S Oyadomari

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi Roles of CHOP/GADD153 in endoplasmic reticulum stress
    S Oyadomari
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Cell Death Differ 11:381-9. 2004
  2. ncbi Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells
    K Kawahara
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Ohe-Honmachi, 862-0973, Kumamoto, Japan
    Brain Res Mol Brain Res 90:165-73. 2001
  3. ncbi Induction of CHOP and apoptosis by nitric oxide in p53-deficient microglial cells
    K Kawahara
    Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo, Japan
    FEBS Lett 506:135-9. 2001
  4. ncbi Coinduction of endothelial nitric oxide synthase and arginine recycling enzymes in aorta of diabetic rats
    S Oyadomari
    Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Nitric Oxide 5:252-60. 2001
  5. ncbi CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes
    T Kimura
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 494:105-11. 2001
  6. ncbi Nitric oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic guanosine monophosphate
    K Kawahara
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Ohe-Honmachi, Kumamoto 862-0973, Japan
    Neurosci Lett 310:89-92. 2001
  7. ncbi Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
    S Tajiri
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cell Death Differ 11:403-15. 2004
  8. ncbi hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria
    T Gotoh
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Cell Death Differ 11:390-402. 2004
  9. pmc Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
    S Oyadomari
    Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 98:10845-50. 2001

Detail Information

Publications9

  1. ncbi Roles of CHOP/GADD153 in endoplasmic reticulum stress
    S Oyadomari
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Cell Death Differ 11:381-9. 2004
    ..Here, we summarize the current understanding of the roles of CHOP/GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease...
  2. ncbi Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells
    K Kawahara
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Ohe-Honmachi, 862-0973, Kumamoto, Japan
    Brain Res Mol Brain Res 90:165-73. 2001
    ..These results strongly suggest that both arginine transport by CAT-2 and citrulline-arginine recycling are important for high-output production of NO in activated microglial cells...
  3. ncbi Induction of CHOP and apoptosis by nitric oxide in p53-deficient microglial cells
    K Kawahara
    Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo, Japan
    FEBS Lett 506:135-9. 2001
    ..These results suggest that NO-induced apoptosis in MG5 cells occurs through the ER stress pathway involving CHOP, but is independent of p53...
  4. ncbi Coinduction of endothelial nitric oxide synthase and arginine recycling enzymes in aorta of diabetic rats
    S Oyadomari
    Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Nitric Oxide 5:252-60. 2001
    ..The results also suggest that TGF-beta1 works antiatherogenically at early stages of diabetes by increasing NO production, whereas prolonged elevation of TGF-beta1 functions atherogenically by inhibiting endothelial cell growth...
  5. ncbi CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes
    T Kimura
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 494:105-11. 2001
    ..Therefore, C/EBPbeta is required for hormonal induction of the genes for ornithine cycle enzymes in primary-cultured hepatocytes, while the deficiency of C/EBPbeta is compensated for in vivo...
  6. ncbi Nitric oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic guanosine monophosphate
    K Kawahara
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Ohe-Honmachi, Kumamoto 862-0973, Japan
    Neurosci Lett 310:89-92. 2001
    ..8-Bromo-cGMP neither induced p21 mRNA nor inhibited [(3)H]thymidine incorporation. These results suggest that NO inhibits the proliferation of MG5 cells by induction of p21, which occurs independent of p53 and cGMP...
  7. ncbi Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
    S Tajiri
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cell Death Differ 11:403-15. 2004
    ..These results indicate that ischemia-induced neuronal cell death is mediated by the ER stress pathway involving CHOP induction...
  8. ncbi hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria
    T Gotoh
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Cell Death Differ 11:390-402. 2004
    ....
  9. pmc Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
    S Oyadomari
    Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 98:10845-50. 2001
    ..We conclude that NO depletes ER Ca(2+), causes ER stress, and leads to apoptosis. Thus, ER Ca(2+) stores are a new target of NO, and the ER stress pathway is a major mechanism of NO-mediated beta cell apoptosis...