Affiliation: New England College of Optometry
- Ocular diurnal rhythms and eye growth regulation: Where we are 50 years after LauberDebora L Nickla
New England College of Optometry, Department of Biosciences, 424 Beacon Street, Boston, MA 02115, USA Electronic address
Exp Eye Res 114:25-34. 2013..The recognition that ocular rhythms may play a role in emmetropization is a first step toward understanding how they may be manipulated in treatment therapies to prevent myopia in humans. ..
- Effects of muscarinic agents on chick choroids in intact eyes and eyecups: evidence for a muscarinic mechanism in choroidal thinningDebora L Nickla
Department of Biomedical Sciences and Disease, The New England College of Optometry, Boston, MA, USA
Ophthalmic Physiol Opt 33:245-56. 2013..We also hypothesized that the effective growth-inhibiting antagonists would thicken the choroid...
- Parasympathetic influences on emmetropization in chicks: evidence for different mechanisms in form deprivation vs negative lens-induced myopiaDebora L Nickla
Department of Biosciences, The New England College of Optometry, Boston, MA 02115, United States
Exp Eye Res 102:93-103. 2012..These results argue for different underlying mechanisms for the growth responses to form deprivation vs negative lens wear. They also imply that choroidal thickening and thinning are not opposing elements of a single mechanism...
- Inhibiting the neuronal isoform of nitric oxide synthase has similar effects on the compensatory choroidal and axial responses to myopic defocus in chicks as does the non-specific inhibitor L-NAMEDebora L Nickla
The New England College of Optometry, Bioscience Department, 424 Beacon St, Boston, MA 02115, USA
Exp Eye Res 88:1092-9. 2009..We conclude that the choroidal compensatory response is influenced by nNOS, possibly from the intrinsic choroidal neurons, or the parasympathetic innervation from the ciliary and/or pterygopalatine ganglia...
- Transient increases in choroidal thickness are consistently associated with brief daily visual stimuli that inhibit ocular growth in chicksDebora L Nickla
The New England College of Optometry, Department of Biosciences, 424 Beacon Street, Boston, MA 02115, USA
Exp Eye Res 84:951-9. 2007..The choroidal response was not significant. These results support the hypothesis that these brief choroidal responses may play a role in ocular growth inhibition...
- Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicksDebora L Nickla
The New England College of Optometry, Dept of Biosciences, 424 Beacon St, Boston, MA 02115, USA
Exp Eye Res 91:715-20. 2010..9 and -2.8 D vs 0.6 D; p < 0.0001), however, the effects on neither axial length nor choroidal thickness were significant. These data support a role for both D1 and D2 receptors in the ocular growth responses...
- Inhibiting the transient choroidal thickening response using the nitric oxide synthase inhibitor l-NAME prevents the ameliorative effects of visual experience on ocular growth in two different visual paradigmsDebora L Nickla
The New England College of Optometry, Bioscience Department, 424 Beacon Street, Boston, MA 02115, USA
Exp Eye Res 83:456-64. 2006..This supports the hypothesis that visually-induced changes in choroidal thickness play a role in the visual regulation of ocular growth...
- The phase relationships between the diurnal rhythms in axial length and choroidal thickness and the association with ocular growth rate in chicksDebora L Nickla
Bioscience Department, The New England College of Optometry, 424 Beacon St, Boston, MA 02115, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:399-407. 2006..There is a positive correlation between the phase difference and growth rate. In conclusion, there is a consistent association between growth rate and phase relationships of the rhythms in axial elongation and choroidal thickness...
- Temporal integration characteristics of the axial and choroidal responses to myopic defocus induced by prior form deprivation versus positive spectacle lens wear in chickensDebora L Nickla
The New England College of Optometry, Biosciences Department, Boston, Massachusetts 02115, USA
Optom Vis Sci 82:318-27. 2005..that induced by positive spectacle lenses, in both cases alternating with form deprivation...
- The multifunctional choroidDebora L Nickla
Department of Biosciences, New England College of Optometry, Boston, MA 02115, USA
Prog Retin Eye Res 29:144-68. 2010....
- The effect of the nonspecific nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on the choroidal compensatory response to myopic defocus in chickensDebora L Nickla
New England College of Optometry, Boston, Massachusetts 02115, USA
Optom Vis Sci 81:111-8. 2004..The underlying mechanism(s) for these changes are unknown. We tested the hypothesis that nitric oxide might play a role...
- The autonomic facial nerve pathway in birds: a tracing study in chickensFalk Schrödl
The New England College of Optometry, Boston, 02115, USA
Invest Ophthalmol Vis Sci 47:3225-33. 2006..The purpose of this study was to find an extraorbital approach to the preganglionic part of cranial nerve VII and to reveal its peripheral terminals and its site of origin in the brain stem...
- Change in the synthesis rates of ocular retinoic acid and scleral glycosaminoglycan during experimentally altered eye growth in marmosetsDavid Troilo
Department of Biomedical Science and Disease, The New England College of Optometry, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 47:1768-77. 2006..The purpose of this study was to examine the possibility that all-trans-retinoic acid (RA) in the eye is a signal related to changes in scleral extracellular matrix in a primate model of postnatal eye growth...
- The response to visual form deprivation differs with age in marmosetsDavid Troilo
New England College of Optometry, Boston, MA 02115, USA
Invest Ophthalmol Vis Sci 46:1873-81. 2005..To characterize the effects of visual form deprivation by diffuser in marmoset monkey eyes across a range of ages...
- Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmosetDebora L Nickla
Department of Biological Science and Disease, New England College of Optometry, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 43:2519-28. 2002..In this study, these same rhythms were sought in the common marmoset, a primate model of eye growth, to establish whether these may play a role in ocular growth regulation across species...
- Ocular diurnal rhythms and eye growthDebora Nickla; Fiscal Year: 2005..The results from these three Aims will bring us closer to understanding the molecular mechanisms underlying ocular growth regulation, and elucidate the influence of the choroid in these mechanisms. ..
- Ocular diurnal rhythms and eye growthDebora L Nickla; Fiscal Year: 2010....