Lisa Mosconi

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD
    Lisa Mosconi
    Department of Clinical Pathophysiology, University of Florence, Italy
    Eur J Nucl Med Mol Imaging 32:486-510. 2005
  2. pmc Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Ann N Y Acad Sci 1147:180-95. 2008
  3. pmc A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
    Einar M Sigurdsson
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:836-47. 2008
  4. doi request reprint The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease
    Barry Reisberg
    Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
    Alzheimers Dement 4:S98-S108. 2008
  5. pmc Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease
    L Mosconi
    Department of Psychiatry, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neurology 72:513-20. 2009
  6. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008
  7. ncbi request reprint (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 48:1129-34. 2007
  8. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
  9. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
  10. pmc Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:5949-54. 2010

Detail Information

Publications45

  1. ncbi request reprint Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD
    Lisa Mosconi
    Department of Clinical Pathophysiology, University of Florence, Italy
    Eur J Nucl Med Mol Imaging 32:486-510. 2005
    ..All told, there is considerable promise that early and specific diagnosis is feasible through a combination of imaging modalities...
  2. pmc Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Ann N Y Acad Sci 1147:180-95. 2008
    ..The present paper reviews findings that implicate hypometabolism and oxidative stress as crucial players in the initiation and progression of synaptic pathology in AD...
  3. pmc A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
    Einar M Sigurdsson
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:836-47. 2008
    ..3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models...
  4. doi request reprint The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease
    Barry Reisberg
    Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
    Alzheimers Dement 4:S98-S108. 2008
    ..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons...
  5. pmc Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease
    L Mosconi
    Department of Psychiatry, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neurology 72:513-20. 2009
    ..This longitudinal FDG-PET study examines whether CMRglc reductions in NL subjects with a maternal history of AD are progressive...
  6. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008
    ....
  7. ncbi request reprint (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 48:1129-34. 2007
    ..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)...
  8. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  9. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  10. pmc Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:5949-54. 2010
    ..Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD...
  11. ncbi request reprint Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York, USA
    J Nucl Med 47:1778-86. 2006
    ....
  12. ncbi request reprint Early detection of Alzheimer's disease using neuroimaging
    Lisa Mosconi
    Center for Brain Health MHL 400, New York University School of Medicine, 560 1st Avenue, New York, NY 10016, USA
    Exp Gerontol 42:129-38. 2007
    ..Overall, these studies show that the use of imaging for the early detection of AD is successful even in the earlier stages of disease when clinical symptoms are not fully expressed and the regional brain damage may be limited...
  13. pmc Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:19067-72. 2007
    ..No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals...
  14. ncbi request reprint Magnetic resonance and PET studies in the early diagnosis of Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, Center for Brain Health, 560 First Avenue, NY 10016, USA
    Expert Rev Neurother 4:831-49. 2004
    ..It is concluded that there is considerable promise for an early and specific diagnosis for Alzheimer's disease by combining information from imaging and biomarker modalities...
  15. pmc FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 36:811-22. 2009
    ....
  16. pmc Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly
    Lidia Glodzik
    Department of Psychiatry, Center for Brain Health, New York University School of Medicine, New York, NY, USA Department of Radiology, New York University School of Medicine, New York, NY, USA Electronic address
    Neurobiol Aging 35:64-71. 2014
    ..50, p = 0.01) and an increase in p-tau(181) (β = -0.50, p = 0.01) only in subjects with HTN. Our findings suggest that the hypertensive group may be sensitive to BP reductions...
  17. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
    ..The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study...
  18. pmc Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Miroslaw Brys
    New York University School of Medicine, NY, USA
    Neurobiol Aging 30:682-90. 2009
    ..To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)...
  19. pmc Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders
    Lidia Glodzik
    Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
    Neurobiol Aging 32:2131-41. 2011
    ....
  20. pmc Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease
    Miroslaw Brys
    New York University School of Medicine, Center for Brain Health, NY 10016, USA
    J Alzheimers Dis 16:351-62. 2009
    ..05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia...
  21. pmc Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
    J Alzheimers Dis 18:509-13. 2009
    ..No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group...
  22. ncbi request reprint Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study
    Lisa Mosconi
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Psychiatry Res 130:141-51. 2004
    ..These results indicate that age-related regional rCMRglu decreases within the frontal and anterior cingulate areas may be more severe in AD patients carrying the ApoE4 allele...
  23. pmc Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
    Lidia Glodzik
    Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:1215-27. 2012
    ..In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage...
  24. pmc Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 34:22-34. 2013
    ..NH and ≥ 71% for MH vs. PH, with relative risk = 1.9-5.1 (p values < 0.005). NL individuals with AD-affected mothers show co-occurring Aβ increases and hypometabolism in AD-vulnerable regions, suggesting an increased risk for AD...
  25. pmc Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 68:913-21. 2010
    ..With a panel of cerebrospinal fluid (CSF) markers, this study examined whether NL MH showed evidence for AD pathology compared with PH and NH...
  26. ncbi request reprint The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neuroimaging Clin N Am 15:803-26, x. 2005
    ..The last section describes problems encountered in the differential diagnosis...
  27. pmc Hippocampal hypometabolism predicts cognitive decline from normal aging
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:676-92. 2008
    ..This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging...
  28. pmc Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    J Cereb Blood Flow Metab 31:671-9. 2011
    ..6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume...
  29. pmc Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
    Susan De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuropsychology 22:469-84. 2008
    ..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions...
  30. pmc Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:624.e1-9. 2012
    ..There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD...
  31. pmc Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
    Yi Li
    New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 35:2169-81. 2008
    ....
  32. pmc Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 27:483-90. 2011
    ..The association between maternal history of LOAD and systemic COX reductions suggests transmission via mitochondrial DNA, which is exclusively maternally inherited in humans...
  33. pmc Structural brain changes in normal individuals with a maternal history of Alzheimer's
    Valentina Berti
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 32:2325.e17-26. 2011
    ..Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals...
  34. pmc Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Hum Genomics 4:170-93. 2010
    ..The review concludes with a discussion of the potential role of brain imaging for identifying endophenotypes in NL individuals at risk for AD, and for directing investigation of potential susceptibility genes for AD...
  35. pmc An entorhinal cortex sulcal pattern is associated with Alzheimer's disease
    Jiong Zhan
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Hum Brain Mapp 30:874-82. 2009
    ..We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (2) associated with a smaller EC size...
  36. ncbi request reprint Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 33:210-21. 2006
    ..This study was designed to examine the utility of visual inspection of medial temporal lobe (MTL) metabolism in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using FDG-PET scans...
  37. pmc Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 20:843-54. 2010
    ..We then briefly review brain Abeta PET imaging studies in AD and discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Abeta-PET to improve the early detection of AD...
  38. ncbi request reprint Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease
    Lisa Mosconi
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy
    J Nucl Med 45:382-92. 2004
    ..This (18)F-FDG PET study assessed the functional interactions-that is, the intercorrelations between the EC and the whole brain in vivo-in normal aging and AD...
  39. ncbi request reprint Toward the validation of functional neuroimaging as a potential biomarker for Alzheimer's disease: implications for drug development
    Alberto Pupi
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Mol Imaging Biol 7:59-68. 2005
    ..However, a thorough analysis combining functional and neuropsychological data has not yet been attempted, and much research is needed to validate the role of FNI as a surrogate endpoint for AD clinical trials...
  40. ncbi request reprint Cerebrospinal fluid biomarkers of Alzheimer's disease in healthy elderly
    Catherine Randall
    Center for Brain Health, New York, NY 10016, USA
    Front Biosci (Landmark Ed) 18:1150-73. 2013
    ..We conducted a review of studies published between 1993 and 2011 and summarized their findings on the role of CSF biomarkers for AD in healthy elderly...
  41. pmc Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies
    Rachel Mistur
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    J Clin Neurol 5:153-66. 2009
    ..Finally, we will discuss the potential to combine different PET tracers and CSF markers of pathology to improve the early detection of AD...
  42. pmc PET/CT in diagnosis of dementia
    Valentina Berti
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Florence, Italy
    Ann N Y Acad Sci 1228:81-92. 2011
    ..In conclusion, PET imaging with different tracers offers reliable biomarkers in dementia, which can assist clinicians in the diagnosis of different dementing disorders, especially in the situation of overlapping phenotypes...
  43. pmc PET/CT in diagnosis of movement disorders
    Valentina Berti
    Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Florence, Italy
    Ann N Y Acad Sci 1228:93-108. 2011
    ....
  44. ncbi request reprint Seeing what Alzheimer saw
    Mony J de Leon
    Nat Med 13:129-31. 2007
  45. doi request reprint Positron emission tomography scans obtained for the evaluation of cognitive dysfunction
    Daniel H S Silverman
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Semin Nucl Med 38:251-61. 2008
    ....

Research Grants2

  1. Maternal history of Alzheimer's predisposes children to amyloid beta-related hy
    Lisa Mosconi; Fiscal Year: 2010
    ..This project will test the hypothesis that hypometabolism in children of AD-mothers is due to a combination of systemically increased oxidative stress from the mitochondria and increasing amyloid-beta deposition. ..