Affiliation: New York Blood Center
- Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infectionsA M Prince
Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
J Viral Hepat 11:236-42. 2004..Quasispecies analysis revealed that in all, except one case, the virus reappearing after downregulation was essentially identical to that of the originally infecting virus...
- Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee modelAlfred M Prince
Laboratory of Virology, Lindsley F Kimball Research Institute, New York Blood Center, NY 10021, USA
J Infect Dis 192:1701-9. 2005..These findings suggest that a universally protective HCV vaccine may need to incorporate epitopes from multiple genotypes...
- Optimization of recombinant vaccinia-based ELISPOT assayMohamed Tarek Shata
Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
J Immunol Methods 283:281-9. 2003..75-0.075 microg/ml. Thus, Cidofovir treatment of the target cells prior to antigen stimulation could be a useful methodology to increase the sensitivity of the ELISPOT assay...
- Evaluation of the performance of 44 assays used in countries with limited resources for the detection of antibodies to hepatitis C virusHeinrich Scheiblauer
International Consortium for Blood Safety ICBS, The New York Blood Center, New York, New York 10021, USA
Transfusion 46:708-18. 2006....
- Stabilized viral nucleic acids in plasma as an alternative shipping method for NATDong Hun Lee
Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York 10021, USA
Transfusion 42:409-13. 2002..An economical and convenient method is described for nucleic acid stabilization by using an RNA stabilizing solution (RNAlater, Ambion) in plasma that is designed for the shipment of samples to tropical countries...
- The uncertain future of research chimpanzeesAlfred M Prince
Science 315:1493-4. 2007
- Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral loadMohamed Tarek M Shata
Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York, NY 10021, USA
J Med Primatol 35:165-71. 2006..In the present study, we attempted to confirm these findings in an animal with a high virus load...
- gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infectionZhi Qiang Yao
Department of Microbiology and Pathology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Virology 346:324-37. 2006..These findings suggest that gC1qR expression on the surface of T cells is crucial for HCV core-mediated T cell suppression and viral clearance, and that represents a novel mechanism by which a virus usurps host machinery for persistence...
- Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzeeJin Won Youn
National Research Laboratory of DNA Medicine, Division of Molecular and Life Science, Postech Biotech Center, Pohang University of Science and Technology, Republic of Korea
Hepatology 42:1429-36. 2005..In conclusion, vaccine-induced E2-specific antibody plays an important role in prevention from nonhomologous virus infection and may provide new insight into the development of an effective HCV vaccine...
- Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversionMaged Al-Sherbiny
Egyptian Reference Diagnostic Center, VACSERA, Cairo, Egypt
Am J Trop Med Hyg 73:44-9. 2005..We speculate induced CMI clears HCV sometimes when anti-HCV is not detectable, and HCV-specific CMI is a useful surrogate marker for exposure to HCV...
- Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzeesMohamed Tarek Shata
New York Blood Center, New York, NY 10021, USA
Virology 314:601-16. 2003..However, increasing the infective doses of HCV to 100 RNA (+) virions overcame the low-inoculum-induced immune response and produced high-level viremia followed by seroconversion...
- DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic micePreeti Pancholi
Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York 10021, USA
J Virol 77:382-90. 2003....
- Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virusJin Won Youn
Laboratory of Virology, The Lindsley F Kimball Research Institute of the New York Blood Center, New York, New York 10065, USA
J Virol 82:10896-905. 2008..This study suggests the potential efficacy of replicating recombinant vaccinia virus-based immunization against chronic HCV infection...
- Individual donor nucleic acid amplification testing for detection of West Nile virusDong Hun Lee
Laboratory of Virology, The Lindsay F Kimball Research Institute of the New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
J Clin Microbiol 43:5111-6. 2005..The assay detected all positive blood donation samples identified by the Roche WNV NAT. The assay can be performed qualitatively for screening and quantitatively for confirmation...
- HIV-1 and HCV infections among antibody-negative blood donorsAlfred M Prince
N Engl J Med 351:2232-5; author reply 2232-5. 2004
- Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in miceThomas Wüest
DeveloGen AG, Rudolf Wissell Str 28, 37092 Göttingen, Germany
Vaccine 22:2717-21. 2004..The results of our study provide proof for the concept that OAdV vectors may be valuable tools for vaccination and immunotherapy even in the face of natural immunity to human adenoviruses...
- Hepatitis B virus infection--natural history and clinical consequencesDon Ganem
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, USA
N Engl J Med 350:1118-29. 2004
- Lack of evidence for HIV type 1-related SIVcpz infection in captive and wild chimpanzees (Pan troglodytes verus) in West AfricaAlfred M Prince
Laboratory of Virology, Lindsley F Kimball Research Institute of the New York Blood Center, New York, New York 10021, USA
AIDS Res Hum Retroviruses 18:657-60. 2002..As it has been convincingly shown that SIVcpz exists in wild Pan troglodytes troglodytes in Central Africa, this suggests that HIV-1 arose in Central Africa, but not in West Africa...
- Neutralization of hepatitis B virus (HBV) by human monoclonal antibody against HBV surface antigen (HBsAg) in chimpanzeesSe Ho Kim
Antibody Engineering Laboratory, Research Center, Green Cross Corp, 341, Bojeong Dong, Giheung gu, Yongin City, Gyunggi Do, 446 799, Republic of Korea
Antiviral Res 79:188-91. 2008..This work demonstrates the neutralization of HBV by HB-C7A monoclonal antibody and shows the possibility of prevention of HBV infection using this antibody in liver transplantation and exposure to HBV...
- PROPHYLACTIC & THERPEUTIC DNA IMMUNIZATION AGAINST HCVAlfred Prince; Fiscal Year: 2003..The immunogenicity of HCV genes presented as fusion proteins with ubiquitin and secreting and non-secreting HCV gene-containing plasmids will be compared. ..