Research Topics
Genomes and Genes | William N RomSummaryAffiliation: New York University School of Medicine Country: USA Publications
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Publications
Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokersWilliam N Rom
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
BMC Cancer 10:234. 2010..Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and metabolism pathways...- Role of oxidants in interstitial lung diseases: pneumoconioses, constrictive bronchiolitis, and chronic tropical pulmonary eosinophiliaWilliam N Rom
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Mediators Inflamm 2011:407657. 2011..A course of prednisone for one week can reduce the oxidant burden and attendant inflammation and may be a strategy to prevent chronic TPE and interstitial lung disease... - Inflammatory biomarkers predict airflow obstruction after exposure to World Trade Center dustAnna Nolan
Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York 10016, USA
Chest 142:412-8. 2012..The World Trade Center (WTC) collapse on September 11, 2001, produced airflow obstruction in a majority of firefighters receiving subspecialty pulmonary evaluation (SPE) within 6.5 years post-September 11, 2001... 
Impact of E1a modifications on tumor-selective adenoviral replication and toxicityHarald Sauthoff
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA
Mol Ther 10:749-57. 2004..However, deletion within the N-terminus in conjunction with a deletion within the Rb-binding domain, or deletion of the p300-TRAM binding domain, induces a more favorable cytotoxicity profile...- Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dustMichael D Weiden
Division of Pulmonary Critical Care, New York University, New York, NY, USA
Chest 137:566-74. 2010..To date, the underlying pathophysiologic cause for this has been open to question... - Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosisYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Infect Dis 195:1303-10. 2007.... - Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophagesNaohiko Tanaka
Division of Pulmonary and Critical Care Medicine, Department of Medicine, N Y U School of Medicine, New York, NY 10016, USA
Am J Respir Cell Mol Biol 33:406-11. 2005..Only macrophages are able to repress HIV-1 LTR promoter activity and inhibit viral replication in response to IL-10 or type I IFN... - Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophagesYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 172:6251-8. 2004..These changes explain in part why TB accelerates the course of AIDS. CXCR4 inhibitors are a rational therapeutic approach in HIV/TB coinfection... - Metabolic syndrome biomarkers predict lung function impairment: a nested case-control studyBushra Naveed
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Am J Respir Crit Care Med 185:392-9. 2012..Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function... - Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dustWilliam N Rom
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
Am J Respir Crit Care Med 166:797-800. 2002..Acute eosinophilic pneumonia is a rare consequence of acute high dust exposure. World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells... - In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agentElena Maksimova
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Lung 186:45-54. 2008..g., reversing ground glass opacities detected on CT scans or resolving airway preneoplasias detected by bronchoscopy before they progress to malignant transformation... - Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time pointsHarald Sauthoff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Hum Gene Ther 14:425-33. 2003..Despite the limitations of immune-incompetent models, an understanding of the interactions between the virus and the tumor-bearing host is important in the design of effective therapies... - Comparison of WTC dust size on macrophage inflammatory cytokine release in vivo and in vitroMichael D Weiden
Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, New York, United States of America
PLoS ONE 7:e40016. 2012..Our hypotheses are that components of WTC dust strongly induce GM-CSF and MDC in AM; and that these two risk factors are in separate inflammatory pathways... - Lung-specific expression of mutant p53 as mouse model for lung cancerKam-Meng Tchou-Wong
Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, NY, USA
Methods Mol Med 74:465-80. 2003 - Characteristics of a residential and working community with diverse exposure to World Trade Center dust, gas, and fumesJoan Reibman
Department of Medicine, New York University School of Medicine, New York, NY 10011, USA
J Occup Environ Med 51:534-41. 2009.... - Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosisBindu Raju
Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Environmental Medicine, New York University School of Medicine, New York, New York, USA
Infect Immun 72:1275-83. 2004..However, only 15 genes were differentially regulated by IFN-gamma. We conclude that iNOS and IP-10 mRNA expression is increased in TB but that aerosol IFN-gamma treatment increases expression of few genes in the human lung... - Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulatorsAlissa K Greenberg
Department of Medicine, New York University School of Medicine, New York 10016, USA
Am J Respir Cell Mol Biol 27:320-8. 2002.... - HIV-1 and bacterial pneumonia in the era of antiretroviral therapyLeopoldo N Segal
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
Proc Am Thorac Soc 8:282-7. 2011..Bacterial pneumonia presents an ongoing challenge in these high-risk individuals, particularly in studying the functions of the innate and acquired immune response... 
Disparity between proximal and distal airway reactivity during methacholine challengeLeopoldo N Segal
André Cournand Pulmonary Physiology Laboratory, New York University School of Medicine, New York, New York 10016, USA
COPD 8:145-52. 2011..This study highlights the importance of disparity between proximal and distal airway behavior, which has implications in understanding pathophysiology of obstructive pulmonary diseases and their response to treatment...- Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyreneHerman Yee
Department of Pathology, NYU School of Medicine, New York, NY 10016, USA
J Environ Pathol Toxicol Oncol 27:267-76. 2008.... - Gene expression profiles of bronchoalveolar cells in pulmonary TBBindu Raju
Department of Medicine, Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, 550 First Avenue, NB 7N 24, New York, NY 10016, USA
Tuberculosis (Edinb) 88:39-51. 2008..These gene expression data support the conclusion that pulmonary TB produces a global change in the BAL cell transcriptome with manifestations of either Th1 or Th2 immunity... - S-adenosylmethionine as a biomarker for the early detection of lung cancerAlissa K Greenberg
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Chest 132:1247-52. 2007..We hypothesized that AdoMet levels were elevated in patients with lung cancer and may prove useful as a biomarker for early lung cancer... - CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohortAlissa K Greenberg
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New York, USA
PLoS ONE 7:e39403. 2012..We hypothesized that by reviewing demographic, clinical and nodule characteristics, we could identify risk factors associated with the presence of nodules on screening CT, and with the probability that a NCN was malignant... - Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE)Ilana Belitskaya Levy
Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Environ Pathol Toxicol Oncol 26:281-94. 2007..These in vitro findings in NHBE cells model environment-gene interaction for asbestos and BPDE, highlighting effects of inflammation, fibrosis, proliferation, and DNA damage recognition and repair... - Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cellsZhaohui Feng
Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
Carcinogenesis 24:771-8. 2003..This effect may contribute to the synergism of Cr(VI) and BPDE on mutagenesis and cell transformation, and may also contribute to the higher incidence of lung cancer in Cr(VI)-exposed populations... - Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patientsRany Condos
Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
Infect Immun 71:2058-64. 2003..rIFN-gamma aerosol induces signal transduction and gene expression in BAL cells and should be evaluated for efficacy in a randomized, controlled clinical trial... - Emerging exposures and respiratory health: World Trade Center dustWilliam N Rom
MPH, Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
Proc Am Thorac Soc 7:142-5. 2010.... - Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirusJin Cheng
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
Mol Ther 15:1982-90. 2007..These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus... - Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsisAnna Nolan
Division of Pulmonary Critical Care, New York University, School of Medicine, New York, NY, USA
PLoS ONE 4:e6600. 2009..Therefore, the goal of this study was to determine the individual contribution of CD80/86 family members in regulating inflammation in sepsis... - Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-MHiroshi Kobayashi
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 186:403-10. 2011..PMNs de-repress AMs via CASP-6-mediated IRAK-M cleavage. This regulatory system will blunt lung inflammation unless PMNs infiltrate the alveolar spaces... - Survival after surgery in stage IA and IB non-small cell lung cancerDavid Ost
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York, USA
Am J Respir Crit Care Med 177:516-23. 2008..Whether histologic subtype of non-small cell lung cancer (NSCLC) has an important effect on prognosis after surgery is unknown... - Identification of novel hsp65 RFLPs for Mycobacterium lepraeFrank Martiniuk
Department of Medicine Pulmonary Division, New York University School of Medicine, New York, NY 10016, USA
J Drugs Dermatol 6:268-74. 2007..leprae specific single nucleotide polymorphisms (SNPs). Thus, we describe novel hsp65 RFLPs for M. leprae found in a high frequency making them ideal for future epidemiology and transmission studies... - Functional genomics in lung cancer and biomarker detectionWilliam N Rom
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bellevue Chest Service, NYU School of Medicine, Bellevue 7N24, 550 First Avenue, New York, NY 10016, USA
Am J Respir Cell Mol Biol 29:153-6. 2003 - Clinical correlation of asbestos bodies in BAL fluidPratan Vathesatogkit
Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue Hospital, NB 7N24, 550 First Avenue, New York, NY 10016, USA
Chest 126:966-71. 2004..01). CONCLUSION: In individuals with a history of asbestos exposure, the presence of AB in BAL cells is associated with higher prevalence of parenchymal abnormalities, respiratory symptoms, and reduced pulmonary function... - Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancerKam Meng Tchou-Wong
Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, New York 10016, USA
Am J Respir Cell Mol Biol 27:186-93. 2002..29, 678, mid-p corrected). These results suggest that p53 function is important for protecting mice from both spontaneous and BaP-induced lung cancers... - Increased Production of IL-4 and IL-12p40 from Bronchoalveolar Lavage Cells Are Biomarkers of Mycobacterium tuberculosis in the SputumAnna Nolan
Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York, New York, United States of America
PLoS ONE 8:e59461. 2013..Active TB disease represents immune failure to control latent infection from airborne spread. Acid-fast bacillus (AFB) seen on sputum smear is a biomarker for contagiousness... - Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death proteinHarald Sauthoff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Hum Gene Ther 13:1859-71. 2002..In addition, in combination with a deletion of the ADP, specificity of tumor cell killing is improved... - Regional deposition of aerosolized interferon-gamma in pulmonary tuberculosisRany Condos
Bellevue Chest Service, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, USA
Chest 125:2146-55. 2004..The objective of the current study was to evaluate particle size and deposition pattern in patients with TB receiving aerosol IFN-gamma treatment... - New drugs and regimens for treatment of TBEric Leibert
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, 550 1st Avenue, New York, NY 10016, USA
Expert Rev Anti Infect Ther 8:801-13. 2010..Given that these drugs have novel mechanisms of action, combinations have the prospect to be highly active even against multidrug-resistant organisms... - Aryl hydrocarbon receptor and lung cancerJunchieh J Tsay
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY, U S A
Anticancer Res 33:1247-56. 2013..In this review article we summarize the current understanding of AhR and its role in the development of lung cancer, including its influence on cell proliferation, angiogenesis, inflammation, and apoptosis... - Clinical presentation of pulmonary mycetoma in HIV-infected patientsAlissa K Greenberg
Department of Medicine, Bellevue Chest Service and the Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York 10016, USA
Chest 122:886-92. 2002..A combination of antifungal and antiretroviral therapy may improve the clinical outcome in HIV-infected patients with pulmonary mycetoma... - Preneoplastic lesions of the lungAlissa K Greenberg
Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, USA
Respir Res 3:20. 2002..In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma in situ... - 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 geneZhaohui Feng
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Carcinogenesis 23:1721-7. 2002.... - Cough and bronchial responsiveness in firefighters at the World Trade Center siteDavid J Prezant
Bureau of Health Services, Fire Department of New York City, New York, USA
N Engl J Med 347:806-15. 2002.... - Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screeningHemant K Roy
Department of Medicine, NorthShore University HealthSystem Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
Cancer Res 70:7748-54. 2010..Our results offer proof of concept that buccal PWS may potentially herald a minimally intrusive prescreening test that could be integral to the success of lung cancer population screening programs... - Distal airway function in symptomatic subjects with normal spirometry following World Trade Center dust exposureBeno W Oppenheimer
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Chest 132:1275-82. 2007..We hypothesized that symptomatic individuals following exposure to WTC dust may have functional abnormalities in distal airways not detectable with routine spirometry... - Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosisJacqueline M Achkar
New York University School of Medicine, New York, New York 10016, USA
Clin Vaccine Immunol 13:1291-3. 2006..We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis... - Surfactant protein A modulates the inflammatory response in macrophages during tuberculosisJeffrey A Gold
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine and Bellevue Hospital Chest Service, New York, New York 10016, USA
Infect Immun 72:645-50. 2004..This protein augments inflammation in the presence of infection and inhibits inflammation in uninfected macrophages, protecting uninvolved lung segments from the deleterious effects of inflammation... - Gender and lung cancerJames Gasperino
Department of Medicine, New York University School of Medicine, NY 10016, USA
Clin Lung Cancer 5:353-9. 2004..This review of the literature will focus on endocrine factors and tobacco carcinogens as risk factors for lung cancer in women... - Basic pathogenetic mechanisms in silicosis: current understandingBinaya Rimal
Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, New York 10016, USA
Curr Opin Pulm Med 11:169-73. 2005..Potential therapeutic strategies include inhibition of cytokines such as IL-1, TNF alpha, the use of anti-oxidants, and the inhibition of apoptosis... - Molecular and genetic aspects of lung cancerWilliam N Rom
Bellevue Chest Service, NYU Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY, USA
Methods Mol Med 75:3-26. 2003 - Helios gene gun particle delivery for therapy of acid maltase deficiencyFrank Martiniuk
New York University School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care, New York, New York 1001, USA
DNA Cell Biol 21:717-25. 2002..Muscle weakness in the hind and forelimbs was reversed. These data suggest that particle delivery of the GAA cDNA by the Helios gene gun may be a safe, effective treatment for GSDII... - Case series report of a linezolid-containing regimen for extensively drug-resistant tuberculosisRany Condos
Bellevue Chest Service, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, 550 1st Ave, NBV 7N24, New York, NY 10016, USA
Chest 134:187-92. 2008..To determine whether linezolid is safe and well tolerated in the treatment of extensively drug-resistant tuberculosis (XDR-TB)... - Selective p38 activation in human non-small cell lung cancerAlissa K Greenberg
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
Am J Respir Cell Mol Biol 26:558-64. 2002.... - Significance of abnormal chest radiograph findings in patients with HIV-1 infection without respiratory symptomsJeffrey A Gold
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, Bellevue Chest Service, New York, NY 10016, USA
Chest 121:1472-7. 2002..The high prevalence of treatable and potentially communicable disorders warrants an aggressive diagnostic approach in these patients...