T G Rossman

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi Evidence that arsenite acts as a cocarcinogen in skin cancer
    Toby G Rossman
    The Nelson Institute of Environmental Medicine and The NYU Cancer Institute, New York University School of Medicine, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 198:394-404. 2004
  2. ncbi Mechanism of arsenic carcinogenesis: an integrated approach
    Toby G Rossman
    Kaplan Comprehensive Cancer Center, The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 533:37-65. 2003
  3. ncbi Cloning genes whose levels of expression are altered by metals: implications for human health research
    T G Rossman
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Am J Ind Med 38:335-9. 2000
  4. ncbi fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence
    Toby G Rossman
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Oncogene 22:1817-21. 2003
  5. ncbi Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies
    Toby G Rossman
    The Nelson Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Environ Health Perspect 110:749-52. 2002
  6. ncbi Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis
    T G Rossman
    Nelson Institute of Environmental Medicine, Kaplan Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Appl Pharmacol 176:64-71. 2001
  7. ncbi Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity
    B L Vogt
    Nelson Institute of Environmental Medicine and Kaplan Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 478:159-68. 2001
  8. ncbi Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein
    T G Rossman
    New York University Medical Center, Nelson Institute of Environmental Medicine, and Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA
    Mutat Res 402:103-10. 1998
  9. ncbi Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis
    T G Rossman
    Nelson Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University Medical Center, NY 10016, USA
    Carcinogenesis 20:311-6. 1999
  10. ncbi Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity
    P Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Sci 64:90-9. 2001

Research Grants

  1. TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    Toby Rossman; Fiscal Year: 2007

Collaborators

Detail Information

Publications24

  1. ncbi Evidence that arsenite acts as a cocarcinogen in skin cancer
    Toby G Rossman
    The Nelson Institute of Environmental Medicine and The NYU Cancer Institute, New York University School of Medicine, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 198:394-404. 2004
    ....
  2. ncbi Mechanism of arsenic carcinogenesis: an integrated approach
    Toby G Rossman
    Kaplan Comprehensive Cancer Center, The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 533:37-65. 2003
    ..This review will try to integrate all of these issues, with a strong bias toward effects that are produced by environmentally relevant arsenic concentrations...
  3. ncbi Cloning genes whose levels of expression are altered by metals: implications for human health research
    T G Rossman
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Am J Ind Med 38:335-9. 2000
    ..The application of this information in the development of new biomarkers of exposure and effect, in identifying individuals with altered susceptibility to metal compounds, and in the choice of genes for microarrays is discussed...
  4. ncbi fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence
    Toby G Rossman
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Oncogene 22:1817-21. 2003
    ..Alternatively, FUBI may act as a substitute or inhibitor of ubiquitin, to which it is most closely related, or to close ubiquitin-like relatives UCRP, FAT10, and/or Nedd8...
  5. ncbi Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies
    Toby G Rossman
    The Nelson Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Environ Health Perspect 110:749-52. 2002
    ..It is possible that lung and bladder cancers associated with arsenic in drinking water may also require a carcinogenic partner...
  6. ncbi Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis
    T G Rossman
    Nelson Institute of Environmental Medicine, Kaplan Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Appl Pharmacol 176:64-71. 2001
    ..These results are consistent with the hypothesis that arsenic acts as a cocarcinogen with a second (genotoxic) agent by inhibiting DNA repair and/or enhancing positive growth signaling...
  7. ncbi Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity
    B L Vogt
    Nelson Institute of Environmental Medicine and Kaplan Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 478:159-68. 2001
    ..We suggest that the absence of normal p53 functioning, along with increased positive growth signaling in the presence of DNA damage may result in defective DNA repair and account for the comutagenic effects of arsenite...
  8. ncbi Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein
    T G Rossman
    New York University Medical Center, Nelson Institute of Environmental Medicine, and Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA
    Mutat Res 402:103-10. 1998
    ....
  9. ncbi Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis
    T G Rossman
    Nelson Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University Medical Center, NY 10016, USA
    Carcinogenesis 20:311-6. 1999
    ....
  10. ncbi Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity
    P Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Sci 64:90-9. 2001
    ..We suggest that neuropilin-1, heparin sulfate 6-sulfotransferase, and thrombospondin-1 may be important targets for lead-induced developmental neurotoxicity...
  11. ncbi Reduction of spontaneous mutagenesis in mismatch repair-deficient and proficient cells by dietary antioxidants
    K Mure
    The Nelson Institute of Environmental Medicine and The Kaplan Cancer Center, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 480:85-95. 2001
    ..Blocking spontaneous mutagenesis, perhaps with a cocktail of antioxidants, should reduce the risk of cancer in people with a genetic defect in mismatch repair as well as other individuals...
  12. ncbi Arsenite-induced alterations of DNA photodamage repair and apoptosis after solar-simulation UVR in mouse keratinocytes in vitro
    Feng Wu
    New York University School of Medicine, Nelson Institute of Environmental Medicine, and New York University Cancer Institute, Tuxedo, New York 10987, USA
    Environ Health Perspect 113:983-6. 2005
    ..9 microM and a median lethal dose (LD50) of UVR of 0.05 kJ/m2. If the present results are applicable in vivo, inhibition of UVR-induced apoptosis may contribute to arsenite's enhancement of UVR-induced skin carcinogenesis...
  13. ncbi Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin
    Ahmed N Uddin
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 26:2179-86. 2005
    ..These results show that vitamin E and p-XSC protect strongly against arsenite-induced enhancement of UVR carcinogenesis...
  14. ncbi Further evidence against a direct genotoxic mode of action for arsenic-induced cancer
    Catherine B Klein
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 222:289-97. 2007
    ....
  15. ncbi Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells
    Chengfeng Yang
    Department of Environmental Medicine and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    Toxicology 213:81-96. 2005
    ..Overall, our findings suggest that inflammatory cytokines play an important role in the suppressive effects of CAPE on As-induced cell transformation and in the selective cytotoxicity of CAPE to As-transformed HOS cells...
  16. ncbi Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study
    Fredric J Burns
    Department of Environmental Medicine, School of Medicine, New York University, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Environ Health Perspect 112:599-603. 2004
    ....
  17. ncbi Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice
    Ahmed N Uddin
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 221:329-38. 2007
    ....
  18. ncbi Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations
    Kanae Mure
    New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, New York 10987, USA
    Environ Mol Mutagen 41:322-31. 2003
    ..Our results suggest that long-term exposure to low concentrations of arsenite may affect signaling pathways that result in a progressive genomic instability...
  19. ncbi In vitro bioavailability of heavy metals in pressure-treated wood dust
    Terry Gordon
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Sci 67:32-7. 2002
    ..Thus, these bioassays suggest that metals become bioavailable during in vitro culture of phagocytic V79 cells with CCA wood dust...
  20. ncbi Letter to the editor
    Toby G Rossman
    Cancer Lett 231:339-40; author reply 341. 2006
  21. ncbi Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds
    Shaker A Mousa
    The Pharmaceutical Research Institute and Albany College of Pharmacy, 9 Samaritan Road, Albany, NY 12208, USA
    Carcinogenesis 28:962-7. 2007
    ..These data suggest that the pro-angiogenesis effect of arsenic is initiated at the plasma membrane integrin alphavbeta3, involves activation of the ERK1/2 pathway and is effectively reversed by various selenium-derived compounds...
  22. ncbi Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example
    Elena V Komissarova
    New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 202:99-107. 2005
    ..The NR and MTT assays should be performed only after an interval of at least 48 h after a 24-h exposure to arsenite...
  23. ncbi Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts
    Ping Li
    The Nelson Institute of Environmental Medicine, Tuxedo, NY 10987, USA
    Mol Cell Biochem 255:79-85. 2004
    ..We were also unable to detect evidence for a human homolog for the yeast arsenite efflux gene ACR3, using RT-PCR...
  24. ncbi Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility
    Elena V Komissarova
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 226:199-205. 2008
    ..Expression microarrays can thus be exploited for identifying additional biomarkers of susceptibility to arsenite and to other toxicants...

Research Grants2

  1. TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    Toby Rossman; Fiscal Year: 2007
    ..The Program provides for four predoctoral and two postdoctoral (Ph.D.) positions. ..