Niharika Nath

Summary

Affiliation: New York College of Osteopathic Medicine
Country: USA

Publications

  1. doi request reprint Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States
    Biochem Pharmacol 78:1298-304. 2009
  2. doi request reprint Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells
    Niharika Nath
    Department of Life Sciences, New York Institute of Technology, New York, NY 10023, USA
    Biochem Pharmacol 79:1759-71. 2010
  3. doi request reprint Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents
    Ravinder Kodela
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA
    Bioorg Med Chem Lett 21:7146-50. 2011
  4. doi request reprint Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:715-22. 2012
  5. doi request reprint Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:723-32. 2012
  6. ncbi request reprint NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA
    Biochem Biophys Res Commun 326:93-9. 2005
  7. pmc Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression
    Mitali Chattopadhyay
    Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, USA
    Leuk Res 37:1302-8. 2013
  8. doi request reprint Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:733-40. 2012
  9. doi request reprint JS-K, a nitric oxide-releasing prodrug, modulates ß-catenin/TCF signaling in leukemic Jurkat cells: evidence of an S-nitrosylated mechanism
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States
    Biochem Pharmacol 80:1641-9. 2010
  10. pmc Regulation of neuron survival and death by p130 and associated chromatin modifiers
    David X Liu
    Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 19:719-32. 2005

Collaborators

Detail Information

Publications12

  1. doi request reprint Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States
    Biochem Pharmacol 78:1298-304. 2009
    ..p-NO-ASA blocked the cell cycle transition at S to G2/M phase. These studies suggest a targeted chemopreventive/chemotherapeutic potential for NO-ASA against breast cancer...
  2. doi request reprint Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells
    Niharika Nath
    Department of Life Sciences, New York Institute of Technology, New York, NY 10023, USA
    Biochem Pharmacol 79:1759-71. 2010
    ..The altered gene expression patterns by NO-ASA in Jurkat T cells suggest mechanisms for carcinogen metabolism, anti-proliferative activity and possible chemoprotective activity in T-ALL...
  3. doi request reprint Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents
    Ravinder Kodela
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA
    Bioorg Med Chem Lett 21:7146-50. 2011
    ..Our data suggest that these compounds merit further investigation as potential anti-cancer agents...
  4. doi request reprint Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:715-22. 2012
    ..Taken together, these results demonstrate that HS-NSAIDs have potential anti-growth activity against a wide variety of human cancer cells...
  5. doi request reprint Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:723-32. 2012
    ..The decrease in tumor mass was associated with inhibition of cell proliferation, induction of apoptosis and decrease in NF-κB levels in vivo. HS-ASA has anti-cancer potential against ER- breast cancer and merits further study...
  6. ncbi request reprint NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA
    Biochem Biophys Res Commun 326:93-9. 2005
    ..A denitrated analog of p-NO-ASA did not degrade beta-catenin indicating the importance of the NO-donating moiety. Our findings suggest that NO-ASA merits further study as an agent against leukemia...
  7. pmc Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression
    Mitali Chattopadhyay
    Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, USA
    Leuk Res 37:1302-8. 2013
    ..Aspirin up to 5 mM had no effect on β-catenin expression. HS-ASA also increased caspase-3 protein levels and dose-dependently increased its activity. These effects were substantially blocked by z-VAD-fmk, a pan-caspase inhibitor...
  8. doi request reprint Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:733-40. 2012
    ..Therefore, HS-ASA induces phase-II enzymes, at least in part, through the action of H(2)S and by modulating Nrf2; these effects may be part of its mechanism of action against carcinogenesis...
  9. doi request reprint JS-K, a nitric oxide-releasing prodrug, modulates ß-catenin/TCF signaling in leukemic Jurkat cells: evidence of an S-nitrosylated mechanism
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States
    Biochem Pharmacol 80:1641-9. 2010
    ..The NO scavenger PTIO abrogated the JS-K mediated degradation of β-catenin demonstrating the need for NO...
  10. pmc Regulation of neuron survival and death by p130 and associated chromatin modifiers
    David X Liu
    Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 19:719-32. 2005
    ..Thus, neuron survival and death are dependent on the integrity of E2F4-p130-HDAC/Suv39H1 complexes...
  11. pmc Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association
    Niharika Nath
    Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031
    Proc Natl Acad Sci U S A 100:12584-9. 2003
    ..This effect, occurring at NO-ASA concentrations far below those required to inhibit cell growth, may be a critical early event in the chemopreventive activity of NO-ASA against colon cancer...
  12. pmc Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin
    Niharika Nath
    Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY, USA
    Drug Des Devel Ther 7:389-96. 2013
    ..Previously we showed that an aromatic spacer enhanced the potency of a particular NO-NSAID compared to an aliphatic spacer...