Sylvia Lee-Huang

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 307:1029-37. 2003
  2. ncbi Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 415:384-9. 2011
  3. ncbi Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin
    S Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:2678-81. 1999
  4. ncbi Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 354:879-84. 2007
  5. ncbi Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 354:872-8. 2007
  6. ncbi A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions
    Hui Guang Li
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 391:340-5. 2010
  7. ncbi Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    Biochemistry 44:4648-55. 2005
  8. ncbi Production of antiviral and antitumor proteins MAP30 and GAP31 in cucurbits using the plant virus vector ZYMV-AGII
    Tzahi Arazi
    ViroGene Ltd, Hod Hasharon, Israel
    Biochem Biophys Res Commun 292:441-8. 2002

Research Grants

  1. Interactions Between Olive Leaf Extract and HIV Drugs
    Sylvia Lee Huang; Fiscal Year: 2005

Collaborators

  • Li Zhang
  • Young Tae Chang
  • Y Sun
  • Zhang Li
  • Sylvia Lee Huang
  • Hui Guang Li
  • Tzahi Arazi
  • John Zhang
  • Paul L Huang
  • Philip L Huang
  • Xiang Peng Kong
  • Dawei Zhang
  • HAO CHIA CHEN
  • Yoel Moshe Shiboleth
  • Amit Gal-On
  • Paul Lee Huang
  • Philip Lin Huang

Detail Information

Publications8

  1. ncbi Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 307:1029-37. 2003
    ....
  2. ncbi Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 415:384-9. 2011
    ..Our results offer new insights into the cellular mechanisms of viral transmission and identify mitochondria as new host targets for viral infection...
  3. ncbi Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin
    S Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:2678-81. 1999
    ..We also find that lysozyme from chicken egg white, human milk, and human neutrophils and RNase A from bovine pancreas possess activity against HIV-1. These findings may offer additional strategies for the treatment of HIV-1 infection...
  4. ncbi Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 354:879-84. 2007
    ..These studies demonstrate that molecular modeling of target-ligand interaction coupled with structural-activity analysis should facilitate the design and identification of innovative integrase inhibitors and other therapeutics...
  5. ncbi Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 354:872-8. 2007
    ..Ole and HT exhibit dose-dependent inhibition on HIV-1 fusion core formation with EC(50)s of 66-58nM, with no detectable toxicity. Our findings on effects of HIV-1 integrase are reported in the subsequent article...
  6. ncbi A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions
    Hui Guang Li
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 391:340-5. 2010
    ....
  7. ncbi Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity
    Sylvia Lee-Huang
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    Biochemistry 44:4648-55. 2005
    ..HL9 blocks HIV-1 viral entrance and replication, and modulates gene expression of HIV-infected cells, affecting pathways involved in survival, stress, TGFbeta, p53, NFkappaB, protein kinase C and hedgehog signaling...
  8. ncbi Production of antiviral and antitumor proteins MAP30 and GAP31 in cucurbits using the plant virus vector ZYMV-AGII
    Tzahi Arazi
    ViroGene Ltd, Hod Hasharon, Israel
    Biochem Biophys Res Commun 292:441-8. 2002
    ..This provides valuable alternative food sources of these antiviral, antitumor, and antimicrobial agents for therapeutic applications...

Research Grants3

  1. Interactions Between Olive Leaf Extract and HIV Drugs
    Sylvia Lee Huang; Fiscal Year: 2005
    ..We hope that this information will provide an important knowledge base for anti-HIV therapy of OLE alone or in combination with HAART, as well as contribute to our understanding of viral pathogenesis. ..