Anil Lalwani

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, USA
    Ear Hear 24:342-8. 2003
  2. ncbi request reprint Biological therapy for the inner ear
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, NY 10016, USA
    Expert Opin Biol Ther 4:1811-9. 2004
  3. ncbi request reprint Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
    Anand N Mhatre
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 84:809-18. 2006
  4. ncbi request reprint Generation and characterization of mice with Myh9 deficiency
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Ave, TCH 513, New York, NY 10016, USA
    Neuromolecular Med 9:205-15. 2007
  5. ncbi request reprint Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
  6. ncbi request reprint Developments in cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:28-33. 2002
  7. pmc Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cells
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, NY 10016
    Brain Res 1197:13-22. 2008
  8. ncbi request reprint Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's disease
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Ave, U490A, San Francisco, CA 94143 0526, USA
    Hear Res 170:59-69. 2002
  9. ncbi request reprint Current issues in cochlear gene transfer
    Anil K Lalwani
    Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
    Audiol Neurootol 7:146-51. 2002
  10. ncbi request reprint Further evidence for a third deafness gene within the DFNA2 locus
    Jayne A Goldstein
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143 0526, USA
    Am J Med Genet 108:304-9. 2002

Research Grants

  1. Role of Conventional Myosin MYH9 in Hearing
    Anil Lalwani; Fiscal Year: 2006

Collaborators

  • Anand N Mhatre
  • Nicolas Gürtler
  • CHARLES YOST
  • Ch H Kindler
  • M D Seidman
  • Richard J Smith
  • Yan Li
  • Nirmal P Patel
  • Derk D Purcell
  • Jacob Johnson
  • Lawrence R Lustig
  • Derk Purcell
  • Donald E Coling
  • Nancy Fischbein
  • Pedro E Leon
  • Ryan E Stern
  • Joseph L Hegarty
  • Jayne A Goldstein
  • David R Friedmann
  • Andrew Patel
  • Nancy J Fischbein
  • Colleen Polite
  • John K Niparko
  • Doris Lin
  • Jill Chinnici
  • Jan Larky
  • Holly Venick
  • Jennifer Yeagle
  • Uma Bai
  • Kenneth C Y Yu
  • Ting Ting Huang
  • David Somand
  • Charles J Epstein
  • Bulent Satar
  • Sandy Patel
  • Robert K Jackler

Detail Information

Publications28

  1. ncbi request reprint Cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, USA
    Ear Hear 24:342-8. 2003
  2. ncbi request reprint Biological therapy for the inner ear
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, NY 10016, USA
    Expert Opin Biol Ther 4:1811-9. 2004
    ..Potential areas of interest in gene therapy and its preclinical application to deafness are reviewed, and experimental progress that has occurred in cellular therapy for the inner ear is examined...
  3. ncbi request reprint Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
    Anand N Mhatre
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 84:809-18. 2006
    ..Localization of Myh9 within the stereocilia raises the possibility that mutations of MYH9 may effect hearing loss though disruption of the stereocilia structure...
  4. ncbi request reprint Generation and characterization of mice with Myh9 deficiency
    Anand N Mhatre
    Laboratory of Molecular Genetics, Department of Otolaryngology, New York University School of Medicine, 560 First Ave, TCH 513, New York, NY 10016, USA
    Neuromolecular Med 9:205-15. 2007
    ..The results of these studies do not support the Myh9 haploinsufficiency as a pathogenic factor in the etiology of auditory dysfunction...
  5. ncbi request reprint Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear
    Anand N Mhatre
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 76:296-305. 2004
    ..Identification of Myh9 in the developing and mature inner ear suggests a role for this protein in the development and maintenance of auditory function...
  6. ncbi request reprint Developments in cochlear gene therapy
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:28-33. 2002
  7. pmc Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cells
    Anil K Lalwani
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, NY 10016
    Brain Res 1197:13-22. 2008
    ..Thus, mutant NMHC-IIa may cause hearing loss by affecting hair cell dysfunction through structural and or functional disruption of its stereocilia, plasma membrane, and/or mitochondria...
  8. ncbi request reprint Aquaporin-2 expression in the mammalian cochlea and investigation of its role in Meniere's disease
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Ave, U490A, San Francisco, CA 94143 0526, USA
    Hear Res 170:59-69. 2002
    ....
  9. ncbi request reprint Current issues in cochlear gene transfer
    Anil K Lalwani
    Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
    Audiol Neurootol 7:146-51. 2002
    ..Finally, safety issues regarding dissemination of gene transfer vectors beyond the target cochlea will need to be adequately addressed...
  10. ncbi request reprint Further evidence for a third deafness gene within the DFNA2 locus
    Jayne A Goldstein
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143 0526, USA
    Am J Med Genet 108:304-9. 2002
    ..We have investigated both identified deafness genes in affected and unaffected family members and have not found any disease-causing mutations, suggesting that another hearing impairment gene resides at the DFNA2 locus...
  11. ncbi request reprint Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4
    Anand N Mhatre
    Laboratory of Molecular Genetics, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Neurosci Res 75:25-31. 2004
    ....
  12. ncbi request reprint DFNA54, a third locus for low-frequency hearing loss
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    J Mol Med (Berl) 82:775-80. 2004
    ..Because of the differences in auditory phenotype and the absence of pathogenic mutation in the coding region of POU4F3 it is likely that there is a second gene in 5q31, designated DFNA54, associated with NSHHI...
  13. ncbi request reprint Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosides
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, USA
    Laryngoscope 115:640-4. 2005
    ..Mutation screening in this gene has been recommended before use of aminoglycosides as a preventative strategy to reduce the risk of ototoxicity...
  14. ncbi request reprint Two families with nonsyndromic low-frequency hearing loss harbor novel mutations in Wolfram syndrome gene 1
    Nicolas Gürtler
    Hals Nasen Ohren Klinik, Kantonsspital Aarau, Aarau, Switzerland
    J Mol Med (Berl) 83:553-60. 2005
    ..We confirm that most mutations in WFS1 associated with isolated low-frequency hearing loss are clustered in the C-terminal protein domain coded by exon 8...
  15. ncbi request reprint Two temporal bone computed tomography measurements increase recognition of malformations and predict sensorineural hearing loss
    Derk D Purcell
    Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
    Laryngoscope 116:1439-46. 2006
    ..The objectives of this prospective study were to assess the reproducibility of the measurements of the cochlea and lateral semicircular canal (LSCC) and to determine if abnormal measurements predict sensorineural hearing loss (SNHL)...
  16. ncbi request reprint Alternative splice variants of MYH9
    Yan Li
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    DNA Cell Biol 27:117-25. 2008
    ....
  17. ncbi request reprint Molecular pathogenesis of skull base tumors
    Nirmal P Patel
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York, USA
    Otol Neurotol 25:636-43. 2004
    ..To review contemporary molecular biological literature related to skull base tumor biology and tumorigenesis...
  18. ncbi request reprint GJB2 gene mutations in cochlear implant recipients: prevalence and impact on outcome
    Lawrence R Lustig
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, JHOC, Baltimore, MD 21287, USA
    Arch Otolaryngol Head Neck Surg 130:541-6. 2004
    ..To determine the prevalence of GJB2 gene mutations in patients undergoing cochlear implantation (CI) and their impact on rehabilitative outcome following implantation...
  19. ncbi request reprint Aquaporin 4 expression in the mammalian inner ear and its role in hearing
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue U490A, San Francisco, CA 94143 0526, USA
    Biochem Biophys Res Commun 297:987-96. 2002
    ..In the Aqp4 deficient mouse, cochlear dysfunction is suggested as the primary cause of hearing impairment in the absence of neural conduction abnormality...
  20. ncbi request reprint Auditory phenotype of DFNA1
    Pedro E Leon
    Center for Research and Molecular Biology, University of Costa Rica, San Jose, Costa Rica
    Adv Otorhinolaryngol 61:34-40. 2002
  21. ncbi request reprint Auditory phenotype of DFNA17
    Anil K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Division of Otology, Neurotology, and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, Calif, USA
    Adv Otorhinolaryngol 61:107-12. 2002
  22. ncbi request reprint Audiologic evidence for further genetic heterogeneity at DFNA2
    Ryan E Stern
    Laboratory of Molecular Otology, Epstein Laboratories and Division of Otology, Neurotology and Skull Base Surgery, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94143 0526, USA
    Acta Otolaryngol 122:730-5. 2002
    ..Therefore, this family provides clinical evidence of genetic heterogeneity at the DFNA2 locus and can serve as a model for age-related hearing loss...
  23. ncbi request reprint Establishment of normative cochlear and vestibular measurements to aid in the diagnosis of inner ear malformations
    Derk Purcell
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 94143, USA
    Otolaryngol Head Neck Surg 128:78-87. 2003
    ..We sought to establish normative measurements of the inner ear using computed tomography (CT) of the temporal bone to aid in the diagnosis of inner ear malformations...
  24. ncbi request reprint Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, CA 94143, USA
    Otol Neurotol 24:205-9. 2003
    ..Recently, mutations in MYH9, a nonmuscle myosin heavy chain, have been found in several forms of hereditary macrothrombocytopenia...
  25. ncbi request reprint Effect of SOD1 overexpression on age- and noise-related hearing loss
    Donald E Coling
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143 0526, USA
    Free Radic Biol Med 34:873-80. 2003
    ..The results indicate the complexity of oxidative metabolism in the cochlea is greater than previously hypothesized...
  26. ncbi request reprint GJB2 mutations in the Swiss hearing impaired
    Nicolas Gürtler
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, USA
    Ear Hear 24:440-7. 2003
    ....
  27. ncbi request reprint The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease
    Joseph L Hegarty
    Department of Otolaryngology Head and Neck Surgery, University of California, 400 Parnassus Avenue, San Francisco, CA 94143 0342, U S A
    Laryngoscope 112:8-17. 2002
    ..However, its value in the evaluation and diagnosis of cochlear pathology associated with sensorineural hearing loss (SNHL) has been less clear...
  28. doi request reprint MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function
    Yan Li
    Laboratory of Molecular Otology, Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    Cell Motil Cytoskeleton 65:393-405. 2008
    ..However, the results also indicate that the NMHC-IIA mutants, R702C and R705H do not inactivate or suppress the endogenous wild type NMHC-IIA within the HeLa or HEK293 cell assay system...

Research Grants5

  1. Role of Conventional Myosin MYH9 in Hearing
    Anil Lalwani; Fiscal Year: 2006
    ..In summary, the proposed research will lead to elucidation of the role of MYH9 in hearing and deafness. ..