Alfred Prince

Summary

Affiliation: New York Blood Center
Country: USA

Publications

  1. ncbi request reprint Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infections
    A M Prince
    Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
    J Viral Hepat 11:236-42. 2004
  2. ncbi request reprint Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model
    Alfred M Prince
    Laboratory of Virology, Lindsley F Kimball Research Institute, New York Blood Center, NY 10021, USA
    J Infect Dis 192:1701-9. 2005
  3. ncbi request reprint Optimization of recombinant vaccinia-based ELISPOT assay
    Mohamed Tarek Shata
    Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    J Immunol Methods 283:281-9. 2003
  4. ncbi request reprint Evaluation of the performance of 44 assays used in countries with limited resources for the detection of antibodies to hepatitis C virus
    Heinrich Scheiblauer
    International Consortium for Blood Safety ICBS, The New York Blood Center, New York, New York 10021, USA
    Transfusion 46:708-18. 2006
  5. ncbi request reprint Stabilized viral nucleic acids in plasma as an alternative shipping method for NAT
    Dong Hun Lee
    Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York 10021, USA
    Transfusion 42:409-13. 2002
  6. ncbi request reprint The uncertain future of research chimpanzees
    Alfred M Prince
    Science 315:1493-4. 2007
  7. pmc Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load
    Mohamed Tarek M Shata
    Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
    J Med Primatol 35:165-71. 2006
  8. ncbi request reprint gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection
    Zhi Qiang Yao
    Department of Microbiology and Pathology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Virology 346:324-37. 2006
  9. ncbi request reprint Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee
    Jin Won Youn
    National Research Laboratory of DNA Medicine, Division of Molecular and Life Science, Postech Biotech Center, Pohang University of Science and Technology, Republic of Korea
    Hepatology 42:1429-36. 2005
  10. ncbi request reprint Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversion
    Maged Al-Sherbiny
    Egyptian Reference Diagnostic Center, VACSERA, Cairo, Egypt
    Am J Trop Med Hyg 73:44-9. 2005

Research Grants

Collaborators

  • J M Pawlotsky
  • M T Shata
  • D H Lee
  • YOUNG HAHN
  • L H Tobler
  • Se Ho Kim
  • GEORGE THOMAS STRICKLAND
  • Y W Hu
  • Jin Won Youn
  • Wolfram Pfahler
  • Nancy Tricoche
  • Betsy Brotman
  • Antonella Folgori
  • Francois Loic Cosset
  • Heinrich Scheiblauer
  • Zhi Qiang Yao
  • Maged Al-Sherbiny
  • Don Ganem
  • Thomas Wüest
  • Preeti Pancholi
  • Marlene Dreux
  • Susan Diaz
  • Mohamed El-Nageh
  • Mei Mei Shan
  • Sigrid Nick
  • Howard Fields
  • Nahla Mohamed
  • Young Chul Sung
  • Sonia Stoszek
  • Fatma Abdel-Aziz
  • Sayed F Abdelwahab
  • Hyun Tak Jin
  • Se Hwan Yang
  • Mohamed Abdel-Hamid
  • Nabiel Mikhail
  • Lionello Ruggeri
  • Ahmed Osman
  • Chang Geun Lee
  • Chang Min Kim
  • Alfredo Nicosia
  • Su Hyung Park
  • Dimitri Lavillette
  • Christian Hofmann
  • Gerald W Both
  • Peter Loser
  • Marion Perkus
  • Qingyan Liu

Detail Information

Publications19

  1. ncbi request reprint Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infections
    A M Prince
    Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
    J Viral Hepat 11:236-42. 2004
    ..Quasispecies analysis revealed that in all, except one case, the virus reappearing after downregulation was essentially identical to that of the originally infecting virus...
  2. ncbi request reprint Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model
    Alfred M Prince
    Laboratory of Virology, Lindsley F Kimball Research Institute, New York Blood Center, NY 10021, USA
    J Infect Dis 192:1701-9. 2005
    ..These findings suggest that a universally protective HCV vaccine may need to incorporate epitopes from multiple genotypes...
  3. ncbi request reprint Optimization of recombinant vaccinia-based ELISPOT assay
    Mohamed Tarek Shata
    Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    J Immunol Methods 283:281-9. 2003
    ..75-0.075 microg/ml. Thus, Cidofovir treatment of the target cells prior to antigen stimulation could be a useful methodology to increase the sensitivity of the ELISPOT assay...
  4. ncbi request reprint Evaluation of the performance of 44 assays used in countries with limited resources for the detection of antibodies to hepatitis C virus
    Heinrich Scheiblauer
    International Consortium for Blood Safety ICBS, The New York Blood Center, New York, New York 10021, USA
    Transfusion 46:708-18. 2006
    ....
  5. ncbi request reprint Stabilized viral nucleic acids in plasma as an alternative shipping method for NAT
    Dong Hun Lee
    Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York 10021, USA
    Transfusion 42:409-13. 2002
    ..An economical and convenient method is described for nucleic acid stabilization by using an RNA stabilizing solution (RNAlater, Ambion) in plasma that is designed for the shipment of samples to tropical countries...
  6. ncbi request reprint The uncertain future of research chimpanzees
    Alfred M Prince
    Science 315:1493-4. 2007
  7. pmc Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load
    Mohamed Tarek M Shata
    Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
    J Med Primatol 35:165-71. 2006
    ..In the present study, we attempted to confirm these findings in an animal with a high virus load...
  8. ncbi request reprint gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection
    Zhi Qiang Yao
    Department of Microbiology and Pathology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Virology 346:324-37. 2006
    ..These findings suggest that gC1qR expression on the surface of T cells is crucial for HCV core-mediated T cell suppression and viral clearance, and that represents a novel mechanism by which a virus usurps host machinery for persistence...
  9. ncbi request reprint Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee
    Jin Won Youn
    National Research Laboratory of DNA Medicine, Division of Molecular and Life Science, Postech Biotech Center, Pohang University of Science and Technology, Republic of Korea
    Hepatology 42:1429-36. 2005
    ..In conclusion, vaccine-induced E2-specific antibody plays an important role in prevention from nonhomologous virus infection and may provide new insight into the development of an effective HCV vaccine...
  10. ncbi request reprint Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversion
    Maged Al-Sherbiny
    Egyptian Reference Diagnostic Center, VACSERA, Cairo, Egypt
    Am J Trop Med Hyg 73:44-9. 2005
    ..We speculate induced CMI clears HCV sometimes when anti-HCV is not detectable, and HCV-specific CMI is a useful surrogate marker for exposure to HCV...
  11. ncbi request reprint Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees
    Mohamed Tarek Shata
    New York Blood Center, New York, NY 10021, USA
    Virology 314:601-16. 2003
    ..However, increasing the infective doses of HCV to 100 RNA (+) virions overcame the low-inoculum-induced immune response and produced high-level viremia followed by seroconversion...
  12. pmc DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mice
    Preeti Pancholi
    Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York 10021, USA
    J Virol 77:382-90. 2003
    ....
  13. pmc Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus
    Jin Won Youn
    Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York, New York 10065, USA
    J Virol 82:10896-905. 2008
    ..This study suggests the potential efficacy of replicating recombinant vaccinia virus-based immunization against chronic HCV infection...
  14. pmc Individual donor nucleic acid amplification testing for detection of West Nile virus
    Dong Hun Lee
    Laboratory of Virology, The Lindsay F Kimball Research Institute of the New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    J Clin Microbiol 43:5111-6. 2005
    ..The assay detected all positive blood donation samples identified by the Roche WNV NAT. The assay can be performed qualitatively for screening and quantitatively for confirmation...
  15. ncbi request reprint HIV-1 and HCV infections among antibody-negative blood donors
    Alfred M Prince
    N Engl J Med 351:2232-5; author reply 2232-5. 2004
  16. ncbi request reprint Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice
    Thomas Wüest
    DeveloGen AG, Rudolf Wissell Str 28, 37092 Göttingen, Germany
    Vaccine 22:2717-21. 2004
    ..The results of our study provide proof for the concept that OAdV vectors may be valuable tools for vaccination and immunotherapy even in the face of natural immunity to human adenoviruses...
  17. ncbi request reprint Hepatitis B virus infection--natural history and clinical consequences
    Don Ganem
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, USA
    N Engl J Med 350:1118-29. 2004
  18. ncbi request reprint Lack of evidence for HIV type 1-related SIVcpz infection in captive and wild chimpanzees (Pan troglodytes verus) in West Africa
    Alfred M Prince
    Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York, New York 10021, USA
    AIDS Res Hum Retroviruses 18:657-60. 2002
    ..As it has been convincingly shown that SIVcpz exists in wild Pan troglodytes troglodytes in Central Africa, this suggests that HIV-1 arose in Central Africa, but not in West Africa...
  19. doi request reprint Neutralization of hepatitis B virus (HBV) by human monoclonal antibody against HBV surface antigen (HBsAg) in chimpanzees
    Se Ho Kim
    Antibody Engineering Laboratory, Research Center, Green Cross Corp, 341, Bojeong Dong, Giheung gu, Yongin City, Gyunggi Do, 446 799, Republic of Korea
    Antiviral Res 79:188-91. 2008
    ..This work demonstrates the neutralization of HBV by HB-C7A monoclonal antibody and shows the possibility of prevention of HBV infection using this antibody in liver transplantation and exposure to HBV...

Research Grants5

  1. PROPHYLACTIC & THERPEUTIC DNA IMMUNIZATION AGAINST HCV
    Alfred Prince; Fiscal Year: 2003
    ..The immunogenicity of HCV genes presented as fusion proteins with ubiquitin and secreting and non-secreting HCV gene-containing plasmids will be compared. ..