Affiliation: New York University
- Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infectionGabriel M Ortiz
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
J Virol 76:411-5. 2002..HIV-1-specific CD8+ T cells can increase in number after HAART in subjects treated early after infection who have episodes of transient viremia...
- HIV-1 and the hijacking of dendritic cells: a tug of warMarie Larsson
New York University, School of Medicine, 550 First Avenue, MSB 507, New York, NY 10016, USA
Springer Semin Immunopathol 26:309-28. 2005....
- Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virusMarie Larsson
New York University School of Medicine, New York, NY 10016, USA
J Virol 78:6151-61. 2004....
- In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infectionRachel Lubong Sabado
New York University School of Medicine, New York, New York, United States of America
PLoS ONE 4:e4256. 2009..Activation of T cell responses in lymph nodes requires cell-cell contact between T cells and DCs, which can give concurrent activation of T cells and HIV transmission...
- Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1Rachel L Sabado
Department of Medicine and Pathology, School of Medicine, New York University, NY, USA
Eur J Immunol 37:1752-63. 2007..Our study brings forth new facts regarding the binding, uptake, and processing of chemically inactivated virions leading to efficient antigen presentation and should aid in the design of more effective HIV vaccines...
- Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cellsJean Francois Fonteneau
School of Medicine, New York University, New York, NY 10016, USA
Blood 102:4448-55. 2003..Altogether, these data suggest that antigens derived from apoptotic and necrotic cells require access to the cytosol to intersect with the conventional MHC class I pathway for presentation of cytosolic proteins...
- Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunityJean Francois Fonteneau
Laboratory of Molecular Neuro Oncology, Rockefeller University, New York, NY, USA
Blood 101:3520-6. 2003..Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses...
- Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactionsAnne Sophie Beignon
New York University School of Medicine, New York, New York 10016, USA
J Clin Invest 115:3265-75. 2005....
- Evidence of dysregulation of dendritic cells in primary HIV infectionRachel Lubong Sabado
New York University, School of Medicine, Cancer Institute, New York, NY, USA
Blood 116:3839-52. 2010..Taken together, our data demonstrate that despite the reduction in circulating DC numbers, those that remain in the blood display hyperfunctionality and implicates a possible role for DCs in promoting chronic immune activation...
- Amplification of low-frequency antiviral CD8 T cell responses using autologous dendritic cellsMarie Larsson
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY, USA
AIDS 16:171-80. 2002..To utilize the potent antigen-presenting capacity of mature dendritic cells (MDC) in order to develop a rapid, sensitive method for quantifying antigen-specific CD8 T cells present at low frequency in peripheral blood...
- Interactions between dead cells and dendritic cells in the induction of antiviral CTL responsesJean Francois Fonteneau
Laboratory of Molecular Neuro Oncology, The Rockefeller University New York, New York, NY 10021, USA
Curr Opin Immunol 14:471-7. 2002..This pathway of activating T cells may be critical for the development of effective antiviral immunity in vivo...
- A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapyAndrew W Lee
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
Vaccine 20:A8-A22. 2002..While these results support the use of the MCM-mimic cocktail in clinical DC immunotherapy trials, the roles of it's individual constituents remain to be completely defined...
- DC-virus interplay: a double edged swordMarie Larsson
NYU School of Medicine, 550 First Avenue, MSB507, New York, NY 10016, USA
Semin Immunol 16:147-61. 2004..A constant "tug of war" goes on between dendritic cells and viruses and a main dendritic cell countermeasure is cross-presentation/priming...
- The role of dendritic cells in the pathogenesis of HIV-1 infectionKarin Lore
Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3022, USA
APMIS 111:776-88. 2003..In addition, we discuss the mechanisms through which HIV-1-DC interactions could be exploited to optimise the generation and maintenance of HIV-1-specific T cell immunity...
- Dendritic cell amplification of HIV type 1-specific CD8+ T cell responses in exposed, seronegative heterosexual womenBarbara L Shacklett
Gladstone Institute of Virology and Immunology, University of California San Francisco, PO Box 419100, San Francisco, CA 94110 9100, USA
AIDS Res Hum Retroviruses 18:805-15. 2002..This report also demonstrates the ability of dendritic cells to reveal T cell responses that might be overlooked by other methods...
- Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virusMarie Larsson
The Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York 10021, USA
AIDS 16:1319-29. 2002..Despite this, anti-HIV responses are generated that control viremia following acute infection...
- Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cellsJean Francois Fonteneau
Institut de Biologie, INSERM U463, Nantes, France
J Virol 78:5223-32. 2004..This HIV-1-induced maturation of both DC subsets may explain their disappearance from the blood of patients with high viral loads and may have important consequences on HIV-1 cellular transmission and HIV-1-specific T-cell responses...
- Assessment of visceral pain-related pseudo-affective responses to colorectal distension in mice by intracolonic manometric recordingsSusanne Arvidsson
Integrative Pharmacology Gastrointestinal Biology, AstraZeneca R and D Molndal, Molndal, Sweden
J Pain 7:108-18. 2006..The analgesic effect of compounds could be determined, indicating that the method can be used in pharmacologic studies...
- The dendritic cell: the immune system's adjuvant--a strategy to develop a HCV vaccine?Marie Larsson
Gastroenterology 130:603-6. 2006