I Mohr

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
    I Mohr
    Department of Microbiology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Virol 75:5189-96. 2001
  2. pmc Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells
    Derek Walsh
    Department of Microbiology, NYU Cancer Institute, New York, New York 10016, USA
    J Virol 79:8057-64. 2005
  3. pmc Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor
    Matthew Mulvey
    Department of Microbiology, NYU School of Medicine, MSB214, 550 First Avenue, New York, NY 10016, USA
    J Virol 81:3377-90. 2007
  4. doi request reprint Host translation at the nexus of infection and immunity
    Ian Mohr
    Department of Microbiology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 12:470-83. 2012
  5. ncbi request reprint Neutralizing innate host defenses to control viral translation in HSV-1 infected cells
    Ian Mohr
    New York University School of Medicine, Department of Microbiology, MSB 214, New York, New York 10016, USA
    Int Rev Immunol 23:199-220. 2004
  6. ncbi request reprint Genetic metamorphosis of herpes simplex virus-1 into a biological therapeutic for human cancer
    Ian Mohr
    New York University School of Medicine, Department of Microbiology, 550 First Avenue, New York, NY 10016, USA
    Expert Opin Biol Ther 3:113-25. 2003
  7. ncbi request reprint To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control
    Ian Mohr
    Department of Microbiology, New York University School of Medicine, NY 10016, USA
    Oncogene 24:7697-709. 2005
  8. ncbi request reprint Phosphorylation and dephosphorylation events that regulate viral mRNA translation
    Ian Mohr
    Department of Microbiology, MSB 214, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Virus Res 119:89-99. 2006
  9. pmc Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle
    Matthew Mulvey
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Virol 77:10917-28. 2003
  10. pmc Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions
    Matthew Mulvey
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Virol 80:7354-63. 2006

Collaborators

  • Randal Kaufman
  • Nahum Sonenberg
  • Robert J Schneider
  • Richard J Roller
  • Ganes Sen
  • D A Leib
  • Matthew Mulvey
  • Derek Walsh
  • Cesar Perez
  • Carolina Arias
  • Jeremy Poppers
  • David Khoo
  • Uyanga Chuluunbaatar
  • Stephanie A Campbell
  • Ricardo Sanchez
  • Stephen L Ward
  • Louisa Benboudjema
  • Gregory A Peters
  • S Taneja
  • Caleb McKinney
  • Uyanga Chulunbaatar
  • Stuart Brown
  • Kevan M Shokat
  • Morris E Feldman
  • Angus C Wilson
  • Jack Harbell
  • M Mulvey
  • Rikiro Fukunaga
  • Rie Watanabe-Fukunaga
  • David Halladin
  • Martin Escandon
  • Takeshi Ueda
  • Matthias Gromeier
  • Joanna Notary
  • Vladimir Camarena
  • Donalyn Scheuner
  • Yuehua Gao
  • Sanjay W Pimplikar
  • David Sternberg
  • J MacGregor
  • S Markus
  • S Ha
  • A Ladd
  • J Poppers

Detail Information

Publications27

  1. pmc A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
    I Mohr
    Department of Microbiology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Virol 75:5189-96. 2001
    ..As this gamma34.5 second-site suppressor variant is attenuated and replicates vigorously in neoplastic cells, it may have potential as a replication-competent, viral antitumor agent...
  2. pmc Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells
    Derek Walsh
    Department of Microbiology, NYU Cancer Institute, New York, New York 10016, USA
    J Virol 79:8057-64. 2005
    ....
  3. pmc Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor
    Matthew Mulvey
    Department of Microbiology, NYU School of Medicine, MSB214, 550 First Avenue, New York, NY 10016, USA
    J Virol 81:3377-90. 2007
    ..Strikingly, gB regulates viral protein accumulation in a PERK-dependent manner. This is the first description of a virus-encoded PERK-specific effector and defines a new strategy by which viruses are able to maintain ER homeostasis...
  4. doi request reprint Host translation at the nexus of infection and immunity
    Ian Mohr
    Department of Microbiology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 12:470-83. 2012
    ..This review discusses how diverse pathogens manipulate the host translation machinery and the impact of these interactions on infection biology and the immune response...
  5. ncbi request reprint Neutralizing innate host defenses to control viral translation in HSV-1 infected cells
    Ian Mohr
    New York University School of Medicine, Department of Microbiology, MSB 214, New York, New York 10016, USA
    Int Rev Immunol 23:199-220. 2004
    ..Together, both proteins cooperate to overcome the antiviral response of the host and properly regulate translation in HSV-1-infected cells...
  6. ncbi request reprint Genetic metamorphosis of herpes simplex virus-1 into a biological therapeutic for human cancer
    Ian Mohr
    New York University School of Medicine, Department of Microbiology, 550 First Avenue, New York, NY 10016, USA
    Expert Opin Biol Ther 3:113-25. 2003
    ..In addition, traditional treatment modalities that incorporate viral inoculation, along with efforts to elicit an antitumour immune response following treatment with gamma34.5 derivatives, are discussed...
  7. ncbi request reprint To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control
    Ian Mohr
    Department of Microbiology, New York University School of Medicine, NY 10016, USA
    Oncogene 24:7697-709. 2005
    ....
  8. ncbi request reprint Phosphorylation and dephosphorylation events that regulate viral mRNA translation
    Ian Mohr
    Department of Microbiology, MSB 214, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Virus Res 119:89-99. 2006
    ..In this review, we discuss how various viruses manipulate the phosphorylation state of key cellular translation factors, illustrating the critical nature these interactions play in virus replication, pathogenesis and innate host defense...
  9. pmc Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle
    Matthew Mulvey
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Virol 77:10917-28. 2003
    ..5 mutant virus, previously ascribed solely to the gamma(1)34.5 mutation, actually results from the combined loss of gamma(1)34.5 and Us11 functions, as the gamma(2) Us11 mRNA is not translated in cells infected with a gamma(1)34.5 mutant...
  10. pmc Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions
    Matthew Mulvey
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Virol 80:7354-63. 2006
    ..Thus, one or more previously uncharacterized viral functions exist to counteract the accumulation of phosphorylated eIF2alpha in response to ER stress in HSV-1-infected cells...
  11. pmc Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication
    Uyanga Chuluunbaatar
    Department of Microbiology, New York University School of Medicine, New York, 10016, USA
    Genes Dev 24:2627-39. 2010
    ..Thus, HSV-1 encodes an Akt surrogate with overlapping substrate specificity to activate mTORC1, stimulating translation and virus replication. This establishes Us3 as a unique viral kinase with promising drug development potential...
  12. pmc Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells
    S Taneja
    Department of Urology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:8804-8. 2001
    ..The increased therapeutic potency of this oncolytic virus may be useful in the treatment of a wide variety of cancers...
  13. pmc A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function
    M Mulvey
    Department of Microbiology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Virol 73:3375-85. 1999
    ..Thus, an RNA-binding, ribosome-associated protein (Us11) and a GADD34-related protein (gamma34.5) both function in a signal pathway that regulates translation by modulating eIF2 phosphorylation...
  14. pmc Full resistance of herpes simplex virus type 1-infected primary human cells to alpha interferon requires both the Us11 and gamma(1)34.5 gene products
    Matthew Mulvey
    Department of Microbiology MSB 214, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    J Virol 78:10193-6. 2004
    ..Finally, we establish that the Us11 gene product is required for wild-type levels of replication in alpha interferon-treated cells and, along with the gamma(1)34.5 gene, is an HSV-1-encoded interferon resistance determinant...
  15. pmc Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein
    Ricardo Sanchez
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, MSB214, 550 First Avenue, New York, NY 10016, USA
    J Virol 81:3455-64. 2007
    ..Thus, in addition to PKR and its protein activator, PACT, the HSV-1 Us11 gene product is able to counteract the activity of OAS, a third cellular protein critical for host defense...
  16. ncbi request reprint Translation initiation and viral tricks
    Robert J Schneider
    Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA
    Trends Biochem Sci 28:130-6. 2003
    ..Regardless of the type of translational tricks exploited, viruses typically ensure efficient viral translation, often at the expense of host-cell protein synthesis...
  17. pmc Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation
    David Khoo
    Department of Microbiology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Virol 76:11971-81. 2002
    ..The ability of Us11 to bind dsRNA may be important for inhibiting activation of the cellular PKR kinase in response to dsRNA...
  18. pmc Identification of a lytic-cycle Epstein-Barr virus gene product that can regulate PKR activation
    Jeremy Poppers
    Department of Microbiology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    J Virol 77:228-36. 2003
    ....
  19. pmc Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides
    Louisa Benboudjema
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Virol 77:9192-203. 2003
    ..J. Diefenbach et al., J. Virol. 76:3282-3291, 2002), suggests that these associations may be important for the intracellular movement of viral components...
  20. pmc Assembly of an active translation initiation factor complex by a viral protein
    Derek Walsh
    Department of Microbiology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 20:461-72. 2006
    ....
  21. pmc Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells
    Derek Walsh
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York 10016, USA
    Genes Dev 18:660-72. 2004
    ....
  22. pmc Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells
    Derek Walsh
    Department of Microbiology MSB214, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 28:2648-58. 2008
    ..Furthermore, it suggests that the subcellular distribution of eIF4F components may potentiate the complex assembly...
  23. pmc Activation of host translational control pathways by a viral developmental switch
    Carolina Arias
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York, USA
    PLoS Pathog 5:e1000334. 2009
    ..Thus, herpesvirus reactivation from latency activates the host cap-dependent translation machinery, illustrating the importance of translational regulation in implementing new developmental instructions that drastically alter cell fate...
  24. pmc Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells
    Cesar Perez
    NYU School of Medicine, Department of Microbiology, MSB 214, 550 First Avenue, New York, NY 10016, USA
    J Virol 85:156-64. 2011
    ..Thus, cytoplasmic PABP accumulation is translationally controlled in HCMV-infected cells via a mechanism requiring mTORC1-mediated inhibition of the cellular 4E-BP1 translational repressor...
  25. pmc In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation
    Stephen L Ward
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 77:4626-34. 2003
    ..These data suggest that US11 functions as a PKR antagonist in vivo, although its activity may be modulated by tissue-specific differences in translation regulation...
  26. pmc Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein
    Gregory A Peters
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Virol 76:11054-64. 2002
    ..The binding of Us11 to PKR did not block the binding of PKR to PACT but prevented its activation. Us11 is the first example of a viral protein that can inhibit the action of PACT on PKR...
  27. pmc Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements
    Stephanie A Campbell
    Division of Neurological Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 81:791-9. 2007
    ..Picornavirus regulatory sequences mediating cell type-specific gene expression in the CNS can be utilized to target cancerous cells at the level of translation regulation outside their natural context...