M A Lea

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 33:401-7. 2013
  2. ncbi request reprint Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 31:421-6. 2011
  3. ncbi request reprint Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Anticancer Res 30:3629-35. 2010
  4. doi request reprint Recently identified and potential targets for colon cancer treatment
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Future Oncol 6:993-1002. 2010
  5. ncbi request reprint Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 30:311-8. 2010
  6. ncbi request reprint Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 28:2067-76. 2008
  7. ncbi request reprint Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Anticancer Res 27:741-8. 2007
  8. ncbi request reprint Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Anticancer Res 24:2765-71. 2004
  9. ncbi request reprint Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Cancer Chemother Pharmacol 54:57-63. 2004
  10. ncbi request reprint Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nutr Cancer 43:90-102. 2002

Collaborators

Detail Information

Publications16

  1. pmc Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 33:401-7. 2013
    ..The drug combinations that were examined inhibited proliferation of wild-type and p53-null cells and affected colonic cancer lines with different growth rates...
  2. ncbi request reprint Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 31:421-6. 2011
    ..Combined incubation of 2-deoxyglucose with either of the biguanides prevented the acidification of the medium but enhanced the growth inhibitory effects...
  3. ncbi request reprint Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Anticancer Res 30:3629-35. 2010
    ..Our data indicated that effects of quercetin on colon cancer cell lines can be greatly affected by glycoside modification...
  4. doi request reprint Recently identified and potential targets for colon cancer treatment
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Future Oncol 6:993-1002. 2010
    ..A number of genetic changes in colorectal cancer progression have been identified and offer targets for future therapy...
  5. ncbi request reprint Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 30:311-8. 2010
    ..Several plant polyphenols can inhibit the growth of colon cancer cells but increased specific activity of some differentiation markers seen in Caco-2 cells did not appear to be a general phenomenon in colon cancer cells...
  6. ncbi request reprint Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Anticancer Res 28:2067-76. 2008
    ..It was concluded that several peach and plum phenolic molecules can influence growth and differentiation in human colon cancer cells...
  7. ncbi request reprint Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Anticancer Res 27:741-8. 2007
    ..In addition to butyrate, several HDAC inhibitors can induce differentiation in colon cancer cells and the responses may be enhanced by U0126, GW5074 and LY294002...
  8. ncbi request reprint Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Anticancer Res 24:2765-71. 2004
    ..We conclude that potential PPAR gamma antagonists may fail to reverse the growth inhibitory effect of PPAR gamma ligands and may themselves act as growth inhibitory agents...
  9. ncbi request reprint Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Cancer Chemother Pharmacol 54:57-63. 2004
    ....
  10. ncbi request reprint Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine
    Michael A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nutr Cancer 43:90-102. 2002
    ..The mechanism by which S-allylmercaptocysteine induces histone acetylation remains to be characterized. It may be related in part to metabolism to allyl mercaptan, which is a more effective inhibitor of histone deacetylase...
  11. ncbi request reprint Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide
    M A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103, USA
    Anticancer Res 21:2841-5. 2001
    ..The data suggested that compounds in garlic or their metabolites may increase the acetylation of core nucleosomal histones and thereby favor cell differentiation...
  12. ncbi request reprint Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate
    M A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Int J Cancer 92:784-9. 2001
    ..It was concluded that treatment of mouse erythroleukemia cells with allyl isothiocyanate can cause increased acetylation of histones but the mechanism for this effect requires further elucidation...
  13. ncbi request reprint Induction of histone acetylation and growth regulation in eryrthroleukemia cells by 4-phenylbutyrate and structural analogs
    M A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103, USA
    Anticancer Res 19:1971-6. 1999
    ....
  14. ncbi request reprint Induction of reporter gene expression by inhibitors of histone deacetylase
    M A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103, USA
    Anticancer Res 18:2717-22. 1998
    ....
  15. ncbi request reprint Inhibitory effects of orotate on precursor incorporation into nucleic acids
    M A Lea
    Department of Biochemistry and Molecular Biology, UMDNJ, New Jersey Medical School, Newark 07103
    Chem Biol Interact 75:49-59. 1990
    ..An inhibitory effect of orotate on DNA synthesis was further supported by an observation of decreased incorporation of [3H]deoxyadenosine into DNA and a lower rate of cellular proliferation...
  16. ncbi request reprint Exposure to a deuterated analogue of phenylbutyrate retards S-phase progression in HT-29 colon cancer cells
    Kevin O Clarke
    Department of Surgery, Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G588, Newark, New Jersey 07103, USA
    J Pharm Sci 91:1054-64. 2002
    ..Further studies are needed to elucidate the mechanisms underlying effects of D4PB on the cell cycle...