Research Topics
| William RomSummaryAffiliation: New York University Country: USA Publications
Research Grants
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Detail Information
Publications
Multiple strand displacement amplification of mitochondrial DNA from clinical samplesSamantha Maragh
Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
BMC Med Genet 9:7. 2008..We applied the method to a small group of cancer cases and controls and demonstrated that WGA is capable of increasing the yield of starting DNA material with identical genetic sequence...- Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysisWei Min Gao
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
BMC Cancer 5:110. 2005..We hypothesized that distinctive profiles may result from the differential expression of relatively abundant serum proteins associated with the host response... - Performance of mitochondrial DNA mutations detecting early stage cancerJohn P Jakupciak
Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
BMC Cancer 8:285. 2008..The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites... 
Malignant mesothelioma from neighborhood exposure to anthophyllite asbestosW N Rom
Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue, NY 10016, USA
Am J Ind Med 40:211-4. 2001..Anthophyllite has also been associated with pleural plaques in Finland and Japan among those who live near mines and mills and have neighborhood or environmental exposure...- Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dustWilliam N Rom
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
Am J Respir Crit Care Med 166:797-800. 2002..Acute eosinophilic pneumonia is a rare consequence of acute high dust exposure. World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells... - Emerging exposures and respiratory health: World Trade Center dustWilliam N Rom
MPH, Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
Proc Am Thorac Soc 7:142-5. 2010.... - Lung-specific expression of mutant p53 as mouse model for lung cancerKam-Meng Tchou-Wong
Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
Methods Mol Med 74:465-80. 2003 - Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patientsRany Condos
Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
Infect Immun 71:2058-64. 2003..rIFN-gamma aerosol induces signal transduction and gene expression in BAL cells and should be evaluated for efficacy in a randomized, controlled clinical trial... - Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death proteinHarald Sauthoff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Hum Gene Ther 13:1859-71. 2002..In addition, in combination with a deletion of the ADP, specificity of tumor cell killing is improved... - In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agentElena Maksimova
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Lung 186:45-54. 2008..g., reversing ground glass opacities detected on CT scans or resolving airway preneoplasias detected by bronchoscopy before they progress to malignant transformation... - Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosisYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Infect Dis 195:1303-10. 2007.... - Cough and bronchial responsiveness in firefighters at the World Trade Center siteDavid J Prezant
Bureau of Health Services, Fire Department of New York City, New York, USA
N Engl J Med 347:806-15. 2002.... - Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dustMichael D Weiden
Division of Pulmonary Critical Care, New York University, New York, NY, USA
Chest 137:566-74. 2010..To date, the underlying pathophysiologic cause for this has been open to question... - Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular studyKam Meng Tchou-Wong
Departments of Medicine and Environmental Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
BMC Cancer 6:151. 2006..In this study, we test the hypothesis that heterogeneous cancer cells exhibit variable motility responses such as chemokinesis and chemotaxis that can be characterized molecularly... - Characteristics of a residential and working community with diverse exposure to World Trade Center dust, gas, and fumesJoan Reibman
Department of Medicine, New York University School of Medicine, New York, NY 10011, USA
J Occup Environ Med 51:534-41. 2009.... - Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokersWilliam N Rom
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
BMC Cancer 10:234. 2010..Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and metabolism pathways... - Identification of novel hsp65 RFLPs for Mycobacterium lepraeFrank Martiniuk
Department of Medicine Pulmonary Division, New York University School of Medicine, New York, NY 10016, USA
J Drugs Dermatol 6:268-74. 2007..leprae specific single nucleotide polymorphisms (SNPs). Thus, we describe novel hsp65 RFLPs for M. leprae found in a high frequency making them ideal for future epidemiology and transmission studies... - Regional deposition of aerosolized interferon-gamma in pulmonary tuberculosisRany Condos
Bellevue Chest Service, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, USA
Chest 125:2146-55. 2004..The objective of the current study was to evaluate particle size and deposition pattern in patients with TB receiving aerosol IFN-gamma treatment... - Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophagesYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 172:6251-8. 2004..These changes explain in part why TB accelerates the course of AIDS. CXCR4 inhibitors are a rational therapeutic approach in HIV/TB coinfection... - Survival after surgery in stage IA and IB non-small cell lung cancerDavid Ost
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York, USA
Am J Respir Crit Care Med 177:516-23. 2008..Whether histologic subtype of non-small cell lung cancer (NSCLC) has an important effect on prognosis after surgery is unknown... - Functional genomics in lung cancer and biomarker detectionWilliam N Rom
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bellevue Chest Service, NYU School of Medicine, Bellevue 7N24, 550 First Avenue, New York, NY 10016, USA
Am J Respir Cell Mol Biol 29:153-6. 2003 - Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokinesYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Exp Med 195:495-505. 2002..Contact between activated lymphocytes and macrophages is necessary to down-regulate inhibitory C/EBPbeta, thereby derepressing the HIV-1 LTR. Lymphocyte-derived cytokines activate NF-kappaB, further enhancing the HIV-1 LTR... - Helios gene gun particle delivery for therapy of acid maltase deficiencyFrank Martiniuk
New York University School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care, New York, New York 1001, USA
DNA Cell Biol 21:717-25. 2002..Muscle weakness in the hind and forelimbs was reversed. These data suggest that particle delivery of the GAA cDNA by the Helios gene gun may be a safe, effective treatment for GSDII... - Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulatorsAlissa K Greenberg
Department of Medicine, New York University School of Medicine, New York 10016, USA
Am J Respir Cell Mol Biol 27:320-8. 2002.... - Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancerKam Meng Tchou-Wong
Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
Am J Respir Cell Mol Biol 27:186-93. 2002..29, 678, mid-p corrected). These results suggest that p53 function is important for protecting mice from both spontaneous and BaP-induced lung cancers... - Selective p38 activation in human non-small cell lung cancerAlissa K Greenberg
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
Am J Respir Cell Mol Biol 26:558-64. 2002.... - Preneoplastic lesions of the lungAlissa K Greenberg
Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, USA
Respir Res 3:20. 2002..In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma in situ... - Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosisBindu Raju
Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Environmental Medicine, New York University School of Medicine, New York, New York, USA
Infect Immun 72:1275-83. 2004..However, only 15 genes were differentially regulated by IFN-gamma. We conclude that iNOS and IP-10 mRNA expression is increased in TB but that aerosol IFN-gamma treatment increases expression of few genes in the human lung... - Impact of E1a modifications on tumor-selective adenoviral replication and toxicityHarald Sauthoff
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA
Mol Ther 10:749-57. 2004..However, deletion within the N-terminus in conjunction with a deletion within the Rb-binding domain, or deletion of the p300-TRAM binding domain, induces a more favorable cytotoxicity profile... - Gene expression profiles of bronchoalveolar cells in pulmonary TBBindu Raju
Department of Medicine, Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, 550 First Avenue, NB 7N 24, New York, NY 10016, USA
Tuberculosis (Edinb) 88:39-51. 2008..These gene expression data support the conclusion that pulmonary TB produces a global change in the BAL cell transcriptome with manifestations of either Th1 or Th2 immunity... - S-adenosylmethionine as a biomarker for the early detection of lung cancerAlissa K Greenberg
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Chest 132:1247-52. 2007..We hypothesized that AdoMet levels were elevated in patients with lung cancer and may prove useful as a biomarker for early lung cancer... - Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in miceKamal D Srivastava
Division of Pulmonary and Critical Care Medicine, Department of Environmental Medicine, New York University School of Medicine, New York, USA
Am J Respir Crit Care Med 165:527-33. 2002..These results demonstrated an association between apoptosis and inflammation in murine silicosis and support a potential role for IL-1beta-dependent NO-mediated apoptosis in the evolution of silicosis... - Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time pointsHarald Sauthoff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Hum Gene Ther 14:425-33. 2003..Despite the limitations of immune-incompetent models, an understanding of the interactions between the virus and the tumor-bearing host is important in the design of effective therapies... - Distal airway function in symptomatic subjects with normal spirometry following World Trade Center dust exposureBeno W Oppenheimer
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Chest 132:1275-82. 2007..We hypothesized that symptomatic individuals following exposure to WTC dust may have functional abnormalities in distal airways not detectable with routine spirometry... - Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirusJin Cheng
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
Mol Ther 15:1982-90. 2007..These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus... - Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosisJacqueline M Achkar
New York University School of Medicine, New York, New York 10016, USA
Clin Vaccine Immunol 13:1291-3. 2006..We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis... 
Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screeningHemant K Roy
Department of Medicine, NorthShore University HealthSystem Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
Cancer Res 70:7748-54. 2010..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs...- Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophagesNaohiko Tanaka
Division of Pulmonary and Critical Care Medicine, Department of Medicine, N Y U School of Medicine, New York, NY 10016, USA
Am J Respir Cell Mol Biol 33:406-11. 2005..Only macrophages are able to repress HIV-1 LTR promoter activity and inhibit viral replication in response to IL-10 or type I IFN... - 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 geneZhaohui Feng
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Carcinogenesis 23:1721-7. 2002.... - Significance of abnormal chest radiograph findings in patients with HIV-1 infection without respiratory symptomsJeffrey A Gold
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, Bellevue Chest Service, New York, NY 10016, USA
Chest 121:1472-7. 2002..The high prevalence of treatable and potentially communicable disorders warrants an aggressive diagnostic approach in these patients... - Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyreneHerman Yee
Department of Pathology, NYU School of Medicine, New York, NY 10016, USA
J Environ Pathol Toxicol Oncol 27:267-76. 2008.... - Gender and lung cancerJames Gasperino
Department of Medicine, New York University School of Medicine, NY 10016, USA
Clin Lung Cancer 5:353-9. 2004..This review of the literature will focus on endocrine factors and tobacco carcinogens as risk factors for lung cancer in women... - Clinical presentation of pulmonary mycetoma in HIV-infected patientsAlissa K Greenberg
Department of Medicine, Bellevue Chest Service and the Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York 10016, USA
Chest 122:886-92. 2002..A combination of antifungal and antiretroviral therapy may improve the clinical outcome in HIV-infected patients with pulmonary mycetoma... - Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cellsZhaohui Feng
Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
Carcinogenesis 24:771-8. 2003..This effect may contribute to the synergism of Cr(VI) and BPDE on mutagenesis and cell transformation, and may also contribute to the higher incidence of lung cancer in Cr(VI)-exposed populations... - Clinical correlation of asbestos bodies in BAL fluidPratan Vathesatogkit
Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue Hospital, NB 7N24, 550 First Avenue, New York, NY 10016, USA
Chest 126:966-71. 2004..01). CONCLUSION: In individuals with a history of asbestos exposure, the presence of AB in BAL cells is associated with higher prevalence of parenchymal abnormalities, respiratory symptoms, and reduced pulmonary function... - New drugs and regimens for treatment of TBEric Leibert
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, 550 1st Avenue, New York, NY 10016, USA
Expert Rev Anti Infect Ther 8:801-13. 2010..Given that these drugs have novel mechanisms of action, combinations have the prospect to be highly active even against multidrug-resistant organisms... - Basic pathogenetic mechanisms in silicosis: current understandingBinaya Rimal
Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, New York 10016, USA
Curr Opin Pulm Med 11:169-73. 2005..Potential therapeutic strategies include inhibition of cytokines such as IL-1, TNF alpha, the use of anti-oxidants, and the inhibition of apoptosis... - Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE)Ilana Belitskaya Levy
Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Environ Pathol Toxicol Oncol 26:281-94. 2007..These in vitro findings in NHBE cells model environment-gene interaction for asbestos and BPDE, highlighting effects of inflammation, fibrosis, proliferation, and DNA damage recognition and repair... - Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sitesHirohumi Arakawa
Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Carcinogenesis 27:639-45. 2006..It has been found that Cr(III)-DNA adducts induce mainly G to T mutations. Therefore, these results suggest that Cr(III)-DNA adduct formation contributes to the p53 gene mutations in lung carcinogenesis... - Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected miceAndre L Moreira
Department of Pathology, New York University School of Medicine, New York, NY, USA
Infect Immun 70:2100-7. 2002..tuberculosis infection leads to immune activation that may exacerbate lung pathology via TNF-alpha-induced inflammation without reducing the bacillary load... - Molecular and genetic aspects of lung cancerWilliam N Rom
Bellevue Chest Service, NYU Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY, USA
Methods Mol Med 75:3-26. 2003 - The burden of exposure-related diffuse lung diseaseSheryl R Goldyn
Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York 10016, USA
Semin Respir Crit Care Med 29:591-602. 2008..As a result, estimates of cost for occupational diseases, including respiratory illnesses, exceed $26 billion annually, and the true economic burden is likely much higher... - Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsisAnna Nolan
Division of Pulmonary Critical Care, New York University, School of Medicine, New York, NY, USA
PLoS ONE 4:e6600. 2009..Therefore, the goal of this study was to determine the individual contribution of CD80/86 family members in regulating inflammation in sepsis... - Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosisKatsushi Kurosu
Department of Respirology B2, Graduate School of Medicine, Chiba University, Chiba, Japan
J Immunol 181:756-67. 2008.... - Detection of lung cancer with volatile markers in the breathMichael Phillips
Menssana Research Inc, Fort Lee, NJ 07024, USA
Chest 123:2115-23. 2003..A predictive model employing nine of these VOCs exhibited sufficient sensitivity and specificity to be considered as a screen for lung cancer in a high-risk population such as adult smokers... - BCL-6 mutations in pulmonary lymphoproliferative disorders: demonstration of an aberrant immunological reaction in HIV-related lymphoid interstitial pneumoniaKatsushi Kurosu
Department of Respirology B2, Graduate School of Medicine, Chiba University, Chiba, Japan
J Immunol 172:7116-22. 2004.... - Oligoclonal T cell expansions in pulmonary lymphoproliferative disorders: demonstration of the frequent occurrence of oligoclonal T cells in human immunodeficiency virus-related lymphoid interstitial pneumoniaKatsushi Kurosu
Department of Respirology, School of Medicine, Chiba University, Chiba, Japan
Am J Respir Crit Care Med 165:254-9. 2002.... - Small particles with big effectsWilliam N Rom
Am J Respir Crit Care Med 173:365-6. 2006 - Detection of lung cancer using weighted digital analysis of breath biomarkersMichael Phillips
Menssana Research Inc, Fort Lee, NJ 07024 6510, United States
Clin Chim Acta 393:76-84. 2008..We developed a non-linear method of multivariate analysis, weighted digital analysis (WDA), and evaluated its ability to predict lung cancer employing volatile biomarkers in the breath... - N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylationZhaohui Feng
Department of Environmental Medicine, New York University Medical Center, Tuxedo, New York 10987, USA
Biochemistry 41:6414-21. 2002..These results suggest that both the unique DNA binding specificity of 4-ABP and cytosine methylation contribute to the mutational spectrum of the p53 gene in human bladder cancer... - Leprosy as immune reconstitution inflammatory syndrome in HIV-positive personsFrank Martiniuk
Emerg Infect Dis 13:1438-40. 2007 - HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetaseYuzhi Dong
Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103, USA
Infect Immun 72:2412-5. 2004..We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins... - Prediction of lung cancer using volatile biomarkers in breathMichael Phillips
Menssana Research Inc, Fort Lee, NJ 07024 6510, USA
Cancer Biomark 3:95-109. 2007..g. alkanes). In patients with lung cancer, induction of high-risk cytochrome p450 genotypes may accelerate catabolism of these VOCs, so that their altered abundance in breath may provide biomarkers of lung cancer... - Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patientHarutaka Katano
Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
Microbes Infect 9:1581-9. 2007..Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case...
Research Grants
- HOST RESPONSE TO TB AND AIDSWilliam Rom; Fiscal Year: 2006..This study is critical in developing efficacious treatment strategies for TB and demonstrating that rIFN-gamma ameliorates the lung fibrosis and destruction in advanced TB. ..
- New York University School of Medicine CTSA Planning GrantWilliam Rom; Fiscal Year: 2006....
- Translational Research Training in Environmental MedicineWilliam Rom; Fiscal Year: 2007..Another change is the request now for a total of eight fellows compared to six in the current granting period. There are also a few changes in the participating faculty but the net number remains essentially unchanged at thirty. ..
- NYU Lung Cancer Biomarker CenterWilliam Rom; Fiscal Year: 2007..Large patient cohorts plus diversity of biomarker phase II studies will result in accelerated translation of feasible lung cancer biomarkers to complement single-breath CT scanning. ..
- Longtitudinal Studies of HIV-Associated Bacterial PneumoniaWilliam Rom; Fiscal Year: 2007..We will freeze and store at -70 degrees plasma, serum, PBMC (RNA, DNA, protein), BAL, from involved/uninvolved lung segments, and sputum for collaborative studies with other NHLBI grantees. ..
- HOST RESPONSE TO TB AND AIDSWilliam Rom; Fiscal Year: 2001....
- IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDSWilliam Rom; Fiscal Year: 2002..tb. proteins in PBMCs and BAL. This proposal will provide critical information on memory immunity in the lung when humans are infected/exposed to M. tb. and how this "protective" immune response to TB may be perturbated in AIDS. ..
- Longtitudinal Studies of HIV-Associated Bacterial PneumoniaWilliam N Rom; Fiscal Year: 2010..We will freeze and store at -70 degrees plasma, serum, PBMC (RNA, DNA, protein), BAL, from involved/uninvolved lung segments, and sputum for collaborative studies with other NHLBI grantees. ..