Virgil Muresan

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1
    Zoia Muresan
    Department of Physiology and Biophysics, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Cell Biol 171:615-25. 2005
  2. pmc Neuritic deposits of amyloid-beta peptide in a subpopulation of central nervous system-derived neuronal cells
    Zoia Muresan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Mol Cell Biol 26:4982-97. 2006
  3. pmc The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration
    Zoia Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Mol Biol Cell 18:3835-44. 2007
  4. pmc The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neurosci 29:3565-78. 2009
  5. pmc Unconventional functions of microtubule motors
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA
    Arch Biochem Biophys 520:17-29. 2012
  6. pmc A persistent stress response to impeded axonal transport leads to accumulation of amyloid-β in the endoplasmic reticulum, and is a probable cause of sporadic Alzheimer's disease
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07101 1709, USA
    Neurodegener Dis 10:60-3. 2012
  7. pmc No conventional function for the conventional kinesin?
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Traffic 9:1823-7. 2008
  8. pmc Seeding neuritic plaques from the distance: a possible role for brainstem neurons in the development of Alzheimer's disease pathology
    Zoia Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Neurodegener Dis 5:250-3. 2008
  9. ncbi c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein
    Zoia Muresan
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Neurosci 25:3741-51. 2005
  10. ncbi A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment
    Zoia Muresan
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4970, USA
    Hum Mol Genet 13:475-88. 2004

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1
    Zoia Muresan
    Department of Physiology and Biophysics, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Cell Biol 171:615-25. 2005
    ..These results indicate that the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP...
  2. pmc Neuritic deposits of amyloid-beta peptide in a subpopulation of central nervous system-derived neuronal cells
    Zoia Muresan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Mol Cell Biol 26:4982-97. 2006
    ..CAD cells appear to recapitulate the biochemical processes leading to Abeta deposition, thus providing an experimental in vitro system for studying the molecular pathobiology of AD...
  3. pmc The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration
    Zoia Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Mol Biol Cell 18:3835-44. 2007
    ..We conclude that distinct pathways of APP phosphorylation operate in proliferating, differentiating, stressed, and degenerating neurons...
  4. pmc The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neurosci 29:3565-78. 2009
    ....
  5. pmc Unconventional functions of microtubule motors
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA
    Arch Biochem Biophys 520:17-29. 2012
    ..Our goal is to provide an overview of these unexpected functions of microtubule motors, and to incite future research in this expanding field...
  6. pmc A persistent stress response to impeded axonal transport leads to accumulation of amyloid-β in the endoplasmic reticulum, and is a probable cause of sporadic Alzheimer's disease
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07101 1709, USA
    Neurodegener Dis 10:60-3. 2012
    ..When persistently activated, due to chronically slowed-down transport, this signaling pathway leads to accumulation of Aβ within the ER...
  7. pmc No conventional function for the conventional kinesin?
    Virgil Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Traffic 9:1823-7. 2008
    ..These novel findings let us wonder what the real function of kinesin-1--the most abundant motor in squid axons--actually is...
  8. pmc Seeding neuritic plaques from the distance: a possible role for brainstem neurons in the development of Alzheimer's disease pathology
    Zoia Muresan
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Neurodegener Dis 5:250-3. 2008
    ..The origin of this seed is unknown. Here, we focused on the events that might trigger the formation of neuritic plaques, aiming to explain how these plaques form in cortical and hippocampal regions...
  9. ncbi c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein
    Zoia Muresan
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Neurosci 25:3741-51. 2005
    ..Thus, APP phosphorylation, transport of the generated pAPP into neurites, and neurite extension are interdependent processes regulated by JIP-3/JNK, in a pathway distinct from stress-activated JNK signaling...
  10. ncbi A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment
    Zoia Muresan
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4970, USA
    Hum Mol Genet 13:475-88. 2004
    ..These results suggest that phosphorylated Cgamma accumulates at the SFC. Thus, APP may play a role in pre-mRNA splicing, and Fe65 and APP phosphorylation may regulate this function...

Research Grants6

  1. Molecular Motors in Transport and Signaling by APP
    Virgil Muresan; Fiscal Year: 2007
    ..This study should reveal key insights into a possible cross-talk between signaling pathways involving APP, JNK, and Cdk5, with implications for brain development and neurodegeneration. ..
  2. Molecular Motors in Transport and Signaling by APP
    Virgil Muresan; Fiscal Year: 2009
    ..This study should reveal key insights into a possible cross-talk between signaling pathways involving APP, JNK, and Cdk5, with implications for brain development and neurodegeneration. ..