Robert G Nagele

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology
    R G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    J Cell Sci 114:377-88. 2001
  2. ncbi Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons
    Peter M Clifford
    New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Brain Res 1142:223-36. 2007
  3. pmc Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera
    Min Han
    University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences at the School of Osteopathic Medicine, Stratford, New Jersey, United States of America
    PLoS ONE 7:e32383. 2012
  4. pmc Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease
    Eric P Nagele
    Biomarker Discovery Center, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, NJ, USA
    PLoS ONE 8:e60726. 2013
  5. pmc Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression
    Gang Yue
    Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Genomics 9:608. 2008
  6. ncbi Chromosomes exhibit preferential positioning in nuclei of quiescent human cells
    R G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey SOM, Stratford, New Jersey 08084, USA
    J Cell Sci 112:525-35. 1999
  7. ncbi Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
    Robert G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Neurobiol Aging 25:663-74. 2004
  8. ncbi Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    Robert G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Brain Res 971:197-209. 2003
  9. ncbi Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-β(1-42) deposition
    Robert G Nagele
    New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    J Alzheimers Dis 25:605-22. 2011
  10. pmc Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera
    Eric Nagele
    Durin Technologies, Inc, New Brunswick, New Jersey, United States of America
    PLoS ONE 6:e23112. 2011

Collaborators

Detail Information

Publications30

  1. ncbi Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology
    R G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    J Cell Sci 114:377-88. 2001
    ....
  2. ncbi Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons
    Peter M Clifford
    New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Brain Res 1142:223-36. 2007
    ..Our results suggest that the blood may serve as a major, chronic source of soluble, exogenous Abeta peptides that can bind selectively to certain subtypes of neurons and accumulate within these cells...
  3. pmc Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera
    Min Han
    University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences at the School of Osteopathic Medicine, Stratford, New Jersey, United States of America
    PLoS ONE 7:e32383. 2012
    ..0%, 96.6%, and 100%, respectively. Results demonstrate that serum autoantibodies can be used as highly specific and accurate biomarkers for PD diagnosis throughout the course of the disease...
  4. pmc Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease
    Eric P Nagele
    Biomarker Discovery Center, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, NJ, USA
    PLoS ONE 8:e60726. 2013
    ....
  5. pmc Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression
    Gang Yue
    Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Genomics 9:608. 2008
    ..These observations make it difficult to understand the role of LPS in brain parenchymal injury...
  6. ncbi Chromosomes exhibit preferential positioning in nuclei of quiescent human cells
    R G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey SOM, Stratford, New Jersey 08084, USA
    J Cell Sci 112:525-35. 1999
    ....
  7. ncbi Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
    Robert G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Neurobiol Aging 25:663-74. 2004
    ....
  8. ncbi Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    Robert G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Brain Res 971:197-209. 2003
    ..Overall, A beta 42 accumulation and the selective lysis of A beta 42-burdened neurons and astrocytes appear to make a major contribution to the observed amyloid plaques in AD brains...
  9. ncbi Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-β(1-42) deposition
    Robert G Nagele
    New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    J Alzheimers Dis 25:605-22. 2011
    ..Thus, in the context of BBB compromise, brain-reactive autoantibodies may be an important risk factor for the initiation and/or progression of AD as well as other neurodegenerative diseases...
  10. pmc Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera
    Eric Nagele
    Durin Technologies, Inc, New Brunswick, New Jersey, United States of America
    PLoS ONE 6:e23112. 2011
    ..Results demonstrate that serum autoantibodies can be used effectively as highly-specific and accurate biomarkers to diagnose AD throughout the course of the disease...
  11. doi Brain-reactive autoantibodies are nearly ubiquitous in human sera and may be linked to pathology in the context of blood-brain barrier breakdown
    Eli C Levin
    New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    Brain Res 1345:221-32. 2010
    ....
  12. doi Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease
    Nimish K Acharya
    New Jersey Institute for Successful Aging NJISA at University of Medicine and Dentistry of New Jersey UMDNJ, School of Osteopathic medicine SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
    J Autoimmun 38:369-80. 2012
    ..The long-term and progressive nature of AD and other neurodegenerative diseases results in chronic exposure of the immune system to these citrullinated products and may drive the continual production of autoantibodies...
  13. doi Alpha7 nicotinic acetylcholine receptor expression by vascular smooth muscle cells facilitates the deposition of Abeta peptides and promotes cerebrovascular amyloid angiopathy
    Peter M Clifford
    University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Brain Res 1234:158-71. 2008
    ....
  14. ncbi Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib
    Nimish K Acharya
    New Jersey Institute for Successful Aging at University of Medicine and Dentistry of New Jersey UMDNJ School of Osteopathic Medicine, Stratford, NJ, USA
    J Alzheimers Dis 35:179-98. 2013
    ..Also, the preferential binding of IgG and coincident accumulation of Aβ42 in the same neurons suggests a mechanistic link between the leak of IgG through the BBB and intraneuronal deposition of Aβ42 in the brain...
  15. ncbi Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism
    Eli C Levin
    University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Brain Res 1298:194-207. 2009
    ....
  16. ncbi Calcium-sensitive ROS-GC1 signaling outside of photoreceptors: a common theme
    Venkateswar Venkataraman
    Departments of Cell Biology, SOM and NJMS University of Medicine and Dentistry, Stratford 08084, USA
    Mol Cell Biochem 230:117-24. 2002
    ..These findings raise the possibility that a common theme of calcium-modulated ROS-GC signaling may be utilized in a wide variety of neurosensory cells. This idea is also supported from evolutionary and functional perspectives...
  17. ncbi Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease
    R G Nagele
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, 08084, USA
    Neuroscience 110:199-211. 2002
    ....
  18. ncbi Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production
    G Yue
    Department of Cell Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, USA
    J Pharmacol Exp Ther 297:915-25. 2001
    ..These results strongly suggest that local elevated level of peroxynitrite produced from increased iNOS expression and activity is a major contributor to colon epithelial apoptosis during colon inflammation...
  19. ncbi Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat
    L J Forman
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford 08084, USA
    Neurochem Res 23:141-8. 1998
    ....
  20. doi Autoantibodies: double agents in human disease
    Nimish K Acharya
    New Jersey Institute for Successful Aging, School of Osteopathic medicine SOM, University of Medicine and Dentistry of New Jersey UMDNJ, Stratford, NJ 08084, USA
    Sci Transl Med 5:186fs19. 2013
    ..this issue)...
  21. pmc Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration
    Jhon Alberto Ochoa-Alvarez
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America
    PLoS ONE 7:e41845. 2012
    ..These studies demonstrate how lectins may be used to help develop dietary agents that target specific receptors to combat malignant cell growth...
  22. ncbi Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat
    F F Sun
    Department of Cell Biology, School of Osteopathic Medicine, UMDNJ, Stratford, New Jersey 08084, USA
    Inflammation 25:33-45. 2001
    ..The data showed that the chronically inflamed tissue expresses a time-dependent changing pattern of TH1 cytokines and adhesion molecules that maintain the infiltration and activation of inflammatory cells and tissue injury...
  23. ncbi Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate
    Xun Li
    Molecular Biology Department, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    Cancer Sci 99:1326-33. 2008
    ....
  24. pmc A novel human hexameric DNA helicase: expression, purification and characterization
    E E Biswas
    Department of Molecular Biology, School of Osteopathic Medicine and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Science Center Room 305 A, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Nucleic Acids Res 29:1733-40. 2001
    ..The maximal level of hHcsA expression was observed in late G(1)/early S phase, suggesting a possible role for this protein during S phase and in DNA synthesis...
  25. ncbi SRC uses Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells
    Yongquan Shen
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Science Center, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Cancer Res 66:1543-52. 2006
    ....
  26. ncbi Negatively calcium-modulated membrane guanylate cyclase signaling system in the rat olfactory bulb
    T Duda
    Unit of Regulatory and Molecular Biology, Department of Cell Biology, NJMS and SOM, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    Biochemistry 40:4654-62. 2001
    ..The findings suggest a novel role for this system in the polarization and depolarization phenomena of mitral cells and also contradict the existing belief that no mGC besides GC-D exists in the olfactory neurons...
  27. ncbi Cerebellar diffuse amyloid plaques are derived from dendritic Abeta42 accumulations in Purkinje cells
    Hoau Yan Wang
    Department of Physiology and Pharmacology, The City University of New York Medical School, New York, New York 10031, USA
    Neurobiol Aging 23:213-23. 2002
    ....
  28. ncbi Lipofuscin and Abeta42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains
    Michael R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, PA 19477, USA
    Neurosci Lett 323:45-9. 2002
    ..Our results show separate and distinct localization patterns of Abeta42 and lipofuscin in neurons and amyloid plaques...
  29. ncbi Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex
    Michael R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA
    Neurosci Lett 333:163-6. 2002
    ..Detection of an abundant intracellular Abeta42 in neurons may provide alternate explanations for the origin of dense-core amyloid plaques in AD cortices other than the conventional chronic extracellular Abeta42 deposition hypothesis...
  30. ncbi Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons
    Michael R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Drug Discovery, Spring House, Pennsylvania, 19477, USA
    Curr Pharm Des 12:677-84. 2006
    ....