Kenneth Maiese

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
    Zhao Zhong Chong
    Department of Neurology and Neurosciences, Cancer Center, University of Medicine and Dentistry New Jersey Medical School, Newark, NJ, USA
    Oxid Med Cell Longev 3:374-91. 2010
  2. pmc PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection
    Zhao Zhong Chong
    Laboratory of Cellular and Molecular Signaling, Newark, NJ, USA
    PLoS ONE 7:e45456. 2012
  3. pmc Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, New Jersey Health Sciences University, Newark, NJ 07101, USA
    Curr Neurovasc Res 10:29-38. 2013
  4. pmc WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy
    Shaohui Wang
    Laboratory of Cellular and Molecular Signaling, Cancer Center, F 1220, New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA
    Curr Neurovasc Res 9:91-101. 2012
  5. pmc Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL
    Shaohui Wang
    Laboratory of Cellular and Molecular Signaling, University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 9:20-31. 2012
  6. pmc Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, New Jersey Health Sciences University, Newark, New Jersey 07101, USA
    Aging (Albany NY) 4:187-201. 2012
  7. pmc mTOR: on target for novel therapeutic strategies in the nervous system
    Kenneth Maiese
    Laboratory of Cellular and Molecular Signaling, Cancer Center, New Jersey Health Sciences University, Newark, NJ 07101, USA
    Trends Mol Med 19:51-60. 2013
  8. pmc Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress
    Jinling Hou
    Department of Neurology and Neurosciences, University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:220-35. 2011
  9. doi request reprint Targeting erythropoietin for chronic neurodegenerative diseases
    Zhao Zhong Chong
    University of Medicine and Dentistry of New Jersey, Cancer Center, New Jersey NJ 07103, USA
    Expert Opin Ther Targets 17:707-20. 2013
  10. pmc SIRT1: new avenues of discovery for disorders of oxidative stress
    Zhao Zhong Chong
    University of Medicine and Dentistry New Jersey Medical School, Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA
    Expert Opin Ther Targets 16:167-78. 2012

Collaborators

Detail Information

Publications25

  1. pmc Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
    Zhao Zhong Chong
    Department of Neurology and Neurosciences, Cancer Center, University of Medicine and Dentistry New Jersey Medical School, Newark, NJ, USA
    Oxid Med Cell Longev 3:374-91. 2010
    ..Here we describe the role of mTOR in the CNS and illustrate the potential for new strategies directed against neurological disorders...
  2. pmc PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection
    Zhao Zhong Chong
    Laboratory of Cellular and Molecular Signaling, Newark, NJ, USA
    PLoS ONE 7:e45456. 2012
    ..Our studies highlight EPO and PRAS40 signaling in the mTOR pathway as potential therapeutic strategies for development against degenerative disorders that lead to cell demise...
  3. pmc Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, New Jersey Health Sciences University, Newark, NJ 07101, USA
    Curr Neurovasc Res 10:29-38. 2013
    ..exposure...
  4. pmc WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy
    Shaohui Wang
    Laboratory of Cellular and Molecular Signaling, Cancer Center, F 1220, New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA
    Curr Neurovasc Res 9:91-101. 2012
    ..New strategies that target WISP1, its autoregulation, and the pathways responsible for neuronal cell injury may bring forth new insight for the treatment of neurodegenerative disorders...
  5. pmc Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL
    Shaohui Wang
    Laboratory of Cellular and Molecular Signaling, University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 9:20-31. 2012
    ..These studies provide novel considerations for the development of WISP1 as an effective and robust therapeutic target not only for neurodegenerative disorders, but also for disease entities throughout the body...
  6. pmc Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, New Jersey Health Sciences University, Newark, New Jersey 07101, USA
    Aging (Albany NY) 4:187-201. 2012
    ..Our data may foster development of novel strategies to use cytoprotectants such as EPO for Alzheimer's disease and other degenerative disorders...
  7. pmc mTOR: on target for novel therapeutic strategies in the nervous system
    Kenneth Maiese
    Laboratory of Cellular and Molecular Signaling, Cancer Center, New Jersey Health Sciences University, Newark, NJ 07101, USA
    Trends Mol Med 19:51-60. 2013
    ..Targeting mTOR in the nervous system can offer exciting new avenues of drug discovery, but crucial to this premise is elucidating the complexity of mTOR signaling for robust and safe clinical outcomes...
  8. pmc Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress
    Jinling Hou
    Department of Neurology and Neurosciences, University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:220-35. 2011
    ....
  9. doi request reprint Targeting erythropoietin for chronic neurodegenerative diseases
    Zhao Zhong Chong
    University of Medicine and Dentistry of New Jersey, Cancer Center, New Jersey NJ 07103, USA
    Expert Opin Ther Targets 17:707-20. 2013
    ....
  10. pmc SIRT1: new avenues of discovery for disorders of oxidative stress
    Zhao Zhong Chong
    University of Medicine and Dentistry New Jersey Medical School, Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA
    Expert Opin Ther Targets 16:167-78. 2012
    ..The sirtuin SIRT1 is expressed throughout the body, has broad biological effects and can significantly affect both cellular survival and longevity during acute and long-term injuries, which involve both oxidative stress and cell metabolism...
  11. pmc Novel directions for diabetes mellitus drug discovery
    Kenneth Maiese
    New Jersey Health Sciences University, Cancer Institute of New Jersey, Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA
    Expert Opin Drug Discov 8:35-48. 2013
    ..New avenues of drug discovery must target the underlying cellular processes of oxidative stress, apoptosis, autophagy, and inflammation that can mediate multi-system pathology during diabetes mellitus...
  12. pmc Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, Cancer Center, F 1220, New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA
    Curr Neurovasc Res 9:239-49. 2012
    ..Our work identifies WISP1, mTOR signaling, and PRAS40 as targets for new strategies directed against Alzheimer's disease and related disorders...
  13. pmc Targeting cardiovascular disease with novel SIRT1 pathways
    Zhao Zhong Chong
    Laboratory of Cellular and Molecular Signaling, Department of Neurology and Neurosciences, Cancer Center, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07101, USA
    Future Cardiol 8:89-100. 2012
    ..Future knowledge regarding SIRT1 and its novel pathways will open new directions for the treatment of cardiovascular disease as well as offer the potential to limit disability from several related disorders...
  14. pmc Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
    Zhao Zhong Chong
    Laboratory of Cellular and Molecular Signaling, Cancer Center, F 1220, New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA
    Prog Neurobiol 99:128-48. 2012
    ..Further knowledge of mTOR and the critical pathways governed by this serine/threonine protein kinase can bring new light for neurodegeneration and other related diseases that currently require new and robust treatments...
  15. pmc Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:270-85. 2011
    ..These studies offer new insights for the development of innovative therapeutic strategies for neurodegenerative disorders that focus upon inflammatory microglia and novel signal transduction pathways...
  16. pmc Targeting disease through novel pathways of apoptosis and autophagy
    Kenneth Maiese
    New Jersey Health Sciences University, Cancer Institute of New Jersey, Laboratory of Cellular and Molecular Signaling, F 1220, 205 South Orange Avenue, Newark, New Jersey 07101, USA
    Expert Opin Ther Targets 16:1203-14. 2012
    ..Development of new therapeutic strategies that target these processes must address their complex role during developmental cell growth as well as during the modulation of toxic cellular environments...
  17. pmc Cardiovascular disease and mTOR signaling
    Zhao Zhong Chong
    Laboratory of Cellular and Molecular Signaling, New Jersey Health Sciences University, Newark, NJ 07101, USA
    Trends Cardiovasc Med 21:151-5. 2011
    ..Future work that further elucidates the vital regulatory pathways of mTOR can offer new therapeutic insights for the treatment of cardiovascular diseases...
  18. pmc Erythropoietin: new directions for the nervous system
    Kenneth Maiese
    Laboratory of Cellular and Molecular Signaling, Cancer Center, F 1220, New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA E Mails Z Z C Y C S S W Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA New Jersey Health Sciences University, Newark, New Jersey 07101, USA
    Int J Mol Sci 13:11102-29. 2012
    ....
  19. pmc Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade
    Kenneth Maiese
    Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA
    Int J Mol Sci 13:13830-66. 2012
    ....
  20. pmc Mammalian target of rapamycin signaling in diabetic cardiovascular disease
    Zhao Zhong Chong
    Laboratory of Cellular and Molecular Signaling, Newark, NJ, USA
    Cardiovasc Diabetol 11:45. 2012
    ..It is therefore vital to understand the complex relationship mTOR and its downstream pathways hold during metabolic disease in order to develop novel strategies for the complications of diabetes mellitus in the cardiovascular system...
  21. pmc EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes
    Zhao Zhong Chong
    Department of Neurology and Neurosciences, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:103-20. 2011
    ....