Darren Locke

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. doi request reprint Post-translational modifications of connexin26 revealed by mass spectrometry
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Biochem J 424:385-98. 2009
  2. ncbi request reprint Isoelectric points and post-translational modifications of connexin26 and connexin32
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, 185 South Orange Ave, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    FASEB J 20:1221-3. 2006
  3. ncbi request reprint Lipid rafts prepared by different methods contain different connexin channels, but gap junctions are not lipid rafts
    Darren Locke
    Department of Pharmacology and Physiology, MSB I 645, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    Biochemistry 44:13027-42. 2005
  4. pmc Connexin channels and phospholipids: association and modulation
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    BMC Biol 7:52. 2009
  5. ncbi request reprint Altered permeability and modulatory character of connexin channels during mammary gland development
    Darren Locke
    Department of Pharmacology and Physiology, UMDNJ, Newark, NJ 07101, USA
    Exp Cell Res 298:643-60. 2004
  6. ncbi request reprint Reversible pore block of connexin channels by cyclodextrins
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biol Chem 279:22883-92. 2004
  7. ncbi request reprint Neutral, acidic, and basic derivatives of anthranilamide that confer different formal charge to reducing oligosaccharides
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, UMDNJ, 185 South Orange Avenue, Newark, NJ 07103, USA
    Carbohydr Res 339:221-31. 2004
  8. ncbi request reprint Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, Newark, NJ 07103, USA
    Cell Commun Adhes 10:239-44. 2003
  9. ncbi request reprint Nature of Cx30-containing channels in the adult mouse mammary gland
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, UMDNJ, Newark, NJ 07103, USA
    Cell Tissue Res 328:97-107. 2007
  10. ncbi request reprint Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates
    Wafaa A Ayad
    Department of Pharmacology and Physiology, New Jersey Medical School, Newark, NJ 07103, USA
    J Biol Chem 281:16727-39. 2006

Detail Information

Publications13

  1. doi request reprint Post-translational modifications of connexin26 revealed by mass spectrometry
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Biochem J 424:385-98. 2009
    ..Knowledge of the PTMs of Cx26 will be instrumental in understanding how alterations in the cellular mechanisms of Cx26 channel biogenesis and function lead to losses in auditory function and disfiguring skin disorders...
  2. ncbi request reprint Isoelectric points and post-translational modifications of connexin26 and connexin32
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, 185 South Orange Ave, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    FASEB J 20:1221-3. 2006
    ..Most of these modifications have not previously been identified for connexins and may be instrumental in guiding and understanding novel aspects of channel trafficking and molecular mechanisms of channel regulation...
  3. ncbi request reprint Lipid rafts prepared by different methods contain different connexin channels, but gap junctions are not lipid rafts
    Darren Locke
    Department of Pharmacology and Physiology, MSB I 645, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    Biochemistry 44:13027-42. 2005
    ..Rafts may be involved in trafficking of plasma membrane connexin channels to gap junctions...
  4. pmc Connexin channels and phospholipids: association and modulation
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    BMC Biol 7:52. 2009
    ..The importance of interactions between connexin channels and phospholipids is poorly understood...
  5. ncbi request reprint Altered permeability and modulatory character of connexin channels during mammary gland development
    Darren Locke
    Department of Pharmacology and Physiology, UMDNJ, Newark, NJ 07101, USA
    Exp Cell Res 298:643-60. 2004
    ..Connexin channel stoichiometry, permeability, and chemical gating character change in precisely the desired fashion after parturition to maximize molecular and electrical coupling to support coordinated milk secretion...
  6. ncbi request reprint Reversible pore block of connexin channels by cyclodextrins
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biol Chem 279:22883-92. 2004
    ..CDs may be useful as molecular tools with which to explore the structure of the connexin pore and to alter molecular movement through connexin channels...
  7. ncbi request reprint Neutral, acidic, and basic derivatives of anthranilamide that confer different formal charge to reducing oligosaccharides
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, UMDNJ, 185 South Orange Avenue, Newark, NJ 07103, USA
    Carbohydr Res 339:221-31. 2004
    ..Furthermore, because glucosaccharides have rigid solution structure, these small fluorescent adducts with different formal charge are ideal tools for molecular sizing studies of membrane pores...
  8. ncbi request reprint Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, Newark, NJ 07103, USA
    Cell Commun Adhes 10:239-44. 2003
    ....
  9. ncbi request reprint Nature of Cx30-containing channels in the adult mouse mammary gland
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, UMDNJ, Newark, NJ 07103, USA
    Cell Tissue Res 328:97-107. 2007
    ..Such changes in connexin expression and channel composition and their chemical modulation are discussed in relation to the various stages of mammary gland development in the adult mouse...
  10. ncbi request reprint Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates
    Wafaa A Ayad
    Department of Pharmacology and Physiology, New Jersey Medical School, Newark, NJ 07103, USA
    J Biol Chem 281:16727-39. 2006
    ..Dynamic regulation of channel composition in vivo may effectively and efficiently modulate intercellular signaling by inositol phosphates...
  11. pmc Mechanism for modulation of gating of connexin26-containing channels by taurine
    Darren Locke
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, USA
    J Gen Physiol 138:321-39. 2011
    ..These studies reveal that AS disrupt a pH-driven cytoplasmic interdomain interaction in Cx26-containing channels, causing closure, and that the Cx26CT has a modulatory role in Cx26 function...
  12. ncbi request reprint Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI
    Darren Locke
    Division of Cardiology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 277:18801-9. 2002
    ....
  13. ncbi request reprint The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion
    Hong Chen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:3011-9. 2002
    ....