Research Topics
Species | Lisa MosconiSummaryAffiliation: New York University Country: USA Publications
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Publications
Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and ADLisa Mosconi
Department of Clinical Pathophysiology, University of Florence, Italy
Eur J Nucl Med Mol Imaging 32:486-510. 2005..All told, there is considerable promise that early and specific diagnosis is feasible through a combination of imaging modalities...
Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Ann N Y Acad Sci 1147:180-95. 2008..The present paper reviews findings that implicate hypometabolism and oxidative stress as crucial players in the initiation and progression of synaptic pathology in AD...- A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic miceEinar M Sigurdsson
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 29:836-47. 2008..3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models... 
The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's diseaseBarry Reisberg
Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
Alzheimers Dement 4:S98-S108. 2008..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons...- Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer'sLisa Mosconi
New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 107:5949-54. 2010..Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD... - Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementiasLisa Mosconi
Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
J Nucl Med 49:390-8. 2008.... - Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolismLisa Mosconi
Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 104:19067-72. 2007..No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals... - FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 36:811-22. 2009.... - Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaintsLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Biol Psychiatry 63:609-18. 2008.... - (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's diseaseLisa Mosconi
New York University School of Medicine, New York, New York 10016, USA
J Nucl Med 48:1129-34. 2007..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)... - Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's diseaseLisa Mosconi
Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 34:1467-79. 2007.... - Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer diseaseL Mosconi
Department of Psychiatry, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
Neurology 72:513-20. 2009..This longitudinal FDG-PET study examines whether CMRglc reductions in NL subjects with a maternal history of AD are progressive... - Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, New York, USA
J Nucl Med 47:1778-86. 2006.... - Early detection of Alzheimer's disease using neuroimagingLisa Mosconi
Center for Brain Health MHL 400, New York University School of Medicine, 560 1st Avenue, New York, NY 10016, USA
Exp Gerontol 42:129-38. 2007..Overall, these studies show that the use of imaging for the early detection of AD is successful even in the earlier stages of disease when clinical symptoms are not fully expressed and the regional brain damage may be limited... - Magnetic resonance and PET studies in the early diagnosis of Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, Center for Brain Health, 560 First Avenue, NY 10016, USA
Expert Rev Neurother 4:831-49. 2004..It is concluded that there is considerable promise for an early and specific diagnosis for Alzheimer's disease by combining information from imaging and biomarker modalities... - The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's diseaseLidia Glodzik-Sobanska
New York University School of Medicine, New York, NY 10016, United States
Neurobiol Aging 30:672-81. 2009..The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study... - Prediction and longitudinal study of CSF biomarkers in mild cognitive impairmentMiroslaw Brys
New York University School of Medicine, NY, USA
Neurobiol Aging 30:682-90. 2009..To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)... - Phosphorylated tau 231, memory decline and medial temporal atrophy in normal eldersLidia Glodzik
Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
Neurobiol Aging 32:2131-41. 2011.... - Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's diseaseMiroslaw Brys
New York University School of Medicine, Center for Brain Health, NY 10016, USA
J Alzheimers Dis 16:351-62. 2009..05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia... - Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathologyLidia Glodzik
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
J Alzheimers Dis 18:509-13. 2009..No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group... - Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET studyLisa Mosconi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Psychiatry Res 130:141-51. 2004..These results indicate that age-related regional rCMRglu decreases within the frontal and anterior cingulate areas may be more severe in AD patients carrying the ApoE4 allele... - Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parentsLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 34:22-34. 2013..NH and ≥ 71% for MH vs. PH, with relative risk = 1.9-5.1 (p values < 0.005). NL individuals with AD-affected mothers show co-occurring Aβ increases and hypometabolism in AD-vulnerable regions, suggesting an increased risk for AD... - Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer'sLisa Mosconi
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Biol Psychiatry 68:913-21. 2010..With a panel of cerebrospinal fluid (CSF) markers, this study examined whether NL MH showed evidence for AD pathology compared with PH and NH... - The role of quantitative structural imaging in the early diagnosis of Alzheimer's diseaseLidia Glodzik-Sobanska
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Neuroimaging Clin N Am 15:803-26, x. 2005..The last section describes problems encountered in the differential diagnosis... - Hippocampal hypometabolism predicts cognitive decline from normal agingLisa Mosconi
New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 29:676-92. 2008..This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging... - Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive declineSusan De Santi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neuropsychology 22:469-84. 2008..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions... - Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapniaLidia Glodzik
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
J Cereb Blood Flow Metab 31:671-9. 2011..6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume... - Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's diseaseLisa Mosconi
New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 33:624.e1-9. 2012..There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD... - Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's diseaseYi Li
New York University School of Medicine, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 35:2169-81. 2008.... - Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's diseaseLisa Mosconi
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
J Alzheimers Dis 27:483-90. 2011..The association between maternal history of LOAD and systemic COX reductions suggests transmission via mitochondrial DNA, which is exclusively maternally inherited in humans... - Structural brain changes in normal individuals with a maternal history of Alzheimer'sValentina Berti
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 32:2325.e17-26. 2011..Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals... - Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genesLisa Mosconi
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Hum Genomics 4:170-93. 2010..The review concludes with a discussion of the potential role of brain imaging for identifying endophenotypes in NL individuals at risk for AD, and for directing investigation of potential susceptibility genes for AD... - An entorhinal cortex sulcal pattern is associated with Alzheimer's diseaseJiong Zhan
Department of Psychiatry, New York University School of Medicine, New York 10016, USA
Hum Brain Mapp 30:874-82. 2009..We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (2) associated with a smaller EC size... - Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PETLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 33:210-21. 2006..We suggest this method be further evaluated for its potential in the early diagnosis of AD... - Alzheimer's disease markers, hypertension, and gray matter damage in normal elderlyLidia Glodzik
Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 33:1215-27. 2012..In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage... - Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imagingLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
J Alzheimers Dis 20:843-54. 2010..We then briefly review brain Abeta PET imaging studies in AD and discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Abeta-PET to improve the early detection of AD... - Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's diseaseLisa Mosconi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy
J Nucl Med 45:382-92. 2004.... - Toward the validation of functional neuroimaging as a potential biomarker for Alzheimer's disease: implications for drug developmentAlberto Pupi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
Mol Imaging Biol 7:59-68. 2005..However, a thorough analysis combining functional and neuropsychological data has not yet been attempted, and much research is needed to validate the role of FNI as a surrogate endpoint for AD clinical trials... - Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF StudiesRachel Mistur
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
J Clin Neurol 5:153-66. 2009..Finally, we will discuss the potential to combine different PET tracers and CSF markers of pathology to improve the early detection of AD... - PET/CT in diagnosis of dementiaValentina Berti
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Florence, Italy
Ann N Y Acad Sci 1228:81-92. 2011..In conclusion, PET imaging with different tracers offers reliable biomarkers in dementia, which can assist clinicians in the diagnosis of different dementing disorders, especially in the situation of overlapping phenotypes... - PET/CT in diagnosis of movement disordersValentina Berti
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Florence, Italy
Ann N Y Acad Sci 1228:93-108. 2011.... - Seeing what Alzheimer sawMony J de Leon
Nat Med 13:129-31. 2007 - Positron emission tomography scans obtained for the evaluation of cognitive dysfunctionDaniel H S Silverman
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Semin Nucl Med 38:251-61. 2008....
Research Grants
- Maternal history of Alzheimer's predisposes children to amyloid beta-related hyLisa Mosconi; Fiscal Year: 2010..This project will test the hypothesis that hypometabolism in children of AD-mothers is due to a combination of systemically increased oxidative stress from the mitochondria and increasing amyloid-beta deposition. ..