Fabio Piano

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint A genome-wide map of conserved microRNA targets in C. elegans
    Sabbi Lall
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Curr Biol 16:460-71. 2006
  2. pmc Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression
    Marlon Stoeckius
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Methods 6:745-51. 2009
  3. pmc Diverse roles of actin in C. elegans early embryogenesis
    Nathalie Velarde
    New York University, Department of Biology and Center for Comparative Functional Genomics, 100 Washington Square East, New York, NY 10003, USA
    BMC Dev Biol 7:142. 2007
  4. ncbi request reprint Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans
    Fabio Piano
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Biol 12:1959-64. 2002
  5. pmc RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Building, 100 Washington Square E, New York, NY 10003, USA
    Nucleic Acids Res 32:D406-10. 2004
  6. ncbi request reprint Toward automatic phenotyping of developing embryos from videos
    Feng Ning
    Courant Institute of Mathematical Sciences, New York University, New York, NY 10003, USA
    IEEE Trans Image Process 14:1360-71. 2005
  7. pmc A Caenorhabditis elegans genetic-interaction map wiggles into view
    Kristin C Gunsalus
    Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA
    J Biol 7:8. 2008
  8. pmc Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism
    Marlon Stoeckius
    Systems Biology of Gene Regulatory Elements, Max Delbrück Center Berlin, Berlin, Germany
    EMBO J 33:1751-66. 2014
  9. pmc Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans
    Aaron Schetter
    Department of Molecular Biology and Genetics, Cornell University, 435 Biotechnology Building, Ithaca, NY 14853, USA
    Dev Biol 289:360-71. 2006
  10. ncbi request reprint EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans
    Rika Maruyama
    Waksman Institute, Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Biol 17:1555-60. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint A genome-wide map of conserved microRNA targets in C. elegans
    Sabbi Lall
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Curr Biol 16:460-71. 2006
    ..Metazoan miRNAs regulate protein-coding genes by binding the 3' UTR of cognate mRNAs. Identifying targets for the 115 known C. elegans miRNAs is essential for understanding their function...
  2. pmc Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression
    Marlon Stoeckius
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Methods 6:745-51. 2009
    ..We discovered complex and orchestrated changes in the expression between and within almost all classes of small RNAs, including microRNAs and 26G-RNAs, during embryogenesis...
  3. pmc Diverse roles of actin in C. elegans early embryogenesis
    Nathalie Velarde
    New York University, Department of Biology and Center for Comparative Functional Genomics, 100 Washington Square East, New York, NY 10003, USA
    BMC Dev Biol 7:142. 2007
    ..The actin cytoskeleton plays critical roles in early development in Caenorhabditis elegans. To further understand the complex roles of actin in early embryogenesis we use RNAi and in vivo imaging of filamentous actin (F-actin) dynamics...
  4. ncbi request reprint Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans
    Fabio Piano
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Biol 12:1959-64. 2002
    ..We find that phenoclusters correlate well with sequence-based functional predictions and thus may be useful in predicting functions of uncharacterized genes...
  5. pmc RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Building, 100 Washington Square E, New York, NY 10003, USA
    Nucleic Acids Res 32:D406-10. 2004
    ..RNAiDB could serve as a model database for distributing and navigating in vivo functional information from large-scale systematic phenotypic analyses in different organisms...
  6. ncbi request reprint Toward automatic phenotyping of developing embryos from videos
    Feng Ning
    Courant Institute of Mathematical Sciences, New York University, New York, NY 10003, USA
    IEEE Trans Image Process 14:1360-71. 2005
    ....
  7. pmc A Caenorhabditis elegans genetic-interaction map wiggles into view
    Kristin C Gunsalus
    Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA
    J Biol 7:8. 2008
    ..A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation...
  8. pmc Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism
    Marlon Stoeckius
    Systems Biology of Gene Regulatory Elements, Max Delbrück Center Berlin, Berlin, Germany
    EMBO J 33:1751-66. 2014
    ..Our data suggest a mechanism in which the polyC motif and binding partners direct degradation of maternal mRNAs. Our data also indicate that endogenous siRNAs but not miRNAs promote mRNA clearance during the OET. ..
  9. pmc Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans
    Aaron Schetter
    Department of Molecular Biology and Genetics, Cornell University, 435 Biotechnology Building, Ithaca, NY 14853, USA
    Dev Biol 289:360-71. 2006
    ..These findings raise the possibility that these nucleoporins may have direct roles in orienting the mitotic spindle and the maintenance of cell polarity...
  10. ncbi request reprint EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans
    Rika Maruyama
    Waksman Institute, Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Biol 17:1555-60. 2007
    ..Therefore, EGG-3 plays a central role in egg activation by influencing polarized F-actin dynamics and the localization or activity of molecules that are directly involved in executing the egg-to-embryo transition...
  11. ncbi request reprint Two phases of astral microtubule activity during cytokinesis in C. elegans embryos
    Fumio Motegi
    Laboratory for Developmental Genomics, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Kobe, 650 0047, Japan
    Dev Cell 10:509-20. 2006
    ..We propose that temporal and spatial regulation of two distinct phases of astral microtubule behavior is crucial in specifying the position and timing of furrowing...
  12. pmc UTRome.org: a platform for 3'UTR biology in C. elegans
    Marco Mangone
    Department of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Nucleic Acids Res 36:D57-62. 2008
    ..The UTRome database thus represents a powerful tool to better understand the biology of 3'UTRs...
  13. pmc Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis
    Sabbi Lall
    Department of Biology, City University of New York Graduate Center, College of Staten Island, Staten Island CUNY, New York, NY 10314, USA
    Mol Biol Cell 16:5880-90. 2005
    ..Together our data provides further evidence that pathways of general mRNA metabolism can be remarkably organized during development, with two different decapping enzymes localized in distinct cytoplasmic domains...
  14. ncbi request reprint mRNA capping enzyme requirement for Caenorhabditis elegans viability
    Priya Srinivasan
    Center for Advanced Biotechnology and Medicine and Graduate Program in Biochemistry, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    J Biol Chem 278:14168-73. 2003
    ..By RNA interference analysis we show that cel-1 is required for embryogenesis. cel-1(RNAi) embryos formed cytoplasmic granules characteristic of a phenocluster of RNA processing genes and died early in development...
  15. pmc A map of the interactome network of the metazoan C. elegans
    Siming Li
    Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 303:540-3. 2004
    ..Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses...
  16. ncbi request reprint RNAi as a tool to study cell biology: building the genome-phenome bridge
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Center, 100 Washington Sq E, New York, New York 10003, USA
    Curr Opin Cell Biol 17:3-8. 2005
    ..The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome...
  17. pmc New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones
    Anita G Fernandez
    Department of Biology, New York University, New York, New York 10003, USA
    Genome Res 15:250-9. 2005
    ..Furthermore, we discovered a striking direct relationship between phylogenetic distribution and the penetrance level of embryonic lethality elicited by RNAi...
  18. ncbi request reprint Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Nature 436:861-5. 2005
    ..We assessed the overall predictive value of such molecular machine models by dynamic localization of ten previously uncharacterized proteins within the living embryo...
  19. ncbi request reprint Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline
    Albertha J M Walhout
    Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 12:1952-8. 2002
    ..Similar integration of interactome, phenome, and transcriptome data should be possible for other biological processes in the nematode and for other organisms, including humans...
  20. ncbi request reprint Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
    Jaeki Min
    Department of Chemistry, New York University, New York, New York 10003, USA
    Nat Chem Biol 3:55-9. 2007
    ..These results suggest that GAPDH is both an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment...
  21. ncbi request reprint MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance
    Anita G Fernandez
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Curr Biol 16:1757-63. 2006
    ..Thus, MEL-28 is downstream of the Ran cycle and is required for both proper nuclear-envelope function and chromatin maintenance...
  22. pmc Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss
    Karin Kiontke
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 101:9003-8. 2004
    ....
  23. ncbi request reprint A peptidomimetic siRNA transfection reagent for highly effective gene silencing
    Yeliz Utku
    Department of Chemistry, New York University, New York, NY 10003, USA
    Mol Biosyst 2:312-7. 2006
    ..We compare the lipitoid reagent to a standard commercial transfection reagent. The lipitoid is highly efficient even in primary IMR-90 human lung fibroblasts in which other commercial reagents are typically ineffective...
  24. pmc A protein domain-based interactome network for C. elegans early embryogenesis
    Mike Boxem
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:534-45. 2008
    ..This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms...

Research Grants13

  1. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2009
    ..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
  2. A systematic RNAi-based map of C. elegans embryogenesis
    FABIO contact PIANO; Fiscal Year: 2010
    ..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
  3. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2004
    ..Since many of these basic functions are carried out by highly conserved proteins, the data gathered in this project will be immediately useful to guide the functional annotation of the human and other genomes. ..
  4. A systematic RNAi-based map of C. elegans embryogenesis
    Kristin C Gunsalus; Fiscal Year: 2011
    ..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
  5. A systematic RNAi-based map of C. elegans embryogenesis
    FABIO contact PIANO; Fiscal Year: 2010
    ..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
  6. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2009
    ..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
  7. Encyclopedia of C elegans 3'UTRS and their regulatory elements
    Fabio Piano; Fiscal Year: 2008
    ..elegans by identifying all the 3'UTRs (sequence elements that regulate gene expression) as well as dissect the 3'UTRs and identify sub-elements that are responsible for the 3'UTR's functions. ..
  8. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2008
    ..Since many of these basic functions are carried out by highly conserved proteins, the data gathered in this project will be immediately useful to guide the functional annotation of the human and other genomes. [unreadable] [unreadable]..
  9. Encyclopedia of C elegans 3'UTRS and their regulatory elements
    Fabio Piano; Fiscal Year: 2007
    ..elegans by identifying all the 3'UTRs (sequence elements that regulate gene expression) as well as dissect the 3'UTRs and identify sub-elements that are responsible for the 3'UTR's functions. ..
  10. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2007
    ..Since many of these basic functions are carried out by highly conserved proteins, the data gathered in this project will be immediately useful to guide the functional annotation of the human and other genomes. [unreadable] [unreadable]..
  11. Function and evolution of microRNAs
    Fabio Piano; Fiscal Year: 2006
    ..This project is an intensive collaboration between a bioinformatics lab (focused on gene regulatory processes), and an experimental lab (RNAi functional genomics in nematodes) [unreadable] [unreadable]..
  12. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2006
    ..Since many of these basic functions are carried out by highly conserved proteins, the data gathered in this project will be immediately useful to guide the functional annotation of the human and other genomes. [unreadable] [unreadable]..
  13. A systematic RNAi-based map of C. elegans embryogenesis
    Fabio Piano; Fiscal Year: 2005
    ..Since many of these basic functions are carried out by highly conserved proteins, the data gathered in this project will be immediately useful to guide the functional annotation of the human and other genomes. ..