William N Rom

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMC Cancer 10:234. 2010
  2. pmc Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mediators Inflamm 2011:407657. 2011
  3. pmc Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters
    Michael D Weiden
    Critical Care and Sleep, New York University, School of Medicine New York, New York, NY 10016, USA
    Eur Respir J 41:1023-30. 2013
  4. pmc Inflammatory biomarkers predict airflow obstruction after exposure to World Trade Center dust
    Anna Nolan
    Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York 10016, USA
    Chest 142:412-8. 2012
  5. ncbi request reprint Impact of E1a modifications on tumor-selective adenoviral replication and toxicity
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Ther 10:749-57. 2004
  6. pmc Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dust
    Michael D Weiden
    Division of Pulmonary Critical Care, New York University, New York, NY, USA
    Chest 137:566-74. 2010
  7. ncbi request reprint Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1303-10. 2007
  8. pmc Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters
    Soo Jung Cho
    Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, NY 10016, USA
    J Clin Immunol 33:1134-42. 2013
  9. pmc Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages
    Naohiko Tanaka
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, N Y U School of Medicine, New York, NY 10016, USA
    Am J Respir Cell Mol Biol 33:406-11. 2005
  10. ncbi request reprint Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 172:6251-8. 2004

Collaborators

Detail Information

Publications65

  1. pmc Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMC Cancer 10:234. 2010
    ..Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and metabolism pathways...
  2. pmc Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophilia
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mediators Inflamm 2011:407657. 2011
    ..A course of prednisone for one week can reduce the oxidant burden and attendant inflammation and may be a strategy to prevent chronic TPE and interstitial lung disease...
  3. pmc Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters
    Michael D Weiden
    Critical Care and Sleep, New York University, School of Medicine New York, New York, NY 10016, USA
    Eur Respir J 41:1023-30. 2013
    ..These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure...
  4. pmc Inflammatory biomarkers predict airflow obstruction after exposure to World Trade Center dust
    Anna Nolan
    Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York 10016, USA
    Chest 142:412-8. 2012
    ..The World Trade Center (WTC) collapse on September 11, 2001, produced airflow obstruction in a majority of firefighters receiving subspecialty pulmonary evaluation (SPE) within 6.5 years post-September 11, 2001...
  5. ncbi request reprint Impact of E1a modifications on tumor-selective adenoviral replication and toxicity
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Ther 10:749-57. 2004
    ..However, deletion within the N-terminus in conjunction with a deletion within the Rb-binding domain, or deletion of the p300-TRAM binding domain, induces a more favorable cytotoxicity profile...
  6. pmc Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dust
    Michael D Weiden
    Division of Pulmonary Critical Care, New York University, New York, NY, USA
    Chest 137:566-74. 2010
    ..To date, the underlying pathophysiologic cause for this has been open to question...
  7. ncbi request reprint Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1303-10. 2007
    ....
  8. pmc Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters
    Soo Jung Cho
    Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, NY 10016, USA
    J Clin Immunol 33:1134-42. 2013
    ..Chitinases and IgE are innate and humoral mediators of obstructive airway disease. We investigated if serum expression of chitinases and IgE early after WTC exposure predicts subsequent obstruction...
  9. pmc Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages
    Naohiko Tanaka
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, N Y U School of Medicine, New York, NY 10016, USA
    Am J Respir Cell Mol Biol 33:406-11. 2005
    ..Only macrophages are able to repress HIV-1 LTR promoter activity and inhibit viral replication in response to IL-10 or type I IFN...
  10. ncbi request reprint Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 172:6251-8. 2004
    ..These changes explain in part why TB accelerates the course of AIDS. CXCR4 inhibitors are a rational therapeutic approach in HIV/TB coinfection...
  11. pmc Metabolic syndrome biomarkers predict lung function impairment: a nested case-control study
    Bushra Naveed
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Am J Respir Crit Care Med 185:392-9. 2012
    ..Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function...
  12. ncbi request reprint Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust
    William N Rom
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Crit Care Med 166:797-800. 2002
    ..Acute eosinophilic pneumonia is a rare consequence of acute high dust exposure. World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells...
  13. ncbi request reprint Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Hum Gene Ther 14:425-33. 2003
    ..Despite the limitations of immune-incompetent models, an understanding of the interactions between the virus and the tumor-bearing host is important in the design of effective therapies...
  14. pmc Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum
    Anna Nolan
    Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e59461. 2013
    ..Active TB disease represents immune failure to control latent infection from airborne spread. Acid-fast bacillus (AFB) seen on sputum smear is a biomarker for contagiousness...
  15. ncbi request reprint In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent
    Elena Maksimova
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Lung 186:45-54. 2008
    ..g., reversing ground glass opacities detected on CT scans or resolving airway preneoplasias detected by bronchoscopy before they progress to malignant transformation...
  16. pmc Comparison of WTC dust size on macrophage inflammatory cytokine release in vivo and in vitro
    Michael D Weiden
    Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e40016. 2012
    ..Our hypotheses are that components of WTC dust strongly induce GM-CSF and MDC in AM; and that these two risk factors are in separate inflammatory pathways...
  17. pmc Characteristics of a residential and working community with diverse exposure to World Trade Center dust, gas, and fumes
    Joan Reibman
    Department of Medicine, New York University School of Medicine, New York, NY 10011, USA
    J Occup Environ Med 51:534-41. 2009
    ....
  18. pmc Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosis
    Bindu Raju
    Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Environmental Medicine, New York University School of Medicine, New York, New York, USA
    Infect Immun 72:1275-83. 2004
    ..However, only 15 genes were differentially regulated by IFN-gamma. We conclude that iNOS and IP-10 mRNA expression is increased in TB but that aerosol IFN-gamma treatment increases expression of few genes in the human lung...
  19. doi request reprint Disparity between proximal and distal airway reactivity during methacholine challenge
    Leopoldo N Segal
    André Cournand Pulmonary Physiology Laboratory, New York University School of Medicine, New York, New York 10016, USA
    COPD 8:145-52. 2011
    ..This study highlights the importance of disparity between proximal and distal airway behavior, which has implications in understanding pathophysiology of obstructive pulmonary diseases and their response to treatment...
  20. ncbi request reprint Lung-specific expression of mutant p53 as mouse model for lung cancer
    Kam Meng Tchou-Wong
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
    Methods Mol Med 74:465-80. 2003
  21. pmc HIV-1 and bacterial pneumonia in the era of antiretroviral therapy
    Leopoldo N Segal
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Proc Am Thorac Soc 8:282-7. 2011
    ..Bacterial pneumonia presents an ongoing challenge in these high-risk individuals, particularly in studying the functions of the innate and acquired immune response...
  22. ncbi request reprint Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators
    Alissa K Greenberg
    Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Cell Mol Biol 27:320-8. 2002
    ....
  23. ncbi request reprint Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyrene
    Herman Yee
    Department of Pathology, NYU School of Medicine, New York, NY 10016, USA
    J Environ Pathol Toxicol Oncol 27:267-76. 2008
    ....
  24. pmc Gene expression profiles of bronchoalveolar cells in pulmonary TB
    Bindu Raju
    Department of Medicine, Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, 550 First Avenue, NB 7N 24, New York, NY 10016, USA
    Tuberculosis (Edinb) 88:39-51. 2008
    ..These gene expression data support the conclusion that pulmonary TB produces a global change in the BAL cell transcriptome with manifestations of either Th1 or Th2 immunity...
  25. doi request reprint One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure
    Soo Jung Cho
    Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine New York, NY, USA
    Respir Med 108:162-70. 2014
    ..We investigated whether a panel of inflammatory cytokines, either associated or not associated with WTC-LI, can predict future chronic rhinosinusitis disease and its severity...
  26. ncbi request reprint Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE)
    Ilana Belitskaya-Levy
    Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Environ Pathol Toxicol Oncol 26:281-94. 2007
    ..These in vitro findings in NHBE cells model environment-gene interaction for asbestos and BPDE, highlighting effects of inflammation, fibrosis, proliferation, and DNA damage recognition and repair...
  27. pmc Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients
    Rany Condos
    Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Infect Immun 71:2058-64. 2003
    ..rIFN-gamma aerosol induces signal transduction and gene expression in BAL cells and should be evaluated for efficacy in a randomized, controlled clinical trial...
  28. pmc S-adenosylmethionine as a biomarker for the early detection of lung cancer
    Alissa K Greenberg
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Chest 132:1247-52. 2007
    ..We hypothesized that AdoMet levels were elevated in patients with lung cancer and may prove useful as a biomarker for early lung cancer...
  29. doi request reprint Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study
    Jun Tsukiji
    Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY, USA
    Biomarkers 19:159-65. 2014
    ..Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN...
  30. ncbi request reprint MMP-2 and TIMP-1 predict healing of WTC-lung injury in New York City firefighters
    Anna Nolan
    Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, 462 First Avenue, NB7N24, New York NY, USA
    Respir Res 15:5. 2014
    ..After 9/11/2001, most FDNY workers had persistent lung function decline but some exposed workers recovered. We hypothesized that the protease/anti-protease balance in serum soon after exposure predicts subsequent recovery...
  31. pmc Early elevation of serum MMP-3 and MMP-12 predicts protection from World Trade Center-lung injury in New York City Firefighters: a nested case-control study
    Sophia Kwon
    Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e76099. 2013
    ..After 9/11/2001, some Fire Department of New York (FDNY) workers had excessive lung function decline. We hypothesized that early serum matrix metalloproteinases (MMP) expression predicts World Trade Center-Lung Injury (WTC-LI) years later...
  32. pmc CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort
    Alissa K Greenberg
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New York, USA
    PLoS ONE 7:e39403. 2012
    ..We hypothesized that by reviewing demographic, clinical and nodule characteristics, we could identify risk factors associated with the presence of nodules on screening CT, and with the probability that a NCN was malignant...
  33. ncbi request reprint Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells
    Zhaohui Feng
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Carcinogenesis 24:771-8. 2003
    ..This effect may contribute to the synergism of Cr(VI) and BPDE on mutagenesis and cell transformation, and may also contribute to the higher incidence of lung cancer in Cr(VI)-exposed populations...
  34. pmc Emerging exposures and respiratory health: World Trade Center dust
    William N Rom
    MPH, Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
    Proc Am Thorac Soc 7:142-5. 2010
    ....
  35. pmc Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis
    Anna Nolan
    Division of Pulmonary Critical Care, New York University, School of Medicine, New York, NY, USA
    PLoS ONE 4:e6600. 2009
    ..Therefore, the goal of this study was to determine the individual contribution of CD80/86 family members in regulating inflammation in sepsis...
  36. ncbi request reprint Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer
    Kam Meng Tchou-Wong
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
    Am J Respir Cell Mol Biol 27:186-93. 2002
    ..29, 678, mid-p corrected). These results suggest that p53 function is important for protecting mice from both spontaneous and BaP-induced lung cancers...
  37. ncbi request reprint Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus
    Jin Cheng
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
    Mol Ther 15:1982-90. 2007
    ..These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus...
  38. doi request reprint Experimental human exposure to air pollutants is essential to understand adverse health effects
    William N Rom
    1 Division of Pulmonary, Critical Care, and Sleep Medicine, and
    Am J Respir Cell Mol Biol 49:691-6. 2013
    ..We find that these studies appear to have been done with proper approval of institutional review boards, were done with informed consent from the participants, and have rarely been associated with serious adverse events...
  39. pmc Hedgehog signaling in neonatal and adult lung
    Li Liu
    Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY, USA
    Am J Respir Cell Mol Biol 48:703-10. 2013
    ..Our data provide strong evidence that Hh signaling can regulate lung stromal cell function in two critical scenarios: normal development in postnatal lung and lung fibrosis in adult lung...
  40. ncbi request reprint Clinical correlation of asbestos bodies in BAL fluid
    Pratan Vathesatogkit
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue Hospital, NB 7N24, 550 First Avenue, New York, NY 10016, USA
    Chest 126:966-71. 2004
    ..Asbestos bodies (AB) in BAL cells are specific markers of asbestos exposure...
  41. ncbi request reprint Functional genomics in lung cancer and biomarker detection
    William N Rom
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bellevue Chest Service, NYU School of Medicine, Bellevue 7N24, 550 First Avenue, New York, NY 10016, USA
    Am J Respir Cell Mol Biol 29:153-6. 2003
  42. pmc Survival after surgery in stage IA and IB non-small cell lung cancer
    David Ost
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York, USA
    Am J Respir Crit Care Med 177:516-23. 2008
    ..Whether histologic subtype of non-small cell lung cancer (NSCLC) has an important effect on prognosis after surgery is unknown...
  43. pmc Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M
    Hiroshi Kobayashi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 186:403-10. 2011
    ..PMNs de-repress AMs via CASP-6-mediated IRAK-M cleavage. This regulatory system will blunt lung inflammation unless PMNs infiltrate the alveolar spaces...
  44. ncbi request reprint Identification of novel hsp65 RFLPs for Mycobacterium leprae
    Frank Martiniuk
    Department of Medicine Pulmonary Division, New York University School of Medicine, New York, NY 10016, USA
    J Drugs Dermatol 6:268-74. 2007
    ..leprae specific single nucleotide polymorphisms (SNPs). Thus, we describe novel hsp65 RFLPs for M. leprae found in a high frequency making them ideal for future epidemiology and transmission studies...
  45. pmc Aryl hydrocarbon receptor and lung cancer
    Junchieh J Tsay
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY, USA
    Anticancer Res 33:1247-56. 2013
    ..In this review article we summarize the current understanding of AhR and its role in the development of lung cancer, including its influence on cell proliferation, angiogenesis, inflammation, and apoptosis...
  46. ncbi request reprint Regional deposition of aerosolized interferon-gamma in pulmonary tuberculosis
    Rany Condos
    Bellevue Chest Service, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, USA
    Chest 125:2146-55. 2004
    ..The objective of the current study was to evaluate particle size and deposition pattern in patients with TB receiving aerosol IFN-gamma treatment...
  47. pmc New drugs and regimens for treatment of TB
    Eric Leibert
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, 550 1st Avenue, New York, NY 10016, USA
    Expert Rev Anti Infect Ther 8:801-13. 2010
    ..Given that these drugs have novel mechanisms of action, combinations have the prospect to be highly active even against multidrug-resistant organisms...
  48. ncbi request reprint Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death protein
    Harald Sauthoff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Hum Gene Ther 13:1859-71. 2002
    ..In addition, in combination with a deletion of the ADP, specificity of tumor cell killing is improved...
  49. doi request reprint Production of a functional human acid maltase in tobacco seeds: biochemical analysis, uptake by human GSDII cells, and in vivo studies in GAA knockout mice
    Frank Martiniuk
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY, 10016, USA
    Appl Biochem Biotechnol 171:916-26. 2013
    ..These data demonstrate indirectly that the tobrhGAA is fully functional, predominantly proteolytically cleaved and contains the minimal phosphorylation and mannose-6-phosphate residues essential for biological activity...
  50. pmc Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis
    Jacqueline M Achkar
    New York University School of Medicine, New York, New York 10016, USA
    Clin Vaccine Immunol 13:1291-3. 2006
    ..We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis...
  51. pmc Preneoplastic lesions of the lung
    Alissa K Greenberg
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, USA
    Respir Res 3:20. 2002
    ..In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma in situ...
  52. ncbi request reprint Gender and lung cancer
    James Gasperino
    Department of Medicine, New York University School of Medicine, NY 10016, USA
    Clin Lung Cancer 5:353-9. 2004
    ..This review of the literature will focus on endocrine factors and tobacco carcinogens as risk factors for lung cancer in women...
  53. ncbi request reprint 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene
    Zhaohui Feng
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 23:1721-7. 2002
    ....
  54. pmc Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening
    Hemant K Roy
    Department of Medicine, NorthShore University HealthSystem Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 70:7748-54. 2010
    ..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs...
  55. ncbi request reprint Basic pathogenetic mechanisms in silicosis: current understanding
    Binaya Rimal
    Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, New York 10016, USA
    Curr Opin Pulm Med 11:169-73. 2005
    ..Silicosis has been studied extensively by basic and clinical scientists, yet little is known about the crucial cellular and molecular mechanisms that initiate and propagate the process of inflammation and scarring...
  56. ncbi request reprint Clinical presentation of pulmonary mycetoma in HIV-infected patients
    Alissa K Greenberg
    Department of Medicine, Bellevue Chest Service and the Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York 10016, USA
    Chest 122:886-92. 2002
    ..To further investigate the impact of HIV status on the presentation and course of pulmonary mycetoma, we conducted a follow-up study...
  57. ncbi request reprint Distal airway function in symptomatic subjects with normal spirometry following World Trade Center dust exposure
    Beno W Oppenheimer
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Chest 132:1275-82. 2007
    ..We hypothesized that symptomatic individuals following exposure to WTC dust may have functional abnormalities in distal airways not detectable with routine spirometry...
  58. pmc Surfactant protein A modulates the inflammatory response in macrophages during tuberculosis
    Jeffrey A Gold
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine and Bellevue Hospital Chest Service, New York, New York 10016, USA
    Infect Immun 72:645-50. 2004
    ..This protein augments inflammation in the presence of infection and inhibits inflammation in uninfected macrophages, protecting uninvolved lung segments from the deleterious effects of inflammation...
  59. ncbi request reprint Cough and bronchial responsiveness in firefighters at the World Trade Center site
    David J Prezant
    Bureau of Health Services, Fire Department of New York City, New York, USA
    N Engl J Med 347:806-15. 2002
    ....
  60. doi request reprint Lung Microbiome for Clinicians. New Discoveries about Bugs in Healthy and Diseased Lungs
    Leopoldo N Segal
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU Human Microbiome Program, New York University School of Medicine, New York, New York
    Ann Am Thorac Soc 11:108-16. 2014
    ..Future investigations with longitudinal follow-up to understand the dynamics of the lung microbiome may lead to the development of new therapeutic targets. ..
  61. ncbi request reprint Molecular and genetic aspects of lung cancer
    William N Rom
    Bellevue Chest Service, NYU Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY, USA
    Methods Mol Med 75:3-26. 2003
  62. ncbi request reprint Helios gene gun particle delivery for therapy of acid maltase deficiency
    Frank Martiniuk
    New York University School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care, New York, New York 1001, USA
    DNA Cell Biol 21:717-25. 2002
    ..Muscle weakness in the hind and forelimbs was reversed. These data suggest that particle delivery of the GAA cDNA by the Helios gene gun may be a safe, effective treatment for GSDII...
  63. ncbi request reprint Significance of abnormal chest radiograph findings in patients with HIV-1 infection without respiratory symptoms
    Jeffrey A Gold
    Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, Bellevue Chest Service, New York, NY 10016, USA
    Chest 121:1472-7. 2002
    ..The objective was to determine the spectrum of disease and the diagnostic modalities employed in these patients...
  64. ncbi request reprint Selective p38 activation in human non-small cell lung cancer
    Alissa K Greenberg
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Am J Respir Cell Mol Biol 26:558-64. 2002
    ....
  65. doi request reprint Case series report of a linezolid-containing regimen for extensively drug-resistant tuberculosis
    Rany Condos
    Bellevue Chest Service, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, 550 1st Ave, NBV 7N24, New York, NY 10016, USA
    Chest 134:187-92. 2008
    ..To determine whether linezolid is safe and well tolerated in the treatment of extensively drug-resistant tuberculosis (XDR-TB)...