Genomes and Genes
Affiliation: New York University School of Medicine
- Synaptic regulation of affective behaviors; role of BDNFIpe Ninan
Department of Psychiatry, NYU School of Medicine, SKI 5 3, 540 1st Ave, NY 10016, United States Electronic address
Neuropharmacology 76:684-95. 2014..This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'...
- The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampusIpe Ninan
Department of Psychiatry and Neurobiology Program, Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 30:8866-70. 2010..Thus, these results show that the BDNF Val66Met polymorphism has a direct effect on NMDA receptor transmission, which may account for changes in synaptic plasticity in the hippocampus...
- Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortexIpe Ninan
Department of Psychiatry, New York University Langone Medical Center, New York 10016, USA
J Neurochem 119:324-31. 2011..The aforementioned suppression of basal glutamatergic neurotransmission and facilitation of activity-dependent synaptic plasticity in the IL-mPFC might be critical for the effect of oxytocin on social cognition...
- Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKIIShumin Liu
Department of Pathology, Taub Institute, Columbia University, New York, NY 10032, USA
Eur J Neurosci 25:3583-96. 2007..Thus, our results suggest that NO, cGMP, GMP-dependent protein kinase and calmodulin-dependent protein kinase II play a key role in the redistribution of alpha-synuclein during plasticity...
- BDNF-mediated neurotransmission relies upon a myosin VI motor complexHiroko Yano
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Neurosci 9:1009-18. 2006..Together, these results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity...
- BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticityKevin G Bath
Department of Psychiatry, Weill Medical College of Cornell, New York, NY 10021, USA
Neuropsychopharmacology 37:1297-304. 2012..The observed effects of the BDNF Val66Met SNP on hippocampal BDNF expression and synaptic plasticity provide a possible mechanistic basis by which this common BDNF SNP may impair efficacy of SSRI drug treatment...
- The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortexSiobhan S Pattwell
Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, New York, USA
J Neurosci 32:2410-21. 2012..The effect of the Val66Met polymorphism on synaptic transmission and plasticity in the IL-mPFC represents a mechanism to account for this impact of SNP on affective disorders and cognitive dysfunction...
- Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's diseaseHong Zhang
Department of Pathology and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
Curr Alzheimer Res 2:137-40. 2005..26 -/+ 2% in WT. Thus, it is likely that presynaptic mechanisms underlying SF but not PPF and PTP, may account for synaptic dysfunction in APP/PS1 mice...
- Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neuronsBalapal S Basavarajappa
Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
J Neurochem 107:1001-13. 2008..These observations, taken together, suggest the participation of ECs as retrograde messengers in the ethanol-induced depression of synaptic activities...
- alpha-Synuclein produces a long-lasting increase in neurotransmitter releaseShumin Liu
Department of Pathology, Columbia University, New York, NY, USA
EMBO J 23:4506-16. 2004..Thus, alpha-synuclein is involved in synaptic plasticity by augmenting transmitter release from the presynaptic terminal...
- A GluR1-cGKII interaction regulates AMPA receptor traffickingYafell Serulle
Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
Neuron 56:670-88. 2007..This work identifies a pathway, downstream from the NMDA receptor (NMDAR) and nitric oxide (NO), which stimulates GluR1 accumulation in the plasma membrane and plays an important role in synaptic plasticity...
- The ARMS/Kidins220 scaffold protein modulates synaptic transmissionJuan Carlos Arevalo
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Mol Cell Neurosci 45:92-100. 2010..These results provide evidence that modulation of ARMS/Kidins220 levels can regulate basal synaptic strength in a specific manner in hippocampal neurons...
- Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacyFabrizio Trinchese
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
J Mol Neurosci 24:15-21. 2004....
- Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal developmentYukio Akaneya
Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America
PLoS ONE 5:e12486. 2010..Members of the ephrin-A family are glycosyl-phosphatidylinositol-anchored to the cell surface and activate EphA receptors, which are receptor tyrosine kinases...
- Altered fear learning across development in both mouse and humanSiobhan S Pattwell
Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 109:16318-23. 2012..These findings provide insight into optimizing treatment outcomes for when, during development, exposure therapies may be most effective...
- Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDaJhon Jairo Sutachan
Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
J Neurosci Res 88:3447-56. 2010..Our results suggest that the ARMS/Kidins220 scaffold protein plays a critical role in the regulation of inhibitory transmission in hippocampal neurons...
- Synaptic autoregulation by metalloproteases and γ-secretaseSophie Restituito
Department of Biochemistry, New York University Langone Medical Center, New York, New York 10016, USA
J Neurosci 31:12083-93. 2011..Our results suggest that activity-dependent substrate cleavage by synaptic metalloproteases and γ-secretase modifies synaptic transmission, providing a novel form of synaptic autoregulation...
- Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in miceSergey V Shmelkov
1 Howard Hughes Medical Institute, Ansary Stem Cell Institute and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA 2 These authors contributed equally to this work
Nat Med 16:598-602, 1p following 602. 2010..Thus, our studies identify Slitrk5 as an essential molecule at corticostriatal synapses and provide a new mouse model of OCD-like behaviors...
- Estimation of the mean from sums with unknown numbers of summandsIpe Ninan
Department of Psychiatry, New York University, New York, New York 10276, USA
Biometrics 62:918-20. 2006..Here, a relatively convenient nonparametric approach to estimation is presented. Data from an experiment in which cationic styrylpyridinium dye FM4-64 was used in cultured mouse hippocampal neurons are used to illustrate the approach...
- Sucrose ingestion induces rapid AMPA receptor traffickingDavid S Tukey
Department of Biochemistry and Molecular Pharmacology, New York, New York 10016, and Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 33:6123-32. 2013..Trafficking is stimulated by a chemosensory pathway that is not dependent on the caloric value of sucrose...
- Selective early-acquired fear memories undergo temporary suppression during adolescenceSiobhan S Pattwell
Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 108:1182-7. 2011..These findings reveal a unique form of brain plasticity in fear learning during early adolescence and may prove informative for understanding endogenous mechanisms to suppress unwanted fear memories...
- Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neuronsIpe Ninan
Department of Psychiatry, New York University School of Medicine, New York 10016, USA
Neuron 42:129-41. 2004..Thus, the present results conclusively prove that presynaptic CaMKII is essential for synaptic plasticity in cultured hippocampal neurons...
- Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factorChristopher N Parkhurst
Molecular Neurobiology Program, The Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
Cell 155:1596-609. 2013..Together, our findings reveal that microglia serve important physiological functions in learning and memory by promoting learning-related synapse formation through BDNF signaling. ..
- The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J miceIan J Orozco
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA Electronic address
Mol Cell Neurosci 58:76-84. 2014..These data provide compelling evidence that dysbindin, a widely suspected susceptibility protein in schizophrenia, is important for AMPAR-mediated synaptic transmission and plasticity in the developing hippocampus. ..