Richard D Morgan

Summary

Affiliation: New England Biolabs
Country: USA

Publications

  1. pmc MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protection
    Richard D Morgan
    New England Biolabs Inc, Ipswich, MA and MCB Department, Brown University, Providence, RI, USA
    Nucleic Acids Res 36:6558-70. 2008
  2. pmc Rational engineering of type II restriction endonuclease DNA binding and cleavage specificity
    Richard D Morgan
    New England Biolabs, Inc, Ipswich, MA 01938, USA
    Nucleic Acids Res 37:5222-33. 2009
  3. pmc The MmeI family: type II restriction-modification enzymes that employ single-strand modification for host protection
    Richard D Morgan
    New England Biolabs, Inc, Ipswich, MA 01938, USA
    Nucleic Acids Res 37:5208-21. 2009
  4. pmc The complex methylome of the human gastric pathogen Helicobacter pylori
    Juliane Krebes
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany, German Center for Infection Research, Hannover Braunschweig Site, Carl Neuberg Strase 1, 30625 Hannover, Germany, New England Biolabs, 240 County Road, Ipswich, MA 01938, USA, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany and Pacific Biosciences, 1380 Willow Road, Menlo Park, CA 94025, USA
    Nucleic Acids Res 42:2415-32. 2014
  5. pmc The methylomes of six bacteria
    Iain A Murray
    New England Biolabs, 240 County Road, Ipswich, MA 01938, USA
    Nucleic Acids Res 40:11450-62. 2012
  6. pmc Engineering a rare-cutting restriction enzyme: genetic screening and selection of NotI variants
    James C Samuelson
    New England Biolabs, Inc 240 County Road, Ipswich, MA 01938, USA
    Nucleic Acids Res 34:796-805. 2006
  7. pmc Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
    Tyson A Clark
    Pacific Biosciences, 1380 Willow Road, Menlo Park, CA 94025, USA
    Nucleic Acids Res 40:e29. 2012
  8. pmc A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes
    Richard J Roberts
    New England Biolabs, Beverly, MA 01915, USA
    Nucleic Acids Res 31:1805-12. 2003
  9. pmc Using shotgun sequence data to find active restriction enzyme genes
    Yu Zheng
    New England Biolabs, Inc, 240 County Road, Ipswich, MA 01938, USA
    Nucleic Acids Res 37:e1. 2009

Detail Information

Publications9

  1. pmc MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protection
    Richard D Morgan
    New England Biolabs Inc, Ipswich, MA and MCB Department, Brown University, Providence, RI, USA
    Nucleic Acids Res 36:6558-70. 2008
    ..The MmeI architecture represents a minimal approach to assembling a restriction-modification system wherein a single DNA recognition domain targets both the endonuclease and DNA methyltransferase activities...
  2. pmc Rational engineering of type II restriction endonuclease DNA binding and cleavage specificity
    Richard D Morgan
    New England Biolabs, Inc, Ipswich, MA 01938, USA
    Nucleic Acids Res 37:5222-33. 2009
    ..The findings suggest a simple mechanism for the evolution of new DNA specificity in Nature...
  3. pmc The MmeI family: type II restriction-modification enzymes that employ single-strand modification for host protection
    Richard D Morgan
    New England Biolabs, Inc, Ipswich, MA 01938, USA
    Nucleic Acids Res 37:5208-21. 2009
    ....
  4. pmc The complex methylome of the human gastric pathogen Helicobacter pylori
    Juliane Krebes
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany, German Center for Infection Research, Hannover Braunschweig Site, Carl Neuberg Strase 1, 30625 Hannover, Germany, New England Biolabs, 240 County Road, Ipswich, MA 01938, USA, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany and Pacific Biosciences, 1380 Willow Road, Menlo Park, CA 94025, USA
    Nucleic Acids Res 42:2415-32. 2014
    ..pylori strains will provide a valuable resource for future studies investigating the role of H. pylori R-M systems in limiting transformation as well as in gene regulation and host interaction. ..
  5. pmc The methylomes of six bacteria
    Iain A Murray
    New England Biolabs, 240 County Road, Ipswich, MA 01938, USA
    Nucleic Acids Res 40:11450-62. 2012
    ....
  6. pmc Engineering a rare-cutting restriction enzyme: genetic screening and selection of NotI variants
    James C Samuelson
    New England Biolabs, Inc 240 County Road, Ipswich, MA 01938, USA
    Nucleic Acids Res 34:796-805. 2006
    ..2 x 10(4) U/mg, a 32-fold increase over variant E156K. A comprehensive analysis indicates that the cleavage specificity of M91V/E156K is relaxed to a small set of 8 bp substrates while retaining activity towards the NotI sequence...
  7. pmc Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
    Tyson A Clark
    Pacific Biosciences, 1380 Willow Road, Menlo Park, CA 94025, USA
    Nucleic Acids Res 40:e29. 2012
    ..In addition, we also find evidence of unanticipated MTase promiscuity with some enzymes apparently also modifying sequences that are related, but not identical, to the cognate site...
  8. pmc A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes
    Richard J Roberts
    New England Biolabs, Beverly, MA 01915, USA
    Nucleic Acids Res 31:1805-12. 2003
    ..It provides explicit categories for the many different Type II enzymes now identified and provides a system for naming the putative genes found by sequence analysis of microbial genomes...
  9. pmc Using shotgun sequence data to find active restriction enzyme genes
    Yu Zheng
    New England Biolabs, Inc, 240 County Road, Ipswich, MA 01938, USA
    Nucleic Acids Res 37:e1. 2009
    ..Active restriction enzyme genes have been identified, and their activity demonstrated biochemically, in the sequenced genomes of Methanocaldococcus jannaschii, Bacillus cereus ATCC 10987 and Methylococcus capsulatus...