Affiliation: New Jersey
Levin B, Sherwin R. Peripheral glucose homeostasis: does brain insulin matter?. J Clin Invest. 2011;121:3392-5 pubmed publisher
Levin B. Glucose-regulated dopamine release from substantia nigra neurons. Brain Res. 2000;874:158-64 pubmed
..These interactions could provide a mechanism whereby glucose modulates motor activity involved in food intake. ..
Levin B, Magnan C, Dunn Meynell A, Le Foll C. Metabolic sensing and the brain: who, what, where, and how?. Endocrinology. 2011;152:2552-7 pubmed publisher
..Thus, these specialized neurons are capable of monitoring and integrating multiple signals from the periphery as a means of regulating peripheral energy homeostasis. ..
Levin B, Brown K, Dunn Meynell A. Differential effects of diet and obesity on high and low affinity sulfonylurea binding sites in the rat brain. Brain Res. 1996;739:293-300 pubmed
..These studies demonstrate a significant population of low affinity sulfonylurea binding sites throughout the forebrain which, along with high affinity sites, are regulated as a function of both weight gain phenotype and diet composition...
Levin B, Dunn Meynell A. In vivo and in vitro regulation of [3H]glyburide binding to brain sulfonylurea receptors in obesity-prone and resistant rats by glucose. Brain Res. 1997;776:146-53 pubmed
..Again, there was little effect on high-affinity binding. Thus, glucose may affect the firing of glucose-responsive neurons by indirectly altering KATP channel function via its effects on low-affinity cell body SUR...
Levin B, Richard D, Michel C, Servatius R. Differential stress responsivity in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1357-64 pubmed
..Thus DIO rats are hyporesponsive to chronic stress compared with DR rats. This is in keeping with several other known differences in hypothalamopituitary and autonomic function in this model...
Levin B, Dunn Meynell A. Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol. 2000;279:R2222-8 pubmed
..Thus sibutramine lowered the defended body weight in association with compensatory changes in those central pathways involved in energy homeostasis...
Levin B, Dunn Meynell A, Ricci M, Cummings D. Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. Am J Physiol Endocrinol Metab. 2003;285:E949-57 pubmed
..These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role. ..
Levin B, Dunn Meynell A, Banks W. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol. 2004;286:R143-50 pubmed
..Defects in leptin transport appear to be an acquired defect associated with the development of obesity and possibly age. ..