Narla Mohandas

Summary

Affiliation: New York Blood Center
Country: USA

Publications

  1. ncbi request reprint New insights into function of red cell membrane proteins and their interaction with spectrin-based membrane skeleton
    N Mohandas
    Red Cell Physiology Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67 th Street, New York, NY 10021, USA
    Transfus Clin Biol 13:29-30. 2006
  2. ncbi request reprint Blood group antigens in health and disease
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Curr Opin Hematol 12:135-40. 2005
  3. pmc Malaria and human red blood cells
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Med Microbiol Immunol 201:593-8. 2012
  4. pmc Red cell membrane: past, present, and future
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 112:3939-48. 2008
  5. pmc Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation
    Marcela Salomao
    The Red Cell Physiology Laboratory, The New York Blood Center, New York, NY, USA
    Blood 116:267-9. 2010
  6. pmc Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane
    Marcela Salomao
    Red Cell Physiology Laboratory and Membrane Biochemistry Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:8026-31. 2008
  7. ncbi request reprint Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) destabilizes erythrocyte membrane skeleton
    Xinhong Pei
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    J Biol Chem 282:26754-8. 2007
  8. doi request reprint Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions
    Hua Wang
    Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th St, New York, NY 10065, USA
    Histochem Cell Biol 134:411-20. 2010
  9. pmc Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility
    Shaomin Yang
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    Mol Cell Biol 31:2276-86. 2011
  10. pmc Membrane remodeling during reticulocyte maturation
    Jing Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York City, NY 10065, USA
    Blood 115:2021-7. 2010

Research Grants

Collaborators

Detail Information

Publications48

  1. ncbi request reprint New insights into function of red cell membrane proteins and their interaction with spectrin-based membrane skeleton
    N Mohandas
    Red Cell Physiology Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67 th Street, New York, NY 10021, USA
    Transfus Clin Biol 13:29-30. 2006
  2. ncbi request reprint Blood group antigens in health and disease
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Curr Opin Hematol 12:135-40. 2005
    ..They have long played an important role in identifying matched blood products for transfusion. Recent studies have identified varied and important functions for some of these molecules in cell physiology and human pathology...
  3. pmc Malaria and human red blood cells
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Med Microbiol Immunol 201:593-8. 2012
    ....
  4. pmc Red cell membrane: past, present, and future
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 112:3939-48. 2008
    ....
  5. pmc Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation
    Marcela Salomao
    The Red Cell Physiology Laboratory, The New York Blood Center, New York, NY, USA
    Blood 116:267-9. 2010
    ..We conclude that aberrant protein sorting is one mechanistic basis for protein deficiencies in HE and HS...
  6. pmc Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane
    Marcela Salomao
    Red Cell Physiology Laboratory and Membrane Biochemistry Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:8026-31. 2008
    ....
  7. ncbi request reprint Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) destabilizes erythrocyte membrane skeleton
    Xinhong Pei
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    J Biol Chem 282:26754-8. 2007
    ..We conjecture that the loss of mechanical cohesion of the membrane may facilitate the exit of the mature merozoites from the cell...
  8. doi request reprint Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions
    Hua Wang
    Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th St, New York, NY 10065, USA
    Histochem Cell Biol 134:411-20. 2010
    ..The characterization of distinct splice forms of various 4.1 proteins with diverse cellular and sub-cellular localization indicates multiple functions for this family of proteins in endocrine functions of adrenal gland...
  9. pmc Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility
    Shaomin Yang
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    Mol Cell Biol 31:2276-86. 2011
    ..Additionally, the finding that infertility is present in B6-129 but not on the B6 background suggests the presence of a major modifier gene(s) that influences 4.1G function and is associated with male infertility...
  10. pmc Membrane remodeling during reticulocyte maturation
    Jing Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York City, NY 10065, USA
    Blood 115:2021-7. 2010
    ..1R in reticulocytes, which leads to a decrease in shear resistance by reducing its interaction with spectrin and actin. These observations begin to unravel the mechanistic basis of crucial changes accompanying reticulocyte maturation...
  11. pmc The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion
    Xinhong Pei
    Red Cell Physiology Laboratory, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Blood 110:1036-42. 2007
    ....
  12. ncbi request reprint Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th Street, New York, New York 10021, USA
    Biochemistry 45:5725-32. 2006
    ..1R, 4.1B, 4.1G, and 4.1N) are widely expressed and the PIP2-binding motifs are highly conserved, it is likely that the functions of other 4.1 proteins are similarly regulated by PIP2 in many different cell types...
  13. ncbi request reprint Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10021, USA
    Biochemistry 44:10681-8. 2005
    ..1R ternary complex in vitro. Furthermore, the binding of 4.1R to 1-301 is greatly enhanced by PIP(2), implying the existence of a regulatory switch in the cell...
  14. pmc Control of erythrocyte membrane-skeletal cohesion by the spectrin-membrane linkage
    Lionel Blanc
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    Biochemistry 49:4516-23. 2010
    ..These findings enabled us to identify an additional important functional role for the spectrin-ankyrin-band 3 link in regulating spectrin self-association in the red cell membrane...
  15. pmc Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT
    Qiaozhen Kang
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Blood 113:6128-37. 2009
    ..1R display an elevated humoral response to immunization with T cell-dependent antigen. Thus, we have defined a hitherto unrecognized role for 4.1R in negatively regulating T-cell activation by modulating intracellular signal transduction...
  16. pmc Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo
    Jingping Hu
    Laboratory of Membrane Biology, New York Blood Center, New York, NY
    Blood 121:3246-53. 2013
    ....
  17. ncbi request reprint Conformational stabilities of the structural repeats of erythroid spectrin and their functional implications
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    J Biol Chem 281:10527-32. 2006
    ....
  18. pmc Tropomyosin modulates erythrocyte membrane stability
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Blood 109:1284-8. 2007
    ..These findings have enabled us identify a function for TM in elevating the mechanical stability of erythrocyte membranes by stabilizing the spectrin-actin-4.1R junctional complex...
  19. ncbi request reprint Thermal stabilities of brain spectrin and the constituent repeats of subunits
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10021, USA
    Biochemistry 45:13670-6. 2006
    ..The greater structural stability of the repeats in alphaII- and betaII-spectrin may account, at least in part, for the higher rigidity of brain compared to erythrocyte spectrin...
  20. pmc Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis
    Jing Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 121:e43-9. 2013
    ..The means to quantitate in vivo murine erythropoiesis using our approach will probably have broad application in the study of altered erythropoiesis in various red cell disorders...
  21. ncbi request reprint Phospholipid binding by proteins of the spectrin family: a comparative study
    Xiuli An
    Red Cell Physiology Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    Biochem Biophys Res Commun 327:794-800. 2005
    ....
  22. pmc Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin
    Lixiang Chen
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    J Cell Sci 124:2478-87. 2011
    ..These data enabled the identification of a functional role for protein 4.1R in keratinocytes by modulating the surface expression of β1 integrin, possibly through a direct association between 4.1R and β1 integrin...
  23. pmc Mammalian alpha I-spectrin is a neofunctionalized polypeptide adapted to small highly deformable erythrocytes
    Marcela Salomao
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:643-8. 2006
    ..We conclude that alphaI-spectrin represents a neofunctionalized spectrin adapted to the rapid make and break of tetramers...
  24. pmc Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, NY, USA
    Blood 112:5212-8. 2008
    ..Importantly, disruption of the Lu-spectrin linkage was accompanied by enhanced cell adhesion to laminin. We conclude that the interaction of the Lu cytoplasmic tail with the cytoskeleton regulates its adhesive receptor function...
  25. pmc Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b)
    Congrong Liu
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    J Biol Chem 288:11407-15. 2013
    ..1R and the second intracellular loop and C terminus of PMCA1b. Our findings have enabled us to define a functional role for 4.1R in small intestinal calcium absorption through regulation of membrane expression of PMCA1b...
  26. pmc The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons
    Steven Einheber
    School of Health Sciences, Hunter College, City University of New York, New York, New York, USA
    Glia 61:240-53. 2013
    ..1B. These results demonstrate that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness...
  27. pmc The erythroid niche: molecular processes occurring within erythroblastic islands
    Narla Mohandas
    The Red Cell Physiology Laboratory, The New York Blood Center, 310 East 67th Street, New York, NY 10065, USA
    Transfus Clin Biol 17:110-1. 2010
    ..Hence, it appears that abnormal protein sorting generates specific protein deficiencies in hereditary elliptocytosis and hereditary spherocytosis...
  28. doi request reprint Inter-subunit interactions in erythroid and non-erythroid spectrins
    Xiuli An
    Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10065, USA
    Biochim Biophys Acta 1814:420-7. 2011
    ....
  29. pmc A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane
    Qiaozhen Kang
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    J Cell Sci 122:1091-9. 2009
    ..Thus, this newly identified Golgi-specific protein 4.1 appears to have an essential role in maintaining the structure of the Golgi and in assembly of a subset of membrane proteins...
  30. ncbi request reprint Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin
    Xinhong Pei
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York, 10021, USA
    J Biol Chem 280:31166-71. 2005
    ..As the presence of KAHRP at the erythrocyte membrane is necessary for cytoadherence in vivo, our findings have implications for the development of new therapies for mitigating the severity of malaria infection...
  31. ncbi request reprint Phosphatidylserine binding sites in red cell spectrin
    Xiuli An
    Red Cell Physiology Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    Blood Cells Mol Dis 32:430-2. 2004
    ..1R for PS) the formation of PS-rich lipid domains, which have been observed in the red cell membrane, may be a result...
  32. doi request reprint Phosphorylation-dependent perturbations of the 4.1R-associated multiprotein complex of the erythrocyte membrane
    Emilie Gauthier
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Biochemistry 50:4561-7. 2011
    ..1R results in structural changes transmitted to the functional interaction centers of the protein. We consider possible implications of our findings for the altered membrane function of normal reticulocytes and sickle red cells...
  33. ncbi request reprint Phosphatidylserine binding sites in erythroid spectrin: location and implications for membrane stability
    Xiuli An
    Red Cell Physiology Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Biochemistry 43:310-5. 2004
    ..1R for PS) the formation of PS-rich lipid domains, which have been observed in the red cell membrane, may be a result...
  34. doi request reprint Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity
    Shaomin Yang
    Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th St, New York, NY 10065, USA
    Biochim Biophys Acta 1788:1458-65. 2009
    ..1R in linking the cadherin/catenin complex to the cytoskeleton through its direct interaction with beta-catenin and in regulating the integrity of adherens junction...
  35. pmc Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis
    Ke Chen
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:17413-8. 2009
    ....
  36. doi request reprint Membrane assembly during erythropoiesis
    Jing Liu
    Laboratory of Red Cell Physiology, New York Blood Center, New York, New York, USA
    Curr Opin Hematol 18:133-8. 2011
    ....
  37. pmc The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume
    Lionel Blanc
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Blood 114:3928-34. 2009
    ..These results lead us to suggest that AQP-1 sorting into exosomes may be the mechanism by which the reticulocyte adapts to environmental changes during its maturation...
  38. pmc Native ultrastructure of the red cell cytoskeleton by cryo-electron tomography
    ANDREA NANS
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA
    Biophys J 101:2341-50. 2011
    ..Based on comparisons with expanded skeletons, we propose that the oligomeric state of spectrin is in a dynamic equilibrium that facilitates remodeling of the network as the cell changes shape in response to shear stress...
  39. doi request reprint Erythroblastic islands, terminal erythroid differentiation and reticulocyte maturation
    Xiuli An
    Laboratory of Membrane Biology, The New York Blood Center, New York, NY, USA
    Int J Hematol 93:139-43. 2011
    ..This review summarizes our current understanding of the role of erythroblastic islands in erythropoiesis, membrane assembly during terminal erythroid differentiation and cellular and membrane reorganization during reticulocyte maturation...
  40. ncbi request reprint Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane
    Xiuli An
    Red Cell Physiology Laboratory, The New York Blood Center, New York, New York 10021, USA
    J Biol Chem 277:31796-800. 2002
    ....
  41. pmc Congenital erythropoietic porphyria: characterization of murine models of the severe common (C73R/C73R) and later-onset genotypes
    David F Bishop
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Mol Med 17:748-56. 2011
    ..Of significance for therapeutic intervention, these mouse models suggest that only 11% of wild-type activity might be needed to reverse the pathology in CEP patients...
  42. pmc Morphological and functional platelet abnormalities in Berkeley sickle cell mice
    Arun S Shet
    The Laboratory of Blood and Vascular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Blood Cells Mol Dis 41:109-18. 2008
    ..Thus, additional studies are needed to assess whether large platelets contribute either to pulmonary hypertension or the large vessel arterial occlusion that produces stroke in some children with sickle cell disease...
  43. doi request reprint Disorders of red cell membrane
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Br J Haematol 141:367-75. 2008
    ..Importantly, the severity of anaemia in both these disorders is directly related to extent of membrane surface area loss. Splenectomy results in amelioration of anaemia...
  44. ncbi request reprint Red blood cell blood group antigens: structure and function
    Marion E Reid
    Laboratology of Immunology and the Lindsley F Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Semin Hematol 41:93-117. 2004
    ....
  45. ncbi request reprint Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain
    Jianbin Peng
    Biochemistry and Molecular Genetics Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, 310 East, 67th St, New York, NY 10021, USA
    Biochim Biophys Acta 1759:562-72. 2006
    ..Taken together, Dusty is a unique evolutionarily selected group of divergent protein kinases that may play important functional roles in the brain and other tissues of vertebrates...
  46. pmc Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm
    Aslihan Turhan
    Department of Medicine, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1079, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 99:3047-51. 2002
    ....
  47. pmc Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
    Sara Gardenghi
    Weill Cornell Medical College, New York, New York, USA
    J Clin Invest 120:4466-77. 2010
    ..These data led us to suggest that therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat the abnormal iron absorption in individuals with β-thalassemia and related disorders...
  48. ncbi request reprint Ribosomal protein S19 expression during erythroid differentiation
    Lydie Da Costa
    New York Blood Center, NY 10021, USA
    Blood 101:318-24. 2003
    ..We anticipate that these findings will contribute to further development of our understanding of the contribution of RPS19 to erythropoiesis...

Research Grants37

  1. PROGRAM PROJECT: RED CELL MEMBRANE STUDIES
    MOHANDAS NARLA; Fiscal Year: 2006
    ..abstract_text> ..
  2. Diamond-Blackfan Anemia and Ribosomal Protein S19
    MOHANDAS NARLA; Fiscal Year: 2007
    ..Furthermore, it is our hope that the new insights generated by our studies might lead to the development of new therapeutic strategies for the treatment of DBA patients presenting with RPS19 gene mutations. ..
  3. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 2010
    ..We anticipate that our findings will lead to the identification of useful therapeutic strategies for the effective clinical management of this debilitating human disease. ..
  4. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 2005
    ..Our application of these refined systems offers great promise for elucidating the cause of painful vaso-occlusion and identifying potential targets for future therapy. ..
  5. RED CELL DEFORMABILITY IN VITRO AND SURVIVAL IN VIVO
    MOHANDAS NARLA; Fiscal Year: 2007
    ..abstract_text> ..
  6. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 2007
    ..We anticipate that our findings will lead to the identification of useful therapeutic strategies for the effective clinical management of this debilitating human disease. ..
  7. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 1991
    ....
  8. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 1993
    ..This in turn, should enable the development and critical testing of hypotheses concerning the contributions of various cellular abnormalities to the pathophysiology of sickle cell disease...
  9. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 2000
    ..The observed heterogeneity in sickle cell adhesion is due to heterogeneity of expression of specific adhesive receptor(s) on distinct sub populations of sickle cells. ..