Rodolfo Llinas

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect
    Rodolfo Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Trends Neurosci 28:325-33. 2005
  2. ncbi request reprint Consciousness and the brain. The thalamocortical dialogue in health and disease
    R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Ann N Y Acad Sci 929:166-75. 2001
  3. pmc Temporal binding via cortical coincidence detection of specific and nonspecific thalamocortical inputs: a voltage-dependent dye-imaging study in mouse brain slices
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 99:449-54. 2002
  4. ncbi request reprint The contribution of Santiago Ramón y Cajal to functional neuroscience
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University Medical School, New York, New York 10016, USA
    Nat Rev Neurosci 4:77-80. 2003
  5. pmc Vesicular reuptake inhibition by a synaptotagmin I C2B domain antibody at the squid giant synapse
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:17855-60. 2004
  6. ncbi request reprint Role of gap junctions in synchronized neuronal oscillations in the inferior olive
    Elena Leznik
    Department of Physiology and Neuroscience, New York University Medical School, NY 10016, USA
    J Neurophysiol 94:2447-56. 2005
  7. ncbi request reprint Electrotonically mediated oscillatory patterns in neuronal ensembles: an in vitro voltage-dependent dye-imaging study in the inferior olive
    Elena Leznik
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 22:2804-15. 2002
  8. pmc A model of thalamocortical relay cells
    Paul A Rhodes
    Department of Physiology and Neuroscience, New York University Medical School, 550 1st Avenue, New York, NY 10016, USA
    J Physiol 565:765-81. 2005
  9. doi request reprint Cocaine acute "binge" administration results in altered thalamocortical interactions in mice
    Francisco J Urbano
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York, USA
    Biol Psychiatry 66:769-76. 2009
  10. pmc The effects of microgravity on the development of surface righting in rats
    Kerry D Walton
    Department of Physiology and Neuroscience, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Physiol 565:593-608. 2005

Research Grants

  1. NEUROBIOLOGY OF CEREBELLAR-BRAINSTEM SYSTEMS
    Rodolfo Llinas; Fiscal Year: 2007
  2. NEUROBIOLOGY OF CEREBELLAR-BRAINSTEM SYSTEMS
    Rodolfo Llinas; Fiscal Year: 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect
    Rodolfo Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Trends Neurosci 28:325-33. 2005
    ..At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels...
  2. ncbi request reprint Consciousness and the brain. The thalamocortical dialogue in health and disease
    R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Ann N Y Acad Sci 929:166-75. 2001
    ..The goal of this paper is to explore the basic assumption that largescale, temporal coincidence of specific and nonspecific thalamic activity generates the functional states that characterize human cognition...
  3. pmc Temporal binding via cortical coincidence detection of specific and nonspecific thalamocortical inputs: a voltage-dependent dye-imaging study in mouse brain slices
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 99:449-54. 2002
    ..Coincidence detection by coactivation of the specific (VB) and nonspecific (CL) thalamic nuclei has been proposed as the basis for the temporal conjunction that supports cognitive binding in the brain...
  4. ncbi request reprint The contribution of Santiago Ramón y Cajal to functional neuroscience
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University Medical School, New York, New York 10016, USA
    Nat Rev Neurosci 4:77-80. 2003
  5. pmc Vesicular reuptake inhibition by a synaptotagmin I C2B domain antibody at the squid giant synapse
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:17855-60. 2004
    ..This set of results addresses the issue of the geometrical arrangement of the Ca(2+) sensor, allowing the C2B domain antibody to restrict Ca(2+)-dependent C2B self-oligomerization without modifying the Ca(2+)-dependent release process...
  6. ncbi request reprint Role of gap junctions in synchronized neuronal oscillations in the inferior olive
    Elena Leznik
    Department of Physiology and Neuroscience, New York University Medical School, NY 10016, USA
    J Neurophysiol 94:2447-56. 2005
    ..The findings support the view that oscillatory properties of single IO neurons endow the system with important reset dynamics, while gap junctions are mainly required for synchronized neuronal ensemble activity...
  7. ncbi request reprint Electrotonically mediated oscillatory patterns in neuronal ensembles: an in vitro voltage-dependent dye-imaging study in the inferior olive
    Elena Leznik
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 22:2804-15. 2002
    ..The possibility that such clustering is a consequence of intrinsic oscillations in ensembles of coupled neurons was tested using mathematical modeling...
  8. pmc A model of thalamocortical relay cells
    Paul A Rhodes
    Department of Physiology and Neuroscience, New York University Medical School, 550 1st Avenue, New York, NY 10016, USA
    J Physiol 565:765-81. 2005
    ..The results thus support a new picture of the dendritic tree of relay cells which may have implications for the manner in which thalamic relay cells integrate descending input from the cortex...
  9. doi request reprint Cocaine acute "binge" administration results in altered thalamocortical interactions in mice
    Francisco J Urbano
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York, USA
    Biol Psychiatry 66:769-76. 2009
    ..Given the substantial involvement of the thalamocortical system in sensory processing and perception, we defined electrophysiology-based protocols to attempt a characterization of cocaine effects on thalamocortical circuits...
  10. pmc The effects of microgravity on the development of surface righting in rats
    Kerry D Walton
    Department of Physiology and Neuroscience, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Physiol 565:593-608. 2005
    ..Further, Earth's gravitational field is not assumed by the developing motor system. Rather, postnatal motor system development is appropriate to the gravitational field in which the animal is reared...
  11. pmc Role of Rab27 in synaptic transmission at the squid giant synapse
    Eunah Yu
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:16003-8. 2008
    ..These results, taken together, indicate that Rab27 is primarily involved in the maturation of recycled vesicles and/or their transport to the presynaptic active zone in the squid giant synapse...
  12. ncbi request reprint Bursting of thalamic neurons and states of vigilance
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York, USA
    J Neurophysiol 95:3297-308. 2006
    ..In addition, thalamocortical activity has been shown to be involved in the genesis of several neuropsychiatric conditions collectively described as thalamocortical dysrhythmia syndrome...
  13. pmc The 'prediction imperative' as the basis for self-awareness
    Rodolfo R Llinas
    New York University School of Medicine, New York, NY 10016, USA
    Philos Trans R Soc Lond B Biol Sci 364:1301-7. 2009
    ..We address how such predictive function may originate from the dynamic properties of neuronal networks...
  14. pmc Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:17819-24. 2007
    ..Hence, although N-type calcium channels can rescue P/Q-dependent synaptic transmission, P/Q calcium channels are essential in the generation of gamma-band activity and resultant cognitive function...
  15. pmc Calcium clearance and its energy requirements in cerebellar neurons
    Maxim V Ivannikov
    Department of Physiology and Neuroscience, NYU School of Medicine, NY 10016, USA
    Cell Calcium 47:507-13. 2010
    ..Taken together, these data suggest that calcium clearance in cerebellar granule and purkinje cells relies on the plasma membrane Ca(2+)-ATPase, and is powered by glycolysis...
  16. pmc Cerebellar neurodegeneration in the absence of microRNAs
    Anne Schaefer
    Laboratory of Molecular and Cellular Neuroscience and 2Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1553-8. 2007
    ..The progressive neurodegeneration in the absence of Dicer raises the possibility of an involvement of miRNAs in neurodegenerative disorders...
  17. ncbi request reprint Robust axonal sprouting and synaptogenesis in organotypic slice cultures of rat cerebellum exposed to increased potassium chloride
    Suzanne Chen
    Department of Otolaryngology and Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Brain Res 1057:88-97. 2005
    ....
  18. pmc Imaging synaptosomal calcium concentration microdomains and vesicle fusion by using total internal reflection fluorescent microscopy
    Yafell Serulle
    Program in Neuroscience and Physiology, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:1697-702. 2007
    ..Moreover, the immediately available vesicular pool represents molecularly trapped vesicles that can be located at a larger distance from the plasma membrane than the field illuminated by total internal reflection fluorescent microscopy...
  19. pmc Modafinil enhances thalamocortical activity by increasing neuronal electrotonic coupling
    Francisco J Urbano
    Department of Physiology and Neuroscience, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:12554-9. 2007
    ..It was further established that this restoration is implemented through a Ca(2+)/calmodulin protein kinase II-dependent step...
  20. pmc Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat
    Eric J Lang
    Department of Physiology and Neuroscience, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    J Physiol 571:101-20. 2006
    ..In sum, the results indicate that MCtx's ability to generate movements is modulated by an oscillatory signal arising in the olivocerebellar system...
  21. pmc Somatomotor and oculomotor inferior olivary neurons have distinct electrophysiological phenotypes
    Francisco J Urbano
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:16550-5. 2006
    ..This finding indicates that motor control, from the perspective of the olivocerebellar system, is fundamentally different for the oculomotor and the somatomotor systems...
  22. pmc Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice
    Soonwook Choi
    New York University School of Medicine, Department of Physiology and Neuroscience, 550 First Ave, MSB 442, New York, NY 10016, USA
    J Physiol 588:3031-43. 2010
    ..These findings were supported by results from a mathematical IO neuronal model that incorporated T and P/Q channel kinetics...
  23. ncbi request reprint Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Medicine and Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain 125:1210-34. 2002
    ..The variations in cerebral metabolism in chronic PVS patients indicate that some cerebral regions can retain partial function in catastrophically injured brains...
  24. pmc The representation of polysemy: MEG evidence
    Liina Pylkkänen
    Department of Linguistics, New York University, New York, NY 10003, USA
    J Cogn Neurosci 18:97-109. 2006
    ....
  25. pmc 1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities
    Yafell Serulle
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:2437-41. 2007
    ....

Research Grants2

  1. NEUROBIOLOGY OF CEREBELLAR-BRAINSTEM SYSTEMS
    Rodolfo Llinas; Fiscal Year: 2007
    ..In fact, the o ..
  2. NEUROBIOLOGY OF CEREBELLAR-BRAINSTEM SYSTEMS
    Rodolfo Llinas; Fiscal Year: 2008
    ..In fact, the o ..