Research Topics
Species | Lisa MosconiSummaryAffiliation: New York University School of Medicine Country: USA Publications
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Detail Information
Publications
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parentsLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 34:22-34. 2013..NH and ≥ 71% for MH vs. PH, with relative risk = 1.9-5.1 (p values < 0.005). NL individuals with AD-affected mothers show co-occurring Aβ increases and hypometabolism in AD-vulnerable regions, suggesting an increased risk for AD...- Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's diseaseLisa Mosconi
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
J Alzheimers Dis 27:483-90. 2011..The association between maternal history of LOAD and systemic COX reductions suggests transmission via mitochondrial DNA, which is exclusively maternally inherited in humans... - Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's diseaseLisa Mosconi
New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 33:624.e1-9. 2012..There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD... - FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts?L Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Q J Nucl Med Mol Imaging 55:250-64. 2011..We then discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Aβ-PET to improve the early detection of AD... - Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer'sLisa Mosconi
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Biol Psychiatry 68:913-21. 2010..With a panel of cerebrospinal fluid (CSF) markers, this study examined whether NL MH showed evidence for AD pathology compared with PH and NH... - Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genesLisa Mosconi
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Hum Genomics 4:170-93. 2010..The review concludes with a discussion of the potential role of brain imaging for identifying endophenotypes in NL individuals at risk for AD, and for directing investigation of potential susceptibility genes for AD... - Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imagingLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
J Alzheimers Dis 20:843-54. 2010..We then briefly review brain Abeta PET imaging studies in AD and discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Abeta-PET to improve the early detection of AD... - The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's diseaseLidia Glodzik-Sobanska
New York University School of Medicine, New York, NY 10016, United States
Neurobiol Aging 30:672-81. 2009..The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study... - Prediction and longitudinal study of CSF biomarkers in mild cognitive impairmentMiroslaw Brys
New York University School of Medicine, NY, USA
Neurobiol Aging 30:682-90. 2009..To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)... - Phosphorylated tau 231, memory decline and medial temporal atrophy in normal eldersLidia Glodzik
Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
Neurobiol Aging 32:2131-41. 2011.... - Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaintsLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Biol Psychiatry 63:609-18. 2008.... - Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's diseaseMiroslaw Brys
New York University School of Medicine, Center for Brain Health, NY 10016, USA
J Alzheimers Dis 16:351-62. 2009..05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia... - Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer'sLisa Mosconi
New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 107:5949-54. 2010..Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD... - Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolismLisa Mosconi
Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 104:19067-72. 2007..No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals... - Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathologyLidia Glodzik
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
J Alzheimers Dis 18:509-13. 2009..No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group... - FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 36:811-22. 2009.... - Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapniaLidia Glodzik
Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
J Cereb Blood Flow Metab 31:671-9. 2011..6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume... - Hippocampal hypometabolism predicts cognitive decline from normal agingLisa Mosconi
New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 29:676-92. 2008..This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging... 
Early detection of Alzheimer's disease using neuroimagingLisa Mosconi
Center for Brain Health MHL 400, New York University School of Medicine, 560 1st Avenue, New York, NY 10016, USA
Exp Gerontol 42:129-38. 2007..Overall, these studies show that the use of imaging for the early detection of AD is successful even in the earlier stages of disease when clinical symptoms are not fully expressed and the regional brain damage may be limited...- Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive declineSusan De Santi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neuropsychology 22:469-84. 2008..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions... - Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's diseaseYi Li
New York University School of Medicine, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 35:2169-81. 2008.... - Structural brain changes in normal individuals with a maternal history of Alzheimer'sValentina Berti
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 32:2325.e17-26. 2011..Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals... - The role of quantitative structural imaging in the early diagnosis of Alzheimer's diseaseLidia Glodzik-Sobanska
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Neuroimaging Clin N Am 15:803-26, x. 2005..The last section describes problems encountered in the differential diagnosis... - Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's diseaseLisa Mosconi
Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 34:1467-79. 2007.... 
Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementiasLisa Mosconi
Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
J Nucl Med 49:390-8. 2008....- Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PETLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Eur J Nucl Med Mol Imaging 33:210-21. 2006..We suggest this method be further evaluated for its potential in the early diagnosis of AD... - Alzheimer's disease markers, hypertension, and gray matter damage in normal elderlyLidia Glodzik
Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 33:1215-27. 2012..In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage... - An entorhinal cortex sulcal pattern is associated with Alzheimer's diseaseJiong Zhan
Department of Psychiatry, New York University School of Medicine, New York 10016, USA
Hum Brain Mapp 30:874-82. 2009..We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (2) associated with a smaller EC size... - (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's diseaseLisa Mosconi
New York University School of Medicine, New York, New York 10016, USA
J Nucl Med 48:1129-34. 2007..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)... - Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, New York, USA
J Nucl Med 47:1778-86. 2006.... - The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's diseaseBarry Reisberg
Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
Alzheimers Dement 4:S98-S108. 2008..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons... - Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Ann N Y Acad Sci 1147:180-95. 2008..The present paper reviews findings that implicate hypometabolism and oxidative stress as crucial players in the initiation and progression of synaptic pathology in AD... - Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF StudiesRachel Mistur
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
J Clin Neurol 5:153-66. 2009..Finally, we will discuss the potential to combine different PET tracers and CSF markers of pathology to improve the early detection of AD... - Magnetic resonance and PET studies in the early diagnosis of Alzheimer's diseaseLisa Mosconi
Department of Psychiatry, New York University School of Medicine, Center for Brain Health, 560 First Avenue, NY 10016, USA
Expert Rev Neurother 4:831-49. 2004..It is concluded that there is considerable promise for an early and specific diagnosis for Alzheimer's disease by combining information from imaging and biomarker modalities... - A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic miceEinar M Sigurdsson
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neurobiol Aging 29:836-47. 2008..3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models...