Maiken Nedergaard

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. doi request reprint Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone
    Hongmin Xu
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci Res 86:1482-500. 2008
  2. ncbi request reprint Beyond the role of glutamate as a neurotransmitter
    Maiken Nedergaard
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Nat Rev Neurosci 3:748-55. 2002
  3. ncbi request reprint New roles for astrocytes: redefining the functional architecture of the brain
    Maiken Nedergaard
    Department of Cell Biology, New York Medical College, Valhalla, NY 10595, USA
    Trends Neurosci 26:523-30. 2003
  4. ncbi request reprint Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons
    Ning Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
    J Neurophysiol 94:4121-30. 2005
  5. doi request reprint A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
  6. ncbi request reprint Paucity of pericytes in germinal matrix vasculature of premature infants
    Alex Braun
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 27:12012-24. 2007
  7. pmc Connexin 43 hemichannels are permeable to ATP
    Jian Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:4702-11. 2008
  8. ncbi request reprint Connexin mediates gap junction-independent resistance to cellular injury
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 23:430-41. 2003
  9. ncbi request reprint Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants
    Nadine El-Khoury
    Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Res 59:673-9. 2006
  10. ncbi request reprint Signaling at the gliovascular interface
    Marie Simard
    Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
    J Neurosci 23:9254-62. 2003

Collaborators

Detail Information

Publications43

  1. doi request reprint Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone
    Hongmin Xu
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci Res 86:1482-500. 2008
    ..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates...
  2. ncbi request reprint Beyond the role of glutamate as a neurotransmitter
    Maiken Nedergaard
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Nat Rev Neurosci 3:748-55. 2002
    ..Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes...
  3. ncbi request reprint New roles for astrocytes: redefining the functional architecture of the brain
    Maiken Nedergaard
    Department of Cell Biology, New York Medical College, Valhalla, NY 10595, USA
    Trends Neurosci 26:523-30. 2003
    ..By these means, astrocytes might establish the functional as well as the structural architecture of the adult brain...
  4. ncbi request reprint Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons
    Ning Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
    J Neurophysiol 94:4121-30. 2005
    ..Our study provides a novel mechanism, astrocytic release of glutamate, for seizure initiation...
  5. doi request reprint A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
    ..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance...
  6. ncbi request reprint Paucity of pericytes in germinal matrix vasculature of premature infants
    Alex Braun
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 27:12012-24. 2007
    ..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature...
  7. pmc Connexin 43 hemichannels are permeable to ATP
    Jian Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:4702-11. 2008
    ..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices...
  8. ncbi request reprint Connexin mediates gap junction-independent resistance to cellular injury
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 23:430-41. 2003
    ..Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival...
  9. ncbi request reprint Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants
    Nadine El-Khoury
    Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Res 59:673-9. 2006
    ....
  10. ncbi request reprint Signaling at the gliovascular interface
    Marie Simard
    Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
    J Neurosci 23:9254-62. 2003
    ..It is speculated that calcium signaling may play a role in astrocytic functions related to the blood-brain barrier, including blood flow regulation, metabolic trafficking, and water homeostasis...
  11. pmc Intercellular calcium signaling mediated by point-source burst release of ATP
    Gregory Arcuino
    Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:9840-5. 2002
    ....
  12. ncbi request reprint Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons
    Jun Xu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 25:1750-60. 2005
    ..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP...
  13. pmc Purinergic signaling regulates neural progenitor cell expansion and neurogenesis
    Jane H C Lin
    Department of Cell Biology, New York Medical College, Valhalla, NY, USA
    Dev Biol 302:356-66. 2007
    ..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof...
  14. ncbi request reprint Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
    ..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
  15. ncbi request reprint Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter
    Praveen Ballabh
    Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
    Pediatr Res 58:791-8. 2005
    ....
  16. ncbi request reprint Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons
    Ning Kang
    Dept of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm 220, Valhalla, NY 10595, USA
    J Neurophysiol 92:873-82. 2004
    ..Thus the postsynaptic KAR-mediated inhibition of GABA(A) currents may contribute to the KAR agonist-induced decrease in the potency of uIPSCs and KA-induced disinhibition...
  17. pmc Astrocyte-mediated activation of neuronal kainate receptors
    Qing Song Liu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 101:3172-7. 2004
    ..By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus...
  18. ncbi request reprint Astrocytes in the aging brain
    Maria Luisa Cotrina
    Department of Anatomy and Cell Biology, New York Medical College, Valhalla, NY 10595, USA
    J Neurosci Res 67:1-10. 2002
  19. ncbi request reprint The blood-brain barrier: an overview: structure, regulation, and clinical implications
    Praveen Ballabh
    Department of Pediatrics, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
    Neurobiol Dis 16:1-13. 2004
    ..Finally, this review describes the pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease...
  20. ncbi request reprint Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Pediatr Res 56:117-24. 2004
    ..of the GM compared with gray and white matter may play a role in GM hemorrhage, whereas a relatively low vascularity of white matter may increase the propensity for the occurrence of periventricular leukomalacia in premature infants..
  21. ncbi request reprint Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells
    Jane H C Lin
    Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 22:4302-11. 2002
    ....
  22. ncbi request reprint DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+
    Takahiro Takano
    Cell Calcium 41:503-4. 2007
  23. ncbi request reprint Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease
    Takahiro Takano
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1097:40-50. 2007
    ....
  24. ncbi request reprint Cortical spreading depression causes and coincides with tissue hypoxia
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
    Nat Neurosci 10:754-62. 2007
    ..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply...
  25. ncbi request reprint Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons
    Christopher M Anderson
    Department of Pharmacology and Therapeutics, University of Manitoba and Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
    Trends Neurosci 29:257-62. 2006
    ....
  26. ncbi request reprint Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    Neeta Singh Roy
    Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
    Exp Neurol 196:224-34. 2005
    ..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy...
  27. ncbi request reprint Astrocyte-mediated control of cerebral microcirculation
    Christopher M Anderson
    Department of Neurology, University of California San Francisco, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Trends Neurosci 26:340-4; author reply 344-5. 2003
    ..This finding represents a breakthrough in our knowledge both of astrocyte function and of the mechanism of activity-dependent cerebral blood flow regulation...
  28. ncbi request reprint Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...
  29. pmc Receptor-mediated glutamate release from volume sensitive channels in astrocytes
    Takahiro Takano
    Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:16466-71. 2005
    ..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions...
  30. pmc An astrocytic basis of epilepsy
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    ..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders...
  31. ncbi request reprint Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor
    Lane Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    Nat Med 14:75-80. 2008
    ....
  32. ncbi request reprint Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity...
  33. ncbi request reprint Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
    Marta C Nunes
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA
    Nat Med 9:439-47. 2003
    ..These experiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells resides in the adult human white matter...
  34. ncbi request reprint Erythropoietin strikes a new cord
    Steven A Goldman
    Nat Med 8:785-7. 2002
  35. doi request reprint Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
    ..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain...
  36. ncbi request reprint New roles for astrocytes (stars at last)
    Bruce Ransom
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, WA 98195, USA
    Trends Neurosci 26:520-2. 2003
    ..But now, at last, astrocytes have our attention...
  37. ncbi request reprint Glial regulation of the cerebral microvasculature
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10021, USA
    Nat Neurosci 10:1369-76. 2007
    ..The involvement of astrocytes in neurovascular coupling has broad implications for the interpretation of functional imaging signals and for the understanding of brain diseases that are associated with neurovascular dysfunction...
  38. pmc Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes
    Jyoti K Jaiswal
    The Rockefeller University, 1230 York Avenue, Box 304, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 104:14151-6. 2007
    ..We have used this approach to demonstrate that lysosomes undergo calcium-triggered exocytosis in astrocytes...
  39. ncbi request reprint Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord
    Neeta S Roy
    Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
    Nat Biotechnol 22:297-305. 2004
    ..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons...
  40. ncbi request reprint Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Drug Deliv Rev 58:773-87. 2006
    ....
  41. ncbi request reprint Astrocytic complexity distinguishes the human brain
    Nancy Ann Oberheim
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Neurosci 29:547-53. 2006
    ..We propose that human cortical evolution has been accompanied by increasing complexity in the form and function of astrocytes, which reflects an expansion of their functional roles in synaptic modulation and cortical circuitry...
  42. ncbi request reprint P2X7 receptor inhibition improves recovery after spinal cord injury
    Xiaohai Wang
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Med 10:821-7. 2004
    ..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI...
  43. ncbi request reprint The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
    Ditte Lovatt
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 27:12255-66. 2007
    ....