S A Newman

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. ncbi Form and function remixed: developmental physiology in the evolution of vertebrate body plans
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, New York, NY, USA
    J Physiol 592:2403-12. 2014
  2. pmc Bare bones pattern formation: a core regulatory network in varying geometries reproduces major features of vertebrate limb development and evolution
    Jianfeng Zhu
    Department of Mathematics, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS ONE 5:e10892. 2010
  3. doi Gene loss, thermogenesis, and the origin of birds
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Ann N Y Acad Sci 1289:36-47. 2013
  4. doi Physico-genetic determinants in the evolution of development
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Science 338:217-9. 2012
  5. pmc The brown adipocyte differentiation pathway in birds: an evolutionary road not taken
    Nadejda V Mezentseva
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    BMC Biol 6:17. 2008
  6. ncbi Before programs: the physical origination of multicellular forms
    Stuart A Newman
    New York Medical College, Valhalla, NY 10595, USA
    Int J Dev Biol 50:289-99. 2006
  7. doi Dynamical patterning modules: physico-genetic determinants of morphological development and evolution
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Phys Biol 5:015008. 2008
  8. doi Activator-inhibitor dynamics of vertebrate limb pattern formation
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Birth Defects Res C Embryo Today 81:305-19. 2007
  9. ncbi Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, New York 10595, USA
    Int J Dev Biol 53:693-705. 2009
  10. doi E.E. Just's "independent irritability" revisited: the activated egg as excitable soft matter
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Mol Reprod Dev 76:966-74. 2009

Collaborators

Detail Information

Publications39

  1. ncbi Form and function remixed: developmental physiology in the evolution of vertebrate body plans
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, New York, NY, USA
    J Physiol 592:2403-12. 2014
    ....
  2. pmc Bare bones pattern formation: a core regulatory network in varying geometries reproduces major features of vertebrate limb development and evolution
    Jianfeng Zhu
    Department of Mathematics, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS ONE 5:e10892. 2010
    ..This process is played out in the developing limb in the context of a gradient of fibroblast growth factor (FGF) emanating from the apical ectodermal ridge (AER)...
  3. doi Gene loss, thermogenesis, and the origin of birds
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Ann N Y Acad Sci 1289:36-47. 2013
    ..g., flight, swimming), and, by altering the mechanical environment of embryonic development, generated skeletal novelties, sometimes abruptly, that became distinctive features of the avian body plan...
  4. doi Physico-genetic determinants in the evolution of development
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Science 338:217-9. 2012
    ....
  5. pmc The brown adipocyte differentiation pathway in birds: an evolutionary road not taken
    Nadejda V Mezentseva
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    BMC Biol 6:17. 2008
    ....
  6. ncbi Before programs: the physical origination of multicellular forms
    Stuart A Newman
    New York Medical College, Valhalla, NY 10595, USA
    Int J Dev Biol 50:289-99. 2006
    ..We suggest several ways in which organisms that were originally formed by predominantly physical mechanisms could have evolved genetic mechanisms to perpetuate their morphologies...
  7. doi Dynamical patterning modules: physico-genetic determinants of morphological development and evolution
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Phys Biol 5:015008. 2008
    ....
  8. doi Activator-inhibitor dynamics of vertebrate limb pattern formation
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Birth Defects Res C Embryo Today 81:305-19. 2007
    ..Finally, we discuss how viewing development as an interplay between molecular-genetic and dynamic physical processes can provide new insight into the origin of congenital anomalies...
  9. ncbi Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, New York 10595, USA
    Int J Dev Biol 53:693-705. 2009
    ....
  10. doi E.E. Just's "independent irritability" revisited: the activated egg as excitable soft matter
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Mol Reprod Dev 76:966-74. 2009
    ..Lastly, the implications of these post-fertilization phenomena for animal evolution, a problem also addressed by Just, are discussed...
  11. ncbi Genes and proteins: dogmas in decline
    Stuart A Newman
    Department of Cell Biology and Anatomy, Basic Science Building, New York Medical College, Valhalla, New York 10595, USA
    J Biosci 32:1041-3. 2007
  12. ncbi Phase transformations in a model mesenchymal tissue
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Phys Biol 1:100-9. 2004
    ..Our studies provide a starting point for the analysis of phase transformations of more complex biomaterials including developing and healing tissues as well as tissue substitutes containing living cells...
  13. ncbi Origination and innovation in the vertebrate limb skeleton: an epigenetic perspective
    Stuart A Newman
    New York Medical College, Valhalla, New York 10595, USA
    J Exp Zool B Mol Dev Evol 304:593-609. 2005
    ..Morphological innovation may take place when such modulatory processes exceed a threshold defined by the dynamics of the skeletogenic system and elements are added or lost...
  14. ncbi The pre-Mendelian, pre-Darwinian world: shifting relations between genetic and epigenetic mechanisms in early multicellular evolution
    Stuart A Newman
    Department of Cell Biology and Anatomy, Basic Science Building, New York Medical College, Valhalla, NY 10595, USA
    J Biosci 30:75-85. 2005
    ..The notion that genes are privileged determinants of biological characters can only be sustained by neglecting questions of evolutionary origination and the evolution of developmental mechanisms...
  15. ncbi Cell state switching factors and dynamical patterning modules: complementary mediators of plasticity in development and evolution
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    J Biosci 34:553-72. 2009
    ..We also provide recently characterized examples of DTFs in cell type switching and DPMs in morphogenesis of avian limb bud mesenchyme, an embryo-derived tissue that retains a high degree of developmental plasticity...
  16. pmc A regulatory network of two galectins mediates the earliest steps of avian limb skeletal morphogenesis
    Ramray Bhat
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    BMC Dev Biol 11:6. 2011
    ..The formation of these condensations depends on cell-matrix and cell-cell interactions, but how they are initiated and patterned is as yet unresolved...
  17. doi Animal egg as evolutionary innovation: a solution to the "embryonic hourglass" puzzle
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, USA
    J Exp Zool B Mol Dev Evol 316:467-83. 2011
    ..Finally, I describe how this new perspective provides a resolution to the embryonic hourglass puzzle...
  18. ncbi Sticky fingers: Hox genes and cell adhesion in vertebrate limb development
    S A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595, USA
    Bioessays 18:171-4. 1996
    ..They misexpressed the product of the Hoxa-13 gene in chick limb buds and demonstrated both skeletal pattern perturbations and changes in cell-cell adhesivity in mesenchyme aberrantly expressing this protein...
  19. ncbi Developmental mechanisms: putting genes in their place
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    J Biosci 27:97-104. 2002
  20. ncbi Epigenetic mechanisms of character origination
    S A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595, USA
    J Exp Zool 288:304-17. 2000
    ..g., the burst of body plans in the early Cambrian, the origins of morphological innovation, homology, and rapid change of form. Our concept entails a new interpretation of the relationship between genes and biological form...
  21. pmc Borrelia burgdorferi binds to, invades, and colonizes native type I collagen lattices
    Maria C Zambrano
    Department of Microbiology and Immunology, New York Medical College, Basic Science Building, Valhalla, NY 10595 1690, USA
    Infect Immun 72:3138-46. 2004
    ..burgdorferi strains to intact collagen matrices permits replacement of the commonly used isotopic binding assay with visual fluorescent microscopic assays and will facilitate future studies of these interactions...
  22. ncbi Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix
    Felipe C Cabello
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Trends Microbiol 15:350-4. 2007
    ..burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved...
  23. ncbi Ectodermal FGFs induce perinodular inhibition of limb chondrogenesis in vitro and in vivo via FGF receptor 2
    Marie Z Moftah
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Dev Biol 249:270-82. 2002
    ....
  24. ncbi Multiscale models for vertebrate limb development
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Curr Top Dev Biol 81:311-40. 2008
    ..Progress in devising computational methods for handling 3D, multiscale, multimodel simulations of organogenesis is discussed, as well as for simulating reaction-diffusion dynamics in domains of irregular shape...
  25. ncbi Is segmentation generic?
    S A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595
    Bioessays 15:277-83. 1993
    ....
  26. ncbi cDNA cloning and spatiotemporal expression during avian embryogenesis of hnRNP A1, a regulatory factor in alternative splicing
    Natalie B Bronstein
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Gene Expr Patterns 3:285-95. 2003
    ..HnRNP A1 protein is expressed at sites of active neurogenesis in the developing central and peripheral nervous systems, regions of known extensive alternative splicing...
  27. ncbi Mechanisms of pattern formation in development and evolution
    Isaac Salazar-Ciudad
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Development 130:2027-37. 2003
    ....
  28. pmc Dynamical mechanisms for skeletal pattern formation in the vertebrate limb
    H G E Hentschel
    Department of Physics, Emory University, Maths Science Center, 400 Dowman Drive, Atlanta, GA 30322, USA
    Proc Biol Sci 271:1713-22. 2004
    ....
  29. pmc Assembly of collagen matrices as a phase transition revealed by structural and rheologic studies
    Gabor Forgacs
    Department of Physics and Biology, University of Missouri, Columbia, Missouri 65211, USA
    Biophys J 84:1272-80. 2003
    ..7 and a critical loss angle being independent of frequency as predicted by percolation theory. Gelation of collagen thus represents a second order phase transition...
  30. ncbi The innovation triad: an EvoDevo agenda
    Gerd B Muller
    Department of Theoretical Biology, University of Vienna, A 1090 Vienna
    J Exp Zool B Mol Dev Evol 304:487-503. 2005
    ....
  31. doi Limb bud and flank mesoderm have distinct "physical phenotypes" that may contribute to limb budding
    Brooke J Damon
    Department of Physics and Astronomy, University of Missouri Columbia, Columbia, MO 65211, USA
    Dev Biol 321:319-30. 2008
    ....
  32. pmc Patterns of mesenchymal condensation in a multiscale, discrete stochastic model
    Scott Christley
    Department of Computer Science, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS Comput Biol 3:e76. 2007
    ..The authors discuss these modes of pattern formation in relation to available experimental evidence for the in vitro system, as well as their implications for understanding limb skeletal patterning during embryonic development...
  33. ncbi The morphostatic limit for a model of skeletal pattern formation in the vertebrate limb
    Mark Alber
    Department of Mathematics, University of Notre Dame, Notre Dame, IN 46556 4618, USA
    Bull Math Biol 70:460-83. 2008
    ..Lastly, we discuss the possible role in limb evolution of selection for increasingly morphostatic developmental mechanisms...
  34. ncbi Editorial: evolutionary innovation and morphological novelty
    Gerd B Muller
    J Exp Zool B Mol Dev Evol 304:485-6. 2005
  35. ncbi Stephen J Gould
    Scott F Gilbert
    J Biosci 27:445-63. 2002
  36. ncbi Interplay between activator-inhibitor coupling and cell-matrix adhesion in a cellular automaton model for chondrogenic patterning
    Maria A Kiskowski
    Department of Mathematics and Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, IN 46556 5670, USA
    Dev Biol 271:372-87. 2004
    ..We discuss the applicability of this model to limb development in vivo and to other organ development...
  37. ncbi Continuous macroscopic limit of a discrete stochastic model for interaction of living cells
    Mark Alber
    Department of Mathematics, University of Notre Dame, Notre Dame, Indiana 46656, USA
    Phys Rev Lett 99:168102. 2007
    ..A general multiscale approach is demonstrated by simulating spongy bone formation, suggesting that self-organizing physical mechanisms can account for this developmental process...
  38. pmc Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling
    Roeland M H Merks
    The Biocomplexity Institute, Department of Physics, Indiana University Bloomington, IN 47405, USA
    Dev Biol 289:44-54. 2006
    ..We validate our simulation results against HUVEC cultures using time-resolved image analysis and find that our simulations quantitatively reproduce in vitro vasculogenesis and subsequent in vitro remodeling...
  39. ncbi A framework for three-dimensional simulation of morphogenesis
    Trevor M Cickovski
    Laboratory for Computational Life Sciences, Department of Computer Science and Engineering, University of Notre Dame, 325 Cushing Hall, Notre Dame, IN 46556, USA
    IEEE/ACM Trans Comput Biol Bioinform 2:273-88. 2005
    ..Binaries and source code are available, along with documentation and input files for sample simulations, at http:// compucell.sourceforge.net...