Research Topics
Genomes and Genes | Tibor RohacsSummaryAffiliation: New Jersey Country: USA Publications
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Publications
Sphingosine and the transient receptor potential channel kinase(s)Tibor Rohacs
UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Br J Pharmacol 168:1291-3. 2013..This commentary briefly summarizes the findings of the study, their potential significance and discusses open question and future directions...- Phosphoinositide regulation of non-canonical transient receptor potential channelsTibor Rohacs
UMDNJ New Jersey Medical School, Newark, NJ, USA
Cell Calcium 45:554-65. 2009..Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume... - Phospholipase C mediated modulation of TRPV1 channelsTibor Rohacs
Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
Mol Neurobiol 37:153-63. 2008..Finally, we also discuss data in the literature indicating that other TRP channels, TRPA1 and some members of the TRPC subfamily, may also be under a similar dual control by PIP2... 
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domainTibor Rohacs
Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1218, New York, New York 10029, USA
Nat Neurosci 8:626-34. 2005..These data suggest that the TRP domain of these channels may serve as a PI(4,5)P(2)-interacting site and that regulation by PI(4,5)P(2) is a common feature of members of the TRP channel family...- Regulation of transient receptor potential (TRP) channels by phosphoinositidesTibor Rohacs
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, 07103, USA
Pflugers Arch 455:157-68. 2007..This review describes mechanisms of modulation of TRP channels mainly by PIP(2) and discusses some future challenges of this fascinating topic... - Regulation of TRP channels by PIP(2)Tibor Rohacs
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
Pflugers Arch 453:753-62. 2007..This review will summarize the current knowledge on PIP(2) regulation of TRP channels and discuss the possibility that PIP(2) is a common regulator of mammalian TRP channels... - Assaying phosphatidylinositol bisphosphate regulation of potassium channelsTibor Rohacs
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
Methods Enzymol 345:71-92. 2002 - Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channelsChike Cao
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
J Biol Chem 288:5278-90. 2013..Overall, our data show a complex interplay between CaM and PI(4,5)P(2) and show that Ca(2+), CaM, and the depletion of PI(4,5)P(2) all contribute to inactivation of TRPV6... - Specificity of activation by phosphoinositides determines lipid regulation of Kir channelsTibor Rohacs
Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
Proc Natl Acad Sci U S A 100:745-50. 2003..1 channel decreasing phosphoinositide specificity allow activation by LC acyl-CoA. Our data demonstrate that differences in phosphoinositide specificity determine the modulation of Kir channel activity by distinct regulatory lipids... - Dual regulation of TRPV1 by phosphoinositidesViktor Lukacs
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
J Neurosci 27:7070-80. 2007..We conclude that phosphoinositides have both inhibitory and activating effects on TRPV1, resulting in complex and distinct regulation at various stimulation levels... - The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segmentTaihao Jin
Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
Mol Cell 10:469-81. 2002..We propose that the force produced by channel-G(beta)gamma interactions is transduced through the rigid region below the helix bundle crossing to bend TM2 at the glycine that serves as a hinge and open the gate... - Regulation of TRPM8 channel activityYevgen Yudin
Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Mol Cell Endocrinol 353:68-74. 2012..This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways... - Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayersEleonora Zakharian
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
J Neurosci 30:12526-34. 2010..Our data demonstrate conclusively that TRPM8 is gated by cold and its chemical agonists directly, and that dependence of its gating on PI(4,5)P(2) is a result of direct specific interactions with the lipid... - Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂Eleonora Zakharian
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
FASEB J 25:3915-28. 2011..Our data establish PtdIns(4,5)P(2) as a direct activator of TRPV6 and demonstrate that intracellular ATP regulates the channel indirectly as a substrate for type III PI4Ks... - Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channelsBaskaran Thyagarajan
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Biol Chem 283:14980-7. 2008..We propose that Ca(2+) influx through TRPV6 activates phospholipase C and the resulting depletion of PI(4,5)P(2) contributes to the inactivation of TRPV6... - Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channelsYevgen Yudin
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
J Physiol 589:6007-27. 2011..We conclude that Ca(2+) influx through TRPM8 activates a Ca(2+)-sensitive PLC isoform, and the resulting depletion of PtdIns(4,5)P(2) plays a major role in desensitization of both cold and menthol responses... - Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transportBaskaran Thyagarajan
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
Mol Pharmacol 75:608-16. 2009..These observations suggest that Ca(2+)-induced inactivation of TRPV6 limits intestinal Ca(2+) absorption and raise the possibility that Ca(2+) absorption can be enhanced pharmacologically by interfering with PLC activation... - Sorcin regulates excitation-contraction coupling in the heartMarian B Meyers
Department of Medicine and Pediatrics, New York University School of Medicine, New York, New York, 10016, USA
J Biol Chem 278:28865-71. 2003..Together, these data indicate that sorcin modulates intracellular Ca2+ cycling and Ca2+ influx pathways in the heart... - Alterations in conserved Kir channel-PIP2 interactions underlie channelopathiesCoeli M B Lopes
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
Neuron 34:933-44. 2002..We find basic residues that interact with PIP(2), two of which have been associated with Andersen's and Bartter's syndromes. We show that several naturally occurring mutants decrease channel-PIP(2) interactions, leading to disease... - Teaching resources. TRP channelsTibor Rohacs
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci STKE 2005:tr14. 2005..quot; The lecture begins with an overview of calcium signaling and then proceeds to describe the function, regulation, and activation of different TRP channel families... - Inorganic polyphosphate modulates TRPM8 channelsEleonora Zakharian
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
PLoS ONE 4:e5404. 2009..We conclude that the TRPM8 protein forms a stable complex with polyP and its presence is essential for normal channel activity... - Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cellsPeter Varnai
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 175:377-82. 2006.... - Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channelsCoeli M B Lopes
Department of Medicine, Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
Channels (Austin) 1:124-34. 2007..Our results suggest that PKA phosphorylation of these channels affects Gq-coupled receptor inhibition through modulation of the channel sensitivity to PIP2...
Research Grants
- Lipid Regulation of Transient Receptor Potential ChannelsTibor Rohacs; Fiscal Year: 2007..Our data will provide mechanistic insight into the regulation of temperature sensitive TRP channel, and may also serve as a basis for better local pain control. ..
- Lipid Regulation of Transient Receptor Potential ChannelsTibor Rohacs; Fiscal Year: 2010..Our data will provide mechanistic insight into the regulation of temperature sensitive TRP channel, and may also serve as a basis for better local pain control. ..