William Rom

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Multiple strand displacement amplification of mitochondrial DNA from clinical samples
    Samantha Maragh
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    BMC Med Genet 9:7. 2008
  2. pmc Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis
    Wei Min Gao
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Cancer 5:110. 2005
  3. pmc Performance of mitochondrial DNA mutations detecting early stage cancer
    John P Jakupciak
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    BMC Cancer 8:285. 2008
  4. ncbi request reprint Malignant mesothelioma from neighborhood exposure to anthophyllite asbestos
    W N Rom
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue, NY 10016, USA
    Am J Ind Med 40:211-4. 2001
  5. ncbi request reprint Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust
    William N Rom
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Crit Care Med 166:797-800. 2002
  6. pmc Emerging exposures and respiratory health: World Trade Center dust
    William N Rom
    MPH, Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
    Proc Am Thorac Soc 7:142-5. 2010
  7. ncbi request reprint Lung-specific expression of mutant p53 as mouse model for lung cancer
    Kam Meng Tchou-Wong
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
    Methods Mol Med 74:465-80. 2003
  8. pmc Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients
    Rany Condos
    Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Infect Immun 71:2058-64. 2003
  9. ncbi request reprint Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death protein
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Hum Gene Ther 13:1859-71. 2002
  10. ncbi request reprint In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent
    Elena Maksimova
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Lung 186:45-54. 2008

Research Grants

Detail Information

Publications64

  1. pmc Multiple strand displacement amplification of mitochondrial DNA from clinical samples
    Samantha Maragh
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    BMC Med Genet 9:7. 2008
    ..We applied the method to a small group of cancer cases and controls and demonstrated that WGA is capable of increasing the yield of starting DNA material with identical genetic sequence...
  2. pmc Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis
    Wei Min Gao
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Cancer 5:110. 2005
    ..We hypothesized that distinctive profiles may result from the differential expression of relatively abundant serum proteins associated with the host response...
  3. pmc Performance of mitochondrial DNA mutations detecting early stage cancer
    John P Jakupciak
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    BMC Cancer 8:285. 2008
    ..The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites...
  4. ncbi request reprint Malignant mesothelioma from neighborhood exposure to anthophyllite asbestos
    W N Rom
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue, NY 10016, USA
    Am J Ind Med 40:211-4. 2001
    ..Anthophyllite has also been associated with pleural plaques in Finland and Japan among those who live near mines and mills and have neighborhood or environmental exposure...
  5. ncbi request reprint Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust
    William N Rom
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Crit Care Med 166:797-800. 2002
    ..Acute eosinophilic pneumonia is a rare consequence of acute high dust exposure. World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells...
  6. pmc Emerging exposures and respiratory health: World Trade Center dust
    William N Rom
    MPH, Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
    Proc Am Thorac Soc 7:142-5. 2010
    ....
  7. ncbi request reprint Lung-specific expression of mutant p53 as mouse model for lung cancer
    Kam Meng Tchou-Wong
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
    Methods Mol Med 74:465-80. 2003
  8. pmc Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients
    Rany Condos
    Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Infect Immun 71:2058-64. 2003
    ..rIFN-gamma aerosol induces signal transduction and gene expression in BAL cells and should be evaluated for efficacy in a randomized, controlled clinical trial...
  9. ncbi request reprint Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death protein
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Hum Gene Ther 13:1859-71. 2002
    ..In addition, in combination with a deletion of the ADP, specificity of tumor cell killing is improved...
  10. ncbi request reprint In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent
    Elena Maksimova
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Lung 186:45-54. 2008
    ..g., reversing ground glass opacities detected on CT scans or resolving airway preneoplasias detected by bronchoscopy before they progress to malignant transformation...
  11. ncbi request reprint Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1303-10. 2007
    ....
  12. ncbi request reprint Cough and bronchial responsiveness in firefighters at the World Trade Center site
    David J Prezant
    Bureau of Health Services, Fire Department of New York City, New York, USA
    N Engl J Med 347:806-15. 2002
    ....
  13. pmc Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dust
    Michael D Weiden
    Division of Pulmonary Critical Care, New York University, New York, NY, USA
    Chest 137:566-74. 2010
    ..To date, the underlying pathophysiologic cause for this has been open to question...
  14. pmc Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study
    Kam Meng Tchou-Wong
    Departments of Medicine and Environmental Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
    BMC Cancer 6:151. 2006
    ..In this study, we test the hypothesis that heterogeneous cancer cells exhibit variable motility responses such as chemokinesis and chemotaxis that can be characterized molecularly...
  15. pmc Characteristics of a residential and working community with diverse exposure to World Trade Center dust, gas, and fumes
    Joan Reibman
    Department of Medicine, New York University School of Medicine, New York, NY 10011, USA
    J Occup Environ Med 51:534-41. 2009
    ....
  16. pmc Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMC Cancer 10:234. 2010
    ..Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and metabolism pathways...
  17. ncbi request reprint Identification of novel hsp65 RFLPs for Mycobacterium leprae
    Frank Martiniuk
    Department of Medicine Pulmonary Division, New York University School of Medicine, New York, NY 10016, USA
    J Drugs Dermatol 6:268-74. 2007
    ..leprae specific single nucleotide polymorphisms (SNPs). Thus, we describe novel hsp65 RFLPs for M. leprae found in a high frequency making them ideal for future epidemiology and transmission studies...
  18. ncbi request reprint Regional deposition of aerosolized interferon-gamma in pulmonary tuberculosis
    Rany Condos
    Bellevue Chest Service, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, USA
    Chest 125:2146-55. 2004
    ..The objective of the current study was to evaluate particle size and deposition pattern in patients with TB receiving aerosol IFN-gamma treatment...
  19. ncbi request reprint Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 172:6251-8. 2004
    ..These changes explain in part why TB accelerates the course of AIDS. CXCR4 inhibitors are a rational therapeutic approach in HIV/TB coinfection...
  20. pmc Survival after surgery in stage IA and IB non-small cell lung cancer
    David Ost
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York, USA
    Am J Respir Crit Care Med 177:516-23. 2008
    ..Whether histologic subtype of non-small cell lung cancer (NSCLC) has an important effect on prognosis after surgery is unknown...
  21. ncbi request reprint Functional genomics in lung cancer and biomarker detection
    William N Rom
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bellevue Chest Service, NYU School of Medicine, Bellevue 7N24, 550 First Avenue, New York, NY 10016, USA
    Am J Respir Cell Mol Biol 29:153-6. 2003
  22. pmc Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokines
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Exp Med 195:495-505. 2002
    ..Contact between activated lymphocytes and macrophages is necessary to down-regulate inhibitory C/EBPbeta, thereby derepressing the HIV-1 LTR. Lymphocyte-derived cytokines activate NF-kappaB, further enhancing the HIV-1 LTR...
  23. ncbi request reprint Helios gene gun particle delivery for therapy of acid maltase deficiency
    Frank Martiniuk
    New York University School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care, New York, New York 1001, USA
    DNA Cell Biol 21:717-25. 2002
    ..Muscle weakness in the hind and forelimbs was reversed. These data suggest that particle delivery of the GAA cDNA by the Helios gene gun may be a safe, effective treatment for GSDII...
  24. ncbi request reprint Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators
    Alissa K Greenberg
    Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Cell Mol Biol 27:320-8. 2002
    ....
  25. ncbi request reprint Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer
    Kam Meng Tchou-Wong
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
    Am J Respir Cell Mol Biol 27:186-93. 2002
    ..29, 678, mid-p corrected). These results suggest that p53 function is important for protecting mice from both spontaneous and BaP-induced lung cancers...
  26. ncbi request reprint Selective p38 activation in human non-small cell lung cancer
    Alissa K Greenberg
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Am J Respir Cell Mol Biol 26:558-64. 2002
    ....
  27. pmc Preneoplastic lesions of the lung
    Alissa K Greenberg
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, USA
    Respir Res 3:20. 2002
    ..In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma in situ...
  28. pmc Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosis
    Bindu Raju
    Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Environmental Medicine, New York University School of Medicine, New York, New York, USA
    Infect Immun 72:1275-83. 2004
    ..However, only 15 genes were differentially regulated by IFN-gamma. We conclude that iNOS and IP-10 mRNA expression is increased in TB but that aerosol IFN-gamma treatment increases expression of few genes in the human lung...
  29. ncbi request reprint Impact of E1a modifications on tumor-selective adenoviral replication and toxicity
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Ther 10:749-57. 2004
    ..However, deletion within the N-terminus in conjunction with a deletion within the Rb-binding domain, or deletion of the p300-TRAM binding domain, induces a more favorable cytotoxicity profile...
  30. pmc Gene expression profiles of bronchoalveolar cells in pulmonary TB
    Bindu Raju
    Department of Medicine, Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, 550 First Avenue, NB 7N 24, New York, NY 10016, USA
    Tuberculosis (Edinb) 88:39-51. 2008
    ..These gene expression data support the conclusion that pulmonary TB produces a global change in the BAL cell transcriptome with manifestations of either Th1 or Th2 immunity...
  31. pmc S-adenosylmethionine as a biomarker for the early detection of lung cancer
    Alissa K Greenberg
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Chest 132:1247-52. 2007
    ..We hypothesized that AdoMet levels were elevated in patients with lung cancer and may prove useful as a biomarker for early lung cancer...
  32. ncbi request reprint Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice
    Kamal D Srivastava
    Division of Pulmonary and Critical Care Medicine, Department of Environmental Medicine, New York University School of Medicine, New York, USA
    Am J Respir Crit Care Med 165:527-33. 2002
    ..These results demonstrated an association between apoptosis and inflammation in murine silicosis and support a potential role for IL-1beta-dependent NO-mediated apoptosis in the evolution of silicosis...
  33. ncbi request reprint Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Hum Gene Ther 14:425-33. 2003
    ..Despite the limitations of immune-incompetent models, an understanding of the interactions between the virus and the tumor-bearing host is important in the design of effective therapies...
  34. ncbi request reprint Distal airway function in symptomatic subjects with normal spirometry following World Trade Center dust exposure
    Beno W Oppenheimer
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Chest 132:1275-82. 2007
    ..We hypothesized that symptomatic individuals following exposure to WTC dust may have functional abnormalities in distal airways not detectable with routine spirometry...
  35. ncbi request reprint Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus
    Jin Cheng
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
    Mol Ther 15:1982-90. 2007
    ..These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus...
  36. pmc Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis
    Jacqueline M Achkar
    New York University School of Medicine, New York, New York 10016, USA
    Clin Vaccine Immunol 13:1291-3. 2006
    ..We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis...
  37. pmc Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening
    Hemant K Roy
    Department of Medicine, NorthShore University HealthSystem Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 70:7748-54. 2010
    ..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs...
  38. pmc Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages
    Naohiko Tanaka
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, N Y U School of Medicine, New York, NY 10016, USA
    Am J Respir Cell Mol Biol 33:406-11. 2005
    ..Only macrophages are able to repress HIV-1 LTR promoter activity and inhibit viral replication in response to IL-10 or type I IFN...
  39. ncbi request reprint 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene
    Zhaohui Feng
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 23:1721-7. 2002
    ....
  40. ncbi request reprint Significance of abnormal chest radiograph findings in patients with HIV-1 infection without respiratory symptoms
    Jeffrey A Gold
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, Bellevue Chest Service, New York, NY 10016, USA
    Chest 121:1472-7. 2002
    ..The objective was to determine the spectrum of disease and the diagnostic modalities employed in these patients...
  41. ncbi request reprint Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyrene
    Herman Yee
    Department of Pathology, NYU School of Medicine, New York, NY 10016, USA
    J Environ Pathol Toxicol Oncol 27:267-76. 2008
    ....
  42. ncbi request reprint Gender and lung cancer
    James Gasperino
    Department of Medicine, New York University School of Medicine, NY 10016, USA
    Clin Lung Cancer 5:353-9. 2004
    ..This review of the literature will focus on endocrine factors and tobacco carcinogens as risk factors for lung cancer in women...
  43. ncbi request reprint Clinical presentation of pulmonary mycetoma in HIV-infected patients
    Alissa K Greenberg
    Department of Medicine, Bellevue Chest Service and the Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York 10016, USA
    Chest 122:886-92. 2002
    ..To further investigate the impact of HIV status on the presentation and course of pulmonary mycetoma, we conducted a follow-up study...
  44. ncbi request reprint Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells
    Zhaohui Feng
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Carcinogenesis 24:771-8. 2003
    ..This effect may contribute to the synergism of Cr(VI) and BPDE on mutagenesis and cell transformation, and may also contribute to the higher incidence of lung cancer in Cr(VI)-exposed populations...
  45. ncbi request reprint Clinical correlation of asbestos bodies in BAL fluid
    Pratan Vathesatogkit
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue Hospital, NB 7N24, 550 First Avenue, New York, NY 10016, USA
    Chest 126:966-71. 2004
    ..Asbestos bodies (AB) in BAL cells are specific markers of asbestos exposure...
  46. pmc New drugs and regimens for treatment of TB
    Eric Leibert
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, 550 1st Avenue, New York, NY 10016, USA
    Expert Rev Anti Infect Ther 8:801-13. 2010
    ..Given that these drugs have novel mechanisms of action, combinations have the prospect to be highly active even against multidrug-resistant organisms...
  47. ncbi request reprint Basic pathogenetic mechanisms in silicosis: current understanding
    Binaya Rimal
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, New York 10016, USA
    Curr Opin Pulm Med 11:169-73. 2005
    ..Silicosis has been studied extensively by basic and clinical scientists, yet little is known about the crucial cellular and molecular mechanisms that initiate and propagate the process of inflammation and scarring...
  48. ncbi request reprint Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE)
    Ilana Belitskaya-Levy
    Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Environ Pathol Toxicol Oncol 26:281-94. 2007
    ..These in vitro findings in NHBE cells model environment-gene interaction for asbestos and BPDE, highlighting effects of inflammation, fibrosis, proliferation, and DNA damage recognition and repair...
  49. ncbi request reprint Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites
    Hirohumi Arakawa
    Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 27:639-45. 2006
    ..It has been found that Cr(III)-DNA adducts induce mainly G to T mutations. Therefore, these results suggest that Cr(III)-DNA adduct formation contributes to the p53 gene mutations in lung carcinogenesis...
  50. pmc Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice
    Andre L Moreira
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Infect Immun 70:2100-7. 2002
    ..tuberculosis infection leads to immune activation that may exacerbate lung pathology via TNF-alpha-induced inflammation without reducing the bacillary load...
  51. ncbi request reprint Molecular and genetic aspects of lung cancer
    William N Rom
    Bellevue Chest Service, NYU Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY, USA
    Methods Mol Med 75:3-26. 2003
  52. pmc The burden of exposure-related diffuse lung disease
    Sheryl R Goldyn
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York 10016, USA
    Semin Respir Crit Care Med 29:591-602. 2008
    ..As a result, estimates of cost for occupational diseases, including respiratory illnesses, exceed $26 billion annually, and the true economic burden is likely much higher...
  53. pmc Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis
    Anna Nolan
    Division of Pulmonary Critical Care, New York University, School of Medicine, New York, NY, USA
    PLoS ONE 4:e6600. 2009
    ..Therefore, the goal of this study was to determine the individual contribution of CD80/86 family members in regulating inflammation in sepsis...
  54. ncbi request reprint Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis
    Katsushi Kurosu
    Department of Respirology B2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 181:756-67. 2008
    ....
  55. ncbi request reprint Detection of lung cancer with volatile markers in the breath
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024, USA
    Chest 123:2115-23. 2003
    ....
  56. ncbi request reprint BCL-6 mutations in pulmonary lymphoproliferative disorders: demonstration of an aberrant immunological reaction in HIV-related lymphoid interstitial pneumonia
    Katsushi Kurosu
    Department of Respirology B2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 172:7116-22. 2004
    ....
  57. ncbi request reprint Oligoclonal T cell expansions in pulmonary lymphoproliferative disorders: demonstration of the frequent occurrence of oligoclonal T cells in human immunodeficiency virus-related lymphoid interstitial pneumonia
    Katsushi Kurosu
    Department of Respirology, School of Medicine, Chiba University, Chiba, Japan
    Am J Respir Crit Care Med 165:254-9. 2002
    ....
  58. ncbi request reprint Small particles with big effects
    William N Rom
    Am J Respir Crit Care Med 173:365-6. 2006
  59. pmc Detection of lung cancer using weighted digital analysis of breath biomarkers
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024 6510, United States
    Clin Chim Acta 393:76-84. 2008
    ..We developed a non-linear method of multivariate analysis, weighted digital analysis (WDA), and evaluated its ability to predict lung cancer employing volatile biomarkers in the breath...
  60. ncbi request reprint N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation
    Zhaohui Feng
    Department of Environmental Medicine, New York University Medical Center, Tuxedo, New York 10987, USA
    Biochemistry 41:6414-21. 2002
    ..These results suggest that both the unique DNA binding specificity of 4-ABP and cytosine methylation contribute to the mutational spectrum of the p53 gene in human bladder cancer...
  61. pmc Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons
    Frank Martiniuk
    Emerg Infect Dis 13:1438-40. 2007
  62. pmc HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase
    Yuzhi Dong
    Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103, USA
    Infect Immun 72:2412-5. 2004
    ..We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins...
  63. ncbi request reprint Prediction of lung cancer using volatile biomarkers in breath
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024 6510, USA
    Cancer Biomark 3:95-109. 2007
    ..g. alkanes). In patients with lung cancer, induction of high-risk cytochrome p450 genotypes may accelerate catabolism of these VOCs, so that their altered abundance in breath may provide biomarkers of lung cancer...
  64. pmc Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient
    Harutaka Katano
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    Microbes Infect 9:1581-9. 2007
    ..Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case...

Research Grants23

  1. HOST RESPONSE TO TB AND AIDS
    William Rom; Fiscal Year: 2006
    ..This study is critical in developing efficacious treatment strategies for TB and demonstrating that rIFN-gamma ameliorates the lung fibrosis and destruction in advanced TB. ..
  2. New York University School of Medicine CTSA Planning Grant
    William Rom; Fiscal Year: 2006
    ....
  3. Translational Research Training in Environmental Medicine
    William Rom; Fiscal Year: 2007
    ..Another change is the request now for a total of eight fellows compared to six in the current granting period. There are also a few changes in the participating faculty but the net number remains essentially unchanged at thirty. ..
  4. NYU Lung Cancer Biomarker Center
    William Rom; Fiscal Year: 2007
    ..Large patient cohorts plus diversity of biomarker phase II studies will result in accelerated translation of feasible lung cancer biomarkers to complement single-breath CT scanning. ..
  5. Longtitudinal Studies of HIV-Associated Bacterial Pneumonia
    William Rom; Fiscal Year: 2007
    ..We will freeze and store at -70 degrees plasma, serum, PBMC (RNA, DNA, protein), BAL, from involved/uninvolved lung segments, and sputum for collaborative studies with other NHLBI grantees. ..
  6. HOST RESPONSE TO TB AND AIDS
    William Rom; Fiscal Year: 2001
    ....
  7. IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDS
    William Rom; Fiscal Year: 2002
    ..tb. proteins in PBMCs and BAL. This proposal will provide critical information on memory immunity in the lung when humans are infected/exposed to M. tb. and how this "protective" immune response to TB may be perturbated in AIDS. ..
  8. Longtitudinal Studies of HIV-Associated Bacterial Pneumonia
    William N Rom; Fiscal Year: 2010
    ..We will freeze and store at -70 degrees plasma, serum, PBMC (RNA, DNA, protein), BAL, from involved/uninvolved lung segments, and sputum for collaborative studies with other NHLBI grantees. ..