys Mol Biol 85:1-32. 2004
  7. pmc Phosphorylation of annexin A1 by TRPM7 kinase: a switch regulating the induction of an α-helix
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States
    Biochemistry 50:2187-93. 2011
  8. ncbi request reprint Regulation of elongation factor-2 kinase by pH
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Biochemistry 41:13444-50. 2002
  9. ncbi request reprint Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel
    Lillia V Ryazanova
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:3708-16. 2004
  10. ncbi request reprint Germline quality control: eEF2K stands guard to eliminate defective oocytes
    Hsueh Ping Chu
    Department of Pharmacology, Rutgers The State University of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Cell 28:561-72. 2014

Research Grants

  1. THE ROLE OF EF-2 KINASE IN DRUG RESISTANCE
    ALEXEY RYAZANOV; Fiscal Year: 2003
  2. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 1999
  3. Regulation of Metal Ion Homeostasis by Channel Kinases
    ALEXEY RYAZANOV; Fiscal Year: 2008
  4. Regulation of Metal Ion Homeostasis by Channel Kinases
    ALEXEY RYAZANOV; Fiscal Year: 2007
  5. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2005
  6. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2004
  7. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2003
  8. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2003
  9. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2002
  10. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2002

Collaborators

  • Ronald E Ellis
  • Li Cai
  • David E Harrison
  • M Wiedmann
  • Bart P Braeckman
  • Chengcheng Hu
  • Haiyan Qi
  • Maxim V Dorovkov
  • Andrzej Mazur
  • Shengkan Jin
  • Andrea Fleig
  • M D W Ward
  • Robert G Nagele
  • Kristopher Clark
  • Carl G Figdor
  • Frank N van Leeuwen
  • Hsueh Ping Chu
  • Elena Nosyreva
  • Sungjin Park
  • Edwin Lasonder
  • Jeroen Middelbeek
  • Eszter S Hars
  • Carsten Schmitz
  • Diana Drennan
  • Lillia V Ryazanova
  • Yuriy Shymkiv
  • James S Novak
  • Alexandra Nguyen
  • Jason J Merkin
  • Peter M Clifford
  • Yi Liao
  • Zhixian Hu
  • Kristen Szabla
  • Ege T Kavalali
  • Lisa M Monteggia
  • Anita E Autry
  • A G Riazanov
  • K S Pavur
  • Dietmar Kuhl
  • Walter Kaufmann
  • David J Linden
  • Constance L Smith-Hicks
  • Natalya G Dulyaninova
  • Paul F Worley
  • Joo Min Park
  • Shoaib Chowdhury
  • Sangmok Kim
  • Richard L Huganir
  • Jin Ah Kim
  • Nick A Morrice
  • Jason D Shepherd
  • Anne R Bresnick
  • Leroy F Liu
  • Bart van Leeuwen
  • Wouter H Moolenaar
  • Leonie Ran
  • Michiel Langeslag
  • Kees Jalink
  • Anne Laure Perraud
  • Bennett J Davenport
  • Xiaoyun Zhao
  • Athar Ansari
  • A N Petrov

Detail Information

Publications19

  1. pmc Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase
    A G Ryazanov
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 94:4884-9. 1997
    ..This suggests that eEF-2 kinase and MHCK A are members of a new class of protein kinases with a novel catalytic domain structure...
  2. ncbi request reprint [Ribosome and the secret of longevity]
    A G Riazanov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, NJ 08854, USA
    Mol Biol (Mosk) 35:727-30. 2001
    ..During aging, the concentration of damaged proteins increases because of decelerating protein turnover, the cause of which is unknown, however, it may be related to the decrease in ribosome concentration...
  3. ncbi request reprint Protein turnover plays a key role in aging
    Alexey G Ryazanov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mech Ageing Dev 123:207-13. 2002
    ..The establishment of such a feedback loop should result in an exponential increase in the amount of protein damage-a protein damage catastrophe-that could be the basis of the general deterioration observed in senescent organisms...
  4. ncbi request reprint Elongation factor-2 kinase and its newly discovered relatives
    Alexey G Ryazanov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway NJ 08854, USA
    FEBS Lett 514:26-9. 2002
    ..Several mammalian alpha-kinases have recently been cloned. Two of these alpha-kinases, named channel-kinases 1 and 2 (ChaK1 and ChaK2) represent a new type of signaling molecules that are protein kinases fused to ion channels...
  5. ncbi request reprint Phosphorylation of annexin I by TRPM7 channel-kinase
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:50643-6. 2004
    ..The N-terminal region plays a crucial role in interaction of annexin 1 with other proteins and membranes, and therefore, phosphorylation of annexin 1 at Ser5 by TRPM7 kinase may modulate function of annexin 1...
  6. ncbi request reprint Alpha-kinases: analysis of the family and comparison with conventional protein kinases
    Diana Drennan
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Prog Biophys Mol Biol 85:1-32. 2004
    ..Differences between alpha-kinases and CPKs, and their possible impact on substrate recognition are discussed...
  7. pmc Phosphorylation of annexin A1 by TRPM7 kinase: a switch regulating the induction of an α-helix
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States
    Biochemistry 50:2187-93. 2011
    ..We also show that phosphorylation at Ser5 dramatically weakens the binding of the peptide to S100A11. Our data suggest that phosphorylation at Ser5 regulates the interaction of annexin A1 with membranes as well as S100A11 protein...
  8. ncbi request reprint Regulation of elongation factor-2 kinase by pH
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Biochemistry 41:13444-50. 2002
    ..Our results suggest that pH-dependent activation of eEF-2K may play a role in the global inhibition of protein synthesis during tissue acidosis, which accompanies such processes as hypoxia and ischemia...
  9. ncbi request reprint Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel
    Lillia V Ryazanova
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:3708-16. 2004
    ..Ca(2+) at concentrations up to 1 mM did not affect kinase activity. Considering intracellular ion concentrations, our results suggest that, among divalent metal ions, only Mg(2+) can directly modulate TRPM7/ChaK1 kinase activity in vivo...
  10. ncbi request reprint Germline quality control: eEF2K stands guard to eliminate defective oocytes
    Hsueh Ping Chu
    Department of Pharmacology, Rutgers The State University of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Cell 28:561-72. 2014
    ..These results suggest that eEF2K-mediated inhibition of protein synthesis renders cells susceptible to apoptosis and functions to eliminate suboptimal germ cells. ..
  11. ncbi request reprint Autophagy regulates ageing in C. elegans
    Eszter S Hars
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Autophagy 3:93-5. 2007
    ..elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation...
  12. pmc Acute suppression of spontaneous neurotransmission drives synaptic potentiation
    Elena Nosyreva
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 33:6990-7002. 2013
    ..These findings uncover an unexpectedly dynamic impact of spontaneous glutamate release on synaptic efficacy and provide new insight into a key synaptic substrate for rapid antidepressant action...
  13. ncbi request reprint Mapping the functional domains of elongation factor-2 kinase
    K S Pavur
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Biochemistry 39:12216-24. 2000
    ..The amino acid sequence of the carboxyl-terminal domain of eEF-2 kinase displays similarity to several proteins, all of which contain repeats of a 36-amino acid motif that we named "motif 36"...
  14. pmc TRPM7, a novel regulator of actomyosin contractility and cell adhesion
    Kristopher Clark
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    EMBO J 25:290-301. 2006
    ..Collectively, our results demonstrate that regulation of cell adhesion by TRPM7 is the combined effect of kinase-dependent and -independent pathways on actomyosin contractility...
  15. doi request reprint TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation
    Kristopher Clark
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Mol Biol 378:790-803. 2008
    ..In conclusion, our data demonstrate that TRPM7 regulates myosin IIA filament stability and localization by phosphorylating a short stretch of amino acids within the alpha-helical tail of the myosin IIA heavy chain...
  16. pmc Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
    Sungjin Park
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
    Neuron 59:70-83. 2008
    ..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD...
  17. ncbi request reprint The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC
    Kristopher Clark
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    FEBS Lett 582:2993-7. 2008
    ..In conclusion, TRPM6 and TRPM7 share exogenous substrates among themselves but not with functionally distant alpha-kinases...
  18. ncbi request reprint The channel kinases TRPM6 and TRPM7 are functionally nonredundant
    Carsten Schmitz
    Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, 80206, USA
    J Biol Chem 280:37763-71. 2005
    ....

Research Grants17

  1. THE ROLE OF EF-2 KINASE IN DRUG RESISTANCE
    ALEXEY RYAZANOV; Fiscal Year: 2003
    ..Experiments will be performed to design and develop specific eEF-2 kinase inhibitors which can serve as pro- apoptotic agents. ..
  2. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 1999
    ..This work will reveal the structural organization and function of a new class of protein kinases, which will provide new and important information about the mechanism of protein phosphorylation. ..
  3. Regulation of Metal Ion Homeostasis by Channel Kinases
    ALEXEY RYAZANOV; Fiscal Year: 2008
    ....
  4. Regulation of Metal Ion Homeostasis by Channel Kinases
    ALEXEY RYAZANOV; Fiscal Year: 2007
    ....
  5. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2005
    ..The experiments described in this grant application are designed to provide a foundation for the development of novel therapeutic reagents that can mimic caloric restriction, circumventing some of the deleterious consequences of aging. ..
  6. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2004
    ..The experiments described in this grant application are designed to provide a foundation for the development of novel therapeutic reagents that can mimic caloric restriction, circumventing some of the deleterious consequences of aging. ..
  7. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2003
    ..The experiments described in this grant application are designed to provide a foundation for the development of novel therapeutic reagents that can mimic caloric restriction, circumventing some of the deleterious consequences of aging. ..
  8. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2003
    ..This work will reveal the structural organization and function of a new class of protein kinases, which will provide new and important information about the mechanism of protein phosphorylation. ..
  9. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2002
    ..The experiments described in this grant application are designed to provide a foundation for the development of novel therapeutic reagents that can mimic caloric restriction, circumventing some of the deleterious consequences of aging. ..
  10. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2002
    ..This work will reveal the structural organization and function of a new class of protein kinases, which will provide new and important information about the mechanism of protein phosphorylation. ..
  11. THE ROLE OF EF-2 KINASE IN DRUG RESISTANCE
    ALEXEY RYAZANOV; Fiscal Year: 2002
    ..Experiments will be performed to design and develop specific eEF-2 kinase inhibitors which can serve as pro- apoptotic agents. ..
  12. THE ROLE OF PROTEIN TURNOVER IN AGING
    ALEXEY RYAZANOV; Fiscal Year: 2001
    ..The experiments described in this grant application are designed to provide a foundation for the development of novel therapeutic reagents that can mimic caloric restriction, circumventing some of the deleterious consequences of aging. ..
  13. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2001
    ..This work will reveal the structural organization and function of a new class of protein kinases, which will provide new and important information about the mechanism of protein phosphorylation. ..
  14. THE ROLE OF EF-2 KINASE IN DRUG RESISTANCE
    ALEXEY RYAZANOV; Fiscal Year: 2001
    ..Experiments will be performed to design and develop specific eEF-2 kinase inhibitors which can serve as pro- apoptotic agents. ..
  15. STRUCTURE/FUNCTION OF EFF-2 KINASE
    ALEXEY RYAZANOV; Fiscal Year: 2000
    ..This work will reveal the structural organization and function of a new class of protein kinases, which will provide new and important information about the mechanism of protein phosphorylation. ..
  16. THE ROLE OF EF-2 KINASE IN DRUG RESISTANCE
    ALEXEY RYAZANOV; Fiscal Year: 2000
    ..Experiments will be performed to design and develop specific eEF-2 kinase inhibitors which can serve as pro- apoptotic agents. ..
  17. Development of New Drugs that Protect Gastrointestinal Tract from Radiation
    ALEXEY RYAZANOV; Fiscal Year: 2007
    ..unreadable] 2. To identify specific inhibitors of eEF2 kinase and to develop lead compounds that can be used to develop drugs that protect gastrointestinal tract from radiation damage. [unreadable] [unreadable] [unreadable]..