Ipe Ninan

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Synaptic regulation of affective behaviors; role of BDNF
    Ipe Ninan
    Department of Psychiatry, NYU School of Medicine, SKI 5 3, 540 1st Ave, NY 10016, United States Electronic address
    Neuropharmacology 76:684-95. 2014
  2. pmc The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus
    Ipe Ninan
    Department of Psychiatry and Neurobiology Program, Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:8866-70. 2010
  3. doi request reprint Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex
    Ipe Ninan
    Department of Psychiatry, New York University Langone Medical Center, New York 10016, USA
    J Neurochem 119:324-31. 2011
  4. ncbi request reprint Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII
    Shumin Liu
    Department of Pathology, Taub Institute, Columbia University, New York, NY 10032, USA
    Eur J Neurosci 25:3583-96. 2007
  5. ncbi request reprint BDNF-mediated neurotransmission relies upon a myosin VI motor complex
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 9:1009-18. 2006
  6. pmc BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell, New York, NY 10021, USA
    Neuropsychopharmacology 37:1297-304. 2012
  7. pmc The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex
    Siobhan S Pattwell
    Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, New York, USA
    J Neurosci 32:2410-21. 2012
  8. ncbi request reprint Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease
    Hong Zhang
    Department of Pathology and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Curr Alzheimer Res 2:137-40. 2005
  9. pmc Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons
    Balapal S Basavarajappa
    Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 107:1001-13. 2008
  10. pmc alpha-Synuclein produces a long-lasting increase in neurotransmitter release
    Shumin Liu
    Department of Pathology, Columbia University, New York, NY, USA
    EMBO J 23:4506-16. 2004

Collaborators

Detail Information

Publications24

  1. pmc Synaptic regulation of affective behaviors; role of BDNF
    Ipe Ninan
    Department of Psychiatry, NYU School of Medicine, SKI 5 3, 540 1st Ave, NY 10016, United States Electronic address
    Neuropharmacology 76:684-95. 2014
    ..This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'...
  2. pmc The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus
    Ipe Ninan
    Department of Psychiatry and Neurobiology Program, Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:8866-70. 2010
    ..Thus, these results show that the BDNF Val66Met polymorphism has a direct effect on NMDA receptor transmission, which may account for changes in synaptic plasticity in the hippocampus...
  3. doi request reprint Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex
    Ipe Ninan
    Department of Psychiatry, New York University Langone Medical Center, New York 10016, USA
    J Neurochem 119:324-31. 2011
    ..The aforementioned suppression of basal glutamatergic neurotransmission and facilitation of activity-dependent synaptic plasticity in the IL-mPFC might be critical for the effect of oxytocin on social cognition...
  4. ncbi request reprint Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII
    Shumin Liu
    Department of Pathology, Taub Institute, Columbia University, New York, NY 10032, USA
    Eur J Neurosci 25:3583-96. 2007
    ..Thus, our results suggest that NO, cGMP, GMP-dependent protein kinase and calmodulin-dependent protein kinase II play a key role in the redistribution of alpha-synuclein during plasticity...
  5. ncbi request reprint BDNF-mediated neurotransmission relies upon a myosin VI motor complex
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 9:1009-18. 2006
    ..Together, these results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity...
  6. pmc BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell, New York, NY 10021, USA
    Neuropsychopharmacology 37:1297-304. 2012
    ..The observed effects of the BDNF Val66Met SNP on hippocampal BDNF expression and synaptic plasticity provide a possible mechanistic basis by which this common BDNF SNP may impair efficacy of SSRI drug treatment...
  7. pmc The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex
    Siobhan S Pattwell
    Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, New York, USA
    J Neurosci 32:2410-21. 2012
    ..The effect of the Val66Met polymorphism on synaptic transmission and plasticity in the IL-mPFC represents a mechanism to account for this impact of SNP on affective disorders and cognitive dysfunction...
  8. ncbi request reprint Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease
    Hong Zhang
    Department of Pathology and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Curr Alzheimer Res 2:137-40. 2005
    ..26 -/+ 2% in WT. Thus, it is likely that presynaptic mechanisms underlying SF but not PPF and PTP, may account for synaptic dysfunction in APP/PS1 mice...
  9. pmc Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons
    Balapal S Basavarajappa
    Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 107:1001-13. 2008
    ..These observations, taken together, suggest the participation of ECs as retrograde messengers in the ethanol-induced depression of synaptic activities...
  10. pmc alpha-Synuclein produces a long-lasting increase in neurotransmitter release
    Shumin Liu
    Department of Pathology, Columbia University, New York, NY, USA
    EMBO J 23:4506-16. 2004
    ..Thus, alpha-synuclein is involved in synaptic plasticity by augmenting transmitter release from the presynaptic terminal...
  11. pmc A GluR1-cGKII interaction regulates AMPA receptor trafficking
    Yafell Serulle
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Neuron 56:670-88. 2007
    ..This work identifies a pathway, downstream from the NMDA receptor (NMDAR) and nitric oxide (NO), which stimulates GluR1 accumulation in the plasma membrane and plays an important role in synaptic plasticity...
  12. pmc The ARMS/Kidins220 scaffold protein modulates synaptic transmission
    Juan Carlos Arevalo
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Neurosci 45:92-100. 2010
    ..These results provide evidence that modulation of ARMS/Kidins220 levels can regulate basal synaptic strength in a specific manner in hippocampal neurons...
  13. ncbi request reprint Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy
    Fabrizio Trinchese
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Mol Neurosci 24:15-21. 2004
    ....
  14. pmc Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development
    Yukio Akaneya
    Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e12486. 2010
    ..Members of the ephrin-A family are glycosyl-phosphatidylinositol-anchored to the cell surface and activate EphA receptors, which are receptor tyrosine kinases...
  15. pmc Altered fear learning across development in both mouse and human
    Siobhan S Pattwell
    Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:16318-23. 2012
    ..These findings provide insight into optimizing treatment outcomes for when, during development, exposure therapies may be most effective...
  16. doi request reprint Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa
    Jhon Jairo Sutachan
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 88:3447-56. 2010
    ..Our results suggest that the ARMS/Kidins220 scaffold protein plays a critical role in the regulation of inhibitory transmission in hippocampal neurons...
  17. pmc Synaptic autoregulation by metalloproteases and γ-secretase
    Sophie Restituito
    Department of Biochemistry, New York University Langone Medical Center, New York, New York 10016, USA
    J Neurosci 31:12083-93. 2011
    ..Our results suggest that activity-dependent substrate cleavage by synaptic metalloproteases and γ-secretase modifies synaptic transmission, providing a novel form of synaptic autoregulation...
  18. pmc Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice
    Sergey V Shmelkov
    1 Howard Hughes Medical Institute, Ansary Stem Cell Institute and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA 2 These authors contributed equally to this work
    Nat Med 16:598-602, 1p following 602. 2010
    ..Thus, our studies identify Slitrk5 as an essential molecule at corticostriatal synapses and provide a new mouse model of OCD-like behaviors...
  19. ncbi request reprint Estimation of the mean from sums with unknown numbers of summands
    Ipe Ninan
    Department of Psychiatry, New York University, New York, New York 10276, USA
    Biometrics 62:918-20. 2006
    ..Here, a relatively convenient nonparametric approach to estimation is presented. Data from an experiment in which cationic styrylpyridinium dye FM4-64 was used in cultured mouse hippocampal neurons are used to illustrate the approach...
  20. pmc Sucrose ingestion induces rapid AMPA receptor trafficking
    David S Tukey
    Department of Biochemistry and Molecular Pharmacology, New York, New York 10016, and Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 33:6123-32. 2013
    ..Trafficking is stimulated by a chemosensory pathway that is not dependent on the caloric value of sucrose...
  21. pmc Selective early-acquired fear memories undergo temporary suppression during adolescence
    Siobhan S Pattwell
    Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:1182-7. 2011
    ..These findings reveal a unique form of brain plasticity in fear learning during early adolescence and may prove informative for understanding endogenous mechanisms to suppress unwanted fear memories...
  22. ncbi request reprint Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons
    Ipe Ninan
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Neuron 42:129-41. 2004
    ..Thus, the present results conclusively prove that presynaptic CaMKII is essential for synaptic plasticity in cultured hippocampal neurons...
  23. pmc Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
    Christopher N Parkhurst
    Molecular Neurobiology Program, The Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Cell 155:1596-609. 2013
    ..Together, our findings reveal that microglia serve important physiological functions in learning and memory by promoting learning-related synapse formation through BDNF signaling. ..
  24. pmc The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice
    Ian J Orozco
    Department of Pathology and Cell Biology, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA Electronic address
    Mol Cell Neurosci 58:76-84. 2014
    ..These data provide compelling evidence that dysbindin, a widely suspected susceptibility protein in schizophrenia, is important for AMPAR-mediated synaptic transmission and plasticity in the developing hippocampus. ..