K K Linask
Affiliation: New Jersey
- N-cadherin-catenin interaction: necessary component of cardiac cell compartmentalization during early vertebrate heart developmentK K Linask
Department of Cell Biology, University of Medicine and Dentistry of New Jersey, Stratford 08084, USA
Dev Biol 185:148-64. 1997....
- N-cadherin/catenin-mediated morphoregulation of somite formationK K Linask
Department of Cell Biology, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
Dev Biol 202:85-102. 1998..It is proposed that the N-cadherin-mediated adhesion process may serve as a common, evolutionarily conserved, link in the differentiation pathways of skeletal and cardiac muscle...
- Regulation of heart morphology: current molecular and cellular perspectives on the coordinated emergence of cardiac form and functionKersti K Linask
Department of Cell Biology, University of Medicine and Dentistry of New Jersey SOM Stratford, NJ 08084, USA
Birth Defects Res C Embryo Today 69:14-24. 2003..During early heart development, in addition to cells being induced to differentiate into cardiomyocytes, pathways are activated that lead to cardiac morphogenesis or the development of form...
- Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart developmentK K Linask
Department of Cell Biology, University of Medicine and Dentistry of New Jersey UMDNJ, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
Dev Dyn 221:249-64. 2001....
- Directionality of heart looping: effects of Pitx2c misexpression on flectin asymmetry and midline structuresKersti K Linask
Department of Cell Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
Dev Biol 246:407-17. 2002..The position of the heart with respect to the embryo midline is defined by the position of the foregut. Incubating embryos in the presence of flectin antibody caused randomization of heart looping or no looping...
- Effects of antisense misexpression of CFC on downstream flectin protein expression during heart loopingKersti K Linask
Department of Cell Biology, University of Medicine and Dentistry of New Jersey SOM, Stratford, New Jersey, USA
Dev Dyn 228:217-30. 2003..Thus, Pitx2 can be experimentally uncoupled from heart looping. The flectin asymmetry continues to be maintained in the secondary heart field during looping...
- Differential expression of flectin in the extracellular matrix and left-right asymmetry in mouse embryonic heart during looping stagesT Tsuda
Department of Cell Biology, University of Medicine and Dentistry of New Jersey, Stratford 08043, USA
Dev Genet 23:203-14. 1998..The remodeling of the extracellular matrix (ECM) including specific flectin expression begins with the looping process. This morphogenetic change of the ECM coincides with the differentiation of each region of the tubular heart...
- Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite productionG Yue
Department of Cell Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, USA
J Pharmacol Exp Ther 297:915-25. 2001..These results strongly suggest that local elevated level of peroxynitrite produced from increased iNOS expression and activity is a major contributor to colon epithelial apoptosis during colon inflammation...
- Myofibrillogenesis in the first cardiomyocytes formed from isolated quail precardiac mesodermAiping Du
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Dev Biol 257:382-94. 2003....
- Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineageJacquelyn Gerhart
Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, USA
J Cell Biol 178:649-60. 2007..Stable programming in the epiblast may ensure that MyoDpos cells express similar signaling molecules in a variety of environments...
- Early temporal-specific responses and differential sensitivity to lithium and Wnt-3A exposure during heart developmentShyam M Manisastry
University of South Florida Children s Research Institute, Department of Pediatrics, St Petersburg, Florida 33701, USA
Dev Dyn 235:2160-74. 2006..Taken together, our results demonstrate that there are temporal-specific responses and differential sensitivities to lithium/Wnt-3A exposure during early heart development...
- Molecular effects of lithium exposure during mouse and chick gastrulation and subsequent valve dysmorphogenesisJizhen Chen
USF Pediatric Cardiology, Department of Pediatrics, Children s Research Institute, St Petersburg, Florida 33701, USA
Birth Defects Res A Clin Mol Teratol 82:508-18. 2008..The objective of this study was to define whether Li mimicry of canonical Wnt/beta-catenin signaling induces cardiac valve defects...
- Cross talk between cell-cell and cell-matrix adhesion signaling pathways during heart organogenesis: implications for cardiac birth defectsKersti K Linask
Department of Pediatrics, University of South Florida, College of Medicine, The Children s Research Institute, St Petersburg, FL 33701, USA
Microsc Microanal 11:200-8. 2005..Lithium exposure results in an anterior-posterior progression of severe cardiac defects...
- Cardiac morphogenesis: matrix metalloproteinase coordination of cellular mechanisms underlying heart tube formation and directionality of loopingKersti K Linask
University of South Florida, Department of Pediatrics, The Children s Research Institute, St Petersburg, Florida 33701, USA
Dev Dyn 233:739-53. 2005....
- A role for the cytoskeleton in heart loopingKersti K Linask
University of South Florida and All Children s Hospital, Department of Pediatrics, The Children s Research Institute, St Petersburg, FL 33701, USA
ScientificWorldJournal 7:280-98. 2007..In recent years, the steps involved in this central and complex process of heart development that is the basis of numerous congenital heart defects are being unraveled...
- Tropomyosin expression and dynamics in developing avian embryonic musclesJushuo Wang
Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Cell Motil Cytoskeleton 65:379-92. 2008..We speculate that the differences in the two muscles is due to the appearance of nebulin in the skeletal myocytes premyofibrils transform into mature myofibrils...
- MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environmentMingda Han
Department of Pediatrics, USF Children s Research Institute, St Petersburg, Florida 33701, USA
Dev Dyn 235:124-31. 2006..These results indicate that cardiac precursor cells are equipped for differentiating in a hypoxic environment using anaerobic metabolism for energy production...