R P Novick

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Molecular genetics of SaPI1--a mobile pathogenicity island in Staphylococcus aureus
    A Ruzin
    Skirball Institute, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Mol Microbiol 41:365-77. 2001
  2. ncbi request reprint Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria
    R P Novick
    Skirball Institute of Biomolecular Medicine New York University School of Medicine 540 First Ave 2nd floor New York NY 10016 USA
    Curr Opin Microbiol 2:40-5. 1999
  3. ncbi request reprint The SaPIs: mobile pathogenicity islands of Staphylococcus
    Richard P Novick
    Skirball Institute, Program in Molecular Pathogenesis, Department of Microbiology, New York University Medical Center, New York, NY 10016, USA
    Chem Immunol Allergy 93:42-57. 2007
  4. ncbi request reprint The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing
    Richard P Novick
    Molecular Pathogenesis Program, Skirball Institute and Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Microbiology 149:2709-17. 2003
  5. ncbi request reprint Autoinduction and signal transduction in the regulation of staphylococcal virulence
    Richard P Novick
    Program in Molecular Pathogenesis, Skirball Institute, Department of Microbiology, New York University School of Medicine, 10016, USA
    Mol Microbiol 48:1429-49. 2003
  6. ncbi request reprint Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus
    Richard P Novick
    Departments of Microbiology and Medicine, Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Plasmid 49:93-105. 2003
  7. doi request reprint Medicine. Combating impervious bugs
    Richard P Novick
    Kimmel Center for Biology and Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 319:910-1. 2008
  8. doi request reprint Quorum sensing in staphylococci
    Richard P Novick
    Kimmel Center for Biology and Medicine, New York University Medical Center, New York, New York 10016, USA
    Annu Rev Genet 42:541-64. 2008
  9. ncbi request reprint Pathogenicity and resistance islands of staphylococci
    R P Novick
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Microbes Infect 3:585-94. 2001
  10. ncbi request reprint The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus
    R P Novick
    Public Health Research Institute of the City of New York, Inc, NY 10016, USA
    Mol Gen Genet 248:446-58. 1995

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Molecular genetics of SaPI1--a mobile pathogenicity island in Staphylococcus aureus
    A Ruzin
    Skirball Institute, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Mol Microbiol 41:365-77. 2001
    ..Among other staphylococcal phages tested, only phi13 interacts with SaPI1, inducing excision but not replication or transfer of the element...
  2. ncbi request reprint Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria
    R P Novick
    Skirball Institute of Biomolecular Medicine New York University School of Medicine 540 First Ave 2nd floor New York NY 10016 USA
    Curr Opin Microbiol 2:40-5. 1999
    ..During the past year, there have been major advances in the structure-function analysis of these peptides and the regulation of a virulence factor by an autoinducing peptide in pneumococci has been demonstrated...
  3. ncbi request reprint The SaPIs: mobile pathogenicity islands of Staphylococcus
    Richard P Novick
    Skirball Institute, Program in Molecular Pathogenesis, Department of Microbiology, New York University Medical Center, New York, NY 10016, USA
    Chem Immunol Allergy 93:42-57. 2007
    ..Following replication, the SaPI DNA is efficiently encapsidated into infectious small-headed phage-like particles, resulting in extremely high transfer frequencies...
  4. ncbi request reprint The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing
    Richard P Novick
    Molecular Pathogenesis Program, Skirball Institute and Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Microbiology 149:2709-17. 2003
    ..aureus senses and responds to its environment...
  5. ncbi request reprint Autoinduction and signal transduction in the regulation of staphylococcal virulence
    Richard P Novick
    Program in Molecular Pathogenesis, Skirball Institute, Department of Microbiology, New York University School of Medicine, 10016, USA
    Mol Microbiol 48:1429-49. 2003
    ..This review is an attempt to integrate a large body of data into the beginnings of a model that will hopefully help to guide research towards a full-scale test...
  6. ncbi request reprint Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus
    Richard P Novick
    Departments of Microbiology and Medicine, Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Plasmid 49:93-105. 2003
    ..Another is that the toxin-carrying units can spread among different (though probably related) species. An interesting question is that of the biological basis for the separation of toxin and resistance determinants...
  7. doi request reprint Medicine. Combating impervious bugs
    Richard P Novick
    Kimmel Center for Biology and Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 319:910-1. 2008
  8. doi request reprint Quorum sensing in staphylococci
    Richard P Novick
    Kimmel Center for Biology and Medicine, New York University Medical Center, New York, New York 10016, USA
    Annu Rev Genet 42:541-64. 2008
    ..We conclude with the suggestion that agr autoactivation, unlike classical enzyme induction, can occur under suboptimal conditions and can distinguish self from non-self by inducing an exclusive and coordinated population wide response...
  9. ncbi request reprint Pathogenicity and resistance islands of staphylococci
    R P Novick
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Microbes Infect 3:585-94. 2001
    ..This review covers a set of newly described variable chromosomal elements, pathogenicity and resistance islands, carrying superantigen and resistance genes, especially toxic shock and methicillin resistance, respectively...
  10. ncbi request reprint The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus
    R P Novick
    Public Health Research Institute of the City of New York, Inc, NY 10016, USA
    Mol Gen Genet 248:446-58. 1995
    ..Since transcription of P2 requires P2 operon products, the P2 operon is autocatalytic, and is thus admirably suited to the need for rapid production of exoproteins at a time when overall growth is coming to a halt...
  11. ncbi request reprint The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus
    J A Lindsay
    Skirball Institute of Biomolecular Medicine, New York University Medical Centre, New York 10016, USA
    Mol Microbiol 29:527-43. 1998
    ..It is designated SaPI2. These PIs are the first in any gram-positive species and the first for which mobility has been demonstrated. Their mobility may be responsible for the spread of TSST-1 production among S. aureus strains...
  12. pmc Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus
    H L Peng
    Public Health Research Institute, New York, New York 10016
    J Bacteriol 170:4365-72. 1988
    ....
  13. ncbi request reprint Bacterial interference caused by autoinducing peptide variants
    G Ji
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Science 276:2027-30. 1997
    ..Cross-inhibition of gene expression represents a type of bacterial interference that could be correlated with the ability of one strain to exclude others from infection or colonization sites, or both...
  14. ncbi request reprint Role of the double-strand origin cruciform in pT181 replication
    R Jin
    Molecular Pathogenesis Program, Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Plasmid 46:95-105. 2001
    ....
  15. pmc Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in Staphylococcus aureus
    S Herbert
    Program in Molecular Pathogenesis, Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 69:2996-3003. 2001
    ..agr and sar expression was minimally affected by subinhibitory clindamycin. These effects varied from strain to strain and do not seem to be responsible for the effects of subinhibitory clindamycin on the overall exoprotein pattern...
  16. pmc Nucleotide sequence: the beta-hemolysin gene of Staphylococcus aureus
    S J Projan
    Department of Applied Genetics, Public Health Research Institute, New York, NY 10016
    Nucleic Acids Res 17:3305. 1989
  17. pmc Nucleotide sequence of pS194, a streptomycin-resistance plasmid from Staphylococcus aureus
    S J Projan
    Department of Plasmid Biology, Public Health Research Institute, New York, NY 10016
    Nucleic Acids Res 16:2179-87. 1988
    ..The fourth, orfD, overlapping the rlx reading frame, is potentially 27 kd, and may also be involved in mobilization...
  18. doi request reprint Regulatory organization of the staphylococcal sae locus
    Rajan P Adhikari
    The Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Microbiology 154:949-59. 2008
    ....
  19. pmc beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
    Elisa Maiques
    Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera CEU, 46113 Moncada, Valencia, Spain
    J Bacteriol 188:2726-9. 2006
    ....
  20. ncbi request reprint Inhibition of rot translation by RNAIII, a key feature of agr function
    Edward Geisinger
    Department of Microbiology, Skirball Institute, NYU Medical Center, New York, NY 10016, USA
    Mol Microbiol 61:1038-48. 2006
    ..We propose that the RNAIII-rot mRNA interaction plays a key role in agr regulation of staphylococcal virulence...
  21. ncbi request reprint svrA, a multi-drug exporter, does not control agr
    John Chen
    Program in Molecular Pathogenesis, Skirball Institute, and Departments of Microbiology and Medicine, New York University Medical Center, New York 10016, USA
    Microbiology 153:1604-8. 2007
    ..These results indicate that svrA does not play a role in Staphylococcus aureus infections via an agr-mediated pathway...
  22. pmc Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer
    Elisa Maiques
    Centro de Investigación y Tecnología Animal, Instituto Valenciano de Investigaciones Agrarias, Apdo 187, 12 400 Segorbe, Castellon, Spain
    J Bacteriol 189:5608-16. 2007
    ..It is suggested that this mechanism involves the encapsidation of standard transducing fragments containing the intact island followed by int-mediated excision, circularization, and integration in the recipient...
  23. ncbi request reprint SaPI operon I is required for SaPI packaging and is controlled by LexA
    Carles Ubeda
    Centro de Investigación y Tecnología Animal, Instituto Valenciano de Investigaciones Agrarias CITA IVIA, Apdo 187, 12 400 Segorbe, Castellon, Spain
    Mol Microbiol 65:41-50. 2007
    ..Interestingly, mutations affecting the latter two genes were not defective in SaPI transfer, but rather encapsidated the island in full-sized phage heads, which would have to contain a multimeric SaPI genome...
  24. pmc A nonsense mutation in agrA accounts for the defect in agr expression and the avirulence of Staphylococcus aureus 8325-4 traP::kan
    Rajan P Adhikari
    Program in Molecular Pathogenesis, Skirball Institute, New York University Medical Center, New York, NY 10016, USA
    Infect Immun 75:4534-40. 2007
    ..J. Biol. Chem., 2004), in contrast to that in the agr-defective 8325-4 traP mutant strain, had the wild-type sequence; further, the traP mutation in that strain, when outcrossed, also had no effect on agr expression...
  25. pmc A pathogenicity island replicon in Staphylococcus aureus replicates as an unstable plasmid
    Carles Ubeda
    Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, Department of Microbiology, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:14182-8. 2007
    ..Plasmids containing the rep-ori complex plus an additional gene, pri, can replicate autonomously in Staphylococcus aureus but are very unstable, probably because of defective segregation...
  26. ncbi request reprint Sequence analysis reveals genetic exchanges and intraspecific spread of SaPI2, a pathogenicity island involved in menstrual toxic shock
    Abhignya Subedi
    Skirball Institute, Department of Microbiology, New York University Medical Center, New York, NY 10016, USA
    Microbiology 153:3235-45. 2007
    ..We show additionally, that SaPIs are widespread among the staphylococci and that most TSS strains carry two or more, including SaPI2...
  27. doi request reprint Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains
    Bo Shopsin
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    J Infect Dis 198:1171-4. 2008
    ..Additionally, carriage of an agr-defective strain was associated with hospitalization, raising the possibility that such strains may be selected in a nosocomial setting...
  28. doi request reprint agr function in clinical Staphylococcus aureus isolates
    Katrina E Traber
    Molecular Pathogenesis Program and Department of Microbiology and Medicine, Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, NY 10016, USA
    Microbiology 154:2265-74. 2008
    ..aureus infections, and that agr(+) and agr(-) variants may have a cooperative interaction in certain types of infections...
  29. ncbi request reprint SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage
    Carles Ubeda
    Centro de Investigación y Tecnología Animal, Instituto Valenciano de Investigaciones Agrarias CITA IVIA, Apdo 187, 12 400 Segorbe, Castellon, Spain
    Mol Microbiol 67:493-503. 2008
    ..We have not yet ascertained any specific function for the second putative regulatory gene, though it is highly conserved among the SaPIs...
  30. pmc Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins
    Maria Angeles Tormo
    Centro de Investigación y Tecnología Animal, Instituto Valenciano de Investigaciones Agrarias, Apdo 187, 12 400 Segorbe, Castellon, Spain
    J Bacteriol 190:2434-40. 2008
    ..Mutational analysis demonstrated that the phage proteins identified were involved only in the formation and possibly the function of SaPI or phage particles, having no role in other SaPI or phage functions...
  31. doi request reprint Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis
    Elizabeth A George
    The Laboratory of Synthetic Protein Chemistry, Rockefeller University, New York, New York 10065, USA
    J Am Chem Soc 130:4914-24. 2008
    ..Our results identify key structural elements that are necessary for AgrC inhibition and reveal key differences between non-cognate and cognate inhibitory requirements...
  32. ncbi request reprint Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretion
    Rajan P Adhikari
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine and Department of Microbiology, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Microbiology 151:3059-69. 2005
    ..Interference with the activation of these and other regulatory determinants probably accounts for much of the inhibitory effect on exoprotein production of sub-MIC concentrations of cerulenin...
  33. pmc The agr radiation: an early event in the evolution of staphylococci
    Jesse S Wright
    Molecular Pathogenesis Program and Department of Microbiology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Ave, New York, NY 10016, USA
    J Bacteriol 187:5585-94. 2005
    ....
  34. pmc High genetic variability of the agr locus in Staphylococcus species
    Philippe Dufour
    Centre Nationale des Toxémies à Staphylococques, EA1655, Faculte de Medecine Laennec, Lyon, France
    J Bacteriol 184:1180-6. 2002
    ..We discuss hypotheses on the mode of action and the molecular evolution of the agr locus based on comparisons between the newly determined sequences...
  35. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
    ..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...
  36. pmc Global repression of exotoxin synthesis by staphylococcal superantigens
    Nikola Vojtov
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 99:10102-7. 2002
    ..TSST-1 not only represses most exoprotein genes but determines its own high expression level by autorepression. We report also that a second superantigen, enterotoxin B, has similar regulatory properties...
  37. ncbi request reprint Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus
    Gholson J Lyon
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Biochemistry 41:10095-104. 2002
    ..These data suggest a model in which activation and inhibition involves different binding orientations within the ligand binding pocket of each receptor...
  38. ncbi request reprint Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?
    George Sakoulas
    Department of Medicine, Division of Laboratory and Transfusion Medicine and Harvard Medical School, Boston, Massachussetts, USA
    J Infect Dis 187:929-38. 2003
    ..This study suggests that some S. aureus strains have an intrinsic survival advantage under a glycopeptide selective pressure, which is possibly related to reduced autolysis after exposure to subinhibitory concentrations of glycopeptide...
  39. ncbi request reprint Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria
    Gholson J Lyon
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Peptides 25:1389-403. 2004
    ..In both cases, the signal activates a complex adaptation response involving many genes...
  40. ncbi request reprint Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule
    Monika Mangold
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Dr Bohrgasse 9 4, Vienna A 1030, Austria
    Mol Microbiol 53:1515-27. 2004
    ..Remarkably, the RNA effector is regulated in a growth phase-dependent fashion and we provide evidence that pel RNA expression is induced by conditioned media...
  41. pmc Novel cassette-based shuttle vector system for gram-positive bacteria
    Emmanuelle Charpentier
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, USA
    Appl Environ Microbiol 70:6076-85. 2004
    ..Questions about gene dosage, complementation, and cis-trans effects can now be conveniently addressed, so that this system constitutes an effective tool for studying gene regulation of staphylococci in various ecosystems...
  42. pmc Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing
    Jesse S Wright
    Molecular Pathogenesis Program and Department of Microbiology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:16168-73. 2004
    ..It is suggested that this recognition scheme provides the fundamental basis for agr activation and interference...
  43. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005
    ..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations...
  44. pmc Staphylococcus intermedius produces a functional agr autoinducing peptide containing a cyclic lactone
    Guangyong Ji
    Departments of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Bacteriol 187:3139-50. 2005
    ..intermedius AgrB protein to generate a cyclic lactone, that it is an autoinducer as well as a cross-inhibitor, and that all of five other S. intermedius strains examined also produce serine-containing AIPs...
  45. ncbi request reprint Antibiotic-induced SOS response promotes horizontal dissemination of pathogenicity island-encoded virulence factors in staphylococci
    Carles Ubeda
    Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera CEU, 46113 Moncada, Valencia, Spain
    Mol Microbiol 56:836-44. 2005
    ..We conclude that SOS induction by therapeutic agents can promote the spread of staphylococcal virulence genes...
  46. pmc Transient interference with staphylococcal quorum sensing blocks abscess formation
    Jesse S Wright
    Molecular Pathogenesis Program and Department of Microbiology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 102:1691-6. 2005
    ..These results may provide a biological rationale for regulation of virulence factor expression by quorum sensing rather than by response to specific host signals...
  47. pmc Effect of mild acid on gene expression in Staphylococcus aureus
    Brian Weinrick
    Program in Molecular Pathogenesis, Skirball Institute, and Department of Microbiology, New York University School of Medicine, 540 First Ave, New York, NY 10016, USA
    J Bacteriol 186:8407-23. 2004
    ..Key results are verified by gene fusion and Northern blot hybridization analyses. The results point to, but do not define, possible regulatory pathways by which the organism senses and responds to a pH stimulus...
  48. ncbi request reprint Reversible and specific extracellular antagonism of receptor-histidine kinase signaling
    Gholson J Lyon
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 277:6247-53. 2002
    ..These results suggest that molecules designed to compete with natural agonists for binding at receptor-histidine kinase sensor domains could represent a general approach to the inhibition of receptor-histidine kinase signaling...
  49. pmc Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor
    Edward Geisinger
    Molecular Pathogenesis Program and Departments of Microbiology and Medicine, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Biol Chem 283:8930-8. 2008
    ..Various types of intermediate activity were observed with other replacement mutations. Preliminary characterization of the AgrC-I-AIP-I interaction suggests that ligand specificity may be sterically determined...
  50. pmc Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and Cag A antigens
    Judith Romero-Gallo
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 9:1313-7. 2002
    ..In addition to establishing a collection of H. pylori isolates from a remote area in the world, we show that use of H. pylori whole-cell and Cag A serology together increases the sensitivity for the detection of colonization...
  51. ncbi request reprint Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus
    Linsheng Zhang
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 277:34736-42. 2002
    ..We speculate that AgrB is a novel protein with proteolytic enzyme activity and a transporter facilitating the export of the processed AgrD peptide...
  52. pmc Use of targetrons to disrupt essential and nonessential genes in Staphylococcus aureus reveals temperature sensitivity of Ll.LtrB group II intron splicing
    Jun Yao
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, The University of Texas at Austin, TX 78712, USA
    RNA 12:1271-81. 2006
    ..In nature, temperature sensitivity of group II intron splicing could limit the temperature range of an organism containing a group II intron inserted in an essential gene...
  53. ncbi request reprint Interrupters on the bacterial party line
    Richard P Novick
    Nat Chem Biol 1:321-2. 2005

Research Grants28

  1. MOLECULAR GENETICS OF EXOTOXIN REGULATION IN S AUREUS
    Richard Novick; Fiscal Year: 2005
    ..In Aim 4, a continuation of a study in which we have identified an autoinducer of streptococcal erythogenic toxin (SPEA) synthesis, is proposed. ..
  2. PEPTIDE AUTOINDUCERS OF STAPHYLOCOCCAL PATHOGENICITY
    Richard Novick; Fiscal Year: 2007
    ..Agr group-specific biotypes will be delineated to identify group-specific traits that may be correlated with pathogenic behavior - site and type of lesion, level of virulence, antibiotic resistance, etc.. ..
  3. MOLECULAR GENETICS OF EXOTOXIN REGULATION IN S AUREUS
    Richard Novick; Fiscal Year: 2007
    ....
  4. Molecular biology of TSST-1 and other superantigen toxins
    Richard Novick; Fiscal Year: 2009
    ..By understanding the biology of these gene transfer systems, it is our hope to be able to control staphylococcal gene transfer and so reduce the danger of staphylococcal disease. ..
  5. MOLECULAR GENETICS OF EXOTOXIN REGULATION IN S AUREUS
    Richard P Novick; Fiscal Year: 2010
    ....
  6. Molecular biology of TSST-1 and other superantigen toxins
    Richard P Novick; Fiscal Year: 2010
    ..By understanding the biology of these gene transfer systems, it is our hope to be able to control staphylococcal gene transfer and so reduce the danger of staphylococcal disease. ..
  7. MOLECULAR GENETICS OF EXOTOXIN REGULATION IN S AUREUS
    Richard Novick; Fiscal Year: 1999
    ..We have discovered an external activator and an external inhibitor of the response and studies are proposed to test these for possible therapeutic use in staphylococcal disease. ..
  8. PEPTIDE AUTOINDUCERS OF STAPHYLOCOCCAL PATHOGENICITY
    Richard Novick; Fiscal Year: 2002
    ..Mutants will also be tested in these models to determine the importance of the autoinduction system, and an attempt will be made to detect expression of agr genes in the animal. ..
  9. Peptide autoinducers of staphylococcal pathogenicity.
    Richard P Novick; Fiscal Year: 2011
    ....