Research Topics
| Joseph LeDouxSummaryAffiliation: New York University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
From fear to safety and back: reversal of fear in the human brainDaniela Schiller
Psychology Department, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 28:11517-25. 2008..These results elucidate how fear is readjusted to appropriately track environmental changes, and the brain mechanisms underlying the flexible control of fear...
The amygdalaJoseph LeDoux
Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA
Curr Biol 17:R868-74. 2007- Rethinking the emotional brainJoseph LeDoux
Center for Neural Science and Department of Psychology, New York University, New York, NY 10003, USA
Neuron 73:653-76. 2012..The survival circuit concept integrates ideas about emotion, motivation, reinforcement, and arousal in the effort to understand how organisms survive and thrive by detecting and responding to challenges and opportunities in daily life... - Fear-related activity in subgenual anterior cingulate differs between men and womenTracy Butler
Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, New York, USA
Neuroreport 16:1233-6. 2005.... - Increased brainstem volume in panic disorder: a voxel-based morphometric studyXenia Protopopescu
Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA
Neuroreport 17:361-3. 2006..This finding has implications for pathophysiologic models of panic disorder, and provides structural evidence for the role of the brainstem in neurocircuitry models of panic disorder... - Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapsesSarina M Rodrigues
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 24:3281-8. 2004..Together, the results of these experiments provide the first comprehensive view of the role of CaMKII in the amygdala during fear conditioning... - The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdalaSarina M Rodrigues
W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 22:5219-29. 2002..Collectively, the results of this study indicate that mGluR5 in the LA plays a crucial role in fear conditioning and in plasticity at synapses involved in fear conditioning... - Ventral medial prefrontal cortex and emotional perseveration: the memory for prior extinction trainingMaria A Morgan
Department of Psychology, New York University, New York, NY, USA
Behav Brain Res 146:121-30. 2003..Third, contextual cues processed by mPFCv may influence extinction performance... - Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear systemAnnemieke M Apergis-Schoute
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 25:5730-9. 2005.... 
The amygdala encodes specific sensory features of an aversive reinforcerJacek Debiec
W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York, USA
Nat Neurosci 13:536-7. 2010..Thus, specific features of the unconditioned stimulus appear to be encoded in the amygdala as part of fear memories stored there...- Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contributionFrancisco Sotres-Bayon
Center for Neural Science, New York University, New York, NY 10003, USA
Cereb Cortex 19:474-82. 2009.... - The role of amygdala nuclei in the expression of auditory signaled two-way active avoidance in ratsJune Seek Choi
Center for Neural Science, New York University, New York, New York 10003, USA
Learn Mem 17:139-47. 2010..The CE is not required, and may in fact constrain the instrumental avoidance response by mediating the generation of competing Pavlovian responses, such as freezing... - Response variation following trauma: a translational neuroscience approach to understanding PTSDRachel Yehuda
Division of Traumatic Stress Studies, Mount Sinai School of Medicine, James J Peters Veteran Affairs, New York, NY 10468, USA
Neuron 56:19-32. 2007..We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD... - The self: clues from the brainJoseph LeDoux
Center for Neural Science, New York University, New York, New York 10003, USA
Ann N Y Acad Sci 1001:295-304. 2003..It is instead, just a way of understanding how these other aspects of who we are relate, deep down, to the brain... - Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiationStephanie C Lazzaro
Center for Neural Science, New York University, New York, New York 10003, USA
Learn Mem 17:489-93. 2010..Since alpha1 blockers are prescribed for hypertension and post-traumatic stress disorder, these results may have important clinical implications... - Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdalaLinnaea E Ostroff
Center for Neural Science, New York University, New York, NY 10003, USA
Proc Natl Acad Sci U S A 107:9418-23. 2010..We conclude that LA synapse size changes bidirectionally with learning and that the spine apparatus has a central role in regulating synapse size and local translation... - Preventing the return of fear in humans using reconsolidation update mechanismsDaniela Schiller
Center for Neural Science, New York University, New York, New York 10003, USA
Nature 463:49-53. 2010..These findings demonstrate the adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories, and suggest a non-invasive technique that can be used safely in humans to prevent the return of fear... - Contributions of the amygdala to emotion processing: from animal models to human behaviorElizabeth A Phelps
Department of Psychology, New York University, 4 6 Washington Place, New York, New York 10003, USA
Neuron 48:175-87. 2005.... - Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortexFrancisco Sotres-Bayon
Center for Neural Science, New York University, New York, New York 10003, USA
Biol Psychiatry 60:329-36. 2006..We also consider the role of the mPFC in a broader neural circuit for extinction that includes the amygdala and hippocampus... - Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdalaJacek Debiec
WM Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, Room 809, NY 10003, USA
Proc Natl Acad Sci U S A 103:3428-33. 2006.... - Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdalaFrancisco Sotres-Bayon
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
Neuropsychopharmacology 32:1929-40. 2007..Thus, our results support a previously not known role for NMDA-dependent plasticity in the lateral amygdala during the acquisition of fear extinction... - Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSDJacek Debiec
Center for Neural Science, New York University, 4 Washington Pl, Room 809, New York, NY 10003, USA
Ann N Y Acad Sci 1071:521-4. 2006..This suggests that noradrenergic blockade may be useful in attenuating traumatic memories, even well-consolidated old memories, in PTSD... - Brain-derived neurotrophic factor: linking fear learning to memory consolidationMarie H Monfils
Center for Neural Science, 4 Washington Place, Room 809, New York University, New York, NY 10003 6621, USA
Mol Pharmacol 72:235-7. 2007..Each induces phosphorylation of cAMP response element-binding protein, which binds to the BDNF promoter, leading to BDNF expression in the LA, and contributes to fear memory consolidation... - Individual differences in fear: isolating fear reactivity and fear recovery phenotypesDavid E A Bush
Center for Neural Science, New York University, New York, NY 10003, USA
J Trauma Stress 20:413-22. 2007..Because clinical disorders may reflect extreme phenotypes, identification of the biological basis for these differences could provide insights into human individual differences in fear... - Extinction-reconsolidation boundaries: key to persistent attenuation of fear memoriesMarie H Monfils
Center for Neural Science, New York University, New York, NY 10003, USA
Science 324:951-5. 2009..This procedure permanently attenuates the fear memory without the use of drugs... - Escape from fear: a detailed behavioral analysis of two atypical responses reinforced by CS terminationChristopher K Cain
W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY 10003, USA
J Exp Psychol Anim Behav Process 33:451-63. 2007..Successful EFF learning also resulted in better long-term elimination of a passive fear reaction (freezing). Factors important for EFF experiments and theoretical considerations are discussed... - Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats--a possible mechanism for the persistence of traumatic memories in PTSDJacek Debiec
W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, NY, USA
Depress Anxiety 28:186-93. 2011..We previously reported that noradrenergic blockade in the rat amygdala impairs reconsolidation of fear memories. Here we investigated the effects of noradrenergic enhancement on reconsolidation of learned fear... - Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memoryTorfi Sigurdsson
Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA
Neuropharmacology 52:215-27. 2007..The results gained from these studies may shed light not only on fear conditioning, but may also help unravel more general cellular mechanisms of learning and memory... - NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdalaElizabeth P Bauer
W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 22:5239-49. 2002..Collectively, the results suggest that two pharmacologically distinct forms of LTP can be isolated in the LA in vitro and that a combination of both contribute to the formation of fear memories in vivo at the cellular level... - Conclusions: from self-knowledge to a science of the selfJacek Debiec
Center for Neural Science, New York University, New York, New York 10003, USA
Ann N Y Acad Sci 1001:305-15. 2003..This conference and volume explored areas where some of the different approaches to the self overlap and will, it is hoped, promote the establishment of a richer, more coherent image of what the self is... - Extinction learning in humans: role of the amygdala and vmPFCElizabeth A Phelps
Department of Psychology and New York University, New York, NY 10003, USA
Neuron 43:897-905. 2004..These results provide evidence that the mechanisms of extinction learning may be preserved across species... - Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complexRaphael Lamprecht
W M Keck Foundation Laboratory for Neurobiology, Center for Neural Science, New York University, New York, NY 10003, USA
Neuron 36:727-38. 2002..Thus, the p190 RhoGAP/ROCK pathway, which regulates the morphology of dendrites and axons during neural development, plays a central role, through a GRB2-mediated molecular complex, in fear memory formation in the lateral amygdala... - Evidence for recovery of fear following immediate extinction in rats and humansDaniela Schiller
Psychology Department, New York University, New York, New York 10003, USA
Learn Mem 15:394-402. 2008..Thus, our data do not support the hypothesis that immediate extinction erases the original memory trace, nor do they suggest that a close temporal proximity of therapeutic intervention to the traumatic event might be advantageous... - Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinctionFrancisco Sotres-Bayon
Center for Neural Science, New York University, New York, New York 10003 6621, USA
Learn Mem 11:525-35. 2004..Based on this result, we propose an updated model for integrating hippocampal-based contextual information with prefrontal-amygdala circuitry... - Heterosynaptic long-term potentiation of inhibitory interneurons in the lateral amygdalaElizabeth P Bauer
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 24:9507-12. 2004..Plasticity of inhibitory transmission within the LA may therefore contribute significantly to LA-mediated functions, such as fear conditioning... - Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioningSevil Duvarci
W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA
Eur J Neurosci 21:283-9. 2005..Our data show that activation of ERK-MAPK signalling pathway and protein synthesis in the LA are required for reconsolidation of auditory fear memories... - The emotional brain, fear, and the amygdalaJoseph LeDoux
Center for Neural Science, New York University, New York, USA
Cell Mol Neurobiol 23:727-38. 2003..3. Before describing research on the role of the amygdala in fear conditioning, though, it will be helpful to briefly examine the historical events that preceded modern research on conditioned fear... - Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spinesJason J Radley
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Brain Res 1134:87-94. 2007.... - Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivoTorfi Siguròsson
Center for Neural Science, New York University, New York, NY 10003, USA
Eur J Neurosci 31:250-62. 2010..These results highlight the divergent nature of short- and long-term plasticity at thalamic and cortical sensory inputs to the LA, pointing to their different roles in the fear learning system... - Long-term potentiation in freely moving rats reveals asymmetries in thalamic and cortical inputs to the lateral amygdalaValérie Doyère
W M Keck Foundation, Laboratory of Neurobiology, Center for Neural Science, NYU, New York, NY 10003, USA
Eur J Neurosci 17:2703-15. 2003.... - Fear conditioning drives profilin into amygdala dendritic spinesRaphael Lamprecht
W M Keck Foundation Laboratory for Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
Nat Neurosci 9:481-3. 2006..A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning... - Molecular mechanisms underlying emotional learning and memory in the lateral amygdalaSarina M Rodrigues
Center for Neural Science, New York University, New York, NY 10003, USA
Neuron 44:75-91. 2004..Given that the neural circuit underlying fear conditioning has been implicated in emotional disorders in humans, the molecular mechanisms of fear conditioning are potential targets for psychotherapeutic drug development... - Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticityKiriana K Cowansage
Center for Neural Science, New York University, New York, USA
Curr Mol Pharmacol 3:12-29. 2010..We conclude by emphasizing the importance of characterizing BDNF signaling cascades in behaviorally-relevant networks, to identify potential drug targets for novel therapeutic interventions... - Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjectsXenia Protopopescu
Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, NY 10021, USA
Biol Psychiatry 57:464-73. 2005..The results also extend previous neuroimaging studies demonstrating relatively increased amygdala response in PTSD and expand these results to a largely female patient population probed with emotionally valenced words... - Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdalaGregory M Sullivan
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Biol Psychiatry 53:863-70. 2003..Doxapram is a respiratory stimulant that reliably evokes panic attacks in patients with panic disorder. We examined doxapram in four rodent models of anxiety and sought to identify brain regions involved in its behavioral effects... - Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonistNesha S Burghardt
W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10032 2695, USA
Biol Psychiatry 62:1111-8. 2007..Here, we extend our findings by assessing the effects of acute SSRI treatment on the expression of previously acquired conditioned fear... - Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioningAnn E Wilensky
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York, New York 10003, USA
J Neurosci 26:12387-96. 2006..These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning... - Optical activation of lateral amygdala pyramidal cells instructs associative fear learningJoshua P Johansen
Center for Neural Science, Department of Psychology, New York University, New York, NY 10003, USA
Proc Natl Acad Sci U S A 107:12692-7. 2010..These results demonstrate in vivo optogenetic control of LA neurons and provide compelling support for the idea that fear learning is instructed by aversive stimulus-induced activation of LA pyramidal cells... - A-kinase anchoring proteins in amygdala are involved in auditory fear memoryMarta A P Moita
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
Nat Neurosci 5:837-8. 2002.... - Sidman instrumental avoidance initially depends on lateral and basal amygdala and is constrained by central amygdala-mediated Pavlovian processesGabriel Lazaro-Munoz
WM Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, NY, USA
Biol Psychiatry 67:1120-7. 2010..Pavlovian freezing was simultaneously assessed to examine the contributions of amygdala nuclei to the transition from reactive to active defensive responding... - The flip side: scientists who rockJoseph LeDoux
Center for Neural Science, New York University, USA
Trends Cogn Sci 15:335-7. 2011..For me, playing music is not a distraction to other life obligations. It makes me better at everything else I do... - Structural plasticity and memoryRaphael Lamprecht
Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA
Nat Rev Neurosci 5:45-54. 2004 - The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptineNesha S Burghardt
W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
Biol Psychiatry 55:1171-8. 2004..The findings also indicate that auditory fear conditioning can be a useful tool in understanding differences in the effects of short-term and long-term antidepressant treatment with serotonergic medications... - Redefining the tonotopic core of rat auditory cortex: physiological evidence for a posterior fieldNeot N Doron
W.M. Keck Laboratories of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Comp Neurol 453:345-60. 2002..Furthermore, our physiological characterization of TE1 reveals that it is larger than suggested by previous anatomical characterizations... - Neural circuitry underlying the regulation of conditioned fear and its relation to extinctionMauricio R Delgado
Department of Psychology, Rutgers University, Newark, NJ 07102, USA
Neuron 59:829-38. 2008..These findings further suggest that humans may have developed complex cognition that can aid in regulating emotional responses while utilizing phylogenetically shared mechanisms of extinction... - Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storageGlenn E Schafe
Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 25:10010-4. 2005.... - A robust automated method to analyze rodent motion during fear conditioningCharles D Kopec
Cold Spring Harbor Laboratory, Jones Building, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Neuropharmacology 52:228-33. 2007..This automated analysis of fear conditioning will permit a more rapid and accurate assessment of the role of LTP in memory... - Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdalaJason J Radley
Laboratory for Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Eur J Neurosci 24:876-84. 2006.... - Cellular and systems reconsolidation in the hippocampusJacek Debiec
Department of Psychiatry, Jagiellonian University Collegium Medicum, 31-501, Cracow, Poland
Neuron 36:527-38. 2002..Thus, hippocampal memories can undergo reconsolidation at both the cellular and systems levels... - Synapse-specific reconsolidation of distinct fear memories in the lateral amygdalaValérie Doyère
Neurobiologie de l Apprentissage, de la Mémoire et de la Communication NAMC, Centre National de la Recherche Scientifique CNRS, UMR8620, Universite Paris Sud, 91405 Orsay, France
Nat Neurosci 10:414-6. 2007..Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses... - Associative plasticity in neurons of the lateral amygdala during auditory fear conditioningHugh T Blair
Department of Psychology, University of California at Los Angeles, Los Angeles, California 90095, USA
Ann N Y Acad Sci 985:485-7. 2003 - New vistas on amygdala networks in conditioned fearDENIS PARE
Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Ave, Newark, NJ 07102, USA
J Neurophysiol 92:1-9. 2004..Thus plasticity in both LA and CE would be necessary for acquisition of conditioned fear. This revised model also accounts for inhibition of conditioned fear after extinction... - Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioningMarta A P Moita
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 37:485-97. 2003..These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning... - Parallels between cerebellum- and amygdala-dependent conditioningJavier F Medina
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neurobiology, University of California, 513 Parnassus Avenue, Room HSE 808, San Francisco, California 94143 0444, USA
Nat Rev Neurosci 3:122-31. 2002..So, anatomically distinct cell populations might contribute differentially to the initial encoding and the long-term storage of memory in these two systems... - Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdalaGlenn E Schafe
Department of Psychology, Yale University, 2 Hillhouse Ave, Box 208205, New Haven, CT 06520, USA
Eur J Neurosci 22:201-11. 2005..Collectively, the findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA... - Putting fear in its place: remapping of hippocampal place cells during fear conditioningMarta A P Moita
Instituto Gulbenkian de Sciencia, P-2780-156 Oeiras, Portugal
J Neurosci 24:7015-23. 2004....
Research Grants
- SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITSJoseph LeDoux; Fiscal Year: 2005..Together, these studies should reveal new information about the cellular basis of fear learning, and may, in the long run, lead to better understanding of the genesis and maintenance, and hopefully the treatment, of pathological fear. ..
- MECHANISMS OF EMOTIONAL MEMORYJoseph LeDoux; Fiscal Year: 2007..abstract_text> ..
- NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONINGJoseph LeDoux; Fiscal Year: 2007..abstract_text> ..
- SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITSJoseph LeDoux; Fiscal Year: 2007....
- Brain Mechanisms of Avoidance: Implications for AddictionJoseph E LeDoux; Fiscal Year: 2010..One area that has received less attention is the role of negative reinforcement and avoidance in addiction and relapse, the main focus of this proposal. ..
- NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONINGJoseph E LeDoux; Fiscal Year: 2010..Such studies of Pavlovian-instrumental interactions will help elucidate anxiety disorders and hopefully lead to improved treatments of these debilitating conditions. ..
- SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITSJoseph LeDoux; Fiscal Year: 1993..The results of these experiments should begin to take our understanding of emotional learning to the level of detailed neural circuits and their synapses and could help in the understanding and treatment of emotional disorders...
- SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITSJoseph LeDoux; Fiscal Year: 2000..These experiments should further our understanding of neural systems that play a role in aversive emotional memory, and in anxiety and related disorders, including posttraumatic stress syndrome and phobia. ..
- MECHANISMS OF EMOTIONAL MEMORYJoseph LeDoux; Fiscal Year: 2002..Together, these studies represent an integrated, multidisciplinary research program aimed at understanding the nature of fear and will hopefully provide information that will be useful in preventing or treating fear disorders. ..
- SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITSJoseph E LeDoux; Fiscal Year: 2010....