Lisa Mosconi

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. doi request reprint Comparing brain amyloid deposition, glucose metabolism, and atrophy in mild cognitive impairment with and without a family history of dementia
    Lisa Mosconi
    Abiant Inc, Grayslake, IL, USA
    J Alzheimers Dis 35:509-24. 2013
  2. pmc Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 34:22-34. 2013
  3. pmc Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 27:483-90. 2011
  4. pmc Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:624.e1-9. 2012
  5. pmc FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts?
    L Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Q J Nucl Med Mol Imaging 55:250-64. 2011
  6. pmc Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 68:913-21. 2010
  7. pmc Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Hum Genomics 4:170-93. 2010
  8. pmc Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 20:843-54. 2010
  9. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
  10. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008

Detail Information

Publications38

  1. doi request reprint Comparing brain amyloid deposition, glucose metabolism, and atrophy in mild cognitive impairment with and without a family history of dementia
    Lisa Mosconi
    Abiant Inc, Grayslake, IL, USA
    J Alzheimers Dis 35:509-24. 2013
    ..While all three biomarkers were abnormal in MCI compared to controls, Aβ deposition was the most prominent abnormality, with MCI MH having the greatest degree of co-occurring hypometabolism...
  2. pmc Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 34:22-34. 2013
    ..NH and ≥ 71% for MH vs. PH, with relative risk = 1.9-5.1 (p values < 0.005). NL individuals with AD-affected mothers show co-occurring Aβ increases and hypometabolism in AD-vulnerable regions, suggesting an increased risk for AD...
  3. pmc Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 27:483-90. 2011
    ..The association between maternal history of LOAD and systemic COX reductions suggests transmission via mitochondrial DNA, which is exclusively maternally inherited in humans...
  4. pmc Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:624.e1-9. 2012
    ..There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD...
  5. pmc FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts?
    L Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Q J Nucl Med Mol Imaging 55:250-64. 2011
    ..We then discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Aβ-PET to improve the early detection of AD...
  6. pmc Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 68:913-21. 2010
    ..With a panel of cerebrospinal fluid (CSF) markers, this study examined whether NL MH showed evidence for AD pathology compared with PH and NH...
  7. pmc Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Hum Genomics 4:170-93. 2010
    ..The review concludes with a discussion of the potential role of brain imaging for identifying endophenotypes in NL individuals at risk for AD, and for directing investigation of potential susceptibility genes for AD...
  8. pmc Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 20:843-54. 2010
    ..We then briefly review brain Abeta PET imaging studies in AD and discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Abeta-PET to improve the early detection of AD...
  9. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
    ..The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study...
  10. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008
    ....
  11. pmc Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Miroslaw Brys
    New York University School of Medicine, NY, USA
    Neurobiol Aging 30:682-90. 2009
    ..To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)...
  12. pmc Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders
    Lidia Glodzik
    Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
    Neurobiol Aging 32:2131-41. 2011
    ....
  13. pmc Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease
    Miroslaw Brys
    New York University School of Medicine, Center for Brain Health, NY 10016, USA
    J Alzheimers Dis 16:351-62. 2009
    ..05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia...
  14. pmc Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:5949-54. 2010
    ..Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD...
  15. pmc Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:19067-72. 2007
    ..No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals...
  16. pmc Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
    Lidia Glodzik
    Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:1215-27. 2012
    ..In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage...
  17. pmc Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
    J Alzheimers Dis 18:509-13. 2009
    ..No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group...
  18. pmc FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 36:811-22. 2009
    ....
  19. pmc Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    J Cereb Blood Flow Metab 31:671-9. 2011
    ..6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume...
  20. pmc Hippocampal hypometabolism predicts cognitive decline from normal aging
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:676-92. 2008
    ..This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging...
  21. ncbi request reprint Early detection of Alzheimer's disease using neuroimaging
    Lisa Mosconi
    Center for Brain Health MHL 400, New York University School of Medicine, 560 1st Avenue, New York, NY 10016, USA
    Exp Gerontol 42:129-38. 2007
    ..Overall, these studies show that the use of imaging for the early detection of AD is successful even in the earlier stages of disease when clinical symptoms are not fully expressed and the regional brain damage may be limited...
  22. pmc Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
    Susan De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuropsychology 22:469-84. 2008
    ..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions...
  23. pmc Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
    Yi Li
    New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 35:2169-81. 2008
    ....
  24. pmc Structural brain changes in normal individuals with a maternal history of Alzheimer's
    Valentina Berti
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 32:2325.e17-26. 2011
    ..Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals...
  25. ncbi request reprint The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neuroimaging Clin N Am 15:803-26, x. 2005
    ..The last section describes problems encountered in the differential diagnosis...
  26. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  27. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  28. ncbi request reprint (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 48:1129-34. 2007
    ..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)...
  29. pmc Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly
    Lidia Glodzik
    Department of Psychiatry, Center for Brain Health, New York University School of Medicine, New York, NY, USA Department of Radiology, New York University School of Medicine, New York, NY, USA Electronic address
    Neurobiol Aging 35:64-71. 2014
    ..50, p = 0.01) and an increase in p-tau(181) (β = -0.50, p = 0.01) only in subjects with HTN. Our findings suggest that the hypertensive group may be sensitive to BP reductions...
  30. ncbi request reprint Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 33:210-21. 2006
    ..This study was designed to examine the utility of visual inspection of medial temporal lobe (MTL) metabolism in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using FDG-PET scans...
  31. pmc An entorhinal cortex sulcal pattern is associated with Alzheimer's disease
    Jiong Zhan
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Hum Brain Mapp 30:874-82. 2009
    ..We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (2) associated with a smaller EC size...
  32. ncbi request reprint Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York, USA
    J Nucl Med 47:1778-86. 2006
    ....
  33. doi request reprint The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease
    Barry Reisberg
    Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
    Alzheimers Dement 4:S98-S108. 2008
    ..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons...
  34. ncbi request reprint Cerebrospinal fluid biomarkers of Alzheimer's disease in healthy elderly
    Catherine Randall
    Center for Brain Health, New York, NY 10016, USA
    Front Biosci (Landmark Ed) 18:1150-73. 2013
    ..We conducted a review of studies published between 1993 and 2011 and summarized their findings on the role of CSF biomarkers for AD in healthy elderly...
  35. pmc Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Ann N Y Acad Sci 1147:180-95. 2008
    ..The present paper reviews findings that implicate hypometabolism and oxidative stress as crucial players in the initiation and progression of synaptic pathology in AD...
  36. pmc Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies
    Rachel Mistur
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    J Clin Neurol 5:153-66. 2009
    ..Finally, we will discuss the potential to combine different PET tracers and CSF markers of pathology to improve the early detection of AD...
  37. ncbi request reprint Magnetic resonance and PET studies in the early diagnosis of Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, Center for Brain Health, 560 First Avenue, NY 10016, USA
    Expert Rev Neurother 4:831-49. 2004
    ..It is concluded that there is considerable promise for an early and specific diagnosis for Alzheimer's disease by combining information from imaging and biomarker modalities...
  38. pmc A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
    Einar M Sigurdsson
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:836-47. 2008
    ..3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models...