Tibor Rohacs

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1218, New York, New York 10029, USA
    Nat Neurosci 8:626-34. 2005
  2. pmc Sphingosine and the transient receptor potential channel kinase(s)
    Tibor Rohacs
    UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Br J Pharmacol 168:1291-3. 2013
  3. ncbi request reprint Regulation of transient receptor potential (TRP) channels by phosphoinositides
    Tibor Rohacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, 07103, USA
    Pflugers Arch 455:157-68. 2007
  4. pmc Phosphoinositide regulation of non-canonical transient receptor potential channels
    Tibor Rohacs
    UMDNJ New Jersey Medical School, Newark, NJ, USA
    Cell Calcium 45:554-65. 2009
  5. pmc Phospholipase C mediated modulation of TRPV1 channels
    Tibor Rohacs
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Mol Neurobiol 37:153-63. 2008
  6. ncbi request reprint Regulation of TRP channels by PIP(2)
    Tibor Rohacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Pflugers Arch 453:753-62. 2007
  7. ncbi request reprint Assaying phosphatidylinositol bisphosphate regulation of potassium channels
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Methods Enzymol 345:71-92. 2002
  8. pmc Interplay between Calmodulin and Phosphatidylinositol 4,5-Bisphosphate in Ca2+-induced Inactivation of Transient Receptor Potential Vanilloid 6 Channels
    Chike Cao
    From the Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103
    J Biol Chem 288:5278-90. 2013
  9. pmc Specificity of activation by phosphoinositides determines lipid regulation of Kir channels
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 100:745-50. 2003
  10. ncbi request reprint Dual regulation of TRPV1 by phosphoinositides
    Viktor Lukacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neurosci 27:7070-80. 2007

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1218, New York, New York 10029, USA
    Nat Neurosci 8:626-34. 2005
    ..These data suggest that the TRP domain of these channels may serve as a PI(4,5)P(2)-interacting site and that regulation by PI(4,5)P(2) is a common feature of members of the TRP channel family...
  2. pmc Sphingosine and the transient receptor potential channel kinase(s)
    Tibor Rohacs
    UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Br J Pharmacol 168:1291-3. 2013
    ..This commentary briefly summarizes the findings of the study, their potential significance and discusses open question and future directions...
  3. ncbi request reprint Regulation of transient receptor potential (TRP) channels by phosphoinositides
    Tibor Rohacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, 07103, USA
    Pflugers Arch 455:157-68. 2007
    ..This review describes mechanisms of modulation of TRP channels mainly by PIP(2) and discusses some future challenges of this fascinating topic...
  4. pmc Phosphoinositide regulation of non-canonical transient receptor potential channels
    Tibor Rohacs
    UMDNJ New Jersey Medical School, Newark, NJ, USA
    Cell Calcium 45:554-65. 2009
    ..Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume...
  5. pmc Phospholipase C mediated modulation of TRPV1 channels
    Tibor Rohacs
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Mol Neurobiol 37:153-63. 2008
    ..Finally, we also discuss data in the literature indicating that other TRP channels, TRPA1 and some members of the TRPC subfamily, may also be under a similar dual control by PIP2...
  6. ncbi request reprint Regulation of TRP channels by PIP(2)
    Tibor Rohacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Pflugers Arch 453:753-62. 2007
    ..This review will summarize the current knowledge on PIP(2) regulation of TRP channels and discuss the possibility that PIP(2) is a common regulator of mammalian TRP channels...
  7. ncbi request reprint Assaying phosphatidylinositol bisphosphate regulation of potassium channels
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Methods Enzymol 345:71-92. 2002
  8. pmc Interplay between Calmodulin and Phosphatidylinositol 4,5-Bisphosphate in Ca2+-induced Inactivation of Transient Receptor Potential Vanilloid 6 Channels
    Chike Cao
    From the Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103
    J Biol Chem 288:5278-90. 2013
    ..Overall, our data show a complex interplay between CaM and PI(4,5)P(2) and show that Ca(2+), CaM, and the depletion of PI(4,5)P(2) all contribute to inactivation of TRPV6...
  9. pmc Specificity of activation by phosphoinositides determines lipid regulation of Kir channels
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 100:745-50. 2003
    ..1 channel decreasing phosphoinositide specificity allow activation by LC acyl-CoA. Our data demonstrate that differences in phosphoinositide specificity determine the modulation of Kir channel activity by distinct regulatory lipids...
  10. ncbi request reprint Dual regulation of TRPV1 by phosphoinositides
    Viktor Lukacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neurosci 27:7070-80. 2007
    ..We conclude that phosphoinositides have both inhibitory and activating effects on TRPV1, resulting in complex and distinct regulation at various stimulation levels...
  11. ncbi request reprint The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment
    Taihao Jin
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Mol Cell 10:469-81. 2002
    ..We propose that the force produced by channel-G(beta)gamma interactions is transduced through the rigid region below the helix bundle crossing to bend TM2 at the glycine that serves as a hinge and open the gate...
  12. pmc Regulation of TRPM8 channel activity
    Yevgen Yudin
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Cell Endocrinol 353:68-74. 2012
    ..This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways...
  13. pmc Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers
    Eleonora Zakharian
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neurosci 30:12526-34. 2010
    ..Our data demonstrate conclusively that TRPM8 is gated by cold and its chemical agonists directly, and that dependence of its gating on PI(4,5)P(2) is a result of direct specific interactions with the lipid...
  14. pmc Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels
    Baskaran Thyagarajan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Biol Chem 283:14980-7. 2008
    ..We propose that Ca(2+) influx through TRPV6 activates phospholipase C and the resulting depletion of PI(4,5)P(2) contributes to the inactivation of TRPV6...
  15. pmc Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂
    Eleonora Zakharian
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    FASEB J 25:3915-28. 2011
    ..Our data establish PtdIns(4,5)P(2) as a direct activator of TRPV6 and demonstrate that intracellular ATP regulates the channel indirectly as a substrate for type III PI4Ks...
  16. pmc Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels
    Yevgen Yudin
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Physiol 589:6007-27. 2011
    ..We conclude that Ca(2+) influx through TRPM8 activates a Ca(2+)-sensitive PLC isoform, and the resulting depletion of PtdIns(4,5)P(2) plays a major role in desensitization of both cold and menthol responses...
  17. pmc Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport
    Baskaran Thyagarajan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Mol Pharmacol 75:608-16. 2009
    ..These observations suggest that Ca(2+)-induced inactivation of TRPV6 limits intestinal Ca(2+) absorption and raise the possibility that Ca(2+) absorption can be enhanced pharmacologically by interfering with PLC activation...
  18. ncbi request reprint Sorcin regulates excitation-contraction coupling in the heart
    Marian B Meyers
    Department of Medicine and Pediatrics, New York University School of Medicine, New York, New York, 10016, USA
    J Biol Chem 278:28865-71. 2003
    ..Together, these data indicate that sorcin modulates intracellular Ca2+ cycling and Ca2+ influx pathways in the heart...
  19. pmc Polyester Modification of the Mammalian TRPM8 Channel Protein: Implications for Structure and Function
    Chike Cao
    Department of Pharmacology and Physiology, New Jersey Medical School, UMDNJ, 185 South Orange Avenue, MSB H626, Newark, NJ 07103, USA
    Cell Rep 4:302-15. 2013
    ..We conclude that the TRPM8 channel undergoes posttranslational modification by PHB and that this modification is required for its normal function. ..
  20. ncbi request reprint Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies
    Coeli M B Lopes
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 34:933-44. 2002
    ..We find basic residues that interact with PIP(2), two of which have been associated with Andersen's and Bartter's syndromes. We show that several naturally occurring mutants decrease channel-PIP(2) interactions, leading to disease...
  21. doi request reprint Recording macroscopic currents in large patches from Xenopus oocytes
    Tibor Rohacs
    UMDNJ, New Jersey Medical School, Newark, NJ, USA
    Methods Mol Biol 998:119-31. 2013
    ..This chapter summarizes our experience with this technique using large patches to study various ion channels expressed in Xenopus oocytes...
  22. pmc Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons
    Viktor Lukacs
    Department of Pharmacology and Physiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
    J Neurosci 33:11451-63. 2013
    ..We propose a comprehensive model in which differential changes in phosphoinositide levels mediated by distinct PLC isoforms result in opposing changes in TRPV1 activity. ..
  23. ncbi request reprint Teaching resources. TRP channels
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci STKE 2005:tr14. 2005
    ..quot; The lecture begins with an overview of calcium signaling and then proceeds to describe the function, regulation, and activation of different TRP channel families...
  24. pmc Inorganic polyphosphate modulates TRPM8 channels
    Eleonora Zakharian
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 4:e5404. 2009
    ..We conclude that the TRPM8 protein forms a stable complex with polyP and its presence is essential for normal channel activity...
  25. pmc Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells
    Peter Varnai
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:377-82. 2006
    ....
  26. ncbi request reprint Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels
    Coeli M B Lopes
    Department of Medicine, Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    Channels (Austin) 1:124-34. 2007
    ..Our results suggest that PKA phosphorylation of these channels affects Gq-coupled receptor inhibition through modulation of the channel sensitivity to PIP2...

Research Grants4

  1. Lipid Regulation of Transient Receptor Potential Channels
    Tibor Rohacs; Fiscal Year: 2007
    ..Our data will provide mechanistic insight into the regulation of temperature sensitive TRP channel, and may also serve as a basis for better local pain control. ..
  2. Lipid Regulation of Transient Receptor Potential Channels
    Tibor Rohacs; Fiscal Year: 2010
    ..Our data will provide mechanistic insight into the regulation of temperature sensitive TRP channel, and may also serve as a basis for better local pain control. ..