Paaby A, Bergland A, Behrman E, Schmidt P. A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation. Evolution. 2014;68:3395-409 pubmed publisher
..These results implicate insulin signaling as a major mediator of life-history adaptation in Drosophila, and suggest that life-history trade-offs can be explained by extensive pleiotropy at a single locus. ..
Paaby A, Blacket M, Hoffmann A, Schmidt P. Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents. Mol Ecol. 2010;19:760-74 pubmed publisher
..This polymorphism provides new characterization of genic regions of functionality within InR, and is likely a component in a suite of genes and traits that respond adaptively to climatic variation. ..