Joseph LeDoux

Summary

Affiliation: New York University
Country: USA

Publications

  1. doi request reprint From fear to safety and back: reversal of fear in the human brain
    Daniela Schiller
    Psychology Department, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 28:11517-25. 2008
  2. ncbi request reprint The amygdala
    Joseph LeDoux
    Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA
    Curr Biol 17:R868-74. 2007
  3. pmc Rethinking the emotional brain
    Joseph LeDoux
    Center for Neural Science and Department of Psychology, New York University, New York, NY 10003, USA
    Neuron 73:653-76. 2012
  4. ncbi request reprint Fear-related activity in subgenual anterior cingulate differs between men and women
    Tracy Butler
    Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, New York, USA
    Neuroreport 16:1233-6. 2005
  5. ncbi request reprint Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 24:3281-8. 2004
  6. ncbi request reprint Increased brainstem volume in panic disorder: a voxel-based morphometric study
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA
    Neuroreport 17:361-3. 2006
  7. ncbi request reprint The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5219-29. 2002
  8. ncbi request reprint Ventral medial prefrontal cortex and emotional perseveration: the memory for prior extinction training
    Maria A Morgan
    Department of Psychology, New York University, New York, NY, USA
    Behav Brain Res 146:121-30. 2003
  9. ncbi request reprint Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system
    Annemieke M Apergis-Schoute
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:5730-9. 2005
  10. pmc The amygdala encodes specific sensory features of an aversive reinforcer
    Jacek Debiec
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York, USA
    Nat Neurosci 13:536-7. 2010

Research Grants

  1. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 2005
  2. MECHANISMS OF EMOTIONAL MEMORY
    Joseph LeDoux; Fiscal Year: 2007
  3. NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONING
    Joseph LeDoux; Fiscal Year: 2007
  4. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 2007
  5. Brain Mechanisms of Avoidance: Implications for Addiction
    Joseph E LeDoux; Fiscal Year: 2010
  6. NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONING
    Joseph E LeDoux; Fiscal Year: 2010
  7. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 1993
  8. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 2000
  9. MECHANISMS OF EMOTIONAL MEMORY
    Joseph LeDoux; Fiscal Year: 2002
  10. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph E LeDoux; Fiscal Year: 2010

Collaborators

Detail Information

Publications66

  1. doi request reprint From fear to safety and back: reversal of fear in the human brain
    Daniela Schiller
    Psychology Department, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 28:11517-25. 2008
    ..These results elucidate how fear is readjusted to appropriately track environmental changes, and the brain mechanisms underlying the flexible control of fear...
  2. ncbi request reprint The amygdala
    Joseph LeDoux
    Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA
    Curr Biol 17:R868-74. 2007
  3. pmc Rethinking the emotional brain
    Joseph LeDoux
    Center for Neural Science and Department of Psychology, New York University, New York, NY 10003, USA
    Neuron 73:653-76. 2012
    ..The survival circuit concept integrates ideas about emotion, motivation, reinforcement, and arousal in the effort to understand how organisms survive and thrive by detecting and responding to challenges and opportunities in daily life...
  4. ncbi request reprint Fear-related activity in subgenual anterior cingulate differs between men and women
    Tracy Butler
    Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, New York, USA
    Neuroreport 16:1233-6. 2005
    ....
  5. ncbi request reprint Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 24:3281-8. 2004
    ..Together, the results of these experiments provide the first comprehensive view of the role of CaMKII in the amygdala during fear conditioning...
  6. ncbi request reprint Increased brainstem volume in panic disorder: a voxel-based morphometric study
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA
    Neuroreport 17:361-3. 2006
    ..This finding has implications for pathophysiologic models of panic disorder, and provides structural evidence for the role of the brainstem in neurocircuitry models of panic disorder...
  7. ncbi request reprint The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5219-29. 2002
    ..Collectively, the results of this study indicate that mGluR5 in the LA plays a crucial role in fear conditioning and in plasticity at synapses involved in fear conditioning...
  8. ncbi request reprint Ventral medial prefrontal cortex and emotional perseveration: the memory for prior extinction training
    Maria A Morgan
    Department of Psychology, New York University, New York, NY, USA
    Behav Brain Res 146:121-30. 2003
    ..Third, contextual cues processed by mPFCv may influence extinction performance...
  9. ncbi request reprint Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system
    Annemieke M Apergis-Schoute
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:5730-9. 2005
    ....
  10. pmc The amygdala encodes specific sensory features of an aversive reinforcer
    Jacek Debiec
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York, USA
    Nat Neurosci 13:536-7. 2010
    ..Thus, specific features of the unconditioned stimulus appear to be encoded in the amygdala as part of fear memories stored there...
  11. pmc Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution
    Francisco Sotres-Bayon
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cereb Cortex 19:474-82. 2009
    ....
  12. pmc The role of amygdala nuclei in the expression of auditory signaled two-way active avoidance in rats
    June Seek Choi
    Center for Neural Science, New York University, New York, New York 10003, USA
    Learn Mem 17:139-47. 2010
    ..The CE is not required, and may in fact constrain the instrumental avoidance response by mediating the generation of competing Pavlovian responses, such as freezing...
  13. ncbi request reprint Response variation following trauma: a translational neuroscience approach to understanding PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Mount Sinai School of Medicine, James J Peters Veteran Affairs, New York, NY 10468, USA
    Neuron 56:19-32. 2007
    ..We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD...
  14. ncbi request reprint The self: clues from the brain
    Joseph LeDoux
    Center for Neural Science, New York University, New York, New York 10003, USA
    Ann N Y Acad Sci 1001:295-304. 2003
    ..It is instead, just a way of understanding how these other aspects of who we are relate, deep down, to the brain...
  15. pmc Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats--a possible mechanism for the persistence of traumatic memories in PTSD
    Jacek Debiec
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, NY, USA
    Depress Anxiety 28:186-93. 2011
    ..We previously reported that noradrenergic blockade in the rat amygdala impairs reconsolidation of fear memories. Here we investigated the effects of noradrenergic enhancement on reconsolidation of learned fear...
  16. pmc Preventing the return of fear in humans using reconsolidation update mechanisms
    Daniela Schiller
    Center for Neural Science, New York University, New York, New York 10003, USA
    Nature 463:49-53. 2010
    ..These findings demonstrate the adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories, and suggest a non-invasive technique that can be used safely in humans to prevent the return of fear...
  17. pmc Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories
    Marie H Monfils
    Center for Neural Science, New York University, New York, NY 10003, USA
    Science 324:951-5. 2009
    ..This procedure permanently attenuates the fear memory without the use of drugs...
  18. ncbi request reprint Contributions of the amygdala to emotion processing: from animal models to human behavior
    Elizabeth A Phelps
    Department of Psychology, New York University, 4 6 Washington Place, New York, New York 10003, USA
    Neuron 48:175-87. 2005
    ....
  19. ncbi request reprint Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex
    Francisco Sotres-Bayon
    Center for Neural Science, New York University, New York, New York 10003, USA
    Biol Psychiatry 60:329-36. 2006
    ..We also consider the role of the mPFC in a broader neural circuit for extinction that includes the amygdala and hippocampus...
  20. pmc Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala
    Jacek Debiec
    WM Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, Room 809, NY 10003, USA
    Proc Natl Acad Sci U S A 103:3428-33. 2006
    ....
  21. ncbi request reprint Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala
    Francisco Sotres-Bayon
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Neuropsychopharmacology 32:1929-40. 2007
    ..Thus, our results support a previously not known role for NMDA-dependent plasticity in the lateral amygdala during the acquisition of fear extinction...
  22. ncbi request reprint Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD
    Jacek Debiec
    Center for Neural Science, New York University, 4 Washington Pl, Room 809, New York, NY 10003, USA
    Ann N Y Acad Sci 1071:521-4. 2006
    ..This suggests that noradrenergic blockade may be useful in attenuating traumatic memories, even well-consolidated old memories, in PTSD...
  23. ncbi request reprint Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory
    Torfi Sigurdsson
    Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA
    Neuropharmacology 52:215-27. 2007
    ..The results gained from these studies may shed light not only on fear conditioning, but may also help unravel more general cellular mechanisms of learning and memory...
  24. ncbi request reprint Brain-derived neurotrophic factor: linking fear learning to memory consolidation
    Marie H Monfils
    Center for Neural Science, 4 Washington Place, Room 809, New York University, New York, NY 10003 6621, USA
    Mol Pharmacol 72:235-7. 2007
    ..Each induces phosphorylation of cAMP response element-binding protein, which binds to the BDNF promoter, leading to BDNF expression in the LA, and contributes to fear memory consolidation...
  25. ncbi request reprint Individual differences in fear: isolating fear reactivity and fear recovery phenotypes
    David E A Bush
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Trauma Stress 20:413-22. 2007
    ..Because clinical disorders may reflect extreme phenotypes, identification of the biological basis for these differences could provide insights into human individual differences in fear...
  26. pmc Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation
    Stephanie C Lazzaro
    Center for Neural Science, New York University, New York, New York 10003, USA
    Learn Mem 17:489-93. 2010
    ..Since alpha1 blockers are prescribed for hypertension and post-traumatic stress disorder, these results may have important clinical implications...
  27. ncbi request reprint Escape from fear: a detailed behavioral analysis of two atypical responses reinforced by CS termination
    Christopher K Cain
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY 10003, USA
    J Exp Psychol Anim Behav Process 33:451-63. 2007
    ..Successful EFF learning also resulted in better long-term elimination of a passive fear reaction (freezing). Factors important for EFF experiments and theoretical considerations are discussed...
  28. pmc Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala
    Linnaea E Ostroff
    Center for Neural Science, New York University, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 107:9418-23. 2010
    ..We conclude that LA synapse size changes bidirectionally with learning and that the spine apparatus has a central role in regulating synapse size and local translation...
  29. ncbi request reprint NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala
    Elizabeth P Bauer
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5239-49. 2002
    ..Collectively, the results suggest that two pharmacologically distinct forms of LTP can be isolated in the LA in vitro and that a combination of both contribute to the formation of fear memories in vivo at the cellular level...
  30. ncbi request reprint Conclusions: from self-knowledge to a science of the self
    Jacek Debiec
    Center for Neural Science, New York University, New York, New York 10003, USA
    Ann N Y Acad Sci 1001:305-15. 2003
    ..This conference and volume explored areas where some of the different approaches to the self overlap and will, it is hoped, promote the establishment of a richer, more coherent image of what the self is...
  31. ncbi request reprint Extinction learning in humans: role of the amygdala and vmPFC
    Elizabeth A Phelps
    Department of Psychology and New York University, New York, NY 10003, USA
    Neuron 43:897-905. 2004
    ..These results provide evidence that the mechanisms of extinction learning may be preserved across species...
  32. ncbi request reprint Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex
    Raphael Lamprecht
    W M Keck Foundation Laboratory for Neurobiology, Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 36:727-38. 2002
    ..Thus, the p190 RhoGAP/ROCK pathway, which regulates the morphology of dendrites and axons during neural development, plays a central role, through a GRB2-mediated molecular complex, in fear memory formation in the lateral amygdala...
  33. ncbi request reprint Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinction
    Francisco Sotres-Bayon
    Center for Neural Science, New York University, New York, New York 10003 6621, USA
    Learn Mem 11:525-35. 2004
    ..Based on this result, we propose an updated model for integrating hippocampal-based contextual information with prefrontal-amygdala circuitry...
  34. ncbi request reprint Heterosynaptic long-term potentiation of inhibitory interneurons in the lateral amygdala
    Elizabeth P Bauer
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 24:9507-12. 2004
    ..Plasticity of inhibitory transmission within the LA may therefore contribute significantly to LA-mediated functions, such as fear conditioning...
  35. ncbi request reprint Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning
    Sevil Duvarci
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA
    Eur J Neurosci 21:283-9. 2005
    ..Our data show that activation of ERK-MAPK signalling pathway and protein synthesis in the LA are required for reconsolidation of auditory fear memories...
  36. pmc Evidence for recovery of fear following immediate extinction in rats and humans
    Daniela Schiller
    Psychology Department, New York University, New York, New York 10003, USA
    Learn Mem 15:394-402. 2008
    ..Thus, our data do not support the hypothesis that immediate extinction erases the original memory trace, nor do they suggest that a close temporal proximity of therapeutic intervention to the traumatic event might be advantageous...
  37. ncbi request reprint Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, NY 10021, USA
    Biol Psychiatry 57:464-73. 2005
    ..The time course of this amygdala response is largely unstudied and is relevant to questions of habituation and sensitization in PTSD exposure therapy...
  38. ncbi request reprint The emotional brain, fear, and the amygdala
    Joseph LeDoux
    Center for Neural Science, New York University, New York, USA
    Cell Mol Neurobiol 23:727-38. 2003
    ..3. Before describing research on the role of the amygdala in fear conditioning, though, it will be helpful to briefly examine the historical events that preceded modern research on conditioned fear...
  39. pmc Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo
    Torfi Siguròsson
    Center for Neural Science, New York University, New York, NY 10003, USA
    Eur J Neurosci 31:250-62. 2010
    ..These results highlight the divergent nature of short- and long-term plasticity at thalamic and cortical sensory inputs to the LA, pointing to their different roles in the fear learning system...
  40. pmc Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1134:87-94. 2007
    ....
  41. ncbi request reprint Long-term potentiation in freely moving rats reveals asymmetries in thalamic and cortical inputs to the lateral amygdala
    Valérie Doyère
    W M Keck Foundation, Laboratory of Neurobiology, Center for Neural Science, NYU, New York, NY 10003, USA
    Eur J Neurosci 17:2703-15. 2003
    ....
  42. ncbi request reprint Fear conditioning drives profilin into amygdala dendritic spines
    Raphael Lamprecht
    W M Keck Foundation Laboratory for Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    Nat Neurosci 9:481-3. 2006
    ..A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning...
  43. ncbi request reprint Molecular mechanisms underlying emotional learning and memory in the lateral amygdala
    Sarina M Rodrigues
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 44:75-91. 2004
    ..Given that the neural circuit underlying fear conditioning has been implicated in emotional disorders in humans, the molecular mechanisms of fear conditioning are potential targets for psychotherapeutic drug development...
  44. ncbi request reprint Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity
    Kiriana K Cowansage
    Center for Neural Science, New York University, New York, USA
    Curr Mol Pharmacol 3:12-29. 2010
    ..We conclude by emphasizing the importance of characterizing BDNF signaling cascades in behaviorally-relevant networks, to identify potential drug targets for novel therapeutic interventions...
  45. ncbi request reprint Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala
    Gregory M Sullivan
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 53:863-70. 2003
    ..Doxapram is a respiratory stimulant that reliably evokes panic attacks in patients with panic disorder. We examined doxapram in four rodent models of anxiety and sought to identify brain regions involved in its behavioral effects...
  46. pmc Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonist
    Nesha S Burghardt
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10032 2695, USA
    Biol Psychiatry 62:1111-8. 2007
    ..Here, we extend our findings by assessing the effects of acute SSRI treatment on the expression of previously acquired conditioned fear...
  47. ncbi request reprint Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning
    Ann E Wilensky
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York, New York 10003, USA
    J Neurosci 26:12387-96. 2006
    ..These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning...
  48. pmc Optical activation of lateral amygdala pyramidal cells instructs associative fear learning
    Joshua P Johansen
    Center for Neural Science, Department of Psychology, New York University, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 107:12692-7. 2010
    ..These results demonstrate in vivo optogenetic control of LA neurons and provide compelling support for the idea that fear learning is instructed by aversive stimulus-induced activation of LA pyramidal cells...
  49. ncbi request reprint A-kinase anchoring proteins in amygdala are involved in auditory fear memory
    Marta A P Moita
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Nat Neurosci 5:837-8. 2002
    ....
  50. pmc Sidman instrumental avoidance initially depends on lateral and basal amygdala and is constrained by central amygdala-mediated Pavlovian processes
    Gabriel Lazaro-Munoz
    WM Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, NY, USA
    Biol Psychiatry 67:1120-7. 2010
    ..Pavlovian freezing was simultaneously assessed to examine the contributions of amygdala nuclei to the transition from reactive to active defensive responding...
  51. doi request reprint The flip side: scientists who rock
    Joseph LeDoux
    Center for Neural Science, New York University, USA
    Trends Cogn Sci 15:335-7. 2011
    ..For me, playing music is not a distraction to other life obligations. It makes me better at everything else I do...
  52. ncbi request reprint Structural plasticity and memory
    Raphael Lamprecht
    Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA
    Nat Rev Neurosci 5:45-54. 2004
  53. ncbi request reprint The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine
    Nesha S Burghardt
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    Biol Psychiatry 55:1171-8. 2004
    ..In this study, we used fear conditioning to begin to understand how acute and chronic SSRI treatment might differentially affect well-characterized fear circuits...
  54. ncbi request reprint Redefining the tonotopic core of rat auditory cortex: physiological evidence for a posterior field
    Neot N Doron
    W M Keck Laboratories of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 453:345-60. 2002
    ..Furthermore, our physiological characterization of TE1 reveals that it is larger than suggested by previous anatomical characterizations...
  55. pmc Neural circuitry underlying the regulation of conditioned fear and its relation to extinction
    Mauricio R Delgado
    Department of Psychology, Rutgers University, Newark, NJ 07102, USA
    Neuron 59:829-38. 2008
    ..These findings further suggest that humans may have developed complex cognition that can aid in regulating emotional responses while utilizing phylogenetically shared mechanisms of extinction...
  56. ncbi request reprint Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storage
    Glenn E Schafe
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 25:10010-4. 2005
    ....
  57. ncbi request reprint A robust automated method to analyze rodent motion during fear conditioning
    Charles D Kopec
    Cold Spring Harbor Laboratory, Jones Building, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuropharmacology 52:228-33. 2007
    ..This automated analysis of fear conditioning will permit a more rapid and accurate assessment of the role of LTP in memory...
  58. ncbi request reprint Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala
    Jason J Radley
    Laboratory for Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Eur J Neurosci 24:876-84. 2006
    ....
  59. ncbi request reprint Cellular and systems reconsolidation in the hippocampus
    Jacek Debiec
    Department of Psychiatry, Jagiellonian University Collegium Medicum, 31 501, Cracow, Poland
    Neuron 36:527-38. 2002
    ..Thus, hippocampal memories can undergo reconsolidation at both the cellular and systems levels...
  60. ncbi request reprint Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
    Valérie Doyère
    Neurobiologie de l Apprentissage, de la Mémoire et de la Communication NAMC, Centre National de la Recherche Scientifique CNRS, UMR8620, Universite Paris Sud, 91405 Orsay, France
    Nat Neurosci 10:414-6. 2007
    ..Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses...
  61. ncbi request reprint Associative plasticity in neurons of the lateral amygdala during auditory fear conditioning
    Hugh T Blair
    Department of Psychology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 985:485-7. 2003
  62. ncbi request reprint New vistas on amygdala networks in conditioned fear
    DENIS PARE
    Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Ave, Newark, NJ 07102, USA
    J Neurophysiol 92:1-9. 2004
    ..Thus plasticity in both LA and CE would be necessary for acquisition of conditioned fear. This revised model also accounts for inhibition of conditioned fear after extinction...
  63. ncbi request reprint Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning
    Marta A P Moita
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 37:485-97. 2003
    ..These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning...
  64. ncbi request reprint Parallels between cerebellum- and amygdala-dependent conditioning
    Javier F Medina
    Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neurobiology, University of California, 513 Parnassus Avenue, Room HSE 808, San Francisco, California 94143 0444, USA
    Nat Rev Neurosci 3:122-31. 2002
    ..So, anatomically distinct cell populations might contribute differentially to the initial encoding and the long-term storage of memory in these two systems...
  65. ncbi request reprint Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala
    Glenn E Schafe
    Department of Psychology, Yale University, 2 Hillhouse Ave, Box 208205, New Haven, CT 06520, USA
    Eur J Neurosci 22:201-11. 2005
    ..Collectively, the findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA...
  66. ncbi request reprint Putting fear in its place: remapping of hippocampal place cells during fear conditioning
    Marta A P Moita
    Instituto Gulbenkian de Sciencia, P 2780 156 Oeiras, Portugal
    J Neurosci 24:7015-23. 2004
    ....

Research Grants27

  1. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 2005
    ..Together, these studies should reveal new information about the cellular basis of fear learning, and may, in the long run, lead to better understanding of the genesis and maintenance, and hopefully the treatment, of pathological fear. ..
  2. MECHANISMS OF EMOTIONAL MEMORY
    Joseph LeDoux; Fiscal Year: 2007
    ..abstract_text> ..
  3. NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONING
    Joseph LeDoux; Fiscal Year: 2007
    ..abstract_text> ..
  4. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 2007
    ....
  5. Brain Mechanisms of Avoidance: Implications for Addiction
    Joseph E LeDoux; Fiscal Year: 2010
    ..One area that has received less attention is the role of negative reinforcement and avoidance in addiction and relapse, the main focus of this proposal. ..
  6. NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONING
    Joseph E LeDoux; Fiscal Year: 2010
    ..Such studies of Pavlovian-instrumental interactions will help elucidate anxiety disorders and hopefully lead to improved treatments of these debilitating conditions. ..
  7. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 1993
    ..The results of these experiments should begin to take our understanding of emotional learning to the level of detailed neural circuits and their synapses and could help in the understanding and treatment of emotional disorders...
  8. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph LeDoux; Fiscal Year: 2000
    ..These experiments should further our understanding of neural systems that play a role in aversive emotional memory, and in anxiety and related disorders, including posttraumatic stress syndrome and phobia. ..
  9. MECHANISMS OF EMOTIONAL MEMORY
    Joseph LeDoux; Fiscal Year: 2002
    ..Together, these studies represent an integrated, multidisciplinary research program aimed at understanding the nature of fear and will hopefully provide information that will be useful in preventing or treating fear disorders. ..
  10. SYNAPTIC TRANSMISSION IN FEAR CONDITIONING CIRCUITS
    Joseph E LeDoux; Fiscal Year: 2010
    ....