Research Topics
| Khush R MittalSummaryAffiliation: New York University Country: USA Publications
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Publications
Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areasKhush R Mittal
Department of Pathology, New York University School of Medicine, 462 First Avenue, New York, NY 10016, USA
Mod Pathol 22:1303-11. 2009..The immunohistochemical profiles and genetic aberrations of the examined cases suggest that uterine leiomyosarcoma could arise from the preexisting leiomyoma-like areas that often have a symplastic or cellular morphology...- Presence of endometrial adenocarcinoma in situ in complex atypical endometrial hyperplasia is associated with increased incidence of endometrial carcinoma in subsequent hysterectomyKhush Mittal
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Mod Pathol 22:37-42. 2009..Use of adenocarcinoma in situ terminology could lead to improved management of patients with complex atypical endometrial hyperplasia... - Application of immunohistochemistry to gynecologic pathologyKhush Mittal
Department of Pathology, NYU School of Medicine and Surgical and Ob Gyn Pathology, Bellevue Hospital, Room 4 west 1, 462 First Ave, New York, NY 10016, USA
Arch Pathol Lab Med 132:402-23. 2008..Immunohistochemical stains are extremely useful in resolving many of these problematic cases. As the knowledge in this area is constantly expanding, it is useful to have this updated information in a review form for easy access... 
Areas with benign morphologic and immunohistochemical features are associated with some uterine leiomyosarcomasKhush Mittal
Department of Pathology, New York University School of Medicine, Bellevue Hospital Center, 462 First Avenue, Room 4W35, New York, NY 10016, USA
Gynecol Oncol 104:362-5. 2007..The benign and malignant areas merged in all cases. Morphologic and immunohistochemical spectrum of changes from benign to malignant is seen in 50% of LMS. This raises the possibility of progression of some leiomyomata to LMS...- Spatial differences in biologic activity of large uterine leiomyomataJian Jun Wei
Department of Pathology, Bellevue Hospital, New York, New York, USA
Fertil Steril 85:179-87. 2006..To evaluate the growth pattern of the large uterine leiomyomata (ULM), we examined the spatial gene distributions, vessel density, proliferative activity, and hyaline degeneration... - Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform moleDorota A Popiolek
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Hum Pathol 37:1426-34. 2006..p57(KIP2) immunohistochemistry is a time- and cost-effective means of distinguishing CHM from its mimics in challenging cases... - Images in pathology. Invasive squamous cell carcinoma of vulva that wanted to be a puppyKhush Mittal
Surgical and Ob-Gyn Pathology, Bellevue Hospital, New York, NY 10016, USA
Int J Surg Pathol 14:335. 2006 - Precursor lesions for uterine leiomyosarcomaKhush Mittal
Hum Pathol 38:1289. 2007 - Endometrial hyperplasia and carcinoma in endometrial polyps: clinicopathologic and follow-up findingsKhush Mittal
Department of Pathology, New York University School of Medicine, New York, NY, USA
Int J Gynecol Pathol 27:45-8. 2008..The above findings reinforce the need for hysterectomy especially in postmenopausal women with atypical complex hyperplasia or carcinoma in endometrial polyps even if these changes appear confined to the polyp in initial sampling... - Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyomaYi Peng
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Mol Cancer Res 6:663-73. 2008..Our findings suggest that the Let-7-mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth... - Ethnic differences in expression of the dysregulated proteins in uterine leiomyomataJian Jun Wei
Department of Pathology, New York University School of Medicine, Bellevue Hospital, 560 First Avenue, New York, NY 10016, USA
Hum Reprod 21:57-67. 2006..Black ethnicity is one of the risk factors for uterine leiomyomata (ULM). Little is known about the ethnic differences in leiomyoma-associated gene products in women with uterine leiomyomata... - Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal originDorota A Popiolek
Department of Pathology, 4W35B, New York University School of Medicine, Belluvue Hospital, 462 First Avenue, New York, NY 10016, USA
Gynecol Oncol 96:249-53. 2005..All reported cases involved an ovary, and one with primary peritoneal origin has not been described. Also, convincing neuroendocrine granules have not been illustrated... - MIB-1 expression in cervical Papanicolaou tests correlates with dysplasia in subsequent cervical biopsiesZhuowen Zeng
Department of Cytopathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA
Appl Immunohistochem Mol Morphol 10:15-9. 2002..It is able to identify cervical disease overlooked by cytologic screening; therefore, it may serve as an adjunct and complimentary tool to cervical cytology... - Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometriumWansong Qiu
Department of Pathalogy, New York University School of Medicine and Medical Center, New York, New York 10016, USA
Int J Gynecol Pathol 22:261-5. 2003.... - Incidental findings in uterine prolapse specimen: frequency and implicationsHong Yin
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Int J Gynecol Pathol 23:26-8. 2004..As long as all grossly visible lesions are sampled, two routine sections were found to be sufficient to identify all significant lesions... - Stromal reaction is a feature of diffusely infiltrating endometrial adenocarcinomaKhush Mittal
Int J Gynecol Pathol 23:91; author reply 91. 2004 - Distinction of low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions based on quantitative analysis of proliferative activityDorota Popiolek
Department of Pathology, New York University School of Medicine, New Bellevue Hospital, New York, NY 10016, USA
Oncol Rep 11:687-91. 2004..MI and ME (percentage) appear helpful in grading equivocal SIL cases... - False-positive squamous cell carcinoma in cervical smears: cytologic-histologic correlation in 19 casesPascale Hummel Levine
Department of Pathology, New York University School of Medicine, New York, New York 10016 6497, USA
Diagn Cytopathol 28:23-7. 2003..Pleomorphic and/or keratinizing dysplasia involving endocervical glands may exhibit the cytologic features of squamous-cell carcinoma on cervical Pap smears... - Endometrial adenocarcinoma in situ in complex atypical hyperplasia: correlation with findings in subsequent hysterectomy specimenKaryna C Ventura
New York University School of Medicine, New York, NY 10016, USA
Int J Surg Pathol 12:225-30. 2004..Identification of AIS in CAH cases provides useful prognostic information... - Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomataJianjun Wei
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Mod Pathol 18:179-88. 2005..One group is associated with an alteration of tuberin and glucocorticoid receptor. The other group is associated with upregulation of human mobility group gene A2 and steroid receptor cofactors... - Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature reviewPascale Hummel Levine
New York University School of Medicine and Kaplan Comprehensive Cancer Center, New York, New York 10016-6497, USA
Int J Surg Pathol 10:231-6. 2002..The recognition of a rhabdoid phenotype is of clinical importance since these tumors are prone to be aggressive... - Significance of the cytologic diagnosis of endocervical glandular involvement in high-grade squamous intraepithelial lesionsPascale Hummel Levine
Department of Pathology, New York University School of Medicine and Kaplan Comprehensive Cancer Center, New York, New York 10016, USA
Diagn Cytopathol 26:217-21. 2002..In our experience, the cytologic diagnosis of EGI on Pap smears did not identify a group of patients with increased frequency of EGI on subsequent cone biopsies... - Pleomorphic liposarcoma of the uterus: case report and literature reviewPascale Hummel Levine
Department of Pathology, New York University Medical Center, New York, NY 10016, USA
Int J Gynecol Pathol 22:407-11. 2003..The tumor recurred 9 months postoperatively. Although a variety of uterine tumors have been associated with tamoxifen treatment, this appears to be the first example of tamoxifen-associated uterine liposarcoma... - Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virusMatjaz Sebenik
North Broward Medical Center, Deerfield Beach, FL 33064, USA
Hum Pathol 38:1282-8. 2007..In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components... - Differential expression of selected gene products in uterine leiomyomata and adenomyosisMary Levy
Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
Fertil Steril 88:220-3. 2007..With appropriate internal controls, there were significant differences in gene expression between adenomyosis and leiomyomata... - Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometriumJon Lecanda
Departments of Pathology and Medicine, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Cancer Res 67:1007-18. 2007..Thus, p27 may be a central target for growth regulation of normal endometrium and in the pathogenesis of ECA... - A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomasTongsheng Wang
Center for Applied Genomics, Public Health Research Institute, Newark, NJ, USA
Genes Chromosomes Cancer 46:336-47. 2007..This article contains Supplementary material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat... 
Differences in mitotic activity may explain observed differences in HIF-1alpha response in cancers and stromaKhush Mittal
PLoS Med 3:e370. 2006- Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomataJian-Jun Wei
Department of Pathology, New York University School of Medicine, New York, New York, USA
Fertil Steril 84:474-84. 2005..A group of patients in their late forties with the larger leiomyomata contributes largely by upregulation of nonsex steroid hormone factors. Adenomyosis is a protective factor preventing large leiomyomata... - Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissuesPatricia A Fetsch
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Lett 235:84-92. 2006..These data suggest a dual function for ABCG2 in some tissues: the excretion of toxins and xenobiotics including anti-cancer agents and a potential, as-yet undefined role in the secretion of endogenous substrates... - Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinomaJean-Pierre Gagner
Department of Pathology, Bellevue Hospital Center, New York University School of Medicine, 462 First Avenue, Room 4W35, New York, NY 10016, USA
Gynecol Oncol 97:219-22. 2005..Comparison of the clinical management of these tumors shows prolonged survival of patients whose treatment included postoperative pelvic external radiotherapy...