Research Topics
Species | Maiken NedergaardSummaryAffiliation: New York Medical College Country: USA Publications
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Detail Information
Publications
Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasoneHongmin Xu
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci Res 86:1482-500. 2008..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates...
Beyond the role of glutamate as a neurotransmitterMaiken Nedergaard
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
Nat Rev Neurosci 3:748-55. 2002..Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes...- New roles for astrocytes: redefining the functional architecture of the brainMaiken Nedergaard
Department of Cell Biology, New York Medical College, Valhalla, NY 10595, USA
Trends Neurosci 26:523-30. 2003..By these means, astrocytes might establish the functional as well as the structural architecture of the adult brain... - Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neuronsNing Kang
Department. of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
J Neurophysiol 94:4121-30. 2005..Our study provides a novel mechanism, astrocytic release of glutamate, for seizure initiation... - A central role of connexin 43 in hypoxic preconditioningJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:681-95. 2008..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance... - Paucity of pericytes in germinal matrix vasculature of premature infantsAlex Braun
Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci 27:12012-24. 2007..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature... - Connexin 43 hemichannels are permeable to ATPJian Kang
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:4702-11. 2008..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices... - Connexin mediates gap junction-independent resistance to cellular injuryJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 23:430-41. 2003..Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival... - Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infantsNadine El-Khoury
Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
Pediatr Res 59:673-9. 2006.... - Signaling at the gliovascular interfaceMarie Simard
Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
J Neurosci 23:9254-62. 2003..It is speculated that calcium signaling may play a role in astrocytic functions related to the blood-brain barrier, including blood flow regulation, metabolic trafficking, and water homeostasis... 
Purinergic signaling regulates neural progenitor cell expansion and neurogenesisJane H C Lin
Department of Cell Biology, New York Medical College, Valhalla, NY, USA
Dev Biol 302:356-66. 2007..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof...- Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neuronsJun Xu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 25:1750-60. 2005..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP... - Intercellular calcium signaling mediated by point-source burst release of ATPGregory Arcuino
Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 99:9840-5. 2002.... - Angiogenic inhibition reduces germinal matrix hemorrhagePraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Nat Med 13:477-85. 2007..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants... - Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matterPraveen Ballabh
Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
Pediatr Res 58:791-8. 2005.... - Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neuronsNing Kang
Dept. of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm. 220, Valhalla, NY 10595, USA
J Neurophysiol 92:873-82. 2004..Thus the postsynaptic KAR-mediated inhibition of GABA(A) currents may contribute to the KAR agonist-induced decrease in the potency of uIPSCs and KA-induced disinhibition... - Astrocyte-mediated activation of neuronal kainate receptorsQing Song Liu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 101:3172-7. 2004..By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus... - Astrocytes in the aging brainMaria Luisa Cotrina
Department of Anatomy and Cell Biology, New York Medical College, Valhalla, NY 10595, USA
J Neurosci Res 67:1-10. 2002 - The blood-brain barrier: an overview: structure, regulation, and clinical implicationsPraveen Ballabh
Department of Pediatrics, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
Neurobiol Dis 16:1-13. 2004..Finally, this review describes the pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease... - Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infantsPraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Pediatr Res 56:117-24. 2004..of the GM compared with gray and white matter may play a role in GM hemorrhage, whereas a relatively low vascularity of white matter may increase the propensity for the occurrence of periventricular leukomalacia in premature infants.. - Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cellsJane H C Lin
Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 22:4302-11. 2002.... - DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+Takahiro Takano
Cell Calcium 41:503-4. 2007 - Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's diseaseTakahiro Takano
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
Ann N Y Acad Sci 1097:40-50. 2007.... - Cortical spreading depression causes and coincides with tissue hypoxiaTakahiro Takano
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
Nat Neurosci 10:754-62. 2007..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply... - Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neuronsChristopher M Anderson
Department of Pharmacology and Therapeutics, University of Manitoba and Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
Trends Neurosci 29:257-62. 2006.... - Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cellsNeeta Singh Roy
Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
Exp Neurol 196:224-34. 2005..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy... - Astrocyte-mediated control of cerebral microcirculationChristopher M Anderson
Department of Neurology, University of California-San Francisco, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Trends Neurosci 26:340-4; author reply 344-5. 2003..This finding represents a breakthrough in our knowledge both of astrocyte function and of the mechanism of activity-dependent cerebral blood flow regulation... - Astrocytic Ca2+ signaling evoked by sensory stimulation in vivoXiaohai Wang
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:816-23. 2006..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity... - Receptor-mediated glutamate release from volume sensitive channels in astrocytesTakahiro Takano
Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:16466-71. 2005..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions... - An astrocytic basis of epilepsyGuo-Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Med 11:973-81. 2005..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders... - Adenosine is crucial for deep brain stimulation-mediated attenuation of tremorLane Bekar
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
Nat Med 14:75-80. 2008.... - Astrocyte-mediated control of cerebral blood flowTakahiro Takano
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:260-7. 2006..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity... - Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brainMarta C Nunes
Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA
Nat Med 9:439-47. 2003..These experiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells resides in the adult human white matter... - Erythropoietin strikes a new cordSteven A Goldman
Nat Med 8:785-7. 2002 - Loss of astrocytic domain organization in the epileptic brainNancy Ann Oberheim
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 28:3264-76. 2008..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain... - New roles for astrocytes (stars at last)Bruce Ransom
Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, WA 98195, USA
Trends Neurosci 26:520-2. 2003..But now, at last, astrocytes have our attention... - Glial regulation of the cerebral microvasculatureCostantino Iadecola
Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10021, USA
Nat Neurosci 10:1369-76. 2007..The involvement of astrocytes in neurovascular coupling has broad implications for the interpretation of functional imaging signals and for the understanding of brain diseases that are associated with neurovascular dysfunction... - Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytesJyoti K Jaiswal
The Rockefeller University, 1230 York Avenue, Box 304, New York, NY 10065, USA
Proc Natl Acad Sci U S A 104:14151-6. 2007..We have used this approach to demonstrate that lysosomes undergo calcium-triggered exocytosis in astrocytes... - Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cordNeeta S Roy
Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
Nat Biotechnol 22:297-305. 2004..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons... - Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brainGuo Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Adv Drug Deliv Rev 58:773-87. 2006.... - Astrocytic complexity distinguishes the human brainNancy Ann Oberheim
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Trends Neurosci 29:547-53. 2006..We propose that human cortical evolution has been accompanied by increasing complexity in the form and function of astrocytes, which reflects an expansion of their functional roles in synaptic modulation and cortical circuitry... - P2X7 receptor inhibition improves recovery after spinal cord injuryXiaohai Wang
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
Nat Med 10:821-7. 2004..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI... - The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortexDitte Lovatt
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 27:12255-66. 2007....