Research Topics
Genomes and Genes | Anand N MhatreSummaryAffiliation: New York University Country: USA Publications
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Detail Information
Publications
Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4Anand N Mhatre
Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
J Neurosci Res 75:25-31. 2004....- Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosidesNicolas Gürtler
Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
Laryngoscope 115:640-4. 2005..Mutation screening in this gene has been recommended before use of aminoglycosides as a preventative strategy to reduce the risk of ototoxicity... 
Clinical and molecular genetic analysis of a family with macrothrombocytopenia and early onset sensorineural hearing lossAnand N Mhatre
Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Avenue, TCH 513, New York, NY 10016, USA
Eur J Med Genet 52:185-90. 2009..Collectively, these results suggest that molecular genetic etiology of the Ghent family disorder may be due to as yet unidentified gene whose mutation(s) yields a phenocopy of the MYH9-related disease...- Generation and characterization of mice with Myh9 deficiencyAnand N Mhatre
Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Ave, TCH 513, New York, NY 10016, USA
Neuromolecular Med 9:205-15. 2007..The results of these studies do not support the Myh9 haploinsufficiency as a pathogenic factor in the etiology of auditory dysfunction... - Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner earAnand N Mhatre
Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
J Neurosci Res 76:296-305. 2004..Identification of Myh9 in the developing and mature inner ear suggests a role for this protein in the development and maintenance of auditory function... - Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9Anand N Mhatre
Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, CA 94143, USA
Otol Neurotol 24:205-9. 2003..Recently, mutations in MYH9, a nonmuscle myosin heavy chain, have been found in several forms of hereditary macrothrombocytopenia... - Developments in cochlear gene therapyAnil K Lalwani
Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, Calif, USA
Adv Otorhinolaryngol 61:28-33. 2002 - Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's diseaseAnand N Mhatre
Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Ave, U490A, San Francisco, CA 94143 0526, USA
Hear Res 170:59-69. 2002.... - Aquaporin 4 expression in the mammalian inner ear and its role in hearingAnand N Mhatre
Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue U490A, San Francisco, CA 94143 0526, USA
Biochem Biophys Res Commun 297:987-96. 2002..In the Aqp4 deficient mouse, cochlear dysfunction is suggested as the primary cause of hearing impairment in the absence of neural conduction abnormality... - GJB2 gene mutations in cochlear implant recipients: prevalence and impact on outcomeLawrence R Lustig
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC, Baltimore, MD 21287, USA
Arch Otolaryngol Head Neck Surg 130:541-6. 2004..To determine the prevalence of GJB2 gene mutations in patients undergoing cochlear implantation (CI) and their impact on rehabilitative outcome following implantation... - Cochlear gene therapyAnil K Lalwani
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, USA
Ear Hear 24:342-8. 2003 - Expression of Myh9 in the mammalian cochlea: localization within the stereociliaAnand N Mhatre
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
J Neurosci Res 84:809-18. 2006..Localization of Myh9 within the stereocilia raises the possibility that mutations of MYH9 may effect hearing loss though disruption of the stereocilia structure... - Auditory phenotype of DFNA17Anil K Lalwani
Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, Calif, USA
Adv Otorhinolaryngol 61:107-12. 2002 - Role of cytomegalovirus, Epstein-Barr virus, and human herpes virus-8 in benign lymphoepithelial cysts of the parotid glandThomas L Yen
Department of Otolaryngology--Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143-0342, USA
Laryngoscope 114:1500-5. 2004..0437). CONCLUSION: CMV and HHV-8 does not appear to be associated with BLCs. Although EBV is found more frequently in BLC than in normal parotid controls, further studies are needed to elucidate the role of this virus in BLC pathogenesis... - Quantitative analysis of fungal DNA in chronic rhinosinusitisMichael C Scheuller
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California 94143-0342, USA
Laryngoscope 114:467-71. 2004..Therefore, the quantity of fungi does not explain pathogenicity in patients with chronic rhinosinusitis. However, because of small sample size, the study must be replicated in a larger patient population... - Effect of SOD1 overexpression on age- and noise-related hearing lossDonald E Coling
Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143 0526, USA
Free Radic Biol Med 34:873-80. 2003..The results indicate the complexity of oxidative metabolism in the cochlea is greater than previously hypothesized... - In vitro and in vivo assessment of the ability of adeno-associated virus-brain-derived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insultAnil K Lalwani
Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, 94143 0342, USA
Laryngoscope 112:1325-34. 2002..Administration of adeno-associated virus containing the gene for brain-derived neurotrophic factor will promote spiral ganglion neuron survival after the destruction of hair cells... - Current issues in cochlear gene transferAnil K Lalwani
Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
Audiol Neurootol 7:146-51. 2002..Finally, safety issues regarding dissemination of gene transfer vectors beyond the target cochlea will need to be adequately addressed... - Biological therapy for the inner earNirmal P Patel
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, NY 10016, USA
Expert Opin Biol Ther 4:1811-9. 2004..Potential areas of interest in gene therapy and its preclinical application to deafness are reviewed, and experimental progress that has occurred in cellular therapy for the inner ear is examined... 
Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cellsAnil K Lalwani
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, NY 10016
Brain Res 1197:13-22. 2008..Thus, mutant NMHC-IIa may cause hearing loss by affecting hair cell dysfunction through structural and or functional disruption of its stereocilia, plasma membrane, and/or mitochondria...- Molecular pathogenesis of skull base tumorsNirmal P Patel
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York, USA
Otol Neurotol 25:636-43. 2004..An understanding of these mechanisms will aid the neurotologist in future diagnosis and management of the lesions... - Alternative splice variants of MYH9Yan Li
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
DNA Cell Biol 27:117-25. 2008.... - MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and functionYan Li
Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
Cell Motil Cytoskeleton 65:393-405. 2008..However, the results also indicate that the NMHC-IIA mutants, R702C and R705H do not inactivate or suppress the endogenous wild type NMHC-IIA within the HeLa or HEK293 cell assay system...