Paola Leone

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Long-term follow-up after gene therapy for canavan disease
    Paola Leone
    Department of Cell Biology, Cell and Gene Therapy Center, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08034, USA
    Sci Transl Med 4:165ra163. 2012
  2. pmc Aspartoacylase supports oxidative energy metabolism during myelination
    Jeremy S Francis
    Cell and Gene Therapy Center, Department of Cell Biology, University of Medicine and Dentistry of NJ, Stratford, New Jersey 08084, USA
    J Cereb Blood Flow Metab 32:1725-36. 2012
  3. ncbi request reprint Serial 1H-MRS in GM2 gangliosidoses
    Mitra Assadi
    Division of Neurology, University of Medicine and Dentistry of New Jersey, 3 Cooper Plaza, Suite 320, Camden, NJ 08103, USA
    Eur J Pediatr 167:347-52. 2008
  4. doi request reprint Endogenous aspartoacylase expression is responsive to glutamatergic activity in vitro and in vivo
    Jeremy S Francis
    Cell and Gene Therapy Center, UMDNJ School of Osteopathic Medicine, Stratford, New Jersey, USA
    Glia 59:1435-46. 2011

Research Grants

Detail Information

Publications4

  1. pmc Long-term follow-up after gene therapy for canavan disease
    Paola Leone
    Department of Cell Biology, Cell and Gene Therapy Center, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08034, USA
    Sci Transl Med 4:165ra163. 2012
    ..AAV2-ASPA gene therapy resulted in a decrease in elevated NAA in the brain and slowed progression of brain atrophy, with some improvement in seizure frequency and with stabilization of overall clinical status...
  2. pmc Aspartoacylase supports oxidative energy metabolism during myelination
    Jeremy S Francis
    Cell and Gene Therapy Center, Department of Cell Biology, University of Medicine and Dentistry of NJ, Stratford, New Jersey 08084, USA
    J Cereb Blood Flow Metab 32:1725-36. 2012
    ..N-acetylaspartic acid is proposed here to support lipid synthesis and energy metabolism via the provision of substrate for both cellular processes during early postnatal development...
  3. ncbi request reprint Serial 1H-MRS in GM2 gangliosidoses
    Mitra Assadi
    Division of Neurology, University of Medicine and Dentistry of New Jersey, 3 Cooper Plaza, Suite 320, Camden, NJ 08103, USA
    Eur J Pediatr 167:347-52. 2008
    ..1H-MRS may be a valuable tool in monitoring the disease progress and response to therapy in GM2 gangliosidoses. Elevation in the mI may prove to be more sensitive than the other metabolite alterations...
  4. doi request reprint Endogenous aspartoacylase expression is responsive to glutamatergic activity in vitro and in vivo
    Jeremy S Francis
    Cell and Gene Therapy Center, UMDNJ School of Osteopathic Medicine, Stratford, New Jersey, USA
    Glia 59:1435-46. 2011
    ....

Research Grants5

  1. Aspartoacylase gene transfer in brain/Canavan Disease
    Paola Leone; Fiscal Year: 2004
    ..abstract_text> ..