T K Li

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Tumor cell death induced by topoisomerase-targeting drugs
    T K Li
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 41:53-77. 2001
  2. ncbi request reprint Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells
    M M Sanders
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway 08854, USA
    Biochem Pharmacol 56:1157-66. 1998
  3. ncbi request reprint Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar
    S P Sim
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Biochemistry 36:13285-91. 1997
  4. ncbi request reprint Mechanism of action of camptothecin
    L F Liu
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Ann N Y Acad Sci 922:1-10. 2000
  5. ncbi request reprint Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells
    S D Desai
    Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Res 61:5926-32. 2001

Collaborators

  • M M Sanders
  • D S Pilch
  • L F Liu
  • S D Desai
  • S P Sim
  • E H Rubin
  • A Rodriguez-Bauman
  • Y Mao
  • M Sun
  • C Yu
  • B Gatto
  • E J LaVoie
  • A A Liu

Detail Information

Publications5

  1. ncbi request reprint Tumor cell death induced by topoisomerase-targeting drugs
    T K Li
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 41:53-77. 2001
    ..The involvement of ubiquitin/26S proteasome and SUMO/UBC9 in these processes, as well as the role of topoisomerase cleavable complexes in apoptotic cell death are discussed...
  2. ncbi request reprint Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells
    M M Sanders
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway 08854, USA
    Biochem Pharmacol 56:1157-66. 1998
    ..Uptake systems remaining as candidates, supported by preliminary data, include transport via vesicles derived from specialized membrane invaginations and selected carrier-mediated organic amine transport systems...
  3. ncbi request reprint Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar
    S P Sim
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Biochemistry 36:13285-91. 1997
    ..Our results suggest that nogalamycin, in contrast to camptothecin, may stimulate TOP1 cleavage by binding to a site(s) distal to the site of cleavage...
  4. ncbi request reprint Mechanism of action of camptothecin
    L F Liu
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Ann N Y Acad Sci 922:1-10. 2000
    ..The second involves SUMO conjugation to topo-I. The potentials roles of these new mechanisms for repair of topo-I-mediated DNA damage in determining CPT sensitivity/resistance in tumor cells are discussed...
  5. ncbi request reprint Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells
    S D Desai
    Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Res 61:5926-32. 2001
    ....