Anand N Mhatre

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4
    Anand N Mhatre
    Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 75:25-31. 2004
  2. ncbi Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosides
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    Laryngoscope 115:640-4. 2005
  3. doi Clinical and molecular genetic analysis of a family with macrothrombocytopenia and early onset sensorineural hearing loss
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Avenue, TCH 513, New York, NY 10016, USA
    Eur J Med Genet 52:185-90. 2009
  4. ncbi Generation and characterization of mice with Myh9 deficiency
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Ave, TCH 513, New York, NY 10016, USA
    Neuromolecular Med 9:205-15. 2007
  5. ncbi Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
  6. ncbi Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, CA 94143, USA
    Otol Neurotol 24:205-9. 2003
  7. ncbi Developments in cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:28-33. 2002
  8. ncbi Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's disease
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Ave, U490A, San Francisco, CA 94143 0526, USA
    Hear Res 170:59-69. 2002
  9. ncbi Aquaporin 4 expression in the mammalian inner ear and its role in hearing
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue U490A, San Francisco, CA 94143 0526, USA
    Biochem Biophys Res Commun 297:987-96. 2002
  10. ncbi GJB2 gene mutations in cochlear implant recipients: prevalence and impact on outcome
    Lawrence R Lustig
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC, Baltimore, MD 21287, USA
    Arch Otolaryngol Head Neck Surg 130:541-6. 2004

Collaborators

Detail Information

Publications23

  1. ncbi Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4
    Anand N Mhatre
    Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 75:25-31. 2004
    ....
  2. ncbi Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosides
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    Laryngoscope 115:640-4. 2005
    ..Mutation screening in this gene has been recommended before use of aminoglycosides as a preventative strategy to reduce the risk of ototoxicity...
  3. doi Clinical and molecular genetic analysis of a family with macrothrombocytopenia and early onset sensorineural hearing loss
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Avenue, TCH 513, New York, NY 10016, USA
    Eur J Med Genet 52:185-90. 2009
    ..Collectively, these results suggest that molecular genetic etiology of the Ghent family disorder may be due to as yet unidentified gene whose mutation(s) yields a phenocopy of the MYH9-related disease...
  4. ncbi Generation and characterization of mice with Myh9 deficiency
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Ave, TCH 513, New York, NY 10016, USA
    Neuromolecular Med 9:205-15. 2007
    ..The results of these studies do not support the Myh9 haploinsufficiency as a pathogenic factor in the etiology of auditory dysfunction...
  5. ncbi Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
    ..Identification of Myh9 in the developing and mature inner ear suggests a role for this protein in the development and maintenance of auditory function...
  6. ncbi Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, CA 94143, USA
    Otol Neurotol 24:205-9. 2003
    ..Recently, mutations in MYH9, a nonmuscle myosin heavy chain, have been found in several forms of hereditary macrothrombocytopenia...
  7. ncbi Developments in cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:28-33. 2002
  8. ncbi Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's disease
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Ave, U490A, San Francisco, CA 94143 0526, USA
    Hear Res 170:59-69. 2002
    ....
  9. ncbi Aquaporin 4 expression in the mammalian inner ear and its role in hearing
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue U490A, San Francisco, CA 94143 0526, USA
    Biochem Biophys Res Commun 297:987-96. 2002
    ..In the Aqp4 deficient mouse, cochlear dysfunction is suggested as the primary cause of hearing impairment in the absence of neural conduction abnormality...
  10. ncbi GJB2 gene mutations in cochlear implant recipients: prevalence and impact on outcome
    Lawrence R Lustig
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC, Baltimore, MD 21287, USA
    Arch Otolaryngol Head Neck Surg 130:541-6. 2004
    ..To determine the prevalence of GJB2 gene mutations in patients undergoing cochlear implantation (CI) and their impact on rehabilitative outcome following implantation...
  11. ncbi Cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, USA
    Ear Hear 24:342-8. 2003
  12. ncbi Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
    Anand N Mhatre
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 84:809-18. 2006
    ..Localization of Myh9 within the stereocilia raises the possibility that mutations of MYH9 may effect hearing loss though disruption of the stereocilia structure...
  13. ncbi Auditory phenotype of DFNA17
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:107-12. 2002
  14. ncbi Role of cytomegalovirus, Epstein-Barr virus, and human herpes virus-8 in benign lymphoepithelial cysts of the parotid gland
    Thomas L Yen
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143 0342, USA
    Laryngoscope 114:1500-5. 2004
    ..To provide background and evaluate the role of herpesviruses in benign lymphoepithelial cysts (BLC) of the parotid gland...
  15. ncbi Quantitative analysis of fungal DNA in chronic rhinosinusitis
    Michael C Scheuller
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, California 94143 0342, USA
    Laryngoscope 114:467-71. 2004
    ..The authors postulated that the quantity of fungal DNA in the nose is determinant of disease, is greater in patients with chronic rhinosinusitis, and is directly correlated to their quality of life...
  16. ncbi Effect of SOD1 overexpression on age- and noise-related hearing loss
    Donald E Coling
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143 0526, USA
    Free Radic Biol Med 34:873-80. 2003
    ..The results indicate the complexity of oxidative metabolism in the cochlea is greater than previously hypothesized...
  17. ncbi In vitro and in vivo assessment of the ability of adeno-associated virus-brain-derived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insult
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, 94143 0342, USA
    Laryngoscope 112:1325-34. 2002
    ..Administration of adeno-associated virus containing the gene for brain-derived neurotrophic factor will promote spiral ganglion neuron survival after the destruction of hair cells...
  18. ncbi Current issues in cochlear gene transfer
    Anil K Lalwani
    Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
    Audiol Neurootol 7:146-51. 2002
    ..Finally, safety issues regarding dissemination of gene transfer vectors beyond the target cochlea will need to be adequately addressed...
  19. ncbi Biological therapy for the inner ear
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, NY 10016, USA
    Expert Opin Biol Ther 4:1811-9. 2004
    ..Potential areas of interest in gene therapy and its preclinical application to deafness are reviewed, and experimental progress that has occurred in cellular therapy for the inner ear is examined...
  20. pmc Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cells
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, NY 10016
    Brain Res 1197:13-22. 2008
    ..Thus, mutant NMHC-IIa may cause hearing loss by affecting hair cell dysfunction through structural and or functional disruption of its stereocilia, plasma membrane, and/or mitochondria...
  21. ncbi Molecular pathogenesis of skull base tumors
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York, USA
    Otol Neurotol 25:636-43. 2004
    ..To review contemporary molecular biological literature related to skull base tumor biology and tumorigenesis...
  22. ncbi Alternative splice variants of MYH9
    Yan Li
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    DNA Cell Biol 27:117-25. 2008
    ....
  23. doi MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function
    Yan Li
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    Cell Motil Cytoskeleton 65:393-405. 2008
    ..However, the results also indicate that the NMHC-IIA mutants, R702C and R705H do not inactivate or suppress the endogenous wild type NMHC-IIA within the HeLa or HEK293 cell assay system...