Michael H Pillinger

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation
    Michael H Pillinger
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 171:6080-9. 2003
  2. ncbi request reprint Update on the management of hyperuricemia and gout
    Michael H Pillinger
    New York Universuty School of Medicine, New York, NY, USA
    Bull NYU Hosp Jt Dis 66:231-9. 2008
  3. ncbi request reprint Hyperuricemia and gout: new insights into pathogenesis and treatment
    Michael H Pillinger
    New York University School of Medicine and Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Bull NYU Hosp Jt Dis 65:215-21. 2007
  4. ncbi request reprint The language used by Helicobacter pylori to regulate human cells
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, NY 10010, USA
    J Infect Dis 196:6-9. 2007
  5. ncbi request reprint Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 282:18722-31. 2007
  6. pmc Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
    Michael H Pillinger
    The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 142:973-82. 2004
  7. ncbi request reprint Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:9973-9. 2005
  8. ncbi request reprint Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts
    Clement E Tagoe
    Division of Rheumatology, New York University School of Medicine Hospital for Joint Diseases, New York, NY 10003, USA
    J Immunol 181:2813-20. 2008
  9. ncbi request reprint Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts
    Paul F Gomez
    Department of Rheumatology, Hospital for Joint Diseases and Department of Medicine, New York University School of Medicine, New York, NY 10003, USA
    J Immunol 175:6924-30. 2005
  10. doi request reprint Prevalence of contraindications and prescription of pharmacologic therapies for gout
    Robert T Keenan
    Section of Rheumatology of the New York Harbor Health Care System, New York Campus of the US Department of Veterans Affairs, New York, USA
    Am J Med 124:155-63. 2011

Detail Information

Publications50

  1. ncbi request reprint Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation
    Michael H Pillinger
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 171:6080-9. 2003
    ....
  2. ncbi request reprint Update on the management of hyperuricemia and gout
    Michael H Pillinger
    New York Universuty School of Medicine, New York, NY, USA
    Bull NYU Hosp Jt Dis 66:231-9. 2008
    ..Also reviewed are the biological and clinical data behind newly-developed drugs for gout that are likely to receive serious consideration for FDA approval, and clinical use, in the foreseeable future...
  3. ncbi request reprint Hyperuricemia and gout: new insights into pathogenesis and treatment
    Michael H Pillinger
    New York University School of Medicine and Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Bull NYU Hosp Jt Dis 65:215-21. 2007
    ....
  4. ncbi request reprint The language used by Helicobacter pylori to regulate human cells
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, NY 10010, USA
    J Infect Dis 196:6-9. 2007
  5. ncbi request reprint Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 282:18722-31. 2007
    ..These data indicate H. pylori effects on host epithelial MMP-1 expression via ERK, with p38 playing a potential regulatory role...
  6. pmc Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
    Michael H Pillinger
    The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 142:973-82. 2004
    ..In contrast, nabumetone demonstrates anti-inflammatory and potentially arthroprotective effects that have not been previously appreciated...
  7. ncbi request reprint Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:9973-9. 2005
    ..pylori infection and/or cyclooxygenase inhibition may induce epithelial cell signaling to contribute to gastric ulcerogenesis...
  8. ncbi request reprint Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts
    Clement E Tagoe
    Division of Rheumatology, New York University School of Medicine Hospital for Joint Diseases, New York, NY 10003, USA
    J Immunol 181:2813-20. 2008
    ....
  9. ncbi request reprint Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts
    Paul F Gomez
    Department of Rheumatology, Hospital for Joint Diseases and Department of Medicine, New York University School of Medicine, New York, NY 10003, USA
    J Immunol 175:6924-30. 2005
    ..Our data indicate that PGE2 may act to attenuate cytokine-induced inflammatory responses in RA synovial fibroblasts via regulation of the localization of specific NF-kappaB family dimers...
  10. doi request reprint Prevalence of contraindications and prescription of pharmacologic therapies for gout
    Robert T Keenan
    Section of Rheumatology of the New York Harbor Health Care System, New York Campus of the US Department of Veterans Affairs, New York, USA
    Am J Med 124:155-63. 2011
    ..Patients with gout have comorbidities, but the impact of these comorbidities on treatment has not been studied...
  11. pmc Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout
    Daria B Crittenden
    Crystal Diseases Study Group, Division of Rheumatology, New York University School of Medicine, New York, New York 10003, USA
    J Rheumatol 39:1458-64. 2012
    ..We examined whether colchicine use was associated with a reduced risk of myocardial infarction (MI) in patients with gout...
  12. ncbi request reprint Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor
    Mukundan Attur
    Division of Rheumatology, New York University School of Medicine and New York University Hospital for Joint Diseases, New York, NY 10003, USA
    J Immunol 181:5082-8. 2008
    ..Targeting EP4, rather than cyclooxygenase 2, could represent a future strategy for OA disease modification...
  13. ncbi request reprint Update on gout: pathophysiology and potential treatments
    Aryeh M Abeles
    Division of Rheumatology, Medical Arts and Research Building, 263 Farmington Avenue, Farmington, CT 06030, USA
    Curr Pain Headache Rep 11:440-6. 2007
    ..Finally, we provide an overview of the current approach to gout, as well as what treatments are on the horizon...
  14. ncbi request reprint The year in gout: 2011-2012
    Daria B Crittenden
    Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Bull NYU Hosp Jt Dis 70:145-51. 2012
    ..Here we review some of the most important recent advances in gout over the past 12 to 18 months...
  15. pmc Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Arthritis Res Ther 9:R4. 2007
    ..NS398-treated THP-1 macrophages show greater vulnerability to form foam cells. Increased cardiovascular risk with COX inhibition may be ascribed at least in part to altered cholesterol metabolism...
  16. doi request reprint A comparison of arthrocentesis teaching tools: cadavers, synthetic joint models, and the relative utility of different educational modalities in improving trainees' comfort with procedures
    Jessica R Berman
    Division of Rheumatology, The Hospital for Special Surgery Weill Cornell Medical College, New York, NY, USA
    J Clin Rheumatol 18:175-9. 2012
    ..Each year, rheumatology programs across the country teach incoming trainees the skill of arthrocentesis, but the relative effectiveness of various teaching techniques has not been assessed in a systematic way...
  17. doi request reprint Drugs causing muscle disease
    Adam Mor
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, 301 East 17th Street Room 1410, New York, NY 10003, USA
    Rheum Dis Clin North Am 37:219-31, vi. 2011
    ..In this article, some of the commonly used drugs that may induce myopathies, as well as the clinical phenotypes, diagnosis, and management of these syndromes are reviewed...
  18. ncbi request reprint The role of the synovial fibroblast in rheumatoid arthritis: cartilage destruction and the regulation of matrix metalloproteinases
    Aryeh M Abeles
    The Department of Medicine, Division of Rheumatology, NewYork University Hospital for Joint Diseases, New York, New York 10003, USA
    Bull NYU Hosp Jt Dis 64:20-4. 2006
    ....
  19. ncbi request reprint Hyperuricemia, gout, and cardiovascular disease--an important "muddle"
    Robert T Keenan
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, New York 10003, USA
    Bull NYU Hosp Jt Dis 67:285-90. 2009
    ....
  20. doi request reprint New therapies for gout
    Daria B Crittenden
    Crystal Diseases Study Group, Division of Rheumatology, Department of Medicine, NYU School of Medicine NYU Langone Medical Center, New York, New York 10003, USA
    Annu Rev Med 64:325-37. 2013
    ..These new treatments do not obviate the need for lifestyle and dietary management, another area in which significant scientific and clinical progress has recently been made...
  21. ncbi request reprint Carboxyl methylation of Ras regulates membrane targeting and effector engagement
    Vi K Chiu
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 279:7346-52. 2004
    ..Thus, Ras methylation appears to regulate Erk activation both through the localization of Ras as well as the propagation of Ras-dependent signals...
  22. doi request reprint Update on fibromyalgia therapy
    Micha Abeles
    Division of Rheumatology, Department of Medicine, The University of Connecticut School of Medicine, Farmington, USA
    Am J Med 121:555-61. 2008
    ..This review critically and systematically evaluates clinical investigations of medicinal and nonmedicinal treatments for fibromyalgia dating from 1970 to 2007...
  23. ncbi request reprint Drug-induced myopathies
    Adam Mor
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Bull NYU Hosp Jt Dis 67:358-69. 2009
    ..Earlier diagnosis and drug discontinuation raises the likelihood of resolution and recovery...
  24. ncbi request reprint Gout and its comorbidities
    Michael H Pillinger
    New York University School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Bull NYU Hosp Jt Dis 68:199-203. 2010
    ..In addition, we briefly consider several neurological conditions in which the presence of gout or a high serum urate level may be associated with less disease, rather than more...
  25. doi request reprint Febuxostat: a new agent for lowering serum urate
    Robert T Keenan
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Drugs Today (Barc) 45:247-60. 2009
    ..S. FDA in 2009. Possible implications the medication may have in the future on gout and hyperuricemia will also be discussed...
  26. ncbi request reprint Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors
    Aryeh M Abeles
    New York University Hospital for Joint Diseases, and New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 56:2840-53. 2007
    ....
  27. ncbi request reprint The year in gout - 2010-2011
    Daria B Crittenden
    Rheumatology Section, New York Harbor VA Healthcare System New York Campus, New York, New York, USA
    Bull NYU Hosp Jt Dis 69:257-63. 2011
    ....
  28. doi request reprint The role of microRNA in rheumatoid arthritis and other autoimmune diseases
    Victoria Furer
    Division of Rheumatology, Department of Medicine, NYU School of Medicine NYU Hospital for Joint Diseases, New York, NY 10009, USA
    Clin Immunol 136:1-15. 2010
    ..We conclude with a discussion of the implications of miRNA biology in rheumatoid arthritis and other autoimmune disorders...
  29. doi request reprint The role of uric acid and other crystals in osteoarthritis
    Johannes Nowatzky
    Department of Medicine, Division of Rheumatology, New York University Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    Curr Rheumatol Rep 12:142-8. 2010
    ..Given the clinical frequency of gout and that agents exist to modulate serum UA levels, special attention is given to the role of monosodium urate crystals...
  30. pmc Reproducibility of musculoskeletal ultrasound for determining monosodium urate deposition: concordance between readers
    Rennie G Howard
    New York University Langone Medical Center, New York University Hospital for Joint Diseases, and New York Harbor VA Health Care System New York Campus, New York, USA
    Arthritis Care Res (Hoboken) 63:1456-62. 2011
    ..Criteria for sonographic diagnosis of monosodium urate (MSU) crystal deposition have been developed, but the interreader reproducibility of this modality is not well established. We therefore assessed agreement using a systematic approach...
  31. ncbi request reprint The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction
    Adam Mor
    Division of Rheumatology, NYU School of Medicine and The Hospital for Joint Disease, New York, NY 10003, USA
    Clin Immunol 115:118-28. 2005
    ..In this article, we consider the normal role of the FLS in healthy joints, and review evidence that implicates the FLS as a central player in the propagation of rheumatoid arthritis...
  32. pmc Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis
    Jose U Scher
    Division of Rheumatology, New York University and New York University Hospital for Joint Diseases, New York, New York 10003, USA
    Arthritis Rheum 64:3083-94. 2012
    ..To profile the abundance and diversity of subgingival oral microbiota in patients with never-treated, new-onset rheumatoid arthritis (RA)...
  33. doi request reprint The New York City Rheumatology Objective Structured Clinical Examination: five-year data demonstrates its validity, usefulness as a unique rating tool, objectivity, and sensitivity to change
    Jessica R Berman
    New York Hospital The Hospital for Special Surgery, New York, NY, USA
    Arthritis Rheum 61:1686-93. 2009
    ....
  34. ncbi request reprint Familial Mediterranean fever successfully treated with etanercept
    Adam Mor
    Department of Medicine, Division of Rheumatology, New York University School of Medicine Hospital for Joint Diseases, New York, NY 10003, USA
    J Clin Rheumatol 13:38-40. 2007
    ..This case adds to a growing body of evidence suggesting that tumor necrosis factor (TNF) blockade may result in resolution and prevention of further FMF attacks...
  35. ncbi request reprint 15d-PGJ2: the anti-inflammatory prostaglandin?
    Jose U Scher
    The Division of Rheumatology, New York University School of Medicine, New York, NY 10003, USA
    Clin Immunol 114:100-9. 2005
    ..In this review, we summarize the current understanding of 15d-PGJ2 synthesis, biology and main effects both in molecular physiology and pathological states...
  36. ncbi request reprint Interleukin-6 in the pathogenesis of rheumatoid arthritis
    Jean Y Park
    Division of Rheumatology, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, New York 10003, USA
    Bull NYU Hosp Jt Dis 65:S4-10. 2007
    ..The basic biology of IL-6, the in vitro animal data supporting its role in RA, and the human trials to date that test the possible efficacy of IL-6-directed therapy for RA are reviewed...
  37. ncbi request reprint Syphilis mimicking Reiter's syndrome in an HIV-positive patient
    Mitsumasa Kishimoto
    Division of Rheumatology, NYU School of Medicine Hospital for Joint Diseases, New York, New York 10016, USA
    Am J Med Sci 332:90-2. 2006
    ..Because the initial presentation was difficult to distinguish from the symptoms of Reiter's syndrome, a high degree of clinical suspicion was required to accurately diagnose syphilis, a curable and potentially fatal disease...
  38. ncbi request reprint Nitric oxide synthases and osteoarthritis
    Jose U Scher
    The Division of Rheumatology, New York University School of Medicine New York University Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    Curr Rheumatol Rep 9:9-15. 2007
    ..Thus, NO produced by activated chondrocytes in diseased cartilage may modulate disease progression in osteoarthritis and should therefore be considered a potential target for therapeutic intervention...
  39. ncbi request reprint Statins as antiinflammatory and immunomodulatory agents: a future in rheumatologic therapy?
    Aryeh M Abeles
    New York University School of Medicine, The Hospital for Joint Diseases, New York, New York, USA
    Arthritis Rheum 54:393-407. 2006
  40. ncbi request reprint Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    Jean Y Park
    The Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Clin Immunol 119:229-40. 2006
    ..In this review, we summarize the synthesis and secretion of PGE2. In particular, we focus on the three isoforms of the terminal PGES, and discuss the potential of targeting PGES as a more precise strategy for inhibiting PGE2 production...
  41. ncbi request reprint New treatments for gout
    Janet B Mapa
    NYU Hospital for Joint Diseases, Division of Rheumatology, 301 East 17th Street, Room 1410, New York, NY 10003, USA
    Curr Opin Investig Drugs 11:499-506. 2010
    ..While some of these strategies are currently available, others are undergoing regulatory evaluation or are at earlier stages of development...
  42. ncbi request reprint SOMOSAT: Utility of a web-based self-assessment tool in undergraduate medical education
    David E Leaf
    New York University School of Medicine, New York, NY, USA
    Med Teach 31:e211-9. 2009
    ..Relatively few studies have rigorously assessed the effectiveness of computer-based self-assessment in medical education...
  43. ncbi request reprint The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis
    Adam Mor
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, the NYU Hospital for Joint Diseases, NY 10003, USA
    Clin Immunol 125:215-23. 2007
    ..In this manuscript, we review the basic biology of Ras in T lymphocytes, and the ways in which T lymphocyte Ras abnormalities may contribute to the development of a lupus phenotype...
  44. doi request reprint Drug-induced arthritic and connective tissue disorders
    Adam Mor
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10003, USA
    Semin Arthritis Rheum 38:249-64. 2008
    ..We assess the strength of the reported associations, discuss diagnostic features and treatment implications, and consider possible mechanisms for drug-induced genesis of rheumatic conditions...
  45. doi request reprint The anti-inflammatory effects of prostaglandins
    Jose U Scher
    Division of Rheumatology, Department of Medicine, NYU School of Medicine NYU Hospital for Joint Diseases and Department of Medicine, VA NY Harbor Healthcare System, NY Campus, New York, NY, USA
    J Investig Med 57:703-8. 2009
    ..In this review, we summarize the current understanding of PGs as dichotomous molecules in the inflammatory process...
  46. doi request reprint RS3PE presenting in a unilateral pattern: case report and review of the literature
    Robert T Keenan
    Division of Rheumatology, New York University School of Medicine, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Semin Arthritis Rheum 38:428-33. 2009
    ..To review the clinical features and pathophysiologic implications of remitting seronegative symmetrical synovitis with pitting edema (RS(3)PE) presenting in a unilateral manner...
  47. doi request reprint Saturnine gout, redux: a review
    Sam R Dalvi
    Department of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, New York Department of Medicine, Section of Rheumatology, New York Harbor Health Care System of the Department of Veterans Affairs, New York Campus, New York Division of Rheumatology and Immunology, Duke University Health System, Durham, NC Electronic address
    Am J Med 126:450.e1-8. 2013
    ..After describing the role of lead in renal insufficiency and purine metabolism, we conclude with a discussion of specific strategies to manage this clinically important form of secondary gout...
  48. ncbi request reprint Narrative review: the pathophysiology of fibromyalgia
    Aryeh M Abeles
    New York University School of Medicine, New York University Hospital for Joint Diseases, and New York Harbor Healthcare System, New York, New York 10003, USA
    Ann Intern Med 146:726-34. 2007
    ..This review provides an overview of the mechanisms currently thought to be partly responsible for the chronic diffuse pain typical of fibromyalgia...
  49. pmc Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 148:1144-55. 2006
    ..6. These results demonstrate that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis, and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis...
  50. ncbi request reprint Fulminating hydralazine-induced lupus pneumonitis
    Belinda Birnbaum
    Hospital for Joint Diseases, New York University School of Medicine, New York, USA
    Arthritis Rheum 55:501-6. 2006