Andrew Pachner

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Defining the spectrum of Lyme disease: a difficult proposition
    Andrew R Pachner
    J Neuroophthalmol 25:67-8. 2005
  2. ncbi request reprint Multiplex analysis of expression of three IFNbeta-induced genes in antibody-positive MS patients
    Andrew R Pachner
    University of Medicine and Dentistry of New Jersey, Medical School, Newark, NJ 07103, USA
    Neurology 66:444-6. 2006
  3. ncbi request reprint Measurement of binding anti-IFNbeta antibodies in IFNbeta-treated MS patients: lessons for the clinician and basic scientist
    Andrew R Pachner
    J Neuroimmunol 194:5-6. 2008
  4. pmc Lyme borreliosis in rhesus macaques: effects of corticosteroids on spirochetal load and isotype switching of anti-borrelia burgdorferi antibody
    A R Pachner
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 S Orange St, Newark, NJ 07103, USA
    Clin Diagn Lab Immunol 8:225-32. 2001
  5. doi request reprint Experimental models of multiple sclerosis
    Andrew R Pachner
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Opin Neurol 24:291-9. 2011
  6. ncbi request reprint The importance of measuring IFNbeta bioactivity: monitoring in MS patients and the effect of anti-IFNbeta antibodies
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103, USA
    J Neuroimmunol 166:180-8. 2005
  7. ncbi request reprint Intrathecal antibody production in an animal model of multiple sclerosis
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, NJ, USA
    J Neuroimmunol 185:57-63. 2007
  8. ncbi request reprint Lyme neuroborreliosis: infection, immunity, and inflammation
    Andrew R Pachner
    Department of Neurosciences, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Lancet Neurol 6:544-52. 2007
  9. ncbi request reprint Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody
    Andrew R Pachner
    UMDNJ New Jersey Medical School, 185 S Orange Avenue, Newark, NJ 07103, USA
    J Neuroimmunol 190:112-20. 2007
  10. doi request reprint Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study
    Andrew R Pachner
    UMDNJ New Jersey Medical School, 185 South Orange Ave, MSBH506, Newark, NJ 07103, USA
    Neurology 73:1485-92. 2009

Detail Information

Publications31

  1. ncbi request reprint Defining the spectrum of Lyme disease: a difficult proposition
    Andrew R Pachner
    J Neuroophthalmol 25:67-8. 2005
  2. ncbi request reprint Multiplex analysis of expression of three IFNbeta-induced genes in antibody-positive MS patients
    Andrew R Pachner
    University of Medicine and Dentistry of New Jersey, Medical School, Newark, NJ 07103, USA
    Neurology 66:444-6. 2006
    ..The three genes responded in tandem. Correlation of NAb level with bioactivity at low/moderate NAb levels was poor, indicating that for such patients, direct measurement of IFNbeta bioactivity is most reliable...
  3. ncbi request reprint Measurement of binding anti-IFNbeta antibodies in IFNbeta-treated MS patients: lessons for the clinician and basic scientist
    Andrew R Pachner
    J Neuroimmunol 194:5-6. 2008
  4. pmc Lyme borreliosis in rhesus macaques: effects of corticosteroids on spirochetal load and isotype switching of anti-borrelia burgdorferi antibody
    A R Pachner
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 S Orange St, Newark, NJ 07103, USA
    Clin Diagn Lab Immunol 8:225-32. 2001
    ..burgdorferi IgG antibody is much more effective than IgM antibody in decreasing the spirochetal load in infected animals...
  5. doi request reprint Experimental models of multiple sclerosis
    Andrew R Pachner
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Opin Neurol 24:291-9. 2011
    ..The hallmarks of the disease are demyelination, inflammation, axonal injury, and progressive disability. This review explores the experimental models of multiple sclerosis...
  6. ncbi request reprint The importance of measuring IFNbeta bioactivity: monitoring in MS patients and the effect of anti-IFNbeta antibodies
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103, USA
    J Neuroimmunol 166:180-8. 2005
    ..These data reveal that the GEM assay is a useful adjunct in the management of MS patients treated with IFNbeta, and that lost bioactivity returns when anti-IFNbeta antibody levels diminish...
  7. ncbi request reprint Intrathecal antibody production in an animal model of multiple sclerosis
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, NJ, USA
    J Neuroimmunol 185:57-63. 2007
    ..This study provides the first extensive analysis of ITAbP in TMEV infection, and demonstrates that, in this animal model of MS, antibody production within the CNS is likely driven by the presence of the causative pathogen...
  8. ncbi request reprint Lyme neuroborreliosis: infection, immunity, and inflammation
    Andrew R Pachner
    Department of Neurosciences, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Lancet Neurol 6:544-52. 2007
    ..An appreciation of the genetic heterogeneity of the causative pathogen has helped clinicians in their understanding of the diverse presentations of LNB...
  9. ncbi request reprint Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody
    Andrew R Pachner
    UMDNJ New Jersey Medical School, 185 S Orange Avenue, Newark, NJ 07103, USA
    J Neuroimmunol 190:112-20. 2007
    ..Our data raise the possibility that ITAbP contributes significantly to disability, both in this model and in MS...
  10. doi request reprint Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study
    Andrew R Pachner
    UMDNJ New Jersey Medical School, 185 South Orange Ave, MSBH506, Newark, NJ 07103, USA
    Neurology 73:1485-92. 2009
    ..Considerable evidence has accumulated that NAbs diminish or abolish IFNbeta bioactivity, but there is less evidence that NAbs impact clinical efficacy of the drug...
  11. doi request reprint Effect of neutralizing antibodies on biomarker responses to interferon beta: the INSIGHT study
    Andrew R Pachner
    UMDNJ New Jersey Medical School, 185 South Orange Ave, MSBH506, Newark, NJ 07103, USA
    Neurology 73:1493-500. 2009
    ....
  12. doi request reprint Plasma cells in the central nervous system in the Theiler's virus model of multiple sclerosis
    Andrew R Pachner
    UMDNJ New Jersey Medical School, Department of Neurology and Neuroscience, and Cell Biology and Molecular Medicine, Newark, NJ, United States
    J Neuroimmunol 232:35-40. 2011
    ..However, relatively little is known about the plasma cells (PCs) responsible for producing Ig within the CNS...
  13. ncbi request reprint Genotype determines phenotype in experimental Lyme borreliosis
    Andrew R Pachner
    University of Medicine and Dentristry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Ann Neurol 56:361-70. 2004
    ..The results explain to a large extent the disparities between LNB in humans in the United States and Europe...
  14. ncbi request reprint Anti-interferon antibodies: surprises and lessons
    Andrew Pachner
    Department of Neurology and Neurosciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Lancet Neurol 3:515. 2004
  15. ncbi request reprint The measurement of antibodies binding to IFNbeta in MS patients treated with IFNbeta
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Neurology 61:S18-20. 2003
  16. ncbi request reprint Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis
    A R Pachner
    Department of Neurosciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Ann Neurol 50:330-8. 2001
    ....
  17. pmc Humoral immune response associated with lyme borreliosis in nonhuman primates: analysis by immunoblotting and enzyme-linked immunosorbent assay with sonicates or recombinant proteins
    A R Pachner
    Department of Neurosciences, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Clin Diagn Lab Immunol 9:1348-55. 2002
    ..This study supports the hypothesis that recombinant proteins may provide a useful adjunct to current diagnostic testing for Lyme borreliosis...
  18. ncbi request reprint MxA gene expression analysis as an interferon-beta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity
    Andrew Pachner
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 08540, USA
    Mol Diagn 7:17-25. 2003
    ....
  19. ncbi request reprint An improved ELISA for screening for neutralizing anti-IFN-beta antibodies in MS patients
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Neurology 61:1444-6. 2003
    ..The cELISA outperformed the standard ELISA, and may be a suitable screening assay for anti-IFNbeta antibodies in IFNbeta-treated patients with MS...
  20. ncbi request reprint Spinal cord involvement in the nonhuman primate model of Lyme disease
    Yunhong Bai
    Department of Neurology and Neuroscience, and Center for the Study of Emerging Pathogens, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Lab Invest 84:160-72. 2004
    ..C1q mRNA expression was significantly increased in inflamed spinal cord. This is the first comprehensive study of spinal cord involvement in Lyme borreliosis...
  21. ncbi request reprint Intrathecal antibody production in a mouse model of Lyme neuroborreliosis
    Libin Li
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103, USA
    J Neuroimmunol 173:56-68. 2006
    ..Spirochetal infection and ITAb production were identified by complementary methods. This study demonstrates that the mouse model of LNB can be utilized to test hypotheses related to the mechanisms of ITAb production...
  22. ncbi request reprint Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: detection of antibody-mediated decreased bioactivity (ADB)
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Neurology 61:S24-6. 2003
    ..In patients with MS who are treated with IFNbeta, loss of the MxA response is caused by high levels of anti-IFNbeta antibodies and is a sensitive marker of lost bioactivity...
  23. ncbi request reprint Increased expression of B-lymphocyte chemoattractant, but not pro-inflammatory cytokines, in muscle tissue in rhesus chronic Lyme borreliosis
    Andrew R Pachner
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Cytokine 19:297-307. 2002
    ..This study is the first to extensively characterize cytokine gene expression in chronically inflamed tissue in Lyme borreliosis...
  24. pmc Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 71:7087-98. 2003
    ..We conclude that myositis can be a prominent feature of Lyme borreliosis depending on the infecting organism and host immune status...
  25. ncbi request reprint Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Lab Invest 84:1439-50. 2004
    ..We conclude that carditis in NHPs infected with B. burgdorferi is frequent and can persist for years but is mild unless they are immunosupressed...
  26. ncbi request reprint The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosis
    Kavitha Narayan
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Ann Neurol 57:813-23. 2005
    ..We conclude that persistent production of CXCL13 and IgG within infected tissue, two characteristics of ectopic germinal centers, are definitive features of LNB...
  27. doi request reprint The multiple sclerosis severity score (MSSS) predicts disease severity over time
    Andrew R Pachner
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, Newark, NJ, USA
    J Neurol Sci 278:66-70. 2009
    ..We have used this tool to address two questions: Can it be used to predict the accrual of disability over time in individual patients? Do the currently available therapies have an impact upon disease severity over time?..
  28. ncbi request reprint Re: Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    Andrew R Pachner
    Neurology 69:1555; author reply 1565. 2007
  29. pmc Borrelia burgdorferi transcriptome in the central nervous system of non-human primates
    Sukanya Narasimhan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:15953-8. 2003
    ..burgdorferi gene expression in vivo. The results provide a global snapshot of the spirochetal transcriptome in the CNS and should spur the design of experiments aimed at understanding the molecular basis of neuroborreliosis...
  30. ncbi request reprint Expression of Borrelia burgdorferi erp genes during infection of non-human primates
    Jennifer C Miller
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Microb Pathog 39:27-33. 2005
    ..These data strongly suggest that Erp proteins are expressed by B. burgdorferi throughout infection of their vertebrate hosts...
  31. ncbi request reprint Neutralizing antibodies to biological therapies: A "touch of gray" vs a "black and white" story
    Mark S Freedman
    Neurology 69:1386-7. 2007