John S Munger

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix
    John S Munger
    Department of Medicine, New York University, New York, New York 10016, USA
    Cold Spring Harb Perspect Biol 3:a005017. 2011
  2. pmc Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
    Poshala Aluwihare
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Sci 122:227-32. 2009
  3. doi request reprint TGFbeta1 and TGFbeta3 are partially redundant effectors in brain vascular morphogenesis
    Zhenyu Mu
    Department of Cell Biology, NYU Medical Center, 550 First Avenue, New York, NY 10016, USA
    Mech Dev 125:508-16. 2008
  4. pmc Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    J Cell Biol 165:723-34. 2004
  5. ncbi request reprint Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1
    Min Lu
    Pulmonary and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 115:4641-8. 2002
  6. ncbi request reprint Making sense of latent TGFbeta activation
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Cell Sci 116:217-24. 2003
  7. pmc Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis
    Khalid Puthawala
    New York University School of Medicine, Department of Medicine, New York, NY 10282, USA
    Am J Respir Crit Care Med 177:82-90. 2008
  8. pmc What the lung has taught us about latent TGF-beta activation
    Poshala Aluwihare
    New York University School of Medicine, New York, NY, USA
    Am J Respir Cell Mol Biol 39:499-502. 2008
  9. pmc Hedgehog signaling in neonatal and adult lung
    Li Liu
    Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY, USA
    Am J Respir Cell Mol Biol 48:703-10. 2013
  10. ncbi request reprint A genetic screen to identify latent transforming growth factor beta activators
    Justin Annes
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Anal Biochem 327:45-54. 2004

Collaborators

Detail Information

Publications13

  1. pmc Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix
    John S Munger
    Department of Medicine, New York University, New York, New York 10016, USA
    Cold Spring Harb Perspect Biol 3:a005017. 2011
    ..Mutant mice defective in integrin-mediated activators, and humans and mice with fibrillin gene mutations, show the critical role of ECM and integrins in regulating TGF-β signaling...
  2. pmc Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
    Poshala Aluwihare
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Sci 122:227-32. 2009
    ....
  3. doi request reprint TGFbeta1 and TGFbeta3 are partially redundant effectors in brain vascular morphogenesis
    Zhenyu Mu
    Department of Cell Biology, NYU Medical Center, 550 First Avenue, New York, NY 10016, USA
    Mech Dev 125:508-16. 2008
    ..Our results are consistent with a functional connection between TGFbeta1 and TGFbeta3 during development based on a shared mechanism of activation...
  4. pmc Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    J Cell Biol 165:723-34. 2004
    ....
  5. ncbi request reprint Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1
    Min Lu
    Pulmonary and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 115:4641-8. 2002
    ..These data strongly suggest that LAP-TGFbeta1 is a ligand of alpha8beta1 and interaction of alpha8beta1 with LAP-TGFbeta1 may influence cell behavior...
  6. ncbi request reprint Making sense of latent TGFbeta activation
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Cell Sci 116:217-24. 2003
    ..Such a view provides a logical continuity for various aspects of TGFbeta biology and allows us to appreciate TGFbeta biology from a new perspective...
  7. pmc Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis
    Khalid Puthawala
    New York University School of Medicine, Department of Medicine, New York, NY 10282, USA
    Am J Respir Crit Care Med 177:82-90. 2008
    ..Because the integrin alpha(v)beta6 is a major TGF-beta activator in the lung, inhibition of alpha(v)beta6-mediated TGF-beta activation is a logical strategy to treat lung fibrosis...
  8. pmc What the lung has taught us about latent TGF-beta activation
    Poshala Aluwihare
    New York University School of Medicine, New York, NY, USA
    Am J Respir Cell Mol Biol 39:499-502. 2008
  9. pmc Hedgehog signaling in neonatal and adult lung
    Li Liu
    Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY, USA
    Am J Respir Cell Mol Biol 48:703-10. 2013
    ..Our data provide strong evidence that Hh signaling can regulate lung stromal cell function in two critical scenarios: normal development in postnatal lung and lung fibrosis in adult lung...
  10. ncbi request reprint A genetic screen to identify latent transforming growth factor beta activators
    Justin Annes
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Anal Biochem 327:45-54. 2004
    ..The activator expressed by the positive clones can be identified by retrieval of the retrovirus cDNA insert...
  11. pmc Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice
    Zhiwei Yang
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 176:787-93. 2007
    ..These findings indicate that RGD-binding integrins are requisite latent TGFbeta1 activators during development and in the immune system...
  12. ncbi request reprint Transforming growth factor beta signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition
    Trilok V Parekh
    Department of Pathology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cancer Res 62:2778-90. 2002
    ....
  13. ncbi request reprint The integrin alphaVbeta6 binds and activates latent TGFbeta3
    Justin P Annes
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    FEBS Lett 511:65-8. 2002
    ..In particular, the extent to which activation mechanisms differ among the three TGFbeta isoforms is relatively unexplored. We show here that alphaVbeta6 binds and activates latent TGFbeta3...