Research Topics
Species | Fabio PianoSummaryAffiliation: New York University Country: USA Publications
Research Grants
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Detail Information
Publications
A genome-wide map of conserved microRNA targets in C. elegansSabbi Lall
Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
Curr Biol 16:460-71. 2006....
Diverse roles of actin in C. elegans early embryogenesisNathalie Velarde
New York University, Department of Biology and Center for Comparative Functional Genomics, 100 Washington Square East, New York, NY 10003, USA
BMC Dev Biol 7:142. 2007..The actin cytoskeleton plays critical roles in early development in Caenorhabditis elegans. To further understand the complex roles of actin in early embryogenesis we use RNAi and in vivo imaging of filamentous actin (F-actin) dynamics...- Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegansFabio Piano
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
Curr Biol 12:1959-64. 2002..We find that phenoclusters correlate well with sequence-based functional predictions and thus may be useful in predicting functions of uncharacterized genes... - RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projectsKristin C Gunsalus
Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Building, 100 Washington Square E, New York, NY 10003, USA
Nucleic Acids Res 32:D406-10. 2004..RNAiDB could serve as a model database for distributing and navigating in vivo functional information from large-scale systematic phenotypic analyses in different organisms... - Toward automatic phenotyping of developing embryos from videosFeng Ning
Courant Institute of Mathematical Sciences, New York University, New York, NY 10003, USA
IEEE Trans Image Process 14:1360-71. 2005.... - A Caenorhabditis elegans genetic-interaction map wiggles into viewKristin C Gunsalus
Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA
J Biol 7:8. 2008..A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation... - Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegansAaron Schetter
Department of Molecular Biology and Genetics, Cornell University, 435 Biotechnology Building, Ithaca, NY 14853, USA
Dev Biol 289:360-71. 2006..These findings raise the possibility that these nucleoporins may have direct roles in orienting the mitotic spindle and the maintenance of cell polarity... - Two phases of astral microtubule activity during cytokinesis in C. elegans embryosFumio Motegi
Laboratory for Developmental Genomics, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Kobe, 650 0047, Japan
Dev Cell 10:509-20. 2006..We propose that temporal and spatial regulation of two distinct phases of astral microtubule behavior is crucial in specifying the position and timing of furrowing... - EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegansRika Maruyama
Waksman Institute, Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
Curr Biol 17:1555-60. 2007..Therefore, EGG-3 plays a central role in egg activation by influencing polarized F-actin dynamics and the localization or activity of molecules that are directly involved in executing the egg-to-embryo transition... - UTRome.org: a platform for 3'UTR biology in C. elegansMarco Mangone
Department of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Nucleic Acids Res 36:D57-62. 2008..The UTRome database thus represents a powerful tool to better understand the biology of 3'UTRs... - Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germlineAlbertha J M Walhout
Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Curr Biol 12:1952-8. 2002..Similar integration of interactome, phenome, and transcriptome data should be possible for other biological processes in the nematode and for other organisms, including humans... - Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesisSabbi Lall
Department of Biology, City University of New York Graduate Center, College of Staten Island, Staten Island CUNY, New York, NY 10314, USA
Mol Biol Cell 16:5880-90. 2005..Together our data provides further evidence that pathways of general mRNA metabolism can be remarkably organized during development, with two different decapping enzymes localized in distinct cytoplasmic domains... - Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesisKristin C Gunsalus
Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
Nature 436:861-5. 2005..We assessed the overall predictive value of such molecular machine models by dynamic localization of ten previously uncharacterized proteins within the living embryo... - New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clonesAnita G Fernandez
Department of Biology, New York University, New York, New York 10003, USA
Genome Res 15:250-9. 2005..Furthermore, we discovered a striking direct relationship between phylogenetic distribution and the penetrance level of embryonic lethality elicited by RNAi... - mRNA capping enzyme requirement for Caenorhabditis elegans viabilityPriya Srinivasan
Center for Advanced Biotechnology and Medicine and Graduate Program in Biochemistry, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
J Biol Chem 278:14168-73. 2003..By RNA interference analysis we show that cel-1 is required for embryogenesis. cel-1(RNAi) embryos formed cytoplasmic granules characteristic of a phenocluster of RNA processing genes and died early in development... - A map of the interactome network of the metazoan C. elegansSiming Li
Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Science 303:540-3. 2004..Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses... - RNAi as a tool to study cell biology: building the genome-phenome bridgeKristin C Gunsalus
Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Center, 100 Washington Sq E, New York, New York 10003, USA
Curr Opin Cell Biol 17:3-8. 2005..The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome... - Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron lossKarin Kiontke
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Proc Natl Acad Sci U S A 101:9003-8. 2004.... - Forward chemical genetic approach identifies new role for GAPDH in insulin signalingJaeki Min
Department of Chemistry, New York University, New York, New York 10003, USA
Nat Chem Biol 3:55-9. 2007..These results suggest that GAPDH is both an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment... - MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenanceAnita G Fernandez
Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
Curr Biol 16:1757-63. 2006..Thus, MEL-28 is downstream of the Ran cycle and is required for both proper nuclear-envelope function and chromatin maintenance... - A peptidomimetic siRNA transfection reagent for highly effective gene silencingYeliz Utku
Department of Chemistry, New York University, New York, NY 10003, USA
Mol Biosyst 2:312-7. 2006..We compare the lipitoid reagent to a standard commercial transfection reagent. The lipitoid is highly efficient even in primary IMR-90 human lung fibroblasts in which other commercial reagents are typically ineffective... - A protein domain-based interactome network for C. elegans early embryogenesisMike Boxem
Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 134:534-45. 2008..This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms...
Research Grants
- A systematic RNAi-based map of C. elegans embryogenesisFabio Piano; Fiscal Year: 2009..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
- A systematic RNAi-based map of C. elegans embryogenesisKristin C Gunsalus; Fiscal Year: 2011..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
- A systematic RNAi-based map of C. elegans embryogenesisFABIO contact PIANO; Fiscal Year: 2010..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
- A systematic RNAi-based map of C. elegans embryogenesisFabio Piano; Fiscal Year: 2009..elegans. The resulting map will help us understand complex genetic networks underlying development and disease in humans. ..
- Encyclopedia of C elegans 3'UTRS and their regulatory elementsFabio Piano; Fiscal Year: 2007..elegans by identifying all the 3'UTRs (sequence elements that regulate gene expression) as well as dissect the 3'UTRs and identify sub-elements that are responsible for the 3'UTR's functions. ..
- A systematic RNAi-based map of C. elegans embryogenesisFabio Piano; Fiscal Year: 2007..Since many of these basic functions are carried out by highly conserved proteins, the data gathered in this project will be immediately useful to guide the functional annotation of the human and other genomes. ..
- Function and evolution of microRNAsFabio Piano; Fiscal Year: 2006..This project is an intensive collaboration between a bioinformatics lab (focused on gene regulatory processes), and an experimental lab (RNAi functional genomics in nematodes) ..