B Rudy

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein
    Brian D Clark
    Smilow Neuroscience Program, Department of Physiology and Neuroscience New York, USA
    Front Mol Neurosci 1:8. 2008
  2. pmc Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels
    JON K MAFFIE
    Smilow Neuroscience Program, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA
    J Physiol 591:2419-27. 2013
  3. ncbi request reprint Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
    B Rudy
    Dept of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Trends Neurosci 24:517-26. 2001
  4. ncbi request reprint Molecular diversity of K+ channels
    W A Coetzee
    Department of Physiology, New York University School of Medicine, New York 10016, USA
    Ann N Y Acad Sci 868:233-85. 1999
  5. pmc A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents
    T Y Nakamura
    Department of Pediatric Cardiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:12808-13. 2001
  6. pmc Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase
    H Moreno
    Department of Physiology and Neuroscience, New York University School of Medicine, NY 10016, USA
    J Physiol 530:345-58. 2001
  7. ncbi request reprint KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1
    E Vega-Saenz de Miera
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurophysiol 86:130-42. 2001
  8. ncbi request reprint Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex
    M J Saganich
    Department of Physiology, New York University School of Medicine, New York, New York, 10016, USA
    J Neurosci 19:10789-802. 1999
  9. pmc Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor
    M S Nadal
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Physiol 537:801-9. 2001
  10. ncbi request reprint Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2
    T Y Nakamura
    Pediatric Cardiology, NYU School of Medicine, NY 10016, USA
    FEBS Lett 499:205-9. 2001

Research Grants

  1. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2007
  2. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2004
  3. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2009
  4. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2002
  5. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2010
  6. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2000
  7. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2006
  8. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2009
  9. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2009
  10. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2007

Collaborators

  • Jennifer Lanning
  • S Nandi
  • D Contreras
  • M E Martone
  • S Ueda
  • C J McBain
  • D J Pountney
  • E Vega-Saenz de Miera
  • W A Coetzee
  • A Ozaita
  • M S Nadal
  • JON K MAFFIE
  • T Y Nakamura
  • M J Saganich
  • Brian D Clark
  • Y Amarillo
  • H Moreno
  • D Lau
  • T McCormack
  • E C Vega-Saenz de Miera
  • Pierre Edouard Bougis
  • Elena Dvoretskova
  • Marie France Martin-Eauclaire
  • A Chow
  • Marcela Nadal
  • Pavel Strop
  • Elaine Kwon
  • Jon Maffie
  • Hyo Young Jeong
  • M H Ellisman
  • D H Lau
  • M Artman
  • E Machado
  • M Zhadina
  • M Harvey
  • C S Leonard
  • J I Morgan
  • J L Noebels
  • R Paylor
  • M Saganich
  • M F Seldin
  • H Baker
  • J Chiu
  • M Sugimori
  • R Llinas

Detail Information

Publications17

  1. pmc DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein
    Brian D Clark
    Smilow Neuroscience Program, Department of Physiology and Neuroscience New York, USA
    Front Mol Neurosci 1:8. 2008
    ..However, we also found that DPP6 antibodies intensely labeled the hippocampal mossy fiber axons, which lack Kv4 proteins, suggesting that DPP6 proteins may have additional, Kv4-unrelated functions...
  2. pmc Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels
    JON K MAFFIE
    Smilow Neuroscience Program, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA
    J Physiol 591:2419-27. 2013
    ..These studies validate the use of AmmTX3 as a blocker of the Kv4-mediated A-type K+ current in neurons...
  3. ncbi request reprint Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
    B Rudy
    Dept of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Trends Neurosci 24:517-26. 2001
    ....
  4. ncbi request reprint Molecular diversity of K+ channels
    W A Coetzee
    Department of Physiology, New York University School of Medicine, New York 10016, USA
    Ann N Y Acad Sci 868:233-85. 1999
    ....
  5. pmc A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents
    T Y Nakamura
    Department of Pediatric Cardiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:12808-13. 2001
    ..Together, our data provide strong support for the concept that frequenin may be an important Ca(2+)-sensitive regulatory component of native A-type K(+) currents...
  6. pmc Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase
    H Moreno
    Department of Physiology and Neuroscience, New York University School of Medicine, NY 10016, USA
    J Physiol 530:345-58. 2001
    ..Activation of phosphatases via NO or other signals that increase cGMP might be a potent mechanism to regulate Kv3 channel activity in neurons...
  7. ncbi request reprint KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1
    E Vega-Saenz de Miera
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurophysiol 86:130-42. 2001
    ..Medium expression levels were found in neocortex. The KT3.2 gene is located at chromosome 8q24 1-3, and the KT3.3 gene maps to chromosome 20q13.1...
  8. ncbi request reprint Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex
    M J Saganich
    Department of Physiology, New York University School of Medicine, New York, New York, 10016, USA
    J Neurosci 19:10789-802. 1999
    ..Given their functional properties and specific distribution, Eag2 channels may play roles in the regulation of the behavioral state-dependent entry of sensory information to the cerebral cortex...
  9. pmc Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor
    M S Nadal
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Physiol 537:801-9. 2001
    ..4. The time course of the currents expressed by KAF-modified Kv4 channels resembles more closely the time course of the native I(SA) in cerebellar granule cells...
  10. ncbi request reprint Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2
    T Y Nakamura
    Pediatric Cardiology, NYU School of Medicine, NY 10016, USA
    FEBS Lett 499:205-9. 2001
    ..2 and Kv4.1. These results reveal a novel interaction of KChIP1 with these two Kv4 members. This represents a mechanism to further increase the functional diversity of K(+) channels...
  11. ncbi request reprint Differential subcellular localization of the two alternatively spliced isoforms of the Kv3.1 potassium channel subunit in brain
    A Ozaita
    Department of Physiology and Neuroscience and Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurophysiol 88:394-408. 2002
    ..1a protein in dendritic and somatic membrane, respectively. The results support the hypothesis that the alternative spliced C-termini of Kv3 subunits regulate their subcellular targeting in neurons...
  12. ncbi request reprint Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins
    D Lau
    Departments of Physiology and Neuroscience, and Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 20:9071-85. 2000
    ..2 channel elimination suppresses their activity. These data suggest that normal cortical operations depend on the ability of inhibitory interneurons to generate high-frequency firing...
  13. ncbi request reprint Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain
    M J Saganich
    Department of Physiology and Neuroscience and Department of Biochemistry, New York University School of Medicine, New York, New York 10016
    J Neurosci 21:4609-24. 2001
    ..This indicates that the subthreshold current in many neurons may be complex, containing different components mediated by a number of channels with distinct properties and neuromodulatory responses...
  14. ncbi request reprint Contributions of Kv3 channels to neuronal excitability
    B Rudy
    Department of Physiology and Neuroscience, New York University of Medicine, New York 10016, USA
    Ann N Y Acad Sci 868:304-43. 1999
    ..Experimental evidence has now become available showing that Kv3.1-Kv3.2 channels play critical roles in the generation of fast-spiking properties in cortical GABAergic interneurons...
  15. pmc Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells
    E C Vega-Saenz de Miera
    Department of Physiology and Neuroscience, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 94:7059-64. 1997
    ..Conversely, jolting mice with a mutated Scn8a message demonstrates PC abnormalities in rapid, simple spike generation, linking CerIII to the persistent sodium current...
  16. ncbi request reprint Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit
    D J Pountney
    Department of Pediatric Cardiology, New York University School of Medicine, NY 10016, USA
    FEBS Lett 450:191-6. 1999
    ....
  17. ncbi request reprint Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse
    T McCormack
    Department of Physiology, New York University Medical Center, New York, New York 10016, USA
    Genomics 56:360-1. 1999

Research Grants24

  1. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2007
    ..Aim 3 will investigate more directly the physiological significance of DPPX proteins in neurons utilizing gene targeting and antisense technology. ..
  2. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2004
    ..Aim 3 will investigate more directly the physiological significance of DPPX proteins in neurons utilizing gene targeting and antisense technology. ..
  3. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This project investigates the relevance of newly discovered components of ion channels in brain neurons that are important in learning, pain control and the pathogenesis of epilepsy and autism. ..
  4. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2002
    ..2 channels in vitro will also be investigated. ..
  5. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This project investigates the relevance of newly discovered components of ion channels in brain neurons that are important in learning, pain control and the pathogenesis of epilepsy and autism. ..
  6. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2000
    ..2 channels in vitro will also be investigated. ..
  7. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2006
    ..Aim 3 will investigate more directly the physiological significance of DPPX proteins in neurons utilizing gene targeting and antisense technology. ..
  8. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2009
    ..Aim II will utilize electrophysiological recordings from electrically and chemically connected FS cells to understand the role of these channels in generating synchronous activity within FS cell networks. ..
  9. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2009
    ..The proposed experiments seek to validate genetic evidence suggesting that variation in DPP6 predisposes to ALS. The study will advance our knowledge on the mechanisms of this devastating disease. ..
  10. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2007
    ..Aim II will utilize electrophysiological recordings from electrically and chemically connected FS cells to understand the role of these channels in generating synchronous activity within FS cell networks. ..
  11. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2006
    ..Aim II will utilize electrophysiological recordings from electrically and chemically connected FS cells to understand the role of these channels in generating synchronous activity within FS cell networks. ..
  12. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2005
    ..Aim II will utilize electrophysiological recordings from electrically and chemically connected FS cells to understand the role of these channels in generating synchronous activity within FS cell networks. ..
  13. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2005
    ..Aim 3 will investigate more directly the physiological significance of DPPX proteins in neurons utilizing gene targeting and antisense technology. ..
  14. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2004
    ..2 channels in vitro will also be investigated. ..
  15. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2003
    ..Aim 3 will investigate more directly the physiological significance of DPPX proteins in neurons utilizing gene targeting and antisense technology. ..
  16. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2003
    ..2 channels in vitro will also be investigated. ..
  17. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2001
    ..2 channels in vitro will also be investigated. ..
  18. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN THE CNS
    Bernardo Rudy; Fiscal Year: 1999
    ..2 channels in pinched cortical presynaptic terminals. ..
  19. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2010
    ....